Research on Chemical Intermediates

Publisher: Brill Academic Publishers

Journal description

The aim of Research on Chemical Intermediates is to publish current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. Issues also contain articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. The journal is published in one volume of 9 issues per annum.

Current impact factor: 1.22

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.221
2013 Impact Factor 1.54
2012 Impact Factor 0.88
2011 Impact Factor 0.697
2010 Impact Factor 0.715
2009 Impact Factor 0.813
2008 Impact Factor 0.514
2007 Impact Factor 0.647
2006 Impact Factor 0.555
2005 Impact Factor 0.513
2004 Impact Factor 0.446
2003 Impact Factor 0.645
2002 Impact Factor 0.539
2001 Impact Factor 0.556
2000 Impact Factor 0.791
1999 Impact Factor 0.992
1998 Impact Factor 0.941
1997 Impact Factor 1.068
1996 Impact Factor 1.148
1995 Impact Factor 1.168
1994 Impact Factor 0.867
1993 Impact Factor 1.464
1992 Impact Factor 0.931

Impact factor over time

Impact factor

Additional details

5-year impact 1.14
Cited half-life 4.00
Immediacy index 0.27
Eigenfactor 0.00
Article influence 0.20
Website Research on Chemical Intermediates website
Other titles Research on chemical intermediates (Online), Chemical intermediates
ISSN 1568-5675
OCLC 51252705
Material type Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Brill Academic Publishers

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print can only be deposited after acceptance for peer-review
    • Author's post-print and Publisher's version/PDF on author's personal website
    • Author's post-print on institutional website or institutional repository
    • Must link to publisher version
    • Published source must be acknowledged
  • Classification

