The Chinese-German Journal of Clinical Oncology (Chin Ger J Clin Oncol )

Publisher: Chinese-German Society of Medicine; German-Chinese Society of Medicine, Springer Verlag

Journal description

The Chinese-German Journal of Clinical Oncology is an international professional academic periodical on oncology, being co-edited by China and Germany. The Journal, with the authors from around world, especially from China, is dominated in introducing the clinical experience of diagnosis and treatment as well as leading scientific research archievement in the tumor domain, in addition to report basic theory researches which help instruct the clinical practice of oncology and closely connect with the discipline. All the manuscripts are published in English, quarterly issued both internal and external, 64-80 pages, big 16 opens domains, art paper in offset printing, with lay.out by international customs, unified issuing number: ISSN 0178-3351/CN/42-1654/R.

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Website The Chinese-German Journal of Clinical Oncology website
Other titles Chinese-German journal of clinical oncology (Online)
ISSN 1610-1979
OCLC 55949344
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

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Springer Verlag

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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The laryngeal mask airway (LMA) is an established way for airway control during spontaneous ventilation. Its ability to deliver positive pressure ventilation without leakage especially in low flow states is still controversy. The aim of this study is to test the possibility of using LMA in pediatric closed circuit controlled ventilation, and to find out the optimum cuff volume to perform closed system ventilation.Twenty children scheduled for elective surgeries were enrolled in a crossover study. Laryngeal mask airway was used. In stage I, the cuff was inflated with the maximum volume of air as recommended by the manufacturers. Adjustment of volume of air inflated into the LMA cuff to the minimum volume to obtain the effective seal was done at stage II. The leak pressure, intracuff pressure and the leak volume were measured in both stages.The cuff filling volume was significantly lower compared to the maximum cuff inflation volume in stage I. Leakage values showed significantly less values in stage II of the study with smaller cuff inflation volumes. The airway leakage pressure was significantly lower in stage II in comparison to stage I. Cuff inflation pressure in stage I showed marked elevation which dropped significantly after adjustment of cuff volume in stage II.Laryngeal mask airway is an effective tool to provide closed circuit controlled ventilation in pediatrics. Inflation of the cuff by the minimum volume of air needed to reach the just sealing pressure is suggested to minimize the leakage volume.
    The Chinese-German Journal of Clinical Oncology 12/2013; 12(12).
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    ABSTRACT: The purpose of this study was to study the clinical and pathological characteristics of breast intraductal proliferative lesions (IDPLs) and associated with invasive breast cancer.We reviewed 327 cases of breast intraductal proliferative lesions including 53 cases of usual ductal hyperplasia, 57 cases of atypical ductal hyperplasia, 89 cases of ductal carcinoma in situ, and 128 cases coexist with invasive ductal carcinomas. Cases of pure invasive cancer without intraductal proliferative lesions were excluded. The mult IDPLs biological parameters including the express of ER, PR, HER2, HIF-1α and Ki-67 detected by immunohistochemistry S-P method (n = 327) and the levels of CA153, TSGF, CA125 and CEA both in nipple discharge and serum (n = 179) measured with Electrochemiluminescence method and their relationship were studied, and 30 cases of normal pregnant women were compared with.A single histologic subtype was present in 49.85% (163/327) of the cases, two subtypes in 33.03% (108/327), and three in 17.13% (56/327). The most common subtypes present were cribriform (43.12%, 141/327) and solid (38.53%, 126/327), while the comedo (16.35%, 54/327), and micropapillary (12.84%, 42/327) subtypes were less common. Comedo and solid were frequently found together for coexpression as were micropapillary and papillary subtypes. However, Comedo subtype was much less likely to be found with papillary, cribriform or micropapillary subtypes. Additionally, comedo subtypes tend to be hormone receptor negative, Her2 positive and high-grade while the cribriform and solid subtype tends to be hormone receptor positive, Her2 negative and low grade. Papillary subtype was least likely to be associated with an invasive cancer. Furthermore, the nipple discharge and serum levels of CA153, TSGF, CA125 and CEA in coexist with invasive ductal carcinomas patients were significantly higher than those in the benign breast disease (pure intraductal proliferative lesions) and normal pregnant women (P P P P P IDPLs often present more than one histologic subtype and the most common subtypes are cribriform and solid, while comedo and micropapillary subtypes are less common. Our results suggest that the levels of CA153, TSGF, CA125 and CEA in nipple discharge were significantly higher than those in the serum, and is associated with HIF-1α. The aberration of HIF-1α may play a key role during oncogenesis and promote breast cellular transformation into malignancy, a finding useful for further understanding of tumorigenesis. Nipple discharge can be the earliest presenting symptom of breast cancer. The dynamic combined detection of the four tumor markers both in nipple discharge and serum are helpful to the stratification of preoperative patients and benefit to better prewarning markers for monitoring their recurrence and metastasis and clinical staging of tumors in clinic, but cannot increase the sensitivity of judging the patients with early breast cancer.
