Journal of Digestive Diseases

Publisher: Chinese Society of Gastroenterology, Wiley

Journal description

Current impact factor: 1.92

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.924
2012 Impact Factor 1.853
2011 Impact Factor 1.589
2010 Impact Factor 1.87
2009 Impact Factor 1.791

Impact factor over time

Impact factor
Year

Additional details

5-year impact 1.81
Cited half-life 2.80
Immediacy index 0.28
Eigenfactor 0.00
Article influence 0.49
Other titles Journal of digestive diseases (Online)
ISSN 1751-2980
OCLC 123124871
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Wiley

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  • Classification
    ​ yellow

Publications in this journal

  • Kyu-Man Cho, Seon-Young Park, Jin Ook Chung, Chung-Hwan Jun, Tae-Jong Kim, Dong-Jun Son, Ban-Suk Kim, Chang-Hwan Park, Hyun-Soo Kim, Sung-Kyu Choi, Jong-Sun Rew
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    ABSTRACT: The incidence of NSAID-induced enteropathy is currently increasing. However, the clinical predictor of small bowel bleeding (SBB) associated with NSAID-induced enteropathy are unknown. This study aimed to know the risk factors of SBB in chronic NSAID users. We retrospectively compared records of 147 patients receiving NSAIDs at a tertiary-care setting (31 cases with SBB and 124 controls without previous bleeding events) and analyzed clinical predictors of SBB. Thirty-one patients underwent capsule endoscopy to evaluate SBB, 74.2% of which demonstrated evidence of SBB. Non-invasive treatment was performed in 90.3% of patients. Multivariable logistic regression analysis revealed that presence of coronary artery disease (adjusted odds ratio [aOR], 12.4; 95% confidence interval [CI], 1.2-130.3; p=0.04), use of thienopyridine (aOR,16.9;95%CI,3.8-75.7;p<0.001), and prior use of rebamipide (aOR 0.3;95%CI,0.12-0.82;p=0.02) were independently associated with SBB in NSAID users. Coronary artery disease and co-use of thienopyridine were associated with SBB in NSAID users. In patients with coronary artery disease and co-use of thienopyridine, it is necessary for clinicians to monitor for occurrence of SBB when they prescribe NSAIDs. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 07/2015; DOI:10.1111/1751-2980.12269
  • Ahmad Najib Azmi, Wah-Kheong Chan, Khean-Lee Goh
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    ABSTRACT: Hepatocellular carcinoma (HCC) usually presents late. Prognosis depends mainly on tumour size, portal vein involvement, Child-Pugh (CP) score and performance status. We report a rare case of advanced HCC based on Barcelona Clinic Liver Cancer (BCLC) secondary to chronic hepatitis C infection that achieved complete response following sorafenib therapy with sustained complete remission over 48 months. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 07/2015; DOI:10.1111/1751-2980.12270
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    ABSTRACT: MicroRNAs have recently emerged as novel regulators in liver fibrosis. miR-30c and miR-193 are involved in fibrotic remodeling processes and cancer development, respectively. However, their role in liver fibrosis is currently unknown. We analyzed the regulation of miRNAs in carbon tetrachloride (CCl4 )-induced liver fibrosis by microarray. Expression patterns of miR-193 and miR-30c were further confirmed in fibrotic liver samples obtained from two murine models of hepatic fibrosis and human tissues. On a functional level, miRNA-levels were analyzed in the context of transforming-growth-factor mediated activation of hepatic stellate cells (HSC). Finally, predicted targets were assessed for their role in fibrosis by transfecting murine HSC with miRNA mimics. Microarray analysis in murine fibrotic livers revealed a panel of 41 deregulated miRNAs. In addition to previously established miRNAs known to be regulated in liver fibrosis in a TGF-β-dependent manner (e.g. miR-29, miR-133, miR-199a-3p), we show here that miR-193 and miR-30c were specifically downregulated not only in experimental hepatofibrogenesis but also in human liver fibrosis, while they showed a reciprocal expression pattern after recovery from liver fibrosis. Functional experiments confirmed the TGF-β-dependent downregulation of these respective new miRNAs in HSC. Finally, we identified TGF-β2 and SNAIL1, important regulators of the extracellular matrix, as potential target genes of miR-193 and miR-30 in liver fibrosis. These results suggest that miR-30 and miR-193 are members of a network of miRNAs modifying the TGF-β-dependent regulation of ECM-related genes in HSCs in the manifestation and resolution of liver fibrosis. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 06/2015; DOI:10.1111/1751-2980.12266
