Basic &amp Clinical Pharmacology &amp Toxicology (BASIC CLIN PHARMACOL)

Publications in this journal

• Article: PARACETAMOL INTOXICATION IN A RETROSPECTIVE COHORT IN A TERTIARY HOSPITAL

  H. Y. Tong, N. Medrano, A. P. Caparros, A. M. Borobia, J. Frias, E. Ramirez
  Basic &amp Clinical Pharmacology &amp Toxicology 11/2012; 111(S1):25.
• Article: IMPROVING THE SUITABILITY OF LINEZOLID USE DECREASES THE INCIDENCE OF LINEZOLID RESISTANCE AMONG GRAM-POSITIVES

  E. Ramirez, R. Gomez-Gil, A. M. Borobia, C. Zegarra, R. Munoz-Romo, J. Frias
  Basic &amp Clinical Pharmacology &amp Toxicology 11/2012; 111(S1):25.
• Article: DEVELOPMENT AND VALIDATION OF A TOXICOVIGILANCE SYSTEM WITH AUTOMATIC DETECTION OF CASES

  A. P. Caparros, R. Munoz-Romo, M. Quintana, A. M. Borobia, J. Frias, A. J. Carcas
  Basic &amp Clinical Pharmacology &amp Toxicology 11/2012; 111(S1):26.
• Article: EXPRESSION OF INSULIN RECEPTORS ON THE ENDOTHELIUM OF RAT AORTA AFTER ADMINISTRATION OF L-CARNITINE

  T (Papamitsou, D (Barlagiannis, E (Digkas, N (Batziou, P (Papaioannidou, K (Kaidoglou, M (Dermentzopoulou
  Basic &amp Clinical Pharmacology &amp Toxicology 06/2011; 109(SI Suppl 1-ISSN: 1742-7835):105.
• Article: Making cream from bee Propolis for treatment of dermatophytic infections

  Shahin Gavanji
  [show abstract] [hide abstract]
  ABSTRACT: Popolis (bee glue) is a resinous or sometimes wax-like bee hive product that has been used by man since ancient times for its pharmaceutical properties. The antibacterial and antifungal activities are the most popular and among the most extensively investigated biological actions of propolis. ermatophytosis refers to the disease of the skin, hair and nail which caused by dermatophytes. Topical or systemic treatments have been empirically administered, although such drugs are widely used, some of them have been reported as ineffective and even toxic to the host and sometimes it takes time to be cured. Recently, propolis has been attracted the attention of researchers due to its various biological activities and therapeutic properties. The aim of this study was making topical cream from propolis for treatment of dermatophytic infections. Material and methods: For making of different formulations, we used from a base formulation, and then with adding the other materials and some variations established in the base formulation, finally 25 formulations were provided. All of formulations were examined in terms of consistency, stability, PH average, appearance, microbial studies and some other features of cream and the best formulation with the best efficacy was selected. Results: The selected formulation had a very good effect for treatment of experimental dermatophytosis in rabbits in comparison with synthetic products such as some azoles. Conclusion: The natural products are very effective for treatment of many fungal infections and also in comparison with synthetic drugs are more inexpensive and have lower side effects.
  Basic &amp Clinical Pharmacology &amp Toxicology 07/2010; 107(1).
• Article: PHARMACOKINETICS OF INTRAVENOUSLY ADMINISTERED MEMANTINE IN PIGS

  M Achim, L Vlase, D Muntean, A Gal, C Catoi, S E Leucuta
  Basic &amp Clinical Pharmacology &amp Toxicology 08/2009; 105:109.
• Article: PHARMACOKINETIC INTERACTION BETWEEN CARBAMAZEPINE AND IVABRADINE IN HEALTHY VOLUNTEERS

  L Vlase, A Popa, D Muntean, M Neag, S E Leucuta
  Basic &amp Clinical Pharmacology &amp Toxicology 08/2009; 105:107.
• Article: FOOD-DRUG INTERACTION: GRAPEFRUIT JUICE AUGMENTS LINEZOLID BIOAVAILABILITY

  R Cuciureanu, L Vlase, M Cuciureanu, D Muntean, M Nechifor
  Basic &amp Clinical Pharmacology &amp Toxicology 08/2009; 105:109.
• Article: PHARMACOKINETICS AND BIOAVAILABILITY OF CONTROLLED RELEASE SOLID DOSAGE CARBAMAZEPINE FORMULATIONS

  L Vlase, I Tomuta, A Popa, D Muntean, S E Leucuta
  Basic &amp Clinical Pharmacology &amp Toxicology 08/2009; 105:108.
• Article: Tumor necrosis factor alpha as a therapeutic target in treatment of heart failure

  Srdic D, Prostran M, Perunicic J, Lasica R, Radovanovic G, Todorovic Z Stojanovic R
  Basic &amp Clinical Pharmacology &amp Toxicology 06/2009; 105(s1):53.
• Article: Quality of Antibiotic Prescribing for Prophylaxis in Orthopedics Surgery: Results from 4 Departments of Orthopedics in 3 European countries

