Journal of Digestive Diseases

Publisher: Chinese Society of Gastroenterology, Wiley

Journal description

Current impact factor: 1.92

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.924
2012 Impact Factor 1.853
2011 Impact Factor 1.589
2010 Impact Factor 1.87
2009 Impact Factor 1.791

Impact factor over time

Impact factor
Year

Additional details

5-year impact 1.81
Cited half-life 2.80
Immediacy index 0.28
Eigenfactor 0.00
Article influence 0.49
Other titles Journal of digestive diseases (Online)
ISSN 1751-2980
OCLC 123124871
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Wiley

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    • Publisher last contacted on 07/08/2014
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  • Classification
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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: With an increased use of endoscopic retrograde cholangiopancreatography (ERCP), risk factors for complication of cholangiopancreatography procedure has been focused in previous studies. We aimed to identify independent risk factors of post-ERCP pancreatitis and hyperamylasemia by multivariate analysis, and develop a simple scoring system according to risk factors contributing to clinical prevention of post-ERCP pancreatitis. A retrospective single-center analysis was undertaken in 4,234 ERCP procedures between September 2007 and December 2012. Patient- and procedure-related risk factors for PEP and hyperamylasemia were identified by univariate and multivariate regression analyses. A scoring system was developed based on the independent risk factors. Pancreatitis occurred after 226 ERCP procedures (5.3%) and hyperamylasemia after 774 procedures (18.3%). Female gender [odds ratio (OR), 1.449], first-time ERCP (OR, 1.745), no jaundice (OR, 1.917), difficult cannulation (OR, 3.317) and pancreatography (OR, 1.823) all proved to be significant predictive risk factors for PEP. In addition to the similar factors, difficult cannulation (OR, 1.990) and pancreatography (OR, 2.009), age < 60 years (OR, 1.2), prior diabetes (OR, 0.614), biliary duct stent placement (OR, 1.884) and nasobiliary drainage (OR, 1.613) were associated with development of hyperamylasemia. Prophylactic pancreatic duct stent (PS) might prevent the development of PEP of patients in very high-risk group (score ≥ 6). This study emphasizes the role of patient- and procedure-related risk factors as the determining predictors for PEP and hyperamylasemia. Technical procedures, for example, PS, are necessary to prevent PEP in highest-risk patients. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12258
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    ABSTRACT: Thermal ablative therapies continue to acquire favor to be safe and effective for the treatment of patients with non resectable hepatocellular carcinoma. Percutaneous microwave ablative therapy which is a relatively new technique has the advantage in providing faster ablation of larger tumors. This study aimed to evaluate microwave ablation in treatment of large HCCs (5-7cm) and to assess its effect on local tumor progression, prognostic outcome and patient's survival. Twenty six patients with HCC lesions (5-7cm) were managed in our multidisciplinary clinic of Kasr Al Ainy University hospital using microwave ablation. It was performed with the patient under conscious sedation and analgesia, ultrasonography guided using HS AMICA microwave machine, operating at frequency of 2450 MHz and a power up to 100 W. Multiple needle insertions in one or two sessions according to the size of the lesion. Patients were assessed for efficacy and safety. Complete ablation rate, local tumor progression and overall survival analysis were evaluated. Complete ablation was achieved in (19/ 26; 73.1%) of the lesions. Local tumor progression was recorded in 5 treated lesions (19.2%). Distant tumor progression within the liver was recorded in 6 patients (23.1%), with a mean survival of 21.5 months. No major complications or deaths related to the procedure. Microwave ablation by percutaneous approach is safe and effective in the treatment of large HCC tumor. The survival and local tumor control were acceptable. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12259