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    ABSTRACT: The scarcity of the donor livers and the impractical nature of transplantation represent the biggest obstacles for the treatment of liver failure. Adipose-derived stem cells with their ability to differentiate into the hepatic lineage represent a reliable alternative cell source, with clear ethical and practical advantages. Moreover, adipose-derived stem cells can effectively repair liver damage by the dominant indirect pattern and increase the number of hepatocytes by the secondary direct pattern. In recent years, the development of the indirect pattern, which mainly includes immunomodulatory and trophic effects, has become a hot topic in the field of cell engineering. Therefore, adipose-derived stem cells are considered to be an ideal therapeutic stem cell for human liver regeneration. In this article, we review the advantages of adipose-derived stem cells in liver regeneration, and explore the underlying mechanisms. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 06/2015; DOI:10.1111/1751-2980.12268
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    ABSTRACT: Sorafenib is currently the only standard treatment for advanced hepatocellular carcinoma (HCC), though the response rate remains poor (4%). We compared the overall survival after hepatic arterial infusion chemotherapy (HAIC) versus sorafenib monotherapy for advanced HCC. This retrospective study enrolled 177 patients with advanced HCC and Child-Pugh A but free of extrahepatic metastasis. Patients were divided into the HAIC group (n=136, treated with HAIC) and sorafenib group (n=41, treated with sorafenib), and followed to death or withdrawal of therapy. Response to treatment and overall survival were compared. The proportion of patients who showed complete response (CR)/partial response (PR)/stable disease (SD)/progressive disease (PD) were 6/25/41/21% and 2/2/44/42% in the HAIC and sorafenib groups, respectively. The response rate was better in HAIC group (31%) than sorafenib group (4%). The median survival time was 10 months in both HAIC and sorafenib groups. There was no difference in overall survival between the two groups. In patients with macroscopic vascular invasion (MVI) by the case-control method, the response rate was higher for the HAIC group (31%) than sorafenib group (0%). The overall survival was better in the HAIC group (14 months) than sorafenib group (7 months, p=0.005). Multivariate analysis identified MVI (hazard ratio 2.4, p=0.018) as a significant and independent determinant of survival in the sorafenib group. The response rate of HAIC was higher than that of sorafenib monotherapy. Prognosis was favorable in HAIC-responders despite MVI. HAIC might be desirable for advanced HCC patients free of extrahepatic metastasis. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 06/2015; DOI:10.1111/1751-2980.12267
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    ABSTRACT: Eosinophilic esophagitis (EoE) is a disorder of the esophagus characterized by distinctive endoscopic and histologic features. Optimal treatment for EoE has not been defined. A systematic review and meta-analysis were performed to clarify the advantage of steroids therapy for EoE. PubMed, EMBASE, Medline, ISI Wed of Science and the Cochrane Database of Systematic Reviews were searched to obtain relevant randomized controlled trials (RCTs) with comparison of steroids and non-steroids therapy, and retrospective and prospective trials on steroids therapy for EoE till March 2013. RevMan 5.2 was used for analysis. Six RCTs fulfilled inclusion criteria for meta-analysis, with 193 subjects included; And another 2 RCTs, 3 prospective and 5 retrospective trials fulfilled criteria of systematic review. Meta-analysis showed topical steroids significantly decreased the mean and peak esophageal eosinophils (eos) count compared to the non-steroids therapy (MDmean = -23.41, 95%CImean -42.08∼ -4.73, P=0.01 and MDpeak = -51.27, 95%CIpeak -78.62∼ -23.92, P=0.0002). The decease of mean eos was more pronounced in the adult group and when steroids compared to the placebo group (P=0.02 and P= 0.002 respectively). And the decrease of peak eos count remained significant independent of patient age, types of steroids (P<0.05). There were 14 trials showing the efficacy of steroids on decreasing eos count, 10 trials showing improvement of symptoms, and 5 trials showing endoscopic improvement. Only mild adverse effects were reported for topical steroids. Steroids were effective on decreasing the mean and/ or peak eos count for EoE. Its value of improving symptoms and endoscopic changes was not yet determined due to lack of unified criteria. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 06/2015; DOI:10.1111/1751-2980.12265
