Journal of Digestive Diseases

Publisher: Chinese Society of Gastroenterology, Wiley

Current impact factor: 1.96

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.959
2013 Impact Factor 1.924
2012 Impact Factor 1.853
2011 Impact Factor 1.589
2010 Impact Factor 1.87
2009 Impact Factor 1.791

Impact factor over time

Impact factor

Additional details

5-year impact 2.07
Cited half-life 3.40
Immediacy index 0.22
Eigenfactor 0.00
Article influence 0.51
Other titles Journal of digestive diseases (Online)
ISSN 1751-2980
OCLC 123124871
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details


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    • Publisher last contacted on 07/08/2014
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  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Early diagnosis of colorectal cancer (CRC) would bring timely treatment and lessen the mortality. DNA methylation is assumed to be an early event in tumorigenesis and has therefore been proposed as a potential marker for early cancer detection. Accumulating evidence indicated that DNA methylation markers in the stool and blood samples would provide a minimally invasive tool for CRC screening. In addition, certain genes were more likely to have hypermethylated CpG islands in metastatic CRC patients, which may serve as prognosis markers and relapse predictors. Several commercial methylation markers have been launched in the past few years, exhibiting an attractive application prospect. Here, we will review the noninvasive methylation biomarkers used in the screening of CRC systematically, discuss the advantages of methylation assays in different remote media, including blood, stool, as well as bowel lavage fluid, and make comparison with FOBT and CEA tests. Multitarget DNA assays with combination of different methylated genes, have shown the improvement in diagnostic sensitivity. It would be very meaningful to conduct multi-center, large sample studies evaluating those methylated DNA markers systematically in the future.
    Journal of Digestive Diseases 11/2015; DOI:10.1111/1751-2980.12299
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    ABSTRACT: Objective: Pancreatic duct guidewire placement (PDGP) techniques include double guidewire technique (DGT) and trans-pancreatic sphincterotomy (TPS). DGT can be switched to TPS with ease due to the existing guidewire in the pancreatic duct. We combined DGT and TPS as a single technique, named sequential PDGP, and compared the performance of this technique with needle knife precut sphincterotomy (NKPS) in cases of difficult biliary cannulation. Methods: A total of 83 patients with difficult biliary cannulation from 1645 eligible patients were enrolled in a single endoscopy center. 63 patients underwent sequential PDGP and 20 patients underwent NKPS. Cannulation success rate, cannulation time, and ERCP-related complications were compared between the two groups. All data were recorded prospectively. Results: Successful biliary cannulation was achieved in 56 of 63 (88.9%) patients in the sequential PDGP group compared with 14 of 20 (70.0%) patients in the NKPS group (P = 0.095). Cannulation time was 7.49 ± 5.03 min in the sequential PDGP group and 10.60 ± 7.24 min in the NKPS group (P = 0.086). The incidence of post-ERCP pancreatitis was 12.7% in the sequential PDGP group and 10.0% in the NKPS group (P = 1.000). There was no significant difference in the rate of other complications (bleeding, perforation, and cholangitis) between two groups. Conclusions: Sequential PDGP is a safe and effective alternative method to NKPS in cases of difficult biliary cannulation. In patients with failed standard cannulation, sequential PDGP can be considered if the guidewire is inadvertently inserted into the pancreatic duct or can be placed in the pancreatic duct without difficulty.
    Journal of Digestive Diseases 11/2015; DOI:10.1111/1751-2980.12300
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    ABSTRACT: Bronchogenic cyst is a rare benign lesion, but some lesion could transform into malignant tumor. The patients with bronchogenic cyst ofen have no clinical symptoms. Here we report a case of a 55-year-old man with bronchogenic cyst located in small omentums' sac adjacent to gastric cardia. A abdominal cavity mass of the patient was found by endoscopy, endoscopic ultrasonograph, abdominal computed tomography scan(CT). At last the mass was removed by laparoscopic surgery. Histopathology showed that it was lined by ciliated columnar epithelium; the wall contained of cartilage, glands, smooth muscle cells and mucus. So the patient was diagnosis of bronchogenic cyst.