    The Chinese-German Journal of Clinical Oncology 12/2013; 12(12).
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    ABSTRACT: The aim of this study was to study the short-term curative effects and adverse reactions of docetaxel (DOC) in concurrent chemoradiotherapy compared to DDP plus 5-Fu (DF) combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma.Thirty-three patients in the experimental group (DOC group) were given DOC 25 mg/m2 ivgtt, d1, 7 times, concurrent radiotherapy was performed from d1. Thirty-three patients in the control group (DF group) were given cisplatin 25 mg/m2 ivgtt d1-3 and 5-Fu 550 mg/m2 iv, d1-5, 3 weeks a cycle, 2 cycles, and concurrent radiotherapy was performed from d1. Six MV X-ray and 9 MeV electronic line for external irradiation were adopted in concurrent radiotherapy.The response rates of DOC group and DF group were 90.9% and 93.9%, the rates of neutropenia were 45.45% and 67.74%, and the rates of oral mucositis were 60.61% and 90.32%.The difference of short-term curative effects between DOC group and DF group was not statistically significant in patients with advanced nasopharyngeal carcinoma. The rates of adverse reactions were lower in DOC group. DOC combined with concurrent radiotherapy could be a new choice for patients with advanced nasopharyngeal carcinoma.
    The Chinese-German Journal of Clinical Oncology 12/2013; 12(12).
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    ABSTRACT: The aim of the study was to explore the role of Wnt/β-catenin signalling pathway in the maintenance, invasion and metastasis of colorectal cancer stem cells.Double immunohistochemical staining was used to detect the expression of EpCAMhigh/CD44+ which is regarded as the marker of colorectal cancer stem cells in 80 cases of colorectal cancer and their corresponding liver metastases. The SP method of immunohistochemistry was used to detect the expression of the key protein β-catenin in the Wnt pathway in these tissue. The expression and correlation of β-catenin and EpCAMhigh/CD44+ in colorectal cancer were analyzed and their role on the biological behavior of colorectal cancer was explored.The abnormal expression of β-catenin was significantly higher in colorectal cancer than in the paraneoplastic normal intestinal mucosa [55% (44/80) vs 10% (2/20), P high/CD44+ was significantly higher in colorectal cancer than in the paraneoplastic normal intestinal mucosa [66.25% (53/80) vs 0% (0/20), P P = 0.079), age (P = 0.416) and the magnitude (P = 0.816) of the tumor (P > 0.05), but it was significantly correlated with degree of differentiation (P = 0.001), depth of invasion (P = 0.001), clinical stage (P = 0.000) and metastasis (P = 0.000). In the colorectal cancer, the expression of EpCAMhigh/CD44+ cells has no correlation with gender (P = 0.934) and the magnitude (P = 0.160) of the tumor (P > 0.05), but was significantly correlated with age (P = 0.021), degree of differentiation (P = 0.013), depth of invasion (P = 0.000), clinical stage (P = 0.000) and metastasis (P = 0.000). In the corresponding liver metastases, we could also detecte EpCAMhigh/CD44+ cells. In cases with abnormal expression of β-catenin, the positive expression rate of EpCAMhigh/CD44+ was significantly higher than those with normal expression of β-catenin (84.1% vs 44.4%), and the difference was statistically significant (P The abnormal activation of Wnt/β-catenin signalling pathway may prompt the abnormal proliferation of the colorectal cancer stem cells, which leads to the recurrence and metastasis of the cancer.
    The Chinese-German Journal of Clinical Oncology 12/2013; 12(12).