Publications in this journal

  • Research on Chemical Intermediates 01/2016; DOI:10.1007/s11164-015-2302-0
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    ABSTRACT: A D-A-D cationic cyclopentadienyl iron complex containing double arylazo chromophores (Fc-diazo) with methoxyl group (Fc-diazo-OMe) was obtained via nucleophilic substitution and well characterized by IR, UV-visible, 1H NMR, and 13C NMR spectroscopy, and MS. UV-Vis absorption and nonlinear optical property of Fc-diazo-OMe were investigated by comparison of Fc-diazo with no methoxyl group (Fc-diazo-H). Quantum chemical calculations of the orbital energy, geometric structure of Fc-diazo-OMe, and Fc-diazo-H were conducted by using density functional methods at the B3PW91/Lanl2dz level. Charge transfer from the highest occupied molecular orbital to the lowest unoccupied molecular orbital was found based on density functional theory. The substitution of the methoxyl group greatly improves the NLO property of Fc-diazo. Fc-diazo-OMe shows effective two-photon absorption, coefficient and third-order nonlinear susceptibility for potential applications as optical materials, while Fc-diazo-H barely shows NLO ability.
    Research on Chemical Intermediates 11/2015; 41(11):8245-8255. DOI:10.1007/s11164-014-1888-y
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    ABSTRACT: A copper-mediated Duff reaction for ortho-selective formylation of phenols has been developed. In the presence of copper species, significant improvements of yield and ortho-selectivity of the Duff formylation were achieved, which provides an easy access to salicylaldehydes from phenols.
    Research on Chemical Intermediates 11/2015; 41(11):8147-8158. DOI:10.1007/s11164-014-1881-5
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    ABSTRACT: Tartaric acid is a highly effective and efficient catalyst for the one-pot synthesis of highly substituted piperidines through a combination of 1,3-dicarbonyl compounds, aromatic aldehydes, and various amines in methanol at room temperature. The advantages of this protocol are good yields, short reaction time, mild reaction conditions, no need for column chromatography, easy access, simple work-up procedure, and a cheap and biodegradable catalyst.
    Research on Chemical Intermediates 11/2015; 41(11):8057-8065. DOI:10.1007/s11164-014-1877-1
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    ABSTRACT: N,N,N0,N0-Tetrachlorobenzene-1,3-disulfonamide and poly(N,N0-dichloro- N-ethyl-benzene-1,3-disulfonamide) are new catalysts promoted by one-pot, facile and four-component synthesis of new substituted 1,4-dihydropyridine derivatives from the reaction of ammonium acetate, aldehydes and various 1,3-dicarbonyl compounds with good to high yields at room temperature under mild conditions. All the synthesized compounds were evaluated for antibacterial and anti-oxidant activities. Antibacterial activity was determined against four Gram-positive and -negative bacteria, and antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl free radical scavenging. The bioassay results indicated that synthesized 1,4-dihydropyridine derivatives have effective anti-oxidant and antibacterial functions.
    Research on Chemical Intermediates 10/2015; DOI:10.1007/s11164-015-2310-0
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    ABSTRACT: g-C3N4/BiOX (X = Cl, Br, I) composite photocatalysts have been prepared by means of a facile immersion-hydrolysis method. The microstructural and morphological characteristics of the as-prepared composite photocatalysts were investigated by means of X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy. The photodegradation performance of both g-C3N4/BiOCl and g-C3N4/BiOBr composites was superior to that of pure g-C3N4 or the corresponding bismuth oxyhalides, possibly because of efficient separation of photogenerated carriers at the interface between g-C3N4 and BiOX (X = Cl, Br). The photostability of as-prepared g-C3N4/BiOX (X = Cl, Br) composites was also investigated.
    Research on Chemical Intermediates 10/2015; 41(10):6941-6955. DOI:10.1007/s11164-014-1789-0
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    ABSTRACT: In this paper, the preparation and characterization of hydroxyapatite-encapsulated γ-Fe2O3 nanoparticles functionalized with Melamine nanocomposite (γ-Fe2O3@HAp@Melamine) are presented. The resulting nanocomposite was characterized by infrared spectroscopy, scanning electron microscope, thermal gravimetric analysis, X-ray diffraction, vibrating sample magnetometer and elemental analysis. The catalytic activity of γ-Fe2O3@ HAp@Melamine as a magnetic powerful basic nanocatalyst was probed through one-pot synthesis of 1, 4-dihydropyridine and polyhydroquinoline derivatives through Hantzsch condensation reaction under solvent-free thermal conditions. The heterogeneous catalyst could be recovered easily by simple magnetic decantation and reused many times without significant loss of its catalytic activity.
    Research on Chemical Intermediates 10/2015; 41(10):7227-7244. DOI:10.1007/s11164-014-1808-1
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    ABSTRACT: A new simple and sensitive spectrophotometric method for some phenothiazine derivatives has been developed. The proposed method is based on the reaction of phenothiazine derivatives promethazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, prochlorperazine, and trifluoperazine with potassium iodate followed by reaction of liberated iodine with leuco crystal violet (LCV) and measurement of the color of the oxidized LCV at 598 nm. The method showed a good linearity in the ranges 0.05-4.0, 0.02-2.0, 0.05-5.0, 0.1-8.0, and 0.05-2.0 μg mL-1 respectively. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully to the analysis of phenothiazine derivatives in pure form and in their dosage forms, and no interference was observed from common excipients present in pharmaceutical formulations.