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    ABSTRACT: To investigate the influence of posture on the anatomy and function of esophageal sphincters using solid-state high-resolution manometry. Fifty subjects (24 volunteers and 26 gastroesophageal reflux disease patients) were recruited for this study. The subjects underwent esophageal manometry with a 36-channel solid-state catheter in the supine and upright positions. The length and pressure of the esophageal sphincters, as well as the esophageal and intra-abdominal lengths of the lower esophageal sphincter (LES), were investigated. The residual pressure of the upper esophageal sphincter (UES) and the 4-s integrated relaxation pressure were also measured as the patients swallowed 10 consecutive servings of water (5 ml each). The Bland-Altman method was used to assess agreement between these parameters in the supine and upright positions. The LES resting pressure was significantly decreased in the upright position compared with the supine position (13.85 ± 5.90 mmHg vs. 18.09 ± 7.80 mmHg, P=0.000). Weaker integrated relaxation pressures were observed when the patients were in the upright position (5.66 ± 3.33 mmHg vs. 7.80 ± 3.25 mmHg, P=0.000). Compared with the supine position, the upright esophageal length was longer (P=0.004) and the upper border of the LES was lower when the subjects were in the upright position (P=0.050). The agreement between the two positions was acceptable for the esophageal length, LES upper border location and LES pressure measurements. Body position exerts a greater influence on the LES than on the UES. Thus, it is necessary to establish normal values for the LES basal pressure and residual pressure in different positions. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12256
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    ABSTRACT: Patients with inflammatory bowel disease (IBD) are at risk for opportunistic infections secondary to immunosuppressive therapies. Respiratory infections, in particular, are a leading cause of death in IBD patients. Here we present a case of Pneumocystis Carinii pneumonia (PCP) in a patient with Crohn's disease status-post ileostomy and parastomal pyoderma gangrenosum on adalimumab, prednisone, and methotrexate. Her hospital course was complicated by recurrent pneumothorax post-bronchoscopy requiring chemical pleurodesis with doxycycline. Although the initial pneumothorax was not spontaneous, we expect that the PCP contributed to its reoccurrence and need for pleurodesis. To our knowledge, this is the first case of PCP infection requiring pleurodesis in a non-HIV patient. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12257
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    ABSTRACT: Background The aim of this study was to evaluate the safety and efficacy of the intramuscular injection of either mitomycin C or dexamethasone in association with an endoscopic dilation for benign esophageal strictures after esophageal surgery or ESD (Endoscopic Submucosal Dissection).Methods Patients with benign esophageal strictures were retrospectively analyzed in this study. These patients were divided into 3 groups, including the mitomycin C group (mitomycin C injections in association with an endoscopic dilation), the dexamethasone group (dexamethasone injections and dilation) and the dilation group (saline injections and dilation). The patients’ characteristics, locations of the lesion, number of previous dilations, diameters after dilation, dysphagia grades before and after the procedure and follow-ups were compared.ResultsA total of 74 patients were enrolled in this retrospective case control study, 25 in the mitomycin C group, 25 in the dexamethasone group and 24 in the dilation group. The mean dysphagia-free period was 4.88±1.66 months in the mitomycin C group, 4.02±1.77 months in the dexamethasone group, and 2.41±1.26 months in the dilation group (P<0.05). There were no significant differences in the three groups for the other indices.Conclusion The intramuscular injection of either mitomycin C or dexamethasone may prolong the dysphagia-free period and decrease the frequency of repeat dilations compared with conventional endoscopic dilations in patients with benign esophageal strictures. Mitomycin C may have predominant advantages compared with the other two methods.