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    ABSTRACT: A case with an Alpha-fetoprotein-producing (AFP-producing) carcinoma originating from the rectum was described. A 41-year-old man, who underwent a palliative surgery for rectal carcinoma, was diagnosed with occupying liver lesions and a remarkable AFP elevation (3484.61 ng/mL), and the AFP declined obviously 10 days after the palliative surgery. So we carried out a biopsy of the liver lesions. The histopathology was reported as low differentiation adenocarcinoma. The immunohistochemistry of the tumor cells via liver biopsy showed: Villin, CDX-2 was positive, Glypican-3 was partial positive, CK7, CK20, AFP, Hepatocyte were all negative. The initial histopathology was reported as an AFP-producing rectum adenocarcinoma with liver metastasis, which was a rare disease. So far, only 17 reports, none has been reported in China. Then, we summarize the characteristic of the disease: diagnosed with hepatic metastasis, raised serum AFP and a poor outcome, in addition to primary symptoms. This kind of disease is highly malignant.
    The Chinese-German Journal of Clinical Oncology 12/2013; 12(12).
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    ABSTRACT: The aim of this study was to evaluate effect and mechanism of 125I radioactive particles interposed radiotherapy between organizations on lung cancer.Fourteen cases of patients diagnosed with non-small cell lung cancer (NSCLC), the use of the B-, CT-guided, according to preoperative imaging and treatment planning system (TPS) program for radioactive particles interposed 125I interstitial radiotherapy.All patients were successfully 125I interstitial radioactive particles interposed radiotherapy. Postoperative local complete tumor remission in 9 cases, partial remission in 5 cases, the efficiency of 100%. No case of serious complications. After 3 to 4 weeks of chemotherapy after 11 cases. 4 cases of lung cancer with bone metastases, pain completely disappeared after treatment. Up to now, five cases have died due to tumor progression, survival time of 12 to 16 months. Nine cases still under follow-up observation and treatment.125I radioactive particles interposed radiotherapy between organizations of lung cancer, simple operation, trauma, fewer complications, conformal high, high local tumor dose, efficacy, and is a supplement of modern radiotherapy techniques for the treatment of lung cancer provides a comprehensive line of the method of effective.
    The Chinese-German Journal of Clinical Oncology 12/2013; 12(12).
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    ABSTRACT: The aim of the study was to evaluate the efficacy and tolerability of single-agent gemcitabine in the maintenance treatment of histologically confirmed metastatic breast cancer cases.The 45 patients carried efficacious chemotherapy were divided into maintenance therapy group (n = 23) and control group (n = 22) according to the different treatment methods. Patients in the maintenance therapy group received gemcitabine therapy until 6 cycles, disease progression or adverse effect intolerance. Within the control group, the patients were given best supportive care. Follow-up was made until disease progression, death or 2 years. The short-term clinical efficacy and adverse effects, progression-free survival (PFS) and median survival of recurrence (MSR) of these two groups were compared and analyzed.Compared with the control group, the experiment group had higher response rate (RR; 73.9% vs 31.8%; P P P > 0.05). Most of the treatment-related adverse events were mild, and the most common adverse event was hematologic toxicity. The 3 cases occurred grades 3–4 neutropenia and 3 cases occurred grades 3–4 thrombocytopenia. The 1 patient stopped treatment because of grade 3 allergic reaction, and 4 patients required dose reduction for grade 4 adverse events. Other adverse effects were grades 1–2, and all were recovered after symptomatic treatment. There was no significant side effect which threatened the life.In the extension maintenance treatment, gemcitabine can consolidate the therapeutic effect in advance and significantly prolong median PFS of metastatic breast cancer patients. In conclusion, gemcitabine monotherapy with a favorable safety profile is an effective maintenance treatment in metastatic breast cancer patients.
    The Chinese-German Journal of Clinical Oncology 12/2013; 12(12).