    Journal of Digestive Diseases 10/2015; DOI:10.1111/1751-2980.12295
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    ABSTRACT: Aims: Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this monocentric, retrospective, cohort study was to report the incidence of SVT and to determinate its risk factors. Methods: All consecutive patients with pancreatitis managed in our hospital were included. The primary outcome was the occurrence of SVT and data were collected in coherence with Ranson criteria. Results: Three-hundred and eighteen patients were included, of whom 124 were women (38.9%). Biliary lithiasis was the main cause of pancreatitis (n = 156, 49%). A total of 19 SVT were identified (6%). In univariate analysis, alcohol, smoking and male gender were associated with SVT (respectively p = 0.007, p = 0.005, p = 0.003). Biological parameters significantly associated with thrombosis were lactate dehydrogenase < 500 UI/L and glycemia ≥ 10 mmol/L (respectively p = 0.009 and p = 0.016). In multivariate analysis, Quick prothrombin time > 75% was a protective factor against thrombosis (OR = 0.178; p = 0.024). Leukocytes ≥10 G/L (OR = 6; p = 0.032), Glycemia ≥10 mmol/L (OR = 6; p = 0.018), lactate dehydrogenase < 500 UI/L (OR = 13; p = 0.002) and alcoholic etiology (OR = 16;p =0.003) were risk factors for thrombosis. Conclusions: Alcoholism associated with malevgender and smoking should focus the physician's attention on the risk of SVT. When further associated with certain biological parameters, the physician should propose therapeutic anticoagulation to prevent SVT.
    Journal of Digestive Diseases 10/2015; DOI:10.1111/1751-2980.12298
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    ABSTRACT: Aim: Genome-wide association studies identified single-nucleotide polymorphisms in genes that might influence intestinal barrier function (HNF4A, ECM1, CDH1 and LAMB1) to increase the risk for ulcerative colitis (UC). The aim of our study was to detect causative sequence alterations and provide a functional link to a disturbed intestinal permeability in UC. Methods: First, 19 UC patients with increased intestinal permeability (IP, lactulose/mannitol ratio measured by sugar drink test) were identified from a large database, and exon/intron boundaries, coding and promoter regions of HNF4A, ECM1, CDH1 and LAMB1 were sequenced. Variants with putative protein alterations were studied for an association to IP in 82 UC patients. A case-control analysis including a genotype phenotype correlation was performed in 743 patients with inflammatory bowel disease (IBD), and 473 controls. Results: In UC patients, we identified 11 missense-mutations, 12 synonymous mutations, one in the putative ECM1 promoter region, and three mutations in between the exon-intron boundaries (CDH1, HNF4A). For several variants prediction tools revealed damaging protein alterations. None of the studied variants, however, showed an association to an increased IP in UC. In the case-control analysis, the frequency of all investigated variants did not differ between UC, Crohn`s disease, and controls. Furthermore no significant association was found to a distinct phenotype. Conclusions: Despite our large sequencing approach, we could not identify protein altering variants in the genes HNF4A, ECM1, CDH1 and LAMB1 which could explain an impaired intestinal barrier function in UC. The functional relevance of these genes in IBD remains unknown.
