Pakistan Journal of Medical Sciences Online (PAK J MED SCI)

Journal description

Pakistan Journal of Medical Sciences (Pak J Med Sci) is a peer reviewed journal. It is published quarterly and we practice open peer review system. It has controlled circulation. Objective: The journal aims at promoting the art and science of medicine to improve healthcare besides being a useful source of CME for healthcare professionals offering healthy, balanced and constructive debates on controversial issues that effect medicine, keeping up the professional ethics in medical journalism.

Current impact factor: 0.10

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 0.098
2012 Impact Factor 0.101
2011 Impact Factor 0.161
2010 Impact Factor 0.166
2009 Impact Factor 0.203

Impact factor over time

Impact factor
Year

Additional details

5-year impact 0.19
Cited half-life 4.90
Immediacy index 0.08
Eigenfactor 0.00
Article influence 0.04
Website Pakistan Journal of Medical Sciences Online website
ISSN 1682-024X

Publications in this journal

  • Pakistan Journal of Medical Sciences Online 03/2015; 31(2). DOI:10.12669/pjms.312.6753
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    ABSTRACT: ABSTRACT Objectives: To investigate immune cell densities in pre-neoplastic (DCIS), cancer (IDC) and control breast tissues. Methods: A total of four preneoplastic, 104 cancer and 104 control samples were analyzed. Morphological classification and prognostic scoring along with quantification of immune cells/mm2 was performed. Data were entered and analyzed using SPSS version 16. Correlation of immune cell densities with various tumour sub-types was investigated using paired t-test and ANOVA. A p-value of <0.05 was considered as significant. Results: Our data show increased infiltration of lymphocytes (mean lymphocytes = 287.6cells/mm2 ) as well as myelocytes (mean lymphocytes = 117.1cells/mm2 ) in pre-neoplastic tissues. This infiltration was significantly high compared to cancer (p-value<0.001) as well as control tissues (p-value <0.001). Moreover, we report increased infiltration of lymphocytes in cancer tissues compared to controls (p-value<0.001). There was no difference in lymphocyte densities within various tumour sub-types (all p-values >0.05). Conclusion: Leukocytes may play a role in early stages of breast carcinogenesis.
    Pakistan Journal of Medical Sciences Online 01/2015; 31(02). DOI:10.12669/pjms.312.6481
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    ABSTRACT: Objective: To explore financial wellness (FW) awareness amongst public and private sector medical college students of Karachi. Methods: A cross sectional questionnaire based survey was conducted on medical students from 3 public and 5 private sector medical colleges of Karachi from February 2011 to December 2011. All ethnic groups having age range of 18-23 years were included. A questionnaire tailored from wellness wheel evaluated the responses of FW on a four point Likert’s scale ranging from 0-3(never, sometimes, mostly, and always). Factor analysis explored common FW factors among both public and private sector medical college (MC) students. Results: Private MC Students were better in terms of making short and long terms financial goals compared to students in public sector. The students of public MC were more focused to make and restricting to given budgets (p=0.05). The FW element of keeping savings in bank account was responded more by private MC candidates (P < 0.0001) but was spent thrift as well (P < 0.0001). Factor analysis revealed two factors; ‘Financial Security Wellness’ which was better in Private MC Students (p=0.001) and ‘Care towards Expenses Wellness” in which results were not significant. Conclusion: Both groups of medical college students lacked FW awareness element in terms of caring towards financial expenses. The awareness of importance of financial security was practiced better by private MC students in terms of making short and long term financial goals and keeping savings in bank accounts. They were however deficient in the knowledge of making and restricting themselves to budgets. KEY WORDS: Financial wellness, Financial literacy, Financial Security, Medical students, Wellness wheel, Pakistan.
    Pakistan Journal of Medical Sciences Online 12/2014; Pak J Med Sci 2015 Vol. 31 No. 1 www.pjms.com.pk.
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    ABSTRACT: In this study, we examined the euphoric effect of propofol and its high satisfaction ratio regarding its liability to be abused, particularly in painless procedures, such as colonoscopy. Fifty subjects aged between 18 and 65 years who fulfilled the criteria for ASA 1-2 and were prepared for colonoscopy were enrolled into this study. For intravenous sedation induction, 2 mg/kg propofol was used, and additional injections were administered according to BIS values. After colonoscopy, the subjects were taken to a recovery room and observed for 30 minutes. Patients were interviewed with the modified Brice questionnare regarding the incidence and the content of dreams. A 5-point Likert scale was used to classify their dreams, and the content of the dreams was also recorded. To assess the subjective effects of propofol, the patients were asked to use the Hall and Van der Castle emotion scale; their biological states were also assessed. The patients' feelings regarding propofol were each rated as absent or present. We used the