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    ABSTRACT: The aim of the study was to investigate whether enhanced anti-tumor effects of endostar (ES) on radiation involved hypoxia inducible factor-1α (HIF-1α) and basic fibroblast growth factor (bFGF).A549 cells were divided into four groups: control group; endostar (ES) group; radiation (RT) group; endostar plus radiation (ES + RT) group. The inhibition of proliferation rates of A549 cells was measured by cell counting kit-8 (CCK-8). HIF-1α and bFGF expression levels were checked by enzyme linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR).The proliferation inhibition rate in the ES + RT group was higher than that in other groups. On the other hand, the expressions of HIF-1α and bFGF in the ES + RT group were significantly reduced compared to other groups. HIF-1α and bFGF levels were positively correlated (r = 0.80, P Our results suggest that endostar could enhance anti-tumor effect of radiation by reducing expressions of HIF-1α and bFGF.
    The Chinese-German Journal of Clinical Oncology 12/2013; 12(12).
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    ABSTRACT: Ferritin is a kind of glycoprotein synthesized by the liver. Being the main form of stored iron in the body, it plays an important role in the iron balance. When the iron level in the body increases, ferritin can intake and storage the iron avoiding the cytotoxicity caused by the high level of intracellular iron; when body needs more iron, ferritin can release iron at any time. Recent studies have found that tumor tissue can synthesize and secrete ferritin. Ferritin levels increase in liver cancer, lung cancer, pancreatic cancer, breast cancer, leukemia and other malignancies. In this paper, we reviewed the relationship between the changed ferritin and the malignancy disease.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):551-554.
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    ABSTRACT: Objective The aim of the study was to observe the clinical effects of Shenqi Fuzheng injection decreasing sideeffects of chemotherapy for patients with ovarian epithelial cancer. Methods The 36 cases of ovarian epithelial cancer in The Third Affiliated Hospital of SUN Yat-sen University (Guangzhou, China) from June 2010 to June 2013, were randomly divided into the study group and the control group. The study group contained 18 cases using Shenqi Fuzheng injection combined with TP (Taxol + Carboplatin/cisplatin) chemotherapy, and the control group contained 18 cases only using TP chemotherapy without Shenqi Fuzheng injection. During and after chemotherapy, the side-effects and therapy effects were observed. Results The grade II of nausea and vomit were less in the study group than that in the control group, which was significantly different (P P > 0.05). There was less degree of decrease of lymphocyte in the study group than that in the control group, which was significantly different (P P > 0.05). There was no significant difference in chemotherapy effect between the two groups (P > 0.05). Conclusion Shenqi Fuzheng injection can in some degree relieve the side effects of TP chemotherapy for the patients with ovarian epithelial cancer, including relieving nausea and vomiting, protecting lymphocytes, and has no conflict effect on chemotherapy efficacy.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):537-539.
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    ABSTRACT: Objective We aimed to study the success and false negative rate of sentinel lymph node biopsy (SLNB) in different clinical stages breast cancer patients being carried out with neoadjuvant chemotherapy (NAC), and the clinical significance of SLNB, we conducting this trial. Methods One hunderd and thirty-seven cases were enrolled in this clinical research from March 2003 to March 2007. All of the patients’ sentinel lymph nodes were detected with 99mTc-Dx and methylene blue. There were 61 patients with stage T1–2N0M0 carried SLNB without NAC (group A), 76 cases were carried out NAC 3–4 cycles before SLNB, including 39 T2–4N0–1M0 cases (group B) and 27 T2–4N2–3M0 cases (group C). The success and false negative rate of SLNB were analysed with chi-square test. Results In group A, the successful and false negative rate of SLNB were 92.31% (36/39), 8.57% (3/35), and in group B and C were 92.31% (36/39), 8.57% (3/35) and 74.07 % (20/27), 18.52 % (5/27), respectively. The successful rate of group C decreased and false negative rate increased significantly compared with group A and B (P P > 0.05). Conclusion The SLNB can accurately predict lymph node status of axillary lymph node in N0–1 stage patients with NAC, but in N2–3 stage patients the success rate decreased and false rate increased negative significantly.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):521-523.
