JOP: Journal of the pancreas (J Pancreas)

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Website Journal of the Pancreas website
Other titles JOP. Journal of the Pancreas, Journal of the pancreas
ISSN 1590-8577
OCLC 46677991
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publications in this journal

  • JOP: Journal of the pancreas 11/2015; 16(6):633 - 644.
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    ABSTRACT: Chronic pancreatitis is an emerging and poorly understood disease in childhood. Total pancreatectomy with islet cell autotransplantation is being proposed as a treatment for chronic pancreatitis and recent studies report a more favorable outcome in children compared to adults. Herein, we review the therapeutic alternatives for pediatric chronic pancreatitis, focusing primarily on TP/IAT.
    JOP: Journal of the pancreas 11/2015; 16(4):335-341.
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    ABSTRACT: Objectives The natural history of obstructive pancreatitis is poorly known. We analyzed a consecutive surgical series of distal pancreatectomy to better characterize obstructive pancreatitis. Methods We retrospectively reviewed all patients with obstructive pancreatitis undergoing distal pancreatectomy at our institution from 1990-2005 excluding patients with pancreatic cancer. Obstructive pancreatitis was defined as chronic pancreatitis with: (1) stricture of the main pancreatic duct; (2) normal-appearing pancreas downstream to the stricture, and (3) dilatation of the pancreatic duct upstream to the stricture. Clinical charts were reviewed to determine prior history of acute pancreatitis, and patients were grouped by history of acute pancreatitis. Chi-square, Fisher’s exact, and student’s t-test analysis were used to evaluate differences in demographics and presenting characteristics between groups. Results Forty-eight (5.1%) of 946 patients had obstructive pancreatitis with 39 (81.3%) patients with prior acute pancreatitis and 9 (18.8%) without. Necrotizing pancreatitis was reported in 36% of the patients in the acute pancreatitis group. No necrosis was observed in those individuals without history of acute pancreatitis. Conclusions Prior acute pancreatitis was the most common cause of obstructive pancreatitis; however, nine patients had isolated strictures of the pancreatic duct without prior acute pancreatitis which can be labeled as focal chronic pancreatitis, distinct from other types of chronic pancreatitis both morphologically and etiologically.
    JOP: Journal of the pancreas 09/2015; 16(5):449-451.
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    ABSTRACT: The potential of lazaroid U-74389G in attenuating injury after ischemia and reperfusion has been reported in various organs. The present study focuses specifically on the pancreas and aims to examine any effects of U-74389G in a swine model of pancreatic ischemia and reperfusion, encompassing ischemic preconditioning. Twelve pigs, weighing 28-35 kg, were randomized into two experimental groups. Group A (control group, n=6): Two periods of ischemic preconditioning (5 min each) separated by a 5-min rest interval; then ischemia time 30 min and reperfusion for 120 min. Group B (n=6): the same as above, with U-74389G intravenous injection in the inferior vena cava immediately prior to the initiation of reperfusion. Blood sampling and pancreatic biopsies were conducted at 0, 30, 60, 90 and 120 min after reperfusion. Repeated-measures ANOVA was undertaken to evaluate differences between the two study groups. No statistically significant differences were noted concerning the histopathological parameters in the control and therapy groups (P=0.563 for edema, P=0.241 for hemorrhage, P=0.256 for leukocyte infiltration, P=0.231 for acinar necrosis and P=0.438 for vacuolization). In accordance with the above, serum metabolic data (glucose, creatinine, urea, total and direct bilirubin, total calcium, amylase, lipase, SGOT/AST, SGPT/ALT, ALP, GGT, LDH, CRP, insulin) were not significantly different between the two groups; similarly, tumor necrosis factor-α values (P=0.705) and tissue malondialdehyde levels (P=0.628) did not differ between the two groups. This swine model of pancreatic ischemia and reperfusion, encompassing preconditioning, indicates that U-74389G lazaroid does not seem to exert protective effects from pancreatic damage.
    JOP: Journal of the pancreas 03/2015; 16(2):176-84.