    Research on Chemical Intermediates 10/2015; 41(10):7481-7495. DOI:10.1007/s11164-014-1838-8
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    ABSTRACT: The inhibition effect of quince pulp extract (QPE) on the adsorption and corrosion of carbon steel in 1M HCl solution was investigated using the weight loss method, potentiodynamic polarization and impedance spectroscopy measurements. At first, the quince extract was characterized, its polyphenolic content was qualitatively and quantitatively determined and its anti-oxidant activity was assessed. The HPLC-DAD-MS showed that the quince extract contained a high quantity of polyphenols with the main compounds being neochlorogenic acid, rutin and chlorogenic acid (7.68, 9.05 and 18.57 mg/g fw, respectively), which represent together about 84 % of total phenolics. The extract exhibited a strong antioxidant potential as it inhibited 87 % of the DPPH· anionic radical. The polarization measurements indicate that the extract acts as a mixed inhibitor. The values of inhibition efficiency increase with inhibitor concentration reaching a maximum value (88 %) at 5 × 10-1 g/L. The presence of QPE enhances the values of R t and reduces the C dl values. The adsorption of QPE under consideration on a steel/acidic solution interface at all temperatures follows the Langmuir adsorption isotherm. The QPE inhibitor efficiency was temperature-independent.
    Research on Chemical Intermediates 10/2015; 41(10):7463-7480. DOI:10.1007/s11164-014-1837-9
  • M. Lv · H. Zheng · Y. Li · W. Gao ·
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    ABSTRACT: In this investigation, the first introduction of a tert-butyl group into [1,2,4]triazino[5,6-b]indole and indolo[2,3-b]quinoxaline systems, leading to a series of structurally novel 8-(t-butyl)-5H-[1,2,4]triazino[5,6-b]indole-3-thiol and 9-(t-butyl)-6H-indolo[2,3-b]quinoxaline derivatives, has been achieved by condensation of tert-butyl-substituted isatins with benzene-1,2-diamine or thiosemicarbazide. The molecular structures of these newly synthesized compounds were elucidated on the basis of elemental analysis and spectral data.
    Research on Chemical Intermediates 10/2015; 41(10):6927-6939. DOI:10.1007/s11164-014-1788-1
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    ABSTRACT: 3-(2′-Benzothiazolyl)-2,3-dihydroquinazolin-4(1H)- one, 1-((benzo[d]thiazol-2-ylamino) (aryl)-methyl)naphthalen-2-ol and 4H-pyrimido[2,1-b][1,3]benzothiazoles derivatives were prepared via one-pot three-component reaction of arylaldehydes, 2-aminobenzothiazole and isatoic anhydride or β-naphthol or ethyl/methyl acetoacetate in the presence of agar as a highly efficient homogenous catalyst. The use of a non-toxic and biodegradable catalyst, as well as high yields, short reaction time, simple work-up and green conditions are the most important advantages of this method. Graphical Abstract: [Figure not available: see fulltext.]
    Research on Chemical Intermediates 10/2015; 41(10):7377-7391. DOI:10.1007/s11164-014-1818-z
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    ABSTRACT: Biomorphic Ni-Al layered double-hydroxide (LDH) nanosheets with 3D hierarchical structures were synthesized with cotton from discarded T-shirt as templates. The as-prepared samples were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetry-differential thermal analysis, scanning electron microscopy, and energy-dispersive X-ray diffraction. Adsorption of Congo red (CR) by calcined Ni-Al layered double hydroxides (CLDH) from aqueous solution was investigated in detail. Different conditions were evaluated, including solution pH, amount of adsorbent, initial CR concentration, contact time, and temperature. The adsorption kinetics and equilibrium isotherms of the CLDH were studied by use of pseudo-first-order and pseudo-second-order kinetic models, and the Langmuir, Freundlich, and Dubinin-Radushkevich isotherms. Equilibrium isotherms of uptake of CR by CLDH were a good fit to the Freundlich equation, and the adsorption kinetics of CR followed a pseudo-second-order kinetic model. These results suggest that CLDH may be effective adsorbents for the removal of anionic dyes from wastewater.
    Research on Chemical Intermediates 10/2015; 41(10):7899-7914. DOI:10.1007/s11164-014-1865-5
  • Q. Jin · F. Li · Y. Li · F. Jin · L. Jiang ·
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    ABSTRACT: A series of α-alkoxyimino-[1-(4-methylpiperazino-1-yl)carbonylmethyl-1H-benzimidazol-2-yl] acetonitriles were synthesized from o-phenylenediamine, ethyl cyanoacetate, chloroacetyl piperazine, and haloalkane/benzyl chloride by multi-step reactions. The structures of the target compounds were elucidated by IR, 1H NMR, MS, and elemental analysis. All the target compounds were tested for in vitro antifungal activities against Sclerotinia sclerotiorum and Botrytis cinerea by the mycelium growth rate method, and the results indicated that some compounds displayed higher antifungal activity as compared to carbendazim.
    Research on Chemical Intermediates 10/2015; 41(10):7695-7702. DOI:10.1007/s11164-014-1853-9