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    ABSTRACT: Objective The efficacy of preoperative transarterial chemoembolization (TACE) for hepatectomy on hepatocelluar carcinoma (HCC) is still controversial. This study aims to evaluate the efficacy of preoperative TACE on resectable HCC. Methods Pubmed, SCI, Medline, EMBASE, Cochrane Datebase, CNKI were searched. The articles that focused on preoperative TACE for resectable HCC, published from 1990 to 2012, were collected by computerized search of literatures and manual search of bibliographies. The relevant clinical trials’ data were reviewed by meta-analysis using the random effects model or fixed effect model by heterogeneity. The outcomes were expressed as odds ratio (OR) with 95% confidence intervals (CIs). Results A total of 1347 patients were included in these 7 studies, the cases were divided into the preoperative TACE group and the non-preoperative TACE group, and there was no difference between the two groups in the 3-year disease-free survival rate, with an odds ratio of 1.14 (95% CI = 0.90–1.45, P = 0.27); the 5-year disease-free survival rate in the preoperative TACE group was better than that in the non-TACE group with an odds ratio of 1.35 (95% CI = 1.07–1.74, P = 0.02); the 5-year overall survival rate in the preoperative TACE group was higher than that in the non-TACE group with an odds ratio of 0.59 (95% CI = 0.46–0.77, P Conclusion The present data suggests that preoperative TACE has no different in improving the 3-year disease-free survival rate with non-TACE group for resectable HCC, while it can improve the 5-year disease-free survival rate and the 5-year overall survival rate. More randomized controlled trials using large sample size are needed to provide sufficient evidence to confirm current conclusion.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):532-536.
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    ABSTRACT: Objective Male breast cancer is a rare disease with an incidence of about 1% of breast cancers in USA, but relatively lack of the information of male breast cancer in China, especially in Southwest of China, led us to study its incidence trends. Methods Chongqing is one of the biggest and the most important areas that is located in Southwest of China. There are around 31.4 million people who live in approximate 82 402.95 km2 area of Chongqing. Data about breast cancer patients registered in the Center for Disease Prevention and Control of Chongqing (China) were statistically collected from 187 hospitals, about 58 hospitals in city and 129 hospitals in country, and over 6.2 million people were studied every year. It was tried to represent all the people in villages and cities in Chongqing, China. Results The incidence of male breast cancer in Southwest of China ranged from 0.34/100 000 to 1.45/100 000 between 2007 and 2011, while the incidence of female breast cancer ranged from 15.40/100000 to 21.66/100000 at the same time. The rate of male breast cancer to female breast cancer ranged from 0.02:1 to 0.07:1, male breast cancer accounted for 1.96% to 6.5% (with the mean value of 2.9%) of breast cancers in Southwest of China from 2007 to 2010. Conclusion In Southwest of China male breast cancer accounts for about 2.9% of breast cancers which is higher than that in United States. It is important for policy makers and health manager to seriously consider breast cancer in future plan in Southwest of China.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):524-527.
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    ABSTRACT: Objective The work is a comparative study between two modalities of radiation therapy, the aim of which is to compare 3D conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) in treating posterior fossa boost in children with high risk medulloblastoma; dosimetrically evaluating and comparing both techniques as regard target coverage and doses to organs at risk (OAR). Methods Twenty patients with high risk medulloblastoma were treated by 3D-CRT technique. A dosimetric comparison was done by performing two plans for the posterior fossa boost, 3D-CRT and IMRT plans, for the same patient using Eclipse planning system (version 8.6). Results IMRT had a better conformity index compared to 3D-CRT plans (P value of 0.000). As for the dose homogeneity it was also better in the IMRT plans, yet it hasn’t reached the statistical significant value. Also, doses received by the cochleae, brainstem and spinal cord were significantly less in the IMRT plans than those of 3D-CRT (P value Conclusion IMRT technique was clearly able to improve conformity and homogeneity index, spare the cochleae, reduce dose to the brainstem and spinal cord in comparison to 3D-CRT technique.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):540-545.
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    ABSTRACT: Primary extraosseous Ewing’s sarcoma is a very rare clinical entity. In the report, we present the case of a 36-year-old female patient who underwent resection of lung mass and was diagnosed as having Ewing’s sarcoma by pathological examination. The clinical, imaging, and pathologic features of the case are described and discussed.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):555-558.
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    ABSTRACT: The absence of effective therapies for castration-resistant prostate cancer (CRPC) establishes the need to develop novel therapeutic modality, such as targeted gene therapy, which is ideal for the treatment of CRPC. But its application has been limited due to lack of favorable gene vector and the reduction of “bystander effect”. Consequently, scientists all over the world focus their main experimental research on the following four aspects: targeted gene, vector, transfer means and comprehensive therapy. In this paper, we reviewed the latest advances of experimental research on targeted gene therapy for prostate cancer.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):546-550.
