Annals of internal medicine (Ann Intern Med)

Publications in this journal

• Article: The Status of Baby Boomers' Health in the United States: The Healthiest Generation? King DE, Matheson E, Chirina S, Shankar A, Broman-Fulks J. JAMA Intern Med. 2013 Feb 4:1-2. doi: 10.1001/jamainternmed.2013.2006

  The Status of Baby Boomers' Health in the United States: The Healthiest Generation
  Annals of internal medicine 02/2014;
• Article: The big problem.

  Priyanka Gosain
  Annals of internal medicine 05/2013; 158(9):703.
• Article: Pulmonary hypertension.

  Jess Mandel, David Poch
  Annals of internal medicine 05/2013; 158(9):ITC5-1.
• Article: Melanotan and the posterior reversible encephalopathy syndrome.

  Diego Kaski, Nina Stafford, Amrish Mehta, Ieuan Harry Jenkins, Paresh Malhotra
  Annals of internal medicine 05/2013; 158(9):707-8.
• Article: Action to Stop Smoking in Suspected Tuberculosis (ASSIST) in Pakistan: A Cluster Randomized, Controlled Trial.

  Kamran Siddiqi, Amir Khan, Maqsood Ahmad, Omara Dogar, Mona Kanaan, James N Newell, Heather Thomson
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  ABSTRACT: Tobacco use is responsible for a large proportion of the total disease burden from tuberculosis. Pakistan is one of the 10 high-burden countries for both tuberculosis and tobacco use. To assess the effectiveness of a behavioral support intervention and bupropion in achieving 6-month continuous abstinence in adult smokers with suspected pulmonary tuberculosis. Cluster randomized, controlled trial. (Current Controlled Trials: ISRCTN08829879) Health centers in the Jhang and Sargodha districts in Pakistan. 1955 adult smokers with suspected tuberculosis. Health centers were randomly assigned to provide 2 brief behavioral support sessions (BSS), BSS plus 7 weeks of bupropion therapy (BSS+), or usual care. The primary end point was continuous abstinence at 6 months after the quit date and was determined by carbon monoxide levels in patients. Secondary end points were point abstinence at 1 and 6 months. Both treatments led to statistically significant relative risks (RRs) for abstinence compared with usual care (RR for BSS+, 8.2 [95% CI, 3.7 to 18.2]; RR for BSS, 7.4 [CI, 3.4 to 16.4]). Equivalence between the treatments could not be established. In the BSS+ group, 275 of 606 patients (45.4% [CI, 41.4% to 49.4%]) achieved continuous abstinence compared with 254 of 620 (41.0% [CI, 37.1% to 45.0%]) in the BSS group and 52 of 615 (8.5% [CI, 6.4% to 10.9%]) in the usual care group. There was substantial heterogeneity of program effects across clusters. Imbalances in the urban and rural proportions and smoking habits among treatment groups, and inability to confirm adherence to bupropion treatment and validate longer-term abstinence or the effect of smoking cessation on tuberculosis outcomes. Behavioral support alone or in combination with bupropion is effective in promoting cessation in smokers with suspected tuberculosis. International Development Research Centre.
  Annals of internal medicine 05/2013; 158(9):667-75.
• Article: An acute change in lung allocation score and survival after lung transplantation: a cohort study.

  Wayne M Tsuang, David M Vock, C Ashley Finlen Copeland, David J Lederer, Scott M Palmer
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  ABSTRACT: Chinese translation Lung transplantation is an effective treatment for patients with advanced lung disease. In the United States, lungs are allocated on the basis of the lung allocation score (LAS), a composite measure of transplantation urgency and utility. Clinical deteriorations result in increases to the LAS; however, whether the trajectory of the LAS has prognostic significance is uncertain. To determine whether an acute increase in the LAS before lung transplantation is associated with reduced posttransplant survival. Retrospective cohort study of adult lung transplant recipients listed for at least 30 days between 4 May 2005 (LAS implementation) and 31 December 2010 in the United Network for Organ Sharing registry. An acute increase in the LAS was defined as an LAS change (LASΔ) greater than 5 units between the 30 days before and the time of transplantation. Multivariable Cox proportional hazard models were used to examine the relationship between an LASΔ >5 and posttransplant graft survival. All U.S. lung transplantation centers. 5749 lung transplant recipients. Survival time after lung transplantation. 702 (12.2%) patients experienced an LASΔ >5. These patients had significantly worse posttransplant survival (hazard ratio, 1.31 [95% CI, 1.11 to 1.54]; P = 0.001]) after adjustment for the LAS at transplantation (LAS-T) and other clinical covariates. The effect of an LASΔ >5 was independent of the LAS-T, underlying diagnosis, center volume, or donor characteristics. Analysis was based on center-reported data. An acute increase in LAS before transplantation is associated with posttransplant survival after adjustment for LAS-T. Further emphasis on serial assessment of the LAS could improve the ability to offer accurate prediction of survival after transplantation. National Institutes of Health.
  Annals of internal medicine 05/2013; 158(9):650-7.
• Article: Hepatitis C virus testing of persons born during 1945-1965.

  Ephraim Back
  Annals of internal medicine 05/2013; 158(9):704-5.
• Article: Probiotics for the Prevention of Clostridium difficile-Associated Diarrhea.

  David Louis Keller
  Annals of internal medicine 05/2013; 158(9):706.
• Article: Hepatitis C virus testing of persons born during 1945-1965.

  Richard B Lynn
  Annals of internal medicine 05/2013; 158(9):704.
• Article: Probiotics for the Prevention of Clostridium difficile-Associated Diarrhea.

