PLoS Computational Biology (PLOS COMPUT BIOL)
PLoS Computational Biology features works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. Readers include life and computational scientists, who can take the important findings presented here to the next level of discovery.
- Impact factor5.22Show impact factor historyHide impact factor history
- WebsitePLoS Computational Biology website
Other titlesPLOS computational biology (Online), PLOS computational biology, Public Library of Science computational biology, Computational biology
Material typeDocument, Periodical, Internet resource
Document typeInternet Resource, Computer File, Journal / Magazine / Newspaper
- Author can archive a pre-print version
- Author can archive a post-print version
- Creative Commons Attribution License
- Eligible UK authors may deposit in OpenDepot
- Publisher's version/PDF may be used
Publications in this journal
Article: Computational Biomarker Pipeline from Discovery to Clinical Implementation: Plasma Proteomic Biomarkers for Cardiac TransplantationPLoS Computational Biology 01/2013;
PLoS Computational Biology 05/2012;
PLoS Computational Biology 01/2012; 8:e1002344.
PLoS Computational Biology 01/2012; 8(1):e1002327.
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ABSTRACT: The mechanism by which homologous chromosomes pair during meiosis, as a prelude to recombination, has long been mysterious. At meiosis, the telomeres in many organisms attach to the nuclear envelope and move together to form the telomere bouquet, perhaps to facilitate the homologous search. It is believed that diffusion alone is not sufficient to account for the formation of the bouquet, and that some directed movement is also required. Here we consider the formation of the telomere bouquet in a wheat-rye hybrid both experimentally and using mathematical modelling. The large size of the wheat nucleus and wheat's commercial importance make chromosomal pairing in wheat a particularly interesting and important process, which may well shed light on pairing in other organisms. We show that, prior to bouquet formation, sister chromatid telomeres are always attached to a hemisphere of the nuclear membrane and tend to associate in pairs. We study a mutant lacking the Ph1 locus, a locus ensuring correct homologous chromosome pairing, and discover that bouquet formation is delayed in the wild type compared to the mutant. Further, we develop a mathematical model of bouquet formation involving diffusion and directed movement, where we show that directed movement alone is sufficient to explain bouquet formation dynamics.PLoS Computational Biology 01/2012; 8(12):e1002812.
PLoS Computational Biology 01/2012;
Article: plcb-03-08-07 1..14PLoS Computational Biology 01/2007;
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.
ISSN: 1995-7645, Impact factor: 0.37
Public Library of Science, Public...
ISSN: 1932-6203, Impact factor: 4.09
ISSN: 1878-0407, Impact factor: 1.72
ISSN: 1873-6254, Impact factor: 2.22
ISSN: 1873-4847, Impact factor: 4.29
ScienceDirect (Online service), Elsevier
ISSN: 1873-426X, Impact factor: 2.03
ISSN: 1873-3344, Impact factor: 3.25
Panepistēmio tēs Krētēs
ISSN: 1791-244X, Impact factor: 1.98