JAMA The Journal of the American Medical Association (J Am Med Assoc)

Publications in this journal

• Article: Development of trustworthy practice guidelines--reply.

  David F Ransohoff, Michael Pignone, Harold C Sox
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1890-1.
• Article: Prehospital airway management for out-of-hospital cardiac arrest--reply.

  Kohei Hasegawa, Atsushi Hiraide, David F M Brown
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1889-90.
• Article: Prehospital airway management for out-of-hospital cardiac arrest.

  Michael Bernhard, Torben K Becker, Bernd W Böttiger
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1888.
• Article: JAMA patient page. Lung cancer screening.

  Phillip M Boiselle, Cassio Lynm, Edward H Livingston
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1948.
• Article: Investments in infrastructure for diverse research resources and the health of the public.

  Bruce M Psaty, Eric B Larson
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1895-6.
• Article: Developing quality measures to address overuse.

  Jason S Mathias, David W Baker
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1897-8.
• Article: Prehospital airway management for out-of-hospital cardiac arrest.

  Tatsuya Norii, Tetsuo Hatanaka
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1888-9.
• Article: Scientists mine web search data to identify epidemics and adverse events.

  Bridget M Kuehn
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1883-4.
• Article: Reducing shocks and improving outcomes with implantable defibrillators.

  Merritt H Raitt
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1937-8.
• Article: A piece of my mind. Status update: whose photo is that?

  Karen Michelle Devon
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1901-2.
• Article: The Cochrane Collaboration turns 20: assessing the evidence to inform clinical care.

  M J Friedrich
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1881-2.
• Article: The cover. Ocean Park #54.

  Thomas B Cole
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1870.
• Article: Dengue more prevalent than previously thought.

  Mike Mitka
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1882.
• Article: Evidence lacking for benefit from oral cancer screening.

  Mike Mitka
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1884.
• Article: Elective cesarean delivery on maternal request.

  Jeffrey Ecker
  [show abstract] [hide abstract]
  ABSTRACT: Some pregnant women prefer cesarean delivery and request it without maternal or fetal indication rather than proceeding with a plan for vaginal delivery. To review approaches for counseling women who ask for cesarean delivery without maternal or fetal indication (known as cesarean delivery on maternal request [CDMR]). An Agency for Healthcare Research and Quality evidence report of studies published after 1990, a 2006 National Institutes of Health state-of-the-science conference report, and published literature were examined. The prevalence of CDMR in the United States is not precisely known but probably occurs in less than 3% of all deliveries. Most practicing obstetricians have received requests for CDMR from patients. Compared with a plan for vaginal delivery, CDMR may be associated with lower rates of hemorrhage, maternal incontinence, and rare but serious neonatal outcomes. However, CDMR is associated with a higher risk of neonatal respiratory morbidity. Adverse consequences of CDMR may be manifested only in future pregnancies. Repeated cesarean deliveries have higher rates of operative complications, placental abnormalities such as placenta previa and accreta, and consequent gravid hysterectomy. There is no immediate expectation for CDMR to reduce the health risks of mothers or infants. Accordingly, counseling and decisions regarding CDMR should be made after considering a woman's full reproductive plans.
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1930-6.
• Article: Identification of genetic loci associated with Helicobacter pylori serologic status.

  Julia Mayerle, Caroline M den Hoed, Claudia Schurmann, Lisette Stolk, Georg Homuth, Marjolein J Peters, Lisette G Capelle, Kathrin Zimmermann, Fernando Rivadeneira, Sybille Gruska, [......], Matthias Nauck, Florian Ernst, Frank-Ulrich Weiss, Albert Hofman, Martin Zenker, Heyo K Kroemer, Holger Prokisch, Andre G Uitterlinden, Markus M Lerch, Ernst Kuipers
  [show abstract] [hide abstract]
  ABSTRACT: Helicobacter pylori is a major cause of gastritis and gastroduodenal ulcer disease and can cause cancer. H. pylori prevalence is as high as 90% in some developing countries but 10% of a given population is never colonized, regardless of exposure. Genetic factors are hypothesized to confer H. pylori susceptibility. To identify genetic loci associated with H. pylori seroprevalence in 2 independent population-based cohorts and to determine their putative pathophysiological role by whole-blood RNA gene expression profiling. Two independent genome-wide association studies (GWASs) and a subsequent meta-analysis were conducted for anti-H. pylori IgG serology in the Study of Health in Pomerania (SHIP) (recruitment, 1997-2001 [n = 3830]) as well as the Rotterdam Study (RS-I) (recruitment, 1990-1993) and RS-II (recruitment, 2000-2001 [n = 7108]) populations. Whole-blood RNA gene expression profiles were analyzed in RS-III (recruitment, 2006-2008 [n = 762]) and SHIP-TREND (recruitment, 2008-2012 [n = 991]), and fecal H. pylori antigen in SHIP-TREND (n = 961). MAIN OUTCOMES AND MEASURES: H. pylori seroprevalence. Of 10,938 participants, 6160 (56.3%) were seropositive for H. pylori. GWASs identified the toll-like receptor (TLR) locus (4p14; top-ranked single-nucleotide polymorphism (SNP), rs10004195; P = 1.4 × 10(-18); odds ratio, 0.70 [95% CI, 0.65 to 0.76]) and the FCGR2A locus (1q23.3; top-ranked SNP, rs368433; P = 2.1 × 10(-8); odds ratio, 0.73 [95% CI, 0.65 to 0.81]) as associated with H. pylori seroprevalence. Among the 3 TLR genes at 4p14, only TLR1 was differentially expressed per copy number of the minor rs10004195-A allele (β = -0.23 [95% CI, -0.34 to -0.11]; P = 2.1 × 10(-4)). Individuals with high fecal H. pylori antigen titers (optical density >1) also exhibited the highest 25% of TLR1 expression levels (P = .01 by χ2 test). Furthermore, TLR1 exhibited an Asn248Ser substitution in the extracellular domain strongly linked to the rs10004195 SNP. GWAS meta-analysis identified an association between TLR1 and H. pylori seroprevalence, a finding that requires replication in nonwhite populations. If confirmed, genetic variations in TLR1 may help explain some of the observed variation in individual risk for H. pylori infection.
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1912-20.
• Article: Helicobacter pylori susceptibility in the GWAS era.

  Emad M El-Omar
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1939-40.
• Article: Development of trustworthy practice guidelines.

  Melissa C Brouwers
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1890.
• Article: Incidence of fall-related traumatic brain injuries among older Finnish adults between 1970 and 2011.

  Niina Korhonen, Seppo Niemi, Jari Parkkari, Harri Sievänen, Pekka Kannus
  JAMA The Journal of the American Medical Association 05/2013; 309(18):1891-2.