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    ABSTRACT: The incidence of early esophageal adenocarcinoma has increased significantly in the last decades. Prognosis is highly dependent on the choice of treatment. Early stages can be treated by endoscopic resection, whereas advanced carcinomas have to be sent to surgery. Esophageal resection is associated with high perioperative mortality (1-5%) even in specialized centers. Early diagnosis enables a curative endoscopic treatment option. Patients with gastrointestinal symptoms and familial risk for esophageal cancer should undergo an upper GI-endoscopy. Technical progress has developed high definition endoscopes and technical add-ons which help endoscopists to find fine irregularities in the esophageal mucosa but interpretations still remain challenging. In this review we discuss the novel and old diagnostic procedures and their value, as well as the actual recommendations in diagnose and treatment of early Barrett's carcinoma. Database of Pubmed and Medline was searched and analysed to provide all relevant literature to this review Conclusion: Endoscopic resection is the therapy of choice in early adenocarcinoma of the esophagus. It is mandatory to perform subsequent ablation of all residual Barrett's mucosa to avoid metachronous lesions. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 06/2015; DOI:10.1111/1751-2980.12264
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    ABSTRACT: Regeneration of the partial allograft and the growth of children may cause kinking of the bile outflow tract after pediatric living donor liver transplantation (LDLT), but bile duct kinking after adult LDLT is rarely reported. We herein present our experience with treatments of two patients who suffered from anastomotic strictures caused by severe bile duct kinking after LDLT. The first patient was a 57-year-old woman with hepatitis B virus (HBV)-related liver cirrhosis, who developed a biliary stricture 5 months after receiving a right-lobe LDLT. Subsequently, endoscopic and percutaneous treatments were attempted, but they both failed to solve the problem. The second was a 44-year-old woman, and she also had HBV-related liver cirrhosis. A biliary stricture occurred 14 months after LDLT. Likewise, the guide wire failed to pass through the stricture site when endoscopic interventions were conducted. Afterwards, both of the two cases underwent reexploration. It was observed that compensatory hypertrophy of the allografts resulted in kinking and sharp angulation of the bile ducts, and the anastomotic sites were found to be severely stenotic. Finally, re-anastomosis by Roux-en-Y procedure was successfully performed, and long-term stenosis-free survival was achieved in both of them. Our experience suggests that bile duct kinking after LDLT may play a role in the high incidence of anastomotic strictures in adult LDLT recipients, which may also result in the treatment failure of the non-surgical techniques for anastomotic strictures. Re-anastomosis in the form of Roux-en-Y hepaticojejunostomy is an effective surgical option for the treatment of such a condition. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 06/2015; DOI:10.1111/1751-2980.12263
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    ABSTRACT: Thermal ablative therapies continue to acquire favor to be safe and effective for the treatment of patients with non resectable hepatocellular carcinoma. Percutaneous microwave ablative therapy which is a relatively new technique has the advantage in providing faster ablation of larger tumors. This study aimed to evaluate microwave ablation in treatment of large HCCs (5-7cm) and to assess its effect on local tumor progression, prognostic outcome and patient's survival. Twenty six patients with HCC lesions (5-7cm) were managed in our multidisciplinary clinic of Kasr Al Ainy University hospital using microwave ablation. It was performed with the patient under conscious sedation and analgesia, ultrasonography guided using HS AMICA microwave machine, operating at frequency of 2450 MHz and a power up to 100 W. Multiple needle insertions in one or two sessions according to the size of the lesion. Patients were assessed for efficacy and safety. Complete ablation rate, local tumor progression and overall survival analysis were evaluated. Complete ablation was achieved in (19/ 26; 73.1%) of the lesions. Local tumor progression was recorded in 5 treated lesions (19.2%). Distant tumor progression within the liver was recorded in 6 patients (23.1%), with a mean survival of 21.5 months. No major complications or deaths related to the procedure. Microwave ablation by percutaneous approach is safe and effective in the treatment of large HCC tumor. The survival and local tumor control were acceptable. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12259