    Journal of Digestive Diseases 10/2015; DOI:10.1111/1751-2980.12296
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    ABSTRACT: BACKGROUND Rifaximin therapy could improve gut-derived endotoxin in patients with liver cirrhosis. However, the experience of long-term rifaximin administration in Chinese population is limited.AIMTo evaluate the efficacy, safety and tolerability of different doses of rifaximin in Chinese patients with hepatic cirrhosis.METHODS The random open prospective study included a 2-week treatment period and the next 4-week observation phase. Patients with liver cirrhosis were randomly assigned to low-dose rifaximin group, high-dose rifaximin group, and control group in a 1:1:1 ratio. Patients in low-dose and high-dose rifaximin group received 400 mg, 600 mg rifaximin two times a day for two weeks, respectively. All the other therapeutic strategies remained unchanged in the three groups as far as possible.RESULTSSixty patients with liver cirrhosis were screened and 43 met the eligibility. After 2 weeks treatment, the serum level of endotoxin in low-dose rifaximin group (1.1 ± 0.8EU/ml) and high-dose rifaximin group (1.0 ± 0.8EU/ml) was significantly lower than that in control group (2.5 ± 1.8EU/ml), while no difference was shown between the two rifaximin treatment groups. The effect of high-dose rifaximin on endotoxemia could lasted to at least 4 weeks after drug withdrawal. A significant reduction in the abundance of the taxa Veillonellaceae and increase in the abundance of Bacteroides were shown after two weeks rifaximin therapy. The incidence of adverse events and serious adverse events was similar in the three groups.CONCLUSIONS Our findings indicated low-dose (800 mg/d) rifaximin could be analogous to high-dose (1200 mg/d) rifaximin to reduce the serum endotoxin level after two-weeks treatment. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 10/2015; DOI:10.1111/1751-2980.12294
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    ABSTRACT: Background and aim: Understanding issues pertaining to quality of life is essential for any disease, particularly in liver transplantation recipients. The aim: Of this study was to evaluate the impact of liver transplantation on the Quality of life in Egyptian recipients METHODS: Prospective study carried out in Ain Shams Center for Organ Transplantation, Cairo, Egypt. It included 35 recipients evaluated for health related quality of life using Short Form 36 score (arabic version) and Beck Depression Inventory scores pre-transplantation 1, 3and 6 months after. Results: The mean age for the patients was 49.27 ± 8.16.Seventeen patients were highly educated.Our results showed statistically significant improvement in all dimensions of health related quality of life after liver transplantation. Physical functioning was 45.00 ± 34.34 before liver transplantation while one month and six months after liver transplantation it was 57.50 ± 20.66 and 74.83 ± 19.27 respectively (p > 0.001). Seventeen patients completed their first year after transplantation, the results showed statistically significant improvement in all dimensions of Health related quality of life one year after liver transplantation except in the mental health, role emotional and social function domains. Conclusion: Health related quality of life is important aspect of liver transplantation procedure that shouldn't be neglected. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 10/2015; DOI:10.1111/1751-2980.12293
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    ABSTRACT: Aim: Small fundic submucosal tumors originating from the muscularis propria impose great difficulty on conventional therapies. We aim to evaluate endoscopic cap-aspiration lumpectomy as a new and simple full-thickness resection. Methods: Patients with small fundic submucosal tumors were included. Cap-aspiration lumpectomy was performed by suctioning the submucosal tumors into a transparent cap, which was ligated by a metal snare and resected. The wall deficit was closed using endoclips. Results: The study enrolled 28 patients. The mean total operation time was 23.9 minutes. The procedure resulted in 20/28 (71.4%) active perforations. Endoclips closed the wall defect in all 20 cases. Cap-aspiration lumpectomy achieved 28/28(100%) en bloc resection rate. Pneumoperitoneum developed in one patient and self-limited peritonitis developed in 2 patients, which were all managed successfully. Gastrointestinal stromal tumors were found in 20/28 (71.4%) resected tumors. No recurrence was found during follow-up. Conclusions: Cap-aspiration lumpectomy may be a simple, feasible and safe full-thickness resection for small submucosal tumors arising in the muscularis propria at the gastric fundus. Further randomized studies are needed. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 10/2015; DOI:10.1111/1751-2980.12292