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    ABSTRACT: Objective The aim of this study was to investigate the effects of radiofrequency treatment on sodium/iodide symporter expression of thyroid cancer cells. Methods In 29 thyroid cancer patients with low or no expression of soda \ iodide symporter, the radio frequency combined 131I therapy was used, the whole-body scintigraphy and serum Ig were detected before and after the radiofrequency treatment. Results The whole-body scintigraphy showed that 4 cases (4/29) before radiofrequency treatment had positive iodine uptake, 19 cases (19/29) two weeks after radiofrequency treatment had the positive iodine uptake, 12 cases (12/29) four weeks after radiofrequency treatment had the positive iodine uptake. Four weeks after radiofrequency treatment, 5 cases had increased serum Ig levels, 17 cases had decreased serum Ig levels, 7 cases showed no change. 25 cases (25/29) were effective, 15 cases (15/29) were cured. Conclusion The radiofrequency induced the non-expressed the sodium/iodide symporter of thyroid cancer cells regain the iodine intake ability, it improved the clinical efficacy of 131I therapy in dedifferentiated thyroid cancer.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):516-520.
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    ABSTRACT: Objective Recombinant human Endostatin (rh-Endostatin, YH-16) can reverse cisplatin resistance in A549/DDP cells. However, the possible effect of rh-Endostatin in reversing DDP-resistance in A549/DDP cells and the mechanism are needed to be investigated. Methods Lung adenocarcinoma cell line A549 and its DDP-resistant cell line A549/DDP were treated with DDP and/or recombinant human Endostatin. Difference in drug resistance was analyzed between different regimens and between different cell lines after a 72 h-treatment in vitro. And below the non-cytotoxic concentration of rh-Endostatin, the possibility of rh-Endostatin in reversing DDP-resistance in A549/DDP was evaluated. The resistance protein which was detected in the study included P glycoprotein (P-gp) and topoisomerase II (Topo-II). Results Rh-Endostatin below 400 μg/mL showed no cytotoxicity in either A549 or A549/DDP after 72 h-treatment with it. The inhibited concentration of 50% (IC50) observed for DDP was (0.79 ± 0.05) μg/mL in A549 and (13.2 ± 1.1) in A549/DDP respectively. IC50 was reduced to 2.57 ± 0.05 μg/mL in A549/DDP treated by rh-Endostatin below the non-cytotoxic concentrations in combination with DDP, with a reversal fold (RF) of 5.14 and a relative reversal rate of 85.6%. Apoptotic rates were 2.01%, 13.47% and 29.26% respectively for cells treated with rh-Endostain, DDP, and the combination. The rate of the A549/DDP control group was 0.99%. The expression level of P-gp or Topo-II was higher in A549/DDP cells than in A549 cells. Rh-Endostatin may partially reverse DDP-resistance in A549/DDP cells in vitro, with a probable mechanism related to lowering expression of P-gp and Topo-II. Conclusion Rh-Endostatin of non-cytotoxic dose partially reversed cisplatin resistance in cisplatin-resistant human lung adenocarcinoma cell line A549/DDP. Rh-Endostatin reversed the resistance of A549/DDP cells to DDP, which may be related to decreased protein expression of P-gp and Topo-II in A549/DDP cells.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):509-515.
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    ABSTRACT: Objective The aim of this study was to discuss HIF-1α expression and vasculogenic mimicry (VM) in hepatocellular carcinoma (HCC) and their relationship with the clinical pathological features and clinical significance. Methods Two hundred and seven specimens from patients in The Affiliated Hospital of North Sichuan Medical College who received hepatic cell carcinoma resection were tested by immunohistochemistry and double staining of CD31 and PSA. Then detected the expression of HIF-1α, VM, and analysed the relationship between clinical pathology. Results The HIF-1α positive rate was 71.01% and its expression was associated with liver cirrhosis, tumor size and TNM stage (P P = 0.0041). Conclusion Hypoxia may be the reason for VM in high invasive HCC, regulating the tumor microenvironment may have great significance in inhibiting invasion and metastasis of HCC.
    The Chinese-German Journal of Clinical Oncology 11/2013; 12(11):528-531.