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    ABSTRACT: With an increased use of endoscopic retrograde cholangiopancreatography (ERCP), risk factors for complication of cholangiopancreatography procedure has been focused in previous studies. We aimed to identify independent risk factors of post-ERCP pancreatitis and hyperamylasemia by multivariate analysis, and develop a simple scoring system according to risk factors contributing to clinical prevention of post-ERCP pancreatitis. A retrospective single-center analysis was undertaken in 4,234 ERCP procedures between September 2007 and December 2012. Patient- and procedure-related risk factors for PEP and hyperamylasemia were identified by univariate and multivariate regression analyses. A scoring system was developed based on the independent risk factors. Pancreatitis occurred after 226 ERCP procedures (5.3%) and hyperamylasemia after 774 procedures (18.3%). Female gender [odds ratio (OR), 1.449], first-time ERCP (OR, 1.745), no jaundice (OR, 1.917), difficult cannulation (OR, 3.317) and pancreatography (OR, 1.823) all proved to be significant predictive risk factors for PEP. In addition to the similar factors, difficult cannulation (OR, 1.990) and pancreatography (OR, 2.009), age < 60 years (OR, 1.2), prior diabetes (OR, 0.614), biliary duct stent placement (OR, 1.884) and nasobiliary drainage (OR, 1.613) were associated with development of hyperamylasemia. Prophylactic pancreatic duct stent (PS) might prevent the development of PEP of patients in very high-risk group (score ≥ 6). This study emphasizes the role of patient- and procedure-related risk factors as the determining predictors for PEP and hyperamylasemia. Technical procedures, for example, PS, are necessary to prevent PEP in highest-risk patients. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12258
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    ABSTRACT: To investigate the influence of posture on the anatomy and function of esophageal sphincters using solid-state high-resolution manometry. Fifty subjects (24 volunteers and 26 gastroesophageal reflux disease patients) were recruited for this study. The subjects underwent esophageal manometry with a 36-channel solid-state catheter in the supine and upright positions. The length and pressure of the esophageal sphincters, as well as the esophageal and intra-abdominal lengths of the lower esophageal sphincter (LES), were investigated. The residual pressure of the upper esophageal sphincter (UES) and the 4-s integrated relaxation pressure were also measured as the patients swallowed 10 consecutive servings of water (5 ml each). The Bland-Altman method was used to assess agreement between these parameters in the supine and upright positions. The LES resting pressure was significantly decreased in the upright position compared with the supine position (13.85 ± 5.90 mmHg vs. 18.09 ± 7.80 mmHg, P=0.000). Weaker integrated relaxation pressures were observed when the patients were in the upright position (5.66 ± 3.33 mmHg vs. 7.80 ± 3.25 mmHg, P=0.000). Compared with the supine position, the upright esophageal length was longer (P=0.004) and the upper border of the LES was lower when the subjects were in the upright position (P=0.050). The agreement between the two positions was acceptable for the esophageal length, LES upper border location and LES pressure measurements. Body position exerts a greater influence on the LES than on the UES. Thus, it is necessary to establish normal values for the LES basal pressure and residual pressure in different positions. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12256
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    ABSTRACT: Patients with inflammatory bowel disease (IBD) are at risk for opportunistic infections secondary to immunosuppressive therapies. Respiratory infections, in particular, are a leading cause of death in IBD patients. Here we present a case of Pneumocystis Carinii pneumonia (PCP) in a patient with Crohn's disease status-post ileostomy and parastomal pyoderma gangrenosum on adalimumab, prednisone, and methotrexate. Her hospital course was complicated by recurrent pneumothorax post-bronchoscopy requiring chemical pleurodesis with doxycycline. Although the initial pneumothorax was not spontaneous, we expect that the PCP contributed to its reoccurrence and need for pleurodesis. To our knowledge, this is the first case of PCP infection requiring pleurodesis in a non-HIV patient. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12257
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    ABSTRACT: AIMThe overlap of gastroesophageal reflux disease (GERD) and functional gastrointestinal disorders (FGID) is not by chance, but there is little data on Chinese general population, especially on rural population. This survey was conducted to investigate the prevalence of GERD and functional bowel disorders (FBD) overlap in general population in rural areas in China.METHODS Population-based, cross-sectional study was launched in six villages of Nanmazhuang areas in Lankao County, Henan Province during December 2010 and October 2011. Questionnaire of GERD and Rome III was used as diagnostic tool for investigating the prevalence of GERD and functional bowel disorders (FBD) overlap.RESULTS2950 of 3700 residents (qualified rate 80%) were used in analysis. The average age (mean±SD) was 42.37±16.76. Among the residents, 4.78% (n=141) was diagnosed with GERD and 4.64% (n=137) with FBD. Percentage of subjects with FBD in GERD was significantly greater than that in the non-GERD group (25.53% vs 3.60%, P<0.05). Prevalence of GERD in FBD was significantly higher than the non-FBD group (26.28% vs 3.73%, P<0.05). The prevalence of GERD-FBD overlap in general rural population was 1.22%. Logistic regression analysis indicated that anxiety was independent predictor of GERD-FBD overlap in GERD and GERD-FBD overlap in FBD (OR=1.05, 95%CI: 1.02-1.09; OR=1.06, 95%CI: 1.02-1.10, respectively).CONCLUSIONSGERD and FBD overlap is more common than expected by chance in general rural population, and anxiety is significantly related to the overlap.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12262