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    ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide with a reported prevalence ranging from 6-33%, depending on the studied population. It encompasses a spectrum of liver manifestations ranging from simple steatosis (also known as nonalcoholic fatty liver, NAFL) to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, which may ultimately progress to hepatocellular carcinoma. NAFLD is strongly associated with components of the metabolic syndrome, mainly obesity and type 2 diabetes mellitus. NAFLD patients are at increased risk of liver-related as well as cardiovascular mortality. Current paradigm suggests a benign course for NAFL whereas NASH is considered to be the progressive phenotype. Although previously under-recognized accumulating evidence suggests that NAFL may also progress, suggesting a higher number of patients at risk than previously appreciated. Liver-biopsy remains the gold standard for definitive diagnosis, but the majority of patients can be diagnosed accurately by noninvasive methods. Approved therapies for NAFLD are still lacking and lifestyle modifications aiming at weight-loss remain the mainstay of NAFLD treatment. Intensive research could identify insulin resistance, lipotoxicity and dysbiosis of the gut microbiota as major pathophysiological mechanisms, leading to the development of promising targeted therapies which are currently investigated in clinical trials. In this review we summarize the current knowledge of NAFLD epidemiology, natural history, diagnosis, pathogenesis, and treatment and consider future directions. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 09/2015; DOI:10.1111/1751-2980.12291
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    ABSTRACT: Objective: The patients who take drugs regularly are increasing, not least due to the prevalence of metabolic and orthopedic diseases. The effects of the use of these drugs on colorectal neoplasms remain unclear, except the preventive effects of non-steroidal anti-inflammatory drugs and low-dose aspirin. Methods: In total, 1318 consecutive patients who underwent total colonoscopy for the first time in their life were cross-sectionally analysed. Personal data including comorbidities and all medications were obtained by questionnaire. Blood pressure, body weight, and waist circumference were measured just before colonoscopic examination. Results: Colorectal polyps were found in 577 (43.8%) subjects. The prevalence of colorectal polyps was 57.6% (296/514) in patients receiving hypertension treatment and 35.0% (281/804) in patients without such treatment. A multivariate analysis showed that age, waist circumference, drinking, smoking, and antihypertensive drug use were independent risk factors for colorectal polyps. In a secondary multivariate analysis incorporating the parameters of measured blood pressure and medication status, the number of antihypertensive drugs was strongly associated with the risk of colorectal polyps, whereas blood pressure showed no significant association. Conclusions: Antihypertensive drug use may be a risk factor for colorectal polyps. Furthermore, this risk increases with the intensive use of antihypertensive drugs.
    Journal of Digestive Diseases 09/2015; DOI:10.1111/1751-2980.12289
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    ABSTRACT: To explore the influence of tagging single nucleotide polymorphisms (tagSNPs) at adiponectin gene in the natural course of nonalcoholic fatty liver diseases (NAFLD). The subjects were chosen from our previous survey, which has been published. Totally, 696 people were included. The cohort was followed-up for 3.6-4.8 years (median 4 years). Each subject received interview, physical examination, blood tests and ultrasonic examination at baseline and endpoint. PCR-RFLP was applied to determine seven tagSNPs at adiponectin gene i.e. rs182052, rs16861205, rs822396, rs7627128, rs1501299, rs2241767, rs3774261. Ordinal logistic regression was used to screen risk factors of NAFLD progression as well as susceptibility. Haplotypes analysis was performed to confirm the results. After adjusting age and gender, rs1501299 (G276T), rs2241767 (A45G) and rs3774261 (A712G) were found to be risk factors of both susceptibility (OR: 5.04, 7.47, 3.55 respectively) and progression (OR: 1.73, 3.83, 1.89 respectively) to NAFLD. Nevertheless, rs182052, rs16861205, rs822396 and rs7627128 had no impact on both of them. These findings were confirmed by haplotype analysis. The tagSNPs rs2241767, rs1501299, rs3774261 at adiponectin gene were risk factors NAFLD initiation and progression. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 09/2015; DOI:10.1111/1751-2980.12288
