PLoS Computational Biology (PLOS COMPUT BIOL)

Publications in this journal

• Article: Computational Biomarker Pipeline from Discovery to Clinical Implementation: Plasma Proteomic Biomarkers for Cardiac Transplantation

  Gabriela V. Cohen Freue, Anna Meredith, Derek Smith, Axel Bergman, Mayu Sasaki, Karen K. Y. Lam, Zsuzsanna Hollander, Nina Opushneva, Mandeep Takhar, David Lin, Janet Wilson-McManus, Robert Balshaw, Paul A. Keown, Christoph H. Borchers, Bruce McManus, Raymond T. Ng ¶ mail, W. Robert McMaster ¶, for the Biomarkers in Transplantation, the NCE CECR Prevention of Organ Failure Centre of Excellence Teams
  PLoS Computational Biology 01/2013;
• Article: MC EMiNEM Maps the Interaction Landscape of the Mediator

  T. Niederberger, S. Etzold, M. Lidschreiber, K. C. Maier, D. E. Martin, H. Fröhlich, P. Cramer, A. Tresch
  PLoS Computational Biology 05/2012;
• Article: adjusting phenotypes by noise control

  Kyung Hyuk Kim, Herbert M sauro
  PLoS Computational Biology 01/2012; 8:e1002344.
• Article: Dopamine, affordance and active inference

  Karl J Friston, Tamara Shiner, Thomas FitzGerald, Joseph M Galea, Rick Adams, Harriet Brown, Raymond J Dolan, Rosalyn Moran, Klaas Enno Stephan, Sven Bestmann
  PLoS Computational Biology 01/2012; 8(1):e1002327.
• Article: Quantitative dynamics of telomere bouquet formation

  D. M. Richards, E. Greer, A. C. Martin, G. Moore, P. J. Shaw, M. Howard
  [show abstract] [hide abstract]
  ABSTRACT: The mechanism by which homologous chromosomes pair during meiosis, as a prelude to recombination, has long been mysterious. At meiosis, the telomeres in many organisms attach to the nuclear envelope and move together to form the telomere bouquet, perhaps to facilitate the homologous search. It is believed that diffusion alone is not sufficient to account for the formation of the bouquet, and that some directed movement is also required. Here we consider the formation of the telomere bouquet in a wheat-rye hybrid both experimentally and using mathematical modelling. The large size of the wheat nucleus and wheat's commercial importance make chromosomal pairing in wheat a particularly interesting and important process, which may well shed light on pairing in other organisms. We show that, prior to bouquet formation, sister chromatid telomeres are always attached to a hemisphere of the nuclear membrane and tend to associate in pairs. We study a mutant lacking the Ph1 locus, a locus ensuring correct homologous chromosome pairing, and discover that bouquet formation is delayed in the wild type compared to the mutant. Further, we develop a mathematical model of bouquet formation involving diffusion and directed movement, where we show that directed movement alone is sufficient to explain bouquet formation dynamics.
  PLoS Computational Biology 01/2012; 8(12):e1002812.
• Article: Sarcomeric pattern formation by actin cluster coalescence

  B M Friedrich, E Fischer-Friedrich, N S Gov, S A Safran
  PLoS Computational Biology 01/2012;
• Article: plcb-03-08-07 1..14

  Christian Jacob
  PLoS Computational Biology 01/2007;