    Journal of Digestive Diseases 05/2015; 81(5). DOI:10.1111/1751-2980.12255
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    ABSTRACT: AimAn effect of the H. pylori eradication on the expression level of the FHIT gene and its methylation status was analyzed in gastric mucosa of patients with and without a family history of gastric cancer (FHGC).Methods The 31 patients (13 with the FHGC) were enrolled to the studies. The presence of H. pylori as well as the effectiveness of eradication were confirmed by the UBT, RUT and multiplex PCR (the presence of selected H. pylori strains) for samples from the antrum and corpus. Histopathological assessments were done with hematoxylin-eosin and Giemsa staining. The level of FHIT mRNA was determined by qRT-PCR and the methylation status of the FHIT promoter was assessed in MSP.ResultsAfter H. pylori eradication, regression of inflammation from superficial gastritis to normal mucosa (GN) was observed in 42% of the control patients and in 54% of patients of the FHGC group. The level of FHIT mRNA increased for samples (both, the antrum and corpus) of control patients (p < 0.05), while the gene methylation status remained unchanged (p > 0.05). For the samples of the FHGC patients, the FHIT mRNA level was not changed and the methylation status evenly fluctuated.Conclusions From the clinical point of view, eradication of bacteria, besides reduction of inflammation and regression of histopathological non-atrophic changes, results also in elevation of expression of the FHIT tumor suppressor gene in FHGC negative patients and, thus, may contribute to the prevention of gastric cancer development in these patients.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12252
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    ABSTRACT: OBJECTIVE Endoscopic submucosal dissection (ESD) is nowadays commonly performed as a treatment for gastric tumor. However, the sedation with midazolam (MDZ) often did not reach a satisfactory sedation during the procedure and the drug could suppress respiration and blood pressure also. The aim was to investigate the safety and efficacy of dexmedetomidine with on-demand MDZ (DEX group) in comparison with MDZ alone (MDZ group) as a sedative during an ESD of gastric tumor.METHODS Eighty patients undergoing ESD of gastric tumor were randomly assigned to one of two treatment regimens (40 patients of each). We investigated the depth of sedation by using a MOAA/S score (Modified Observers Assessment alertness/sedation), the number of patient's reactions interfering with the proper procedure, sedation related-adverse events, and the satisfaction degree of the patients and doctors.RESULTSEighty patients were randomly assigned to one of two treatment regimens (40 patients of each). There was no statistically significant difference between the two groups regarding age, sex, body mass index, ASA classification, and tumor characteristics. Appropriate sedation rate and the satisfaction degree of the doctors were significantly high in the DEX group. There were more actions of patients interfering with the proper procedure in the MDZ group than in the DEX group. There was no difference in the adverse events between the two groups.CONCLUSIONSDEX with on-demand MDZ for the sedation during gastric ESD is as safe as MDZ alone and the sedation effect of DEX with MDZ is superior to that of MDZ alone.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12254
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    ABSTRACT: PurposeTo quantify the expression of Smad7 and Smad ubiquitin regulatory factor 2 (Smurf2) in the pancreas in Rats of chronic pancreatitis (CP).Methods Sixteen male Wistar rats were randomized dividing into control group and CP group (8/group). CP was induced in rats in vivo by dibutyltin dichloride (DBTC). Four weeks after DBTC administration, histological assessment, masson staining, and measurement of hydroxyproline content in the pancreatic tissues were determined to estimate the inflammation and fibrosis of pancreas. Immunohistochemisty and real-time reverse transcription polymerase chain reaction (RT-PCR) for transforming growth factor-β1 (TGF-β1) and α-smooth muscle actin (α-SMA) were applied to assess activated pancreatic stellate cells (PSCs) and TGF-β1 expressions. Smad7 and Smurf2 expressions in the pancreas were measured using Western blotting and real-time RT-PCR.ResultsDBTC induced typical histopathological characteristics of CP in the model rats with extensive activated PSCs. Comparing to the control group, the expressions of TGF-β1, α-SMA and the content of hydroxyproline in pancreatic tissues in the CP group were significantly raised. Meanwhile, the expression levels of Smad7 mRNAs, Smurf2 mRNAs and proteins were significant increased in fibrotic pancreas, in which, the expressions of Smad7 proteins showed an obviously reduction compared with controls.Conclusion Dysregulation of Smad7 and Smurf2 may associate with the pathogenesis of pancreatic fibrosis through TGF-β signaling pathway.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12253