Morphine-Benzedrine Group scale to measure the euphoric effects of propofol. At the end of the study, subjects scored their satisfaction on a five-point scale. There were no statistically significant differences in sex age, weight, propofol dose, or satisfaction ratio (p>0.05) in the groups, although male patients received a higher dose of propofol and had higher satisfaction ratio. Patients reported no residual after-effects. The incidence of dreaming was 42%. There was no statistically significant difference in dreaming between the sexes, but male patients had a higher dreaming ratio. Dreamers received higher propofol doses and had a higher satisfaction ratio (p>0.05). All dreamers reported happy dreams regarding daily life, and their mean MBG score was 10.5. There was no correlation between MBG scores and propofol doses (r= -0.044, p= 0.761). We conclude that propofol functions as a reward; that patients enjoy its acute effects; and that no residual after-effects should arise. We suggest that propofol may carry potential for abuse, and further abuse liability testing is indicated.
    Pakistan Journal of Medical Sciences Online 11/2014; 30(6):1247-52. DOI:10.12669/pjms.306.5811
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    ABSTRACT: Background and Objective: An early detection of osteoporosis through DEXA procedure will not only improve the disease management practices but also would help in impeding national productivity losses by mass screening and awareness. Our objective was to measure efficacy of DEXA procedure in early detection of osteoporosis and prevention of its complications. Methods: This case series observational study was designed to confirm the bone mineral density by dual energy x-ray absorptiometery (DEXA). The duration of study was three years from November 2010 to October 2013. Subjects aged between 30 (when the risk of osteoporosis is low) to 60 (when osteoporosis is almost sure to be found). Results: Three hundred thirty patients were evaluated. There were 23 (6.96%) male and 307 (93.03%) female. Normal male were 09 (39.10%), osteopenia 11 (47.80%) and osteoporosis 3 (13%). Normal females were 72 (23.50%), osteopenia 140 (45.60%) and osteoporosis 95 (30.90%). P-value was more then 0.005 and not significant. Mean age was 48.73, minimum 30, maximum 60 and SD 7.247. Population category distribution was 243(76.6%) from urban and 87(26.4%) rural. In urban areas normal were 56(23%), osteopenia 113(46.50%) and osteoporosis 74(30.50%). In rural areas normal 25(28.70%), osteopenia 38(43.70%) and osteoporosis 24(27.60%). P-value was 0.567. Out of 330 there were 81(24.54%) normal, 98 ((29.69%) osteoporosis and 151 (45.75%) osteopenia. Conclusion: Osteopenia was the most common diagnosis mostly in younger age group and early diagnosis of this problem can help prevent osteoporosis. KEY WORDS: Osteopenia, Osteoporosis, Dual Energy X-ray Absorptiometry.
    Pakistan Journal of Medical Sciences Online 11/2014; 30(6):1265-1269.
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    ABSTRACT: Objective : This study aims to observe the risk factors of cardiovascular disease in patients after kidney transplantation. Total 102 patients after renal transplantation (group A) and 96 clinic examination cases (group B) were recruited. Blood pressure, blood urea nitrogen (BUN) and creatinine (Cr), blood glucose (GLU), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein A-I ( apoA-I ) of the subjects were tested. These indexes were tested 3 times in group A in the 1, 2, and 3 month after kidney transplantation surgery. Electrocardiogram examination was done in the third month after kidney transplantation surgery. There were significant differences in the incidence of hypertension, hyperglycemia and dyslipidemia between the two groups. After operation, the levels of BUN and Cr decreased significantly in 57 cases of group A without taking antihypertensive drugs (P<0.01). However, there was no significant difference in the blood pressure regardless of the systolic blood pressure (SBP) and diastolic blood pressure (DBP) before and after operation. In group A, the abnormal rate of ECG was 65%, the incidence of ST-T changes, prolongation of QT interval, left ventricular hypertrophy and left ventricular high voltage increased significantly (P<0.01). The incidence of coronary heart disease risk factors such as hypertension and hyperglycemia are high in patients after renal transplantation.
    Pakistan Journal of Medical Sciences Online 11/2014; 30(6):1228-31. DOI:10.12669/pjms.306.5610
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    ABSTRACT: We aimed to analyze the expression of ERCC1, RRM1 and TUBB3 in 305 patients with advanced non-small cell lung cancer (NSCLC) and investigate whether these genes can be used as biomarkers for predicting tumor response and clinical outcome. Total 305 patients with unresectable and locally advanced NSCLC were collected between January 2007 and December 2008. cDNA of ERCC1, RRM1 and TUBB3 was isolated by a fluorescence-based real-time detection method. All the patients were followed up until December 2012. One hundred seventy five patients showed good response and 130 patients showed poor response to chemotherapy. 126 patients died and 166 patients showed progressive disease during the follow-up period. The median levels of ERCC1, RRM1 and TUBB3 mRNA were 0.53±0.13, 0.31±0.15 and 0.18±0.16, respectively. We found that patients with low ERCC1 expression showed a significantly higher rate of good tumor response, and the adjusted OR (95% CI) was 2.16(1.32-3.45). By Cox regression analysis. We also found that low ERCC1 expression level were correlated with longer overall survival of NSCLC patients, with the adjusted HR (95% CI) was 2.15 (1.26-3.35). This study showed that ERCC1 mRNA expression can not affect the response to chemotherapy and clinical outcome of advanced non-small cell lung cancer (NSCLC) patients.