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    ABSTRACT: Achalasia as the primary manifestation of acquired immunodeficiency disease (AIDS) is very rare. There are isolated case reports of AIDS patients presenting with dysphagia symptoms caused by opportunistic infections, such as such as candida, cytomegalovirus, or herpes simplex virus. Here we reported a case of patient with AIDS, who was diagnosed as achalasia by high resolution impedance manometry and recovered only by the combination of antiretroviral and anti-TB therapy. The findings in this patient suggest that HIV may cause achalasia through both neurotrophic effect and opportunistic infection infectious agents. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 09/2015; DOI:10.1111/1751-2980.12287
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    ABSTRACT: To investigate the association between inflammatory bowel disease (IBD) and Gallstone disease (GD) by performing a meta-analysis. PubMed, Medline, Embase, Web of Science, and the Cochrane Library were searched for relevant articles published between January 1980 and February 2015. All statistical analyses were performed using STATA 12.0 software. A fixed-effects model was adopted; heterogeneity was evaluated by chi-square test and I(2) statistic; publication bias was assessed by Begg's and Egger's tests. Five studies qualified for inclusion in the meta-analysis. Patients with IBD had a significantly higher prevalence of GD when compared with subjects in the control group (Odds Ratio [OR] 1.73, 95% Confidence Interval [CI]: 1.40-2.12, P < 0.0001). Subgroup analyses showed a significantly higher prevalence of GD in patients with Crohn's disease (CD) (OR 2.05, 95% CI: 1.61-2.63, P ˂ 0.0001]. However, no significant difference in prevalence of gallstone disease was observed between patients with ulcerative colitis (UC) and controls (OR 1.12, 95% CI: 0.75-1.68, P = 0.585). Studies from Italy, Sweden and U.K revealed a higher prevalence of GD in patients with IBD. No heterogeneity (I(2) = 25.2%, P = 0.228) or publication bias was observed in our meta-analysis (Begg's test, P = 0.711; Egger's test, P = 0.805). Our meta-analysis suggests a trend of higher prevalence of GD in IBD patients, and especially in patients with CD. More rigorous, large scale multi-center studies are required to investigate the association between GD and IBD. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 09/2015; DOI:10.1111/1751-2980.12286
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    ABSTRACT: Autoimmune hepatitis (AIH) is a complex multifactorial liver disease with unknown etiology. It may be induced by certain triggers that cause immune disorders and autoimmune attack in genetically susceptible individuals, which ultimately results in chronic persistent interface inflammation of the liver. The diagnosis of AIH is made based on comprehensive evaluation score system. All AIH patients should receive interventions and the mainstay therapy is prednisone alone or in combination with azathioprine. Further exploratory researches on refractory AIH have been developed. Liver transplantation is still the only effective option for patients with decompensated cirrhosis or hepatic failure.
    Journal of Digestive Diseases 08/2015; 16(9). DOI:10.1111/1751-2980.12285
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    ABSTRACT: Endoscopic resection of a foregut neuroendocrine tumor (NET) is increasingly performed instead of surgery. This study aimed to verify the long-term therapeutic results of endoscopic resection (ER) and surgical resection (SR) in foregut NETs. From 2002 to 2012, a total of 49 patients were confirmed histologically as foregut NETs treated by ER (stomach = 19, duodenum = 14) and SR (stomach = 11, duodenum = 5). The clinicopathological characteristics and therapeutic outcomes were evaluated. Of the 33 patients who underwent ER (endoscopic mucosal resection = 26, endoscopic mucosal dissection = 7), 32 cases were diagnosed as type NET-G1 and one case as neuroendocrine carcinoma (NEC). Of the 16 patients who underwent SR, 10 were diagnosed as NET-G1, two as NET-G2 and four as NEC. The median tumor size was significantly smaller in ER than SR patients (0.7 cm vs. 1.9 cm, p = 0.001). In almost all ER patients (32/33 cases), NET invasion was limited to mucosa and submucosa. Non-curative resections were achieved in eight ER patients (8/33, 24.2%) and in four SR patients (4/16, 25%). No recurrence occurred in seven NET cases defined as non-curative resection with positive resection margins by ER; however, all cases of non-curative resection with lymphatic invasion (ER = 1, SR = 4) experienced recurrence during the follow up period despite complete resections. They were all NEC histologically. ER may have a good prognosis if the tumor size is small and histologically low-grade without lymphatic invasion. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 08/2015; DOI:10.1111/1751-2980.12279