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    ABSTRACT: Background The aim of this study was to evaluate the safety and efficacy of the intramuscular injection of either mitomycin C or dexamethasone in association with an endoscopic dilation for benign esophageal strictures after esophageal surgery or ESD (Endoscopic Submucosal Dissection).Methods Patients with benign esophageal strictures were retrospectively analyzed in this study. These patients were divided into 3 groups, including the mitomycin C group (mitomycin C injections in association with an endoscopic dilation), the dexamethasone group (dexamethasone injections and dilation) and the dilation group (saline injections and dilation). The patients’ characteristics, locations of the lesion, number of previous dilations, diameters after dilation, dysphagia grades before and after the procedure and follow-ups were compared.ResultsA total of 74 patients were enrolled in this retrospective case control study, 25 in the mitomycin C group, 25 in the dexamethasone group and 24 in the dilation group. The mean dysphagia-free period was 4.88±1.66 months in the mitomycin C group, 4.02±1.77 months in the dexamethasone group, and 2.41±1.26 months in the dilation group (P<0.05). There were no significant differences in the three groups for the other indices.Conclusion The intramuscular injection of either mitomycin C or dexamethasone may prolong the dysphagia-free period and decrease the frequency of repeat dilations compared with conventional endoscopic dilations in patients with benign esophageal strictures. Mitomycin C may have predominant advantages compared with the other two methods.
    Journal of Digestive Diseases 05/2015; 81(5). DOI:10.1111/1751-2980.12255
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    ABSTRACT: It is difficult to definitively diagnose congenital esophageal stenosis (CES) with other diseases manifested by dysphagia before surgery. Here we report a case of a 17-year-old male who presented with dysphagia over a 15-year period and initially diagnosed with achalasia at local hospital by esophagogram. Endoscopic ultrasonography performed in our hospital suggested that the muscularis propria had thickened at the narrowing distal esophagus. A double peak wave was observed by high resolution manometry in the lower esophagus during swallowing. EUS and HRM indicated reduced esophageal dyskinesia, which might have been caused by the thickened muscularis propria. CES was diagnosed, and the patient received a peroral endoscopic myotomy. Eventually, the patient underwent surgery because of a perforation, and the histological findings confirmed ectopic tracheobronchial tissue (TBR) in the esophagus, which is indicative of one type of CES. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12261
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    ABSTRACT: AimAn effect of the H. pylori eradication on the expression level of the FHIT gene and its methylation status was analyzed in gastric mucosa of patients with and without a family history of gastric cancer (FHGC).Methods The 31 patients (13 with the FHGC) were enrolled to the studies. The presence of H. pylori as well as the effectiveness of eradication were confirmed by the UBT, RUT and multiplex PCR (the presence of selected H. pylori strains) for samples from the antrum and corpus. Histopathological assessments were done with hematoxylin-eosin and Giemsa staining. The level of FHIT mRNA was determined by qRT-PCR and the methylation status of the FHIT promoter was assessed in MSP.ResultsAfter H. pylori eradication, regression of inflammation from superficial gastritis to normal mucosa (GN) was observed in 42% of the control patients and in 54% of patients of the FHGC group. The level of FHIT mRNA increased for samples (both, the antrum and corpus) of control patients (p < 0.05), while the gene methylation status remained unchanged (p > 0.05). For the samples of the FHGC patients, the FHIT mRNA level was not changed and the methylation status evenly fluctuated.Conclusions From the clinical point of view, eradication of bacteria, besides reduction of inflammation and regression of histopathological non-atrophic changes, results also in elevation of expression of the FHIT tumor suppressor gene in FHGC negative patients and, thus, may contribute to the prevention of gastric cancer development in these patients.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12252