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    ABSTRACT: Silver-doped TiO2 hybrid nanolayers (NLs) were prepared via the sol-gel method using TiCl4 as a precursor, and the products were characterized by X-ray diffraction, atomic force microscopy, scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. A detailed study of the visible light hydrophilicity of Ag-TiO2 NLs by evaluating the contact angle of water droplets on the surface of the layers has been performed. Furthermore, a series of experiments was carried out in order to find the optimum value of dopant concentration. The results revealed that the Ag-TiO2 hybrid NLs extended the light absorption spectrum toward the visible region and considerably enhanced the hydrophilicity of TiO2 NLs under visible light irradiation. The significant enhancement in the visible light hydrophilicity activity of TiO2 NLs under visible light irradiation can be ascribed to the generation of a new electronic state acting as an electron trap in TiO2 and responsible for narrowing the band gap of TiO2 and shifting its optical response from the ultraviolet to the visible light region.
    Research on Chemical Intermediates 10/2015; 41(10):7299-7311. DOI:10.1007/s11164-014-1813-4
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    ABSTRACT: A variety of 4H-chromenes, benzochromenes, 4,5-dihydropyrano[3,2-c]chromenes, 4H-pyran-3-carboxylates, and 3,4-disubstituted isoxazol-5(4H)-ones have been synthesized in high yields by using potassium hydrogen phthalate (KHP) as an inexpensive, commercially available catalyst. It was found that the three-component tandem reaction enabled synthesis of pyran-annulated heterocycles in water at 50 °C. 3,4-Disubstituted isoxazol-5(4H)-ones were synthesized by use of 10 mol% KHP in water at room temperature. Also, treatment of methylene-containing compounds (malononitrile or ethyl cyanoacetate) with aromatic aldehydes in the presence of 5 mol% KHP resulted in α,β-unsaturated nitriles. The procedure is an easily performed, straightforward method for synthesis of a variety of pyran-annulated compounds, isoxazol-5(4H)-one-containing heterocycles, and Knoevenagel adducts. The reaction is safe, uses mild conditions, and is environmentally benign. Other notable advantages are reuse of the catalyst, no use of hazardous organic solvents, and ease of work-up.
    Research on Chemical Intermediates 10/2015; 41(10):7847-7882. DOI:10.1007/s11164-014-1863-7
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    ABSTRACT: New S-alkyl O-hydrogen sulfothioate functionalized silica-coated magnetic nanoparticles were prepared in a simple method and evaluated as an efficient catalyst in synthesis of mono- and bis-spiro-2-amino-4H-pyrans through three or pseudo-five component reaction of isatins or bis-isatins and malononitrile with dimedone or 4-hydroxycoumarin. The yields were excellent, and the catalyst could be recovered simply from the reaction mixture using an external magnet and reused at least five times without noticeable loss of catalytic activity.
    Research on Chemical Intermediates 10/2015; 41(10):7427-7435. DOI:10.1007/s11164-014-1834-z
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    ABSTRACT: The effect of newly synthesized 6-hydroxy-5,7-diphenyl-1,3-diazaadamantane (HDDA) and 5,7-diphenyl-1,3-diazaadamantan-6-one (DDA) against the corrosion of copper in 1 M HNO3 solution was investigated using potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and weight loss measurements. These measurements show that the inhibition efficiency (IE %) obtained by these compounds increased by increasing their concentrations, and maximum IE % to 90.84 % for HDDA and 89.87 % for DDA were found at 300 ppm. Data obtained from EIS studies were analyzed by an equivalent circuit model. EIS plots indicated that the inhibitor performance depends on the adsorption of the molecules on the metal surface. Polarization measurements showed that both HDDA and DDA are mixed-type but predominantly cathodic in 1 M HNO3 solution. The adsorption of inhibitors on the copper surface from the nitric acid follows the Langmuir adsorption isotherm with a negative value of free energy, and these values indicated that adsorption of both HDDA and DDA molecules adsorbs physically on the copper surface. The surface morphology was examined by scanning electron microscope and atomic force microscope. Further, theoretical calculations were carried out and relationships between computed parameters and experimental IE % were discussed. All the results confirmed that e HDDA showed better efficiency in 1 M HNO3 compared to DDA.
    Research on Chemical Intermediates 10/2015; 41(10):7593-7615. DOI:10.1007/s11164-014-1846-8
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    ABSTRACT: Pseudomonas tamsuii TKU015 produced insecticidal materials using squid pen as the sole carbon and nitrogen source. The insecticidal activity of the produced metabolites was evaluated against Drosophila melanogaster larvae. The growth of P. tamsuii TKU015 was accompanied by increased mortality. SDS-PAGE showed the molecular weight of the insecticidal toxin of P. tamsuii TKU015 to be 94.7 kDa, corresponding to the TccC insecticidal protein from P. taiwanensis TKU015. These results showed that P. tamsuii TKU015 could be applicable in controlling Drosophila for developing novel biopesticides in organic agriculture.
    Research on Chemical Intermediates 10/2015; 41(10):7965-7971. DOI:10.1007/s11164-014-1869-1