Revista de neurologia

Journal description

Current impact factor: 0.93

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 0.926
2012 Impact Factor 1.179
2011 Impact Factor 0.652
2010 Impact Factor 1.218
2009 Impact Factor 1.234
2008 Impact Factor 1.083
2007 Impact Factor 0.736
2006 Impact Factor 0.528
2005 Impact Factor 0.391
2004 Impact Factor 0.21
2003 Impact Factor 0.201
2002 Impact Factor 0.289
2001 Impact Factor 0.26
2000 Impact Factor 0.256
1999 Impact Factor 0.265

Impact factor over time

Impact factor

Additional details

5-year impact 0.81
Cited half-life 5.90
Immediacy index 0.46
Eigenfactor 0.00
Article influence 0.13
ISSN 1576-6578

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The use of dual task paradigms has revealed behavioural interactions between certain motor tasks, like standing or walking, and cognitive tasks when performed simultaneously. Despite the potential relevance of these findings accounting for certain neurological symptoms (i.e., falls), or for the design of new therapeutic interventions, there is few information available about such interaction effects in traumatic brain injury (TBI). To assess the presence of cognitive-motor interactions during dual tasking in TBI patients. Twenty TBI patients and 19 healthy matched controls performed two attentional and two working memory tasks (simple reaction times, complex reaction times, 1-back numeric, 1-back spatial) during dual task conditions, that is, at the same time than one motor task (standing and walking), and during single task conditions (without a motor task). Reaction times were recorded in response to all cognitive tasks. Patients exhibit slower performance than controls in all cognitive tasks (p < 0.05). While neither patients nor controls showed changes in reaction times in the two simpler attentional tasks during dual tasking as compared to single tasking conditions, TBI patients do exhibit improvements in working memory tasks (F(2, 74) = 2.9; p < 0.05) during dual tasking-walking (p < 0.02). The possible causes of positive cognitive-motor interactions during simultaneous execution of motor-working memory tasks in TBI patients are discussed, as well as the potential therapeutic value of dual task paradigms in the rehabilitation of these patients.
    Revista de neurologia 09/2015; 61(5):202-10.
  • Revista de neurologia 09/2015; 61(5):238-9.
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    ABSTRACT: Cerebral radiation is an indispensable cornerstone in the treatment of many primary and metastatic brain tumors. However, besides its desired therapeutic effect on tumor cells, a significant proportion of patients will experience neurotoxic side effects as the consequence of radiotherapy. Radiation necrosis can result in progressive neurological symptoms and radiographic changes. To differentiate radiation necrosis from progressive tumor based on imaging can pose a diagnostic challenge because the MRI characteristics may be similar in both situations. Therefore, surgical biopsy and pathological confirmation is sometimes necessary to guide further management. Effective treatment options for cerebral radiation necrosis exist and should be offered to symptomatic patients. A better understanding of the cellular and molecular processes underlying the development of radiation necrosis is necessary to prevent and minimize radiation-associated morbidity and to improve treatment strategies.
    Revista de neurologia 09/2015; 61(5):225-232.
  • Revista de neurologia 09/2015; 61(5):239-40.
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    ABSTRACT: Valproic acid (VPA) is a useful antiepileptic drug for controlling different types of epilepsy. It has several side effects and is associated to increased body weight, as well as metabolic and endocrine disorders, including metabolic syndrome. To determine the prevalence of obesity and metabolic syndrome among paediatric patients with epilepsy treated in monotherapy with VPA. The study was cross-sectional, observational and analytical. A sample of patients treated with VPA between 2010-2014 were studied and the body mass index (BMI), abdominal perimeter, arterial blood pressure, glucose, triglycerides and high density lipoproteins (HDL) were studied in search of obesity and metabolic syndrome. Obesity was defined as a BMI above the 95th percentile, and metabolic syndrome was considered if at least three of the following criteria were fulfilled: abdominal perimeter above the 90th percentile, systolic arterial pressure above the 90th percentile, triglycerides above 110 mg/dL and HDL below 40 mg/dL. A total of 47 patients with a mean age of 10.1 ± 4 years were studied; 51.06% were males. Eight (17%) of them developed obesity and, of those, two (25%) had metabolic syndrome. Three patients went on to become overweight (6%). Statistically significant differences were observed in the mean age in comparison to the BMI groups, where the obese patients were adolescents (ANOVA, p = 0.0001) and those who took more VPA per day were the obese (ANOVA, p = 0.024). Patients treated with VPA who become obese may go on to develop metabolic syndrome. They require careful monitoring and, if they are seen to put on weight, withdrawal of the drug should be considered.
    Revista de neurologia 09/2015; 61(5):193-201.
  • I Egea-Lucas · E Martinez-Mondejar · C F Piqueres-Vidal · M T Frutos-Alegria