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    ABSTRACT: Gastric cancer is the fifth most commonly diagnosed cancer in the world and the third leading cause of cancer-related deaths. The prognosis of gastric cancer is obviously associated with the tumor stage, the 5-year overall survival rates for early gastric cancer exceeding 90%, significantly higher than that of advanced gastric cancer. Endoscopic resection, including endoscopic mucosal resection and endoscopic submucosal dissection, has been adopted as the first treatment option of early gastric cancer in many countries for its minimal invasion and high curative ratio in recent decades. However, the horizontal margin and vertical margin are related to the curative resection of early gastric cancer and the prognosis of patients, thus accurate prediction of tumor boundary and invasive depth before treatment counts for much in planning the most appropriate treatment strategy and promising curative resection. To date, various endoscopic techniques have played role in pretreatment evaluation, such as white-light endoscopy, chromoendoscopy, narrow band imaging and endoscopic ultrasonography. This paper aims to summarize the diagnostic methods, applications and limitations of these different endoscopic techniques for tumor horizontal and vertical margins in early gastric cancer, helping increase preoperative evaluating capabilities and improve the curative resective rate of early gastric cancer. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 04/2015; DOI:10.1111/1751-2980.12251
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    ABSTRACT: To determine whether computer-predicted short RNA structural analogs could inhibit Hepatitis C virus (HCV) genotype 2a, 3a and 4a replication in cultured cells. Short RNA sequences, X12, X12a and X12b, designed to be identical in secondary structure to the X-region in the 3'-untranslated region (3'-UTR) of the HCV 1b genome, as well as shorter stem-loop components of the X-region were inserted into a plasmid, and transfected into separate Huh 7.5 human hepatoma cells stably transfected with subgenomic replicons for genotypes 2a, 3a, and 4a. All replicons included a firefly luciferase reporter gene. Forty-eight hours after plasmid transfection, inhibition of HCV replication was determined by HCV RNA isolation and quantification by real-time polymerase chain reaction, and luciferase assays. All the secondary structural analogs to genotype 1b X-region cross-inhibited genotype 2a, 3a, and 4a replicons. Maximum inhibition by genotype 1b X-region structural analogs were obtained against genotype 2a cells in which X12, X12a and X12b inhibited replication by 30%, 63% and 72%, respectively (P<0.05, for all), compared to an unrelated hepatitis B (HB) viral analog. Despite substantial sequence dissimilarity, HCV RNA genotype 1b X-region analogs cross-inhibited replication of HCV genotypes 2a, 3a, and 4a. Particular conformations and not the sequence of the stem-loops of the X-region are involved in HCV replication. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 04/2015; DOI:10.1111/1751-2980.12250
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    ABSTRACT: To observe the effects of quercetin on chronic mixed reflux esophagitis (RE) in rats (Rattus norvegicus) by inhibiting the nuclear factor κB p65 (NF-κBp65) and interleukin-8 (IL-8) signaling pathway. Forty-eight male, healthy Sprague Dawley rats were randomly divided into six groups of eight rats each: normal intact group, sham operation group, reflux esophagitis model group, omeprazole reflux esophagitis group, 100 mg/kg quercetin reflux esophagitis group, and 200 mg/kg quercetin reflux esophagitis group. The animals were sacrificed after six weeks of treatment. The gross and microscopic scores of esophageal mucosal injury were observed according to diagnostic criteria, and the production of NF-κBp65 and IL-8 was assessed by immunohistochemistry and real-time PCR. Compared with the reflux esophagitis model group, the gross and microscopic scores of esophageal mucosal injury and the NF-κBp65 and IL-8 productions in those of the normal intact group, the sham operation group, the omeprazole reflux esophagitis group, 100 mg/kg quercetin reflux esophagitis group and the 200 mg/kg quercetin reflux esophagitis group were significantly decreased (p<0.05). Compared with the omeprazole group, the gross and microscopic scores of esophageal mucosal injury and the NF-κBp65 and IL-8 productions in those of 100 mg/kg quercetin and 200 mg/kg quercetin reflux esophagitis groups did not increase (p>0.05). There were no statistically significant difference between the 100 mg/kg quercetin reflux esophagitis group and the 200 mg/kg quercetin reflux esophagitis group (p>0.05). Quercetin could prevent esophageal mucosal injury in reflux esophagitis rats by suppressing the NF-κBp65 and IL- 8 signaling pathway. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 04/2015; DOI:10.1111/1751-2980.12249