  Bradley C Johnston, Joshua Z Goldenberg, Gordon H Guyatt
  Annals of internal medicine 05/2013; 158(9):706-7.
• Article: Hepatitis C virus testing of persons born during 1945-1965.

  Bryce D Smith, Deborah Holtzman, John W Ward
  Annals of internal medicine 05/2013; 158(9):705.
• Article: Management Strategies for Asymptomatic Carotid Stenosis: A Systematic Review and Meta-analysis.

  Gowri Raman, Denish Moorthy, Nira Hadar, Issa J Dahabreh, Thomas F O'Donnell, David E Thaler, Edward Feldmann, Joseph Lau, Georgios D Kitsios
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  ABSTRACT: Adults with asymptomatic carotid artery stenosis are at increased risk for ipsilateral carotid territory ischemic stroke. To examine comparative evidence on management strategies for asymptomatic carotid stenosis and the incidence of ipsilateral stroke with medical therapy alone. MEDLINE, Cochrane Central Register of Controlled Trials, U.S. Food and Drug Administration documents, and review of references through 31 December 2012. Randomized, controlled trials (RCTs) and prospective or retrospective nonrandomized, comparative studies of medical therapy alone, carotid endarterectomy (CEA) plus medical therapy, or carotid artery stenting (CAS) plus medical therapy for adults with asymptomatic carotid stenosis, as well as single-group prospective cohort studies of medical therapy, were reviewed. Two investigators extracted information on study and population characteristics, results, and risk of bias. Forty-seven studies in 56 publications were eligible. The RCTs comparing CAS and CEA were clinically heterogeneous; 1 RCT reported more but not statistically significant ipsilateral stroke events (including any periprocedural stroke) in CAS compared with CEA, whereas another RCT, in a population at high surgical risk for CEA, did not. Three RCTs showed that CEA reduced the risk for ipsilateral stroke (including any periprocedural stroke) compared with medical therapy alone, but these results may no longer be applicable to contemporary clinical practice. No RCT compared CAS versus medical therapy alone. The summary incidence of ipsilateral stroke across 26 cohorts receiving medical therapy alone was 1.68% per year. Studies defined asymptomatic status heterogeneously. Participants in RCTs did not receive best-available medical therapy. Future RCTs of asymptomatic carotid artery stenosis should explore whether revascularization interventions provide benefit to patients treated by best-available medical therapy. Agency for Healthcare Research and Quality.
  Annals of internal medicine 05/2013; 158(9):676-85.
• Article: Probiotics for the Prevention of Clostridium difficile-Associated Diarrhea.

  Steven Oscherwitz
  Annals of internal medicine 05/2013; 158(9):706.
• Article: Risk stratification of lung transplant candidates: implications for organ allocation.

  Robert M Kotloff
  Annals of internal medicine 05/2013; 158(9):699-700.
• Article: Comparative Effectiveness of Multivessel Coronary Bypass Surgery and Multivessel Percutaneous Coronary Intervention: A Cohort Study.

  Mark A Hlatky, Derek B Boothroyd, Laurence Baker, Dhruv S Kazi, Matthew D Solomon, Tara I Chang, David Shilane, Alan S Go
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  ABSTRACT: BACKGROUND: Randomized trials of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI) suggest that patient characteristics modify the effect of treatment on mortality. OBJECTIVE: To assess whether clinical characteristics modify the comparative effectiveness of CABG versus PCI in an unselected, general patient population. DESIGN: Observational treatment comparison using propensity score matching and Cox proportional hazards models. SETTING: United States, 1992 to 2008. PATIENTS: Medicare beneficiaries aged 66 years or older. INTERVENTION: Multivessel CABG or multivessel PCI. MEASUREMENTS: The CABG-PCI hazard ratio (HR) for all-cause mortality, with prespecified treatment-by-covariate interaction tests, and the absolute difference in life-years of survival in clinical subgroups after CABG or PCI, both over 5 years of follow-up. RESULTS: Among 105 156 propensity score-matched patients, CABG was associated with lower mortality than PCI (HR, 0.92 [95% CI, 0.90 to 0.95]; P < 0.001). Association of CABG with lower mortality was significantly greater (interaction P values < = 0.002 for each interaction) among patients with diabetes (HR, 0.88), a history of tobacco use (HR, 0.82), heart failure (HR, 0.84), and peripheral arterial disease (HR, 0.85). The overall predicted difference in survival between CABG and PCI treatment over 5 years was 0.053 life-year (range, -0.017 to 0.579 life-years). Patients with diabetes, heart failure, peripheral arterial disease, or tobacco use had the largest predicted differences in survival after CABG, whereas those with none of these factors had slightly better survival after PCI. LIMITATION: Treatments were chosen by patients and physicians rather than randomly assigned. CONCLUSION: Multivessel CABG is associated with lower long-term mortality than multivessel PCI in the community setting. This association is substantially modified by patient characteristics, with improvement in survival concentrated among patients with diabetes, tobacco use, heart failure, or peripheral arterial disease. PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute.
  Annals of internal medicine 04/2013;
• Article: The racist patient.

  Sachin H Jain
  Annals of internal medicine 04/2013; 158(8):632.
• Article: Allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence.

  Gerry R Boss
  Annals of internal medicine 04/2013; 158(8):JC6.
• Article: Review: A dichotomized ABCD2 score has limited ability to predict stroke risk ≤ 90 days after TIA.

  Michael D Hill
  Annals of internal medicine 04/2013; 158(8):JC12.
• Article: Review: Serenoa repens does not improve symptom scale scores in benign prostatic hyperplasia.

  Chris Del Mar
  Annals of internal medicine 04/2013; 158(8):JC10.