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    ABSTRACT: Gelastic seizures are infrequent epileptic seizures in which the main manifestation is inappropriate laughter. They have a variety of causations. A search of the literature did not reveal any cases of pathological laughter that was clearly related with strokes, although there a numerous reports of non-epileptic pathological laughter as a prodromal symptom in stroke patients (fou rire prodromique). We report the case of a patient with infarcted cingulate gyrus who progressed with gelastic seizures at onset and during the course of the clinical process. An 81-year-old female who suddenly presented bouts of difficulties in verbal expression with disconnection from the milieu that were accompanied by fits of unmotivated and uncontrollable laughter that lasted less than five minutes. Following the attacks, her level of consciousness had dropped. In some of the attacks there were also involuntary movements of the upper limbs. Resonance imaging revealed the existence of an acute ischaemic lesion in the left territory of the cingulate gyrus and an electroencephalogram revealed the existence of epileptogenic activity in the left-hand anterior temporal and frontal regions. The clinical profile, the results of the complementary examinations and the response to the antiepileptic treatment allow us to state that in the episode reported in this patient we are dealing with gelastic seizures related to an acute ischaemic lesion in the left cingulate gyrus.
    Revista de neurologia 09/2015; 61(5):211-4.
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    ABSTRACT: Drug-resistant epilepsy, is a condition defined by the International League Against Epilepsy as persistent seizures despite having used at least two appropriate and adequate antiepileptic drug treatments. Approximately 20-30% of patients with epilepsy are going to be resistant to antiepileptic drugs, with different patterns of clinical presentation, which are related to the biological basis of this disease (de novo resistance, relapsing-remitting and progressive). Drug resistant epilepsy, impacts negatively the quality of life and significantly increases the risk of premature death. From the neurobiological point of view, this medical condition is the result of the interaction of multiple variables related to the underlying disease, drug interactions and proper genetic aspects of each patient. Thanks to advances in pharmacogenetics and molecular biology research, currently some hypotheses may explain the cause of this condition and promote the study of new therapeutic options. Currently, overexpression of membrane transporters such as P-glycoprotein, appears to be one of the most important mechanisms in the development of drug resistant epilepsy. The objective of this review is to deepen the general aspects of this clinical condition, addressing the definition, epidemiology, differential diagnosis and the pathophysiological bases.
    Revista de neurologia 08/2015; 61(4):159-66.
  • Revista de neurologia 08/2015; 61(4):191-2.
  • Revista de neurologia 08/2015; 61(4):187-8.
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    ABSTRACT: Poisoning by carbon monoxide is the most frequent form of intoxication in our milieu as a result of exposure to poisonous gases. The effects of carbon monoxide poisoning are not limited to acute exposure, since, following apparent recovery from the acute intoxication, neurological or behavioural disorders may appear. A study was conducted to examine the cases of carbon monoxide poisoning that had occurred in a healthcare area of 80,000 inhabitants over a 10-year period. These patients were then submitted to a follow-up to appraise the appearance of delayed neurological syndrome (DNS) and its relationship with different variables in the initial exposure to the carbon monoxide, in the treatment that was administered or in the severity of the intoxication. It was observed that around 9.1% of those intoxicated by carbon dioxide detected within the healthcare district of Salnes went on to develop DNS, which is more frequent in patients with severe analytical criteria and very unlikely in those who do not have them. Patients with DNS did not express any clinical or analytical manifestations that differed from those who did not have the syndrome; no differences were observed in relation to the oxygen therapy that was administered. The rate of DNS within the healthcare district of Salnes between 2002 and 2012 is 0.84 cases per 100,000 inhabitants per year.
    Revista de neurologia 08/2015; 61(4):153-8.
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    ABSTRACT: Trigeminal neuralgia is one of the most severe facial pain syndromes. The annual incidence varies between 4-13% and has a significant effect on patients' quality of life. When the pain cannot be controlled by pharmacological treatment, several different surgical options can be considered. The choice of technique will be based on observational studies and its application depends on the experience of each centre. To assess the effectiveness and level of evidence of pharmacological and surgical treatment in trigeminal neuralgia, and to analyse the current role of percutaneous techniques in the treatment of this pathology. The initial treatment of trigeminal neuralgia is pharmacological and carbamazepine is the only drug with a sufficiently high level of evidence. The percutaneous surgical techniques are effective and easy to apply, but the tendency for relapses to appear means there is a preference for vascular microdecompression. Yet, there are no reports of comparative studies that determine the superiority of a technique with a good level of evidence. The three most commonly used percutaneous techniques, balloon compression, glycerol rhizotomy and thermocoagulation by radiofrequency, were reviewed. This last technique is the one that has undergone the greatest development in recent years, with the emergence of neurophysiological techniques that make it possible to optimise results. The selection of a surgical technique for use in trigeminal neuralgia does not have much backing from randomised clinical trials. The new procedures in the application of radiofrequency can improve the treatment prospects of this pathology.