  • Journal of Digestive Diseases 04/2015; DOI:10.1111/1751-2980.12248
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    ABSTRACT: Healthy women at reproductive age experience a cyclical alteration of gastrointestinal (GI) symptomatology during the menstrual cycle. Additionally, the majority of healthy women also complain of worsening of GI symptoms either during the premenstrual or menstrual phase. Despite conflicting evidence, studies suggest that sex hormones may increase GI transit time during the luteal phase. Similar phenomenon is also observed in women with underlying inflammatory bowel disease (IBD). The mechanism underlying this complex pathophysiology is still not completely understood. However, a possible influence of sex hormones on the brain-gut-microbiota axis is hypothesized. The diagnosis of IBD is associated with a delay in menarche as well as menstrual function irregularities including alterations in cycle length and duration of flow. There are little data on the effect of menopause on IBD disease activity and there were conflicting data on the effect of IBD diagnosis on the onset of menopause. The role of contraceptives and hormone replacement therapies on the development or disease activity of IBD has not been established. Moreover, IBD patients with concomitant dysmenorrhea report heightened pain during menses. The effect of non-steroidal anti-inflammatory drugs in treating primary dysmenorrhea on the disease course of IBD is unclear. In addition, the effect of IBD medications including immunomodulators and biologics on menstrual function remains unclear. Also, the role of IBD surgery on menstrual irregularities needs to be fully elucidated. Hence, the understanding the influence of menstrual function on IBD disease activity and vice versa and maintenance of a normal menstrual function in those patients is important in improving overall reproductive health and fertility. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 04/2015; DOI:10.1111/1751-2980.12247
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    ABSTRACT: To compare the effects of endoscopic balloon dilation and metal stent placement on achalasia treatment. We retrospectively studied a total of 88 patients with newly diagnosed achalasia between July 2001 and December 2011. The patients received either balloon dilation (n=41) or metal stent placement (n=47). A clinical symptom score and esophageal kinetics index were determined before, 1 week after, and 1 month after the treatment. All the patients were followed up in outpatient clinics or with a telephone interview every 6 months. There were significant improvements in the global symptom scores and esophageal kinetics indices in all patients. No major complications were encountered in either group. There were no significant differences with regard to overall treatment failure or long-term outcome. Balloon dilation and removable stents can effectively relieve clinical manifestations in patients with achalasia. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 03/2015; DOI:10.1111/1751-2980.12241
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    ABSTRACT: Taste is one of the elements related with meal preference. Gastroesophageal reflux disease (GERD) is related with lifestyle including food. It has not been studied about the relation between response for specific taste and GERD. We investigated 280 patients (M: 170, F: 110, mean age 58.6) about the relation between response for specific taste and GERD using a new self-questionnaire (about the response to various taste stimulation and the sensitivity to taste and hot things and about frequency of stomatitis). We asked another self-questionnaire for the diagnosis of GERD (frequency scale for the symptoms of GERD; FSSG: Cut-off score 10). Furthermore, 142 patients in 280 patients who were received upper gastrointestinal endoscopy were investigated about the association of endoscopic esophagitis and favorite taste. In association analyses with response for specific taste and GERD, the group of likely salty things and high frequency of stomatitis had significantly higher incidence rate of GERD. (O.R. 2.059, C.I. 1.215-3.488, P = 0.0073, stomatitis: O.R. 2.861, C.I. 1.558-5.253, P = 0.0007, respectively). In association analyses with endoscopic esophagitis, the group of likely salty and sour things had significantly higher incidence rate of endoscopic esophagitis (salty: O.R. 2.718, C.I. 1.330-5.555, P = 0.0061, sour: O.R. 3.267, C.I. 1.491-7.160, P = 0.0031, respectively). Sensibility and response for specific food taste were associated with GERD. The results of sensibility for hot or salty stimuli and endoscopic esophagitis suggest that the physical stimuli are more important for the esophageal injury. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 03/2015; DOI:10.1111/1751-2980.12246