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    ABSTRACT: There is a considerable high prevalence of vitamin D deficiency, which is defined by the serum level of 25-hydroxyvitamin D [25(OH)D] lower than 20 ng/ml, in all populations of the world. Unfortunately, the prevalence of vitamin D deficiency in patients with intestinal malabsorption syndromes, including cystic fibrosis (CF), celiac disease (CD), short bowel syndrome, and inflammatory bowel disease (IBD), is higher than that in the general population, indicating the presence of disease-specific causative factors. In this review, we aim to present clinical findings to highlight the roles of insufficient sunlight exposure and inflammation in the development of vitamin D deficiency in patients with intestinal malabsorption syndromes. Also, we aim to present experimental evidence that supports a role of vitamin D deficiency in the pathogenesis of IBD. Finally, we review clinical intervention strategies that aim to normalize vitamin D status in and/or even improve the conditions of patients and discuss certain issues that need to be addressed in future research. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 08/2015; DOI:10.1111/1751-2980.12283
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    ABSTRACT: Research on inflammatory bowel disease (IBD) highlighted genes involved in the regulation of inflammatory responses as contributors to disease pathogenesis. Objective of this study was to evaluate associations between IBD and variations in NOD2, TLR4, TNF-α, IL-6, IL-1β, IL-1RN genes, and to use obtained genetic data in predictive modeling. We genotyped 167 IBD patients and 101 healthy donors by PCR-RFLP procedure. Using attained genotype data as input to various classification algorithms, we designed IBD prediction models. Area under the receiver operating curve (AUC) was used as measure of their performance. Significant associations were found between Crohn's disease (CD) and NOD2 minor variants, as well as TLR4 299Gly, TNF-α -308A, IL-6 -174C and IL-1RN VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN VNTR A2. CD and UC showed highly significant difference in allelic distribution of TNF-α G-308A, where A allele was found to be related to CD, and G allele to UC occurrence. Among CD patients, combined effect of gender and TLR4 variants was observed. When all analyzed genotype and gender data were used, prediction performance achieved maximum AUC of 0.69 for CD and 0.60 for UC dataset. These results showed that variations in genes involved in immune regulation are genetic factors of importance in IBD susceptibility that can be used as predictors of disease development. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 08/2015; DOI:10.1111/1751-2980.12281
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    ABSTRACT: The aim of this study was to evaluate the efficacy of esophageal self-expanding metal stent (E-SEMS) insertion for malignant esophageal obstruction (MEO) in patients with or without additional palliative treatments. We retrospectively reviewed the medical records of the patients with E-SEMS for MEO at Seoul National University Hospital. Baseline characteristics, changes of Mellow-Pinkas score about dysphagia, and complications were compared between two groups. A total of 236 E-SEMS were inserted to 192 patients (esophageal cancer 46.4%, gastric cardia cancer 33.3%, lung cancer 15.1%). Mellow-Pinkas score significantly decreased in 1 week (1.66 ± 0.79, P = 0.000) and 1 month (1.71 ± 0.87, P = 0.000) after the insertion of E-SEMS (3.09 ± 0.79). Complications occurred in 54 cases (22.9%); 28 stent obstruction (11.9%), 5 perforation (2.1%), 10 stent migration (4.2%), 5 tracheoesophageal fistula (2.1%), no procedure-related death (0.0%). Most complications were managed with insertion of additional SEMS (74.1%). The risk of stent obstruction was significantly higher in uncovered SEMS than covered (OR 4.31, 95%CI 1.75-4.52, P = 0.001). Mean interval to the development of complication was 74.8 ± 111.1 days. Overall survival (169.0 ± 127.8 days vs. 96.4 ± 90.6 days, P = 0.000) and stent patency (143.3 ± 123.9 days vs. 67.6 ± 71.3 days, P = 0.000) were significantly favorable in the patients with E-SEMS and additional palliative treatments than E-SEMS alone. E-SEMS insertion could be effective and safe for MEO, and the additional palliative treatment might lengthen stent patency by extension of survival. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 08/2015; DOI:10.1111/1751-2980.12280