    Pakistan Journal of Medical Sciences Online 11/2014; 30(6):1403-8. DOI:10.12669/pjms.306.5768
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    ABSTRACT: Background and Objective : Research evidence supports the relationship of psychological and demographic factors with hypertension and these variables are strongest predictors of hypertension which are scarcely studied in Pakistan. The present study was carried out to explore the correlation of depression, anxiety, stress and demographic factors with hypertension. We used correlation research design and a sample of (N = 237), hypertensive patients (N = 137) and their age matched healthy controls (N = 100) was taken from hospitals. Depression, Anxiety and Stress Scale (DASS) (Lovibond & Lovibond, 1995) was used to assess depression, anxiety and stress. RESULTS indicated significant positive correlation between depression (χ (2) MH = 104.18, p < .001), anxiety (χ (2) MH = 78.48, p < .001), stress (χ (2) MH = 110.95, p < .001) and overall negative states (χ (2) MH = 97.43, p < .001) with hypertension. Depression (OR = 1.44, p < .01), anxiety (OR = 1. 76, p < .01) stress (OR = 1.37, p < .01), job and dependents, working hours and weight turned out as predictors of hypertension. Hypertension has significant positive relationship with depression, anxiety, stress and with demographic variables. The findings of the present study will contribute in the existing knowledge of health professionals to enhance public awareness regarding the harmful outcomes of depression, anxiety and stress upon human health.
    Pakistan Journal of Medical Sciences Online 11/2014; 30(6):1293-8. DOI:10.12669/pjms.306.5433
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    ABSTRACT: To determine the frequency of diseases contributing to End Stage Renal Failure (ESRF) and to determine the frequency of seropositivity for hepatitis B and hepatitis C in our patients. This is an observational study of two years duration from January 2012 till December 2013, done at Dow university of Health Sciences. Sample size is 189 by convenient method. Data collection is retrospective. Inclusion criteria includes all patients ever hemodialysed at DIMC with age 14 or above. Exclusion criteria is age below 14. Data maintained and analyzed on SPSS version 16. All categorical data in percentages and numeric data is given in frequencies and mean with Standard deviation. Total number of patients included in study were 189, Males were 94/189 (49.7%), females were 95/189 (50.3%), Male to female ratio was 0.98: 1.0. Mean age was 51.88+15.2, range was14-86 years. Patients started on Hemodialysis were found to have hypertension in 40.2%, both diabetes and hypertension was present in 42.8%, diabetes alone in 3.1% of patients as likely etiology of renal failure. Seropositivity for HBV was found 4/189(2.1%) and HCV in 31/189(16.4%) at initiation of Hemodialysis. Hypertension alone is an important disease found in patients with renal failure as likely cause followed by diabetes. Hepatitis C positivity at start of hemodialysis is 16%.
    Pakistan Journal of Medical Sciences Online 11/2014; 30(6):1327-30. DOI:10.12669/pjms.306.5364
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    ABSTRACT: Evidence-based medicine offers explicit methods to evaluate the evidence grades of literature. However, evidence grades do not meet all the practical needs of physicians. This study is aimed to develop a convenient method for evaluating the clinical value of medical literature from the perspective of the clinician. A literature applicability equation was formulated through the Delphi method and the analytic hierarchy process. A consistency check was used to ascertain the efficacy of the formula. Three senior clinicians assessed 30 articles based on their clinical experiences and subjective opinions, while one independent researcher performed independent assessments of the applicability of 30 articles using the evaluation formula. The literature applicability equation was Y = 3.93X1 + 11.78X2 + 14.83X3 + 44.53X4 + 24.93X5, where Y = literature applicability, X1 = years since publication, X2 = target question covered or not, X3 = sample size, X4 = study type, and X5 = journal quality. Consistency index (CI) values for the first-level indicator ("literature applicability") and the second-level indicators ("pertinence and timeliness" and "quality of results") were 0.0325, 0.0012, and 0.0001, respectively. The weights used to calculate the matrix indicators had satisfactory accordance (random coincidence coefficient = 0.056). A consistency check for the efficacy of the formula revealed kappa = 0.749 and P < .001. Conclusion : The developed and validated literature applicability evaluation formula may be a useful and convenient tool for identifying clinically valuable medical literature.
    Pakistan Journal of Medical Sciences Online 11/2014; 30(6):1377-82. DOI:10.12669/pjms.306.5450