  P. Papaioannidou, V. Vlahovic-Palcevski, G.M. Benoni, the AntibioSurv Working Group on ASPPOC
  Basic &amp Clinical Pharmacology &amp Toxicology 01/2009; 105:S139.
• Article: Quality of Antibiotic Prescribing for Prophylaxis in Neurosurgery: Results from 8 Neurosurgery Departments in 6 European countries

  P. Papaioannidou, K. Nanassis, P. Selviaridis, the AntibioSurv Working Group on ASPPOC
  Basic &amp Clinical Pharmacology &amp Toxicology 01/2009; 105:138.
• Article: Quality of Antibiotic Prescribing for Prophylaxis in Obstetrics and Gynecology: Results from 7 Departments in 5 European countries

  P. Papaioannidou, A. Sabo, V. Vlahovic-Palcevski, the AntibioSurv Working Group on ASPPOC
  Basic &amp Clinical Pharmacology &amp Toxicology 01/2009; 105.
• Article: Early effects of parecoxib on bone healing in rats

  P. Akritopoulos, P. Papaioannidou, I. Hatzokos et al
  Basic &amp Clinical Pharmacology &amp Toxicology 01/2009; 105:89.
• Article: Quality of antibiotic prescribing for prophylaxis in general surgery: results from 15 general surgery departments in 10 countries

  P. Papaioannidou, A. Kamparoudis, A. Sabo, the AntibioSurv Working Group on ASPPOC
  Basic &amp Clinical Pharmacology &amp Toxicology 01/2009; 105:35.
• Article: Protective effects of sasanquasaponin on injury of endothelial cells induced by anoxia and reoxygenation in vitro.

  Qiren Huang, Ming He, Heping Chen, Lijian Shao, Dan Liu, Yongming Luo, Yucheng Dai
  [show abstract] [hide abstract]
  ABSTRACT: The protective effects of sasanquasaponin, an effective compound from Chinese traditional herbs, on ischaemia and reperfusion injury in mouse hearts have been suggested through modulation of intracellular Cl(-) homeostasis. The effects of sasanquasaponin on injury of endothelial cells, however, induced by anoxia and reoxygenation remain unknown. Therefore, the present study attempted to observe the effects of sasanquasaponin on anoxia and reoxygenation injury in endothelial cells and investigate its putative mechanisms. Human umbilical vein endothelial cells (HUVECs) were exposed to normoxia or anoxia and reoxygenation in the absence or presence of sasanquasaponin (10.0, 1.0 and 0.1 micromol/l). Lactate dehydrogenase activity was determined in cultured HUVECs supernatant, and malondialdehyde content, superoxide dismutase and glutathione peroxidase activities were measured in HUVECs by a colorimetric method. Neutrophil adhesion to HUVECs was assayed colorimetrically. The levels of intercellular adhesion molecule-1 and tumour necrosis factor-alpha were detected. The activity of nuclear factor kappa B was determined by flow cytometry. The results show that sasanquasaponin decreased the lactate dehydrogenase activity and malondialdehyde contents, and inhibited the neutrophil adhesion to HUVECs; sasanquasaponin, moreover, inhibited nuclear factor kappa B transnuclear activity, lowered tumour necrosis factor-alpha and intercellular adhesion molecule-1 expression levels. On the other hand, sasanquasaponin increased the mitochondrial superoxide dismutase and glutathione peroxidase activities. It is suggested that sasanquasaponin could protect HUVECs against anoxia and reoxygenation injury, and the protective mechanisms appear to be related to anti-lipoperoxidation and anti-adhesion.
  Basic &amp Clinical Pharmacology &amp Toxicology 12/2007; 101(5):301-8.
• Article: Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats.

  Ibrahim M El-Ashmawy, Amal Saleh, Osama M Salama
  [show abstract] [hide abstract]
  ABSTRACT: Natural dietary antioxidants are extensively studied for their ability to protect cells from miscellaneous damages. Marjoram volatile oil (Origanum majorana L., Lamiaceae) and grape seed extract (Vitis vinifera L., Vitaceae) are potent antioxidants. Effects of administration of marjoram volatile oil or grape seed extract on oral administration of ethanol, simultaneously, daily for 10 weeks were studied through determining epididymal spermatozoal analysis, serum testosterone level, weight and histopathological examination of testis, liver and brain. Glutathione level and lipid peroxidation content as malondialdehyde in the testis, liver and brain were measured. The repeated intake of a great amount of ethanol (10 ml/kg body weight, 25% v/v) was followed by fertility disturbances with low sperm count, impaired sperm motility and decrease in serum testosterone level. Moreover, ethanol toxicity induced significant alterations in the histological structures of the testis, liver and brain. The results revealed a significant increase in lipid peroxidation and decrease in the level of glutathione in the testis, liver and brain in the ethanol-treated group. However, co-administration of the extracts of protective plants resulted in minimizing the hazard effects of ethanol toxicity on male fertility, liver and brain tissues. It may be concluded that marjoram volatile oil and grape seed extract are useful herbal remedies, especially for controlling oxidative damages.
  Basic &amp Clinical Pharmacology &amp Toxicology 12/2007; 101(5):320-7.