    Revista de neurologia 08/2015; 61(3):114-24.
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    ABSTRACT: The development of Parkinson's disease (PD) presents different complications deriving from the disease itself, but also from its treatment. The appearance of side effects with the use of antiparkinsonian drugs is common and their management is complicated, which makes it necessary to determine the epidemiological impact of these problems related with antiparkinsonian medication. To estimate the prevalence of the side effects of the treatment for the motor symptoms of PD and the possible long-term impact. A systematic review was performed in the biomedical databases since the year 2004; the most relevant studies were selected and the frequencies of the most common side effects were identified. The data thus obtained were projected in order to estimate their impact in the long term. Altogether 218 studies were identified, of which 24 were selected for the review. Data were obtained for 20 types of complications deriving from the antiparkinsonian treatment, including heart problems, oedemas and neuropsychiatric symptoms. The estimations performed indicate that the number of patients with PD and therefore the prevalence of the side effects of antiparkinsonian treatments may well double by the year 2050.
    Revista de neurologia 08/2015; 61(3):97-105.
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    ABSTRACT: Few authors have compared the life and work of Cajal and Pavlov and they refer normally to their coincidence at the XIV Medicine International Congress of Madrid in 1903. To describe the theoretical models of both authors and to explain the possible complementarities between the works of Cajal and Pavlov. We describe the principal bases of the 'neuron theory' of Cajal, compared to the 'reticulated theory', the principal results of Cajal's investigations and the contributions he made to the concept of plasticity. We describe the 'Pavlov's conditional reflections theory', its principal postulates, pavlovians laws and the typology of the nervous system according to Pavlov. The works of Cajal and Pavlov can be understood as complementary under Wallon's proposal and in the frame of the 'strategic epistemology', where the advance of the science is achieved from different but complementary strategies that help each other to construct stronger theoretical models.
    Revista de neurologia 08/2015; 61(3):125-36.
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    ABSTRACT: The development of atypical features in rolandic epilepsy is part of a clinical spectrum of phenotypes that are variable, idiopathic and age-dependent, as well as having a genetically determined predisposition. To study the electroclinical characteristics suggesting an atypical development in rolandic epilepsy. A retrospective search was performed in 133 children diagnosed with atypical benign focal epilepsy (ABFE), Landau-Kleffner syndrome and continuous spike-wave during sleep (CSWS). Nine patients were selected, all of whom presented atypical clinical features and an electroencephalogram (EEG) pattern of electrical status epilepticus during sleep (ESES) in the course of their rolandic epilepsy. The average age at onset of rolandic epilepsy was 5 years. Patients showed a deterioration of both their clinical features and their EEG recording one and a half years later, on average. ABFE was observed in three of them and CSWS in six. No cases of Landau-Kleffner syndrome were found. The EEG in wakefulness showed the focus to be in the left centrotemporal region in six patients and in three of them it was on the right-hand side. All the patients presented ESES in the EEG during sleep. An atypical pattern was observed in the regional ESES in three of the patients. Moreover, cognitive and behavioural disorders were detected due to deficits in specific learning areas, such as language, memory, attention and restlessness. The early onset of rolandic epilepsy, the appearance of new seizures with an increased frequency and the frontocentrotemporal focus in the EEG, which increases in frequency, both in wakefulness and in sleep, are all electroclinical characteristics of an atypical development.
    Revista de neurologia 08/2015; 61(3):106-13.
  • Revista de neurologia 08/2015; 61(3):143-4.
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    ABSTRACT: A glioblastoma is a primary brain tumour that is very aggressive and resistant to conventional treatment with chemo- or radiotherapy. Given that epidermic growth factor receptor (EGFR) is altered in 50% of glioblastomas, it is currently one of the most promising therapeutic targets in this kind of tumour. Yet, inhibitors of the kinase activity of EGFR have yielded poor results in clinical trials with patients with glioblastomas. In this review we analyse the function of EGFR in glioblastomas and outline the therapeutic approaches aimed against this receptor in this kind of tumour. This sort of analysis could be a starting point for improving the design of future therapies for glioblastomas, based on inhibiting the EGFR function.
    Revista de neurologia 07/2015; 61(2):85-93.