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    ABSTRACT: OBJECTIVE Endoscopic submucosal dissection (ESD) is nowadays commonly performed as a treatment for gastric tumor. However, the sedation with midazolam (MDZ) often did not reach a satisfactory sedation during the procedure and the drug could suppress respiration and blood pressure also. The aim was to investigate the safety and efficacy of dexmedetomidine with on-demand MDZ (DEX group) in comparison with MDZ alone (MDZ group) as a sedative during an ESD of gastric tumor.METHODS Eighty patients undergoing ESD of gastric tumor were randomly assigned to one of two treatment regimens (40 patients of each). We investigated the depth of sedation by using a MOAA/S score (Modified Observers Assessment alertness/sedation), the number of patient's reactions interfering with the proper procedure, sedation related-adverse events, and the satisfaction degree of the patients and doctors.RESULTSEighty patients were randomly assigned to one of two treatment regimens (40 patients of each). There was no statistically significant difference between the two groups regarding age, sex, body mass index, ASA classification, and tumor characteristics. Appropriate sedation rate and the satisfaction degree of the doctors were significantly high in the DEX group. There were more actions of patients interfering with the proper procedure in the MDZ group than in the DEX group. There was no difference in the adverse events between the two groups.CONCLUSIONSDEX with on-demand MDZ for the sedation during gastric ESD is as safe as MDZ alone and the sedation effect of DEX with MDZ is superior to that of MDZ alone.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12254
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    ABSTRACT: PurposeTo quantify the expression of Smad7 and Smad ubiquitin regulatory factor 2 (Smurf2) in the pancreas in Rats of chronic pancreatitis (CP).Methods Sixteen male Wistar rats were randomized dividing into control group and CP group (8/group). CP was induced in rats in vivo by dibutyltin dichloride (DBTC). Four weeks after DBTC administration, histological assessment, masson staining, and measurement of hydroxyproline content in the pancreatic tissues were determined to estimate the inflammation and fibrosis of pancreas. Immunohistochemisty and real-time reverse transcription polymerase chain reaction (RT-PCR) for transforming growth factor-β1 (TGF-β1) and α-smooth muscle actin (α-SMA) were applied to assess activated pancreatic stellate cells (PSCs) and TGF-β1 expressions. Smad7 and Smurf2 expressions in the pancreas were measured using Western blotting and real-time RT-PCR.ResultsDBTC induced typical histopathological characteristics of CP in the model rats with extensive activated PSCs. Comparing to the control group, the expressions of TGF-β1, α-SMA and the content of hydroxyproline in pancreatic tissues in the CP group were significantly raised. Meanwhile, the expression levels of Smad7 mRNAs, Smurf2 mRNAs and proteins were significant increased in fibrotic pancreas, in which, the expressions of Smad7 proteins showed an obviously reduction compared with controls.Conclusion Dysregulation of Smad7 and Smurf2 may associate with the pathogenesis of pancreatic fibrosis through TGF-β signaling pathway.
    Journal of Digestive Diseases 05/2015; DOI:10.1111/1751-2980.12253
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    ABSTRACT: Gastric cancer is the fifth most commonly diagnosed cancer in the world and the third leading cause of cancer-related deaths. The prognosis of gastric cancer is obviously associated with the tumor stage, the 5-year overall survival rates for early gastric cancer exceeding 90%, significantly higher than that of advanced gastric cancer. Endoscopic resection, including endoscopic mucosal resection and endoscopic submucosal dissection, has been adopted as the first treatment option of early gastric cancer in many countries for its minimal invasion and high curative ratio in recent decades. However, the horizontal margin and vertical margin are related to the curative resection of early gastric cancer and the prognosis of patients, thus accurate prediction of tumor boundary and invasive depth before treatment counts for much in planning the most appropriate treatment strategy and promising curative resection. To date, various endoscopic techniques have played role in pretreatment evaluation, such as white-light endoscopy, chromoendoscopy, narrow band imaging and endoscopic ultrasonography. This paper aims to summarize the diagnostic methods, applications and limitations of these different endoscopic techniques for tumor horizontal and vertical margins in early gastric cancer, helping increase preoperative evaluating capabilities and improve the curative resective rate of early gastric cancer. This article is protected by copyright. All rights reserved.
    Journal of Digestive Diseases 04/2015; DOI:10.1111/1751-2980.12251