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    ABSTRACT: Fecal incontinence (FI) occurs in 20% of diabetes mellitus (DM) patients. We suspect that gut specific biomarkers would correlate with symptoms of incontinence. The recto-anal inhibitory reflex (RAIR) is an enteric anorectal reflex that reflects the integrity of mechanisms in the physiology of fecal continence. We hypothesised that diabetic patients with FI, not constipation, have prolongation of the RAIR and altered Gut specific autonomic tone. Prospective case matched study recruited: 31 type-I DM (19 FI and 12 constipation); 42 type-II DM (26 FI and 16 constipation); 21 controls were studied. Patients underwent the following assessments: cardiovagal autonomic tone [Modified Mayo CASS score], rectal mucosal blood flow [RMBF] (assessment of gut specific autonomic tone) and RAIR. Three phases of the RAIR and the amplitude of maximal reflex relaxation were compared between groups. All subjects completed symptom scores for FI and constipation. RAIR recovery time back to resting pressure was slower in diabetics with FI than controls (8.7 vs 5.0, p<0.01) and was an independent variable correlating with symptoms of faecal incontinence (p<0.05). RAIR recovery time correlated with RMBF (r=0.58, p=0.04). Parameters of the RAIR correlated with anorectal symptoms of faecal incontinence and was associated with gut specific autonomic neuropathy. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 03/2015; DOI:10.1111/1751-2980.12244
  • Journal of Digestive Diseases 03/2015; DOI:10.1111/1751-2980.12242
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    ABSTRACT: The aim of present study was to investigate prevalence of colorectal neoplasm in coronary artery disease (CAD) patients with or without family history of colorectal cancer (CRC). In this cross-sectional study, individuals with suspected CAD but no cancer-related symptoms, underwent coronary angiography for the first time. They were divided into the CAD and non-CAD groups. Colonoscopies were performed in individuals at high-risk tier based on the Asia-Pacific Colorectal Screening (APCS) score. Waist circumference, body height and weight were measured. There were 634 of 1157 (54.8%) individuals in the high-risk tier, 91.0% (577/634) of whom were male smokers. The proportion of CAD patients was 81.5% (517/634). Prevalence of colorectal adenoma was significantly higher in the CAD group than in the non-CAD group (32.1% vs. 22.2%, P<0.05). Similar difference was observed for advanced adenoma (14.7% vs. 8.6%, P<0.05). However, prevalence of cancer did not differ between the two groups. After 83 individuals with family history of CRC were excluded, only the prevalence of adenoma was still significantly higher in the CAD group than in the non-CAD group (25.5% vs.16.0%, P<0.01). Body mass index (BMI) ≥25 correlated with the occurrence of adenoma (odds ratio=2.133, 95% confidence interval: 1.219-3.730, P=0.008) in CAD patients. Even in the absence of family history of CRC, CAD patients at high-risk tier classified by the APCS score still have a remarkable difference in the prevalence of colorectal adenoma. Moreover, the association between the occurrence of adenoma and CAD was stronger in overweight (BMI ≥25) individuals. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 03/2015; DOI:10.1111/1751-2980.12243
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    ABSTRACT: AimThe incidence of proximal gastric carcinoma (PGC) is rising worldwide for unknown reasons. Herein we investigated and compared the risk factors of early PGC with distal gastric carcinoma (DGC) in Chinese patients treated at a single tertiary hospital in China.Methods Risk factors of 379 consecutive surgically resected early gastric carcinomas (EGC) diagnosed with the 2010 WHO criteria were studied through review of medical records and upper endoscopy/biopsy findings, and interviews of patients and family members for demographics, history of environmental toxin exposure (ETE) and dietary habit, family and personal cancer history, and survival. Differences between PGCs (n=115), DGCs (n=264), and age- and gender-matched controls (n=225) were compared statistically.ResultsProportion of early PGCs in all EGC patients was significantly increased year by year (P<0.05). The independent risk factors for both PGC and DGC identified by multivariate analysis were preserved food intake (P<0.05), less fruit intake (P<0.05), and gastric mucosal intestinal metaplasia and atrophy (P<0.05). Advanced age (OR=9.83, P<0.01), personal cancer history (OR=5.09, P<0.05), high BMI (>24) (OR=2.79, P<0.01), and ETE (OR=2.31, P<0.05) were independent risk factors for PGC, but not male gender, tobacco or alcohol abuse, hiatus hernia, gastroesophageal reflux disease, or columnar-lined esophagus. In contrast, family cancer history (OR=2.34, P<0.01) and Helicobacter-pylori infection (OR=2.81, P<0.001) were independent risk factors for DGC.Conclusion Independent risk factors of PGC in Chinese patients were different from those of DGC or esophageal adenocarcinoma, supports PGC classified as a separate gastric carcinoma entity in Chinese population.
    Journal of Digestive Diseases 03/2015; DOI:10.1111/1751-2980.12240