New England Journal of Medicine (New Engl J Med)

Publications in this journal

• Article: Extended anticoagulation in venous thromboembolism.

  Yael Hegerfeldt
  New England Journal of Medicine 06/2013; 368(24):2329.
• Article: Daily chlorhexidine bathing and hospital-acquired infection.

  Anthony L Esposito
  New England Journal of Medicine 06/2013; 368(24):2330.
• Article: Extended anticoagulation in venous thromboembolism.

  Andrew J Franck, Jessica A Bovio
  New England Journal of Medicine 06/2013; 368(24):2328-9.
• Article: Envy--a strategy for reform.

  Nick Seddon, Thomas H Lee
  New England Journal of Medicine 06/2013; 368(24):2245-7.
• Article: Reevaluating "made in America"--two cost-containment ideas from abroad.

  Gerard F Anderson, Amber Willink, Robin Osborn
  New England Journal of Medicine 06/2013; 368(24):2247-9.
• Article: Extended anticoagulation in venous thromboembolism.

  Jonathan L Edwards
  New England Journal of Medicine 06/2013; 368(24):2329.
• Article: The pathogenesis of the antiphospholipid syndrome.

  Matthieu Million, Didier Raoult
  New England Journal of Medicine 06/2013; 368(24):2335.
• Article: Interactive medical case: A patient with migrating polyarthralgias.

  Jonathan D Casey, Anand Vaidya, Daniel H Solomon, Thomas A Gaziano
  New England Journal of Medicine 06/2013; 368(24):e33.
• Article: Case records of the Massachusetts General Hospital. Case 18-2013: a 32-year-old woman with recurrent episodes of altered consciousness.

  Andrew J Cole, Emad Eskandar, Theofanie Mela, Jeffrey L Noebels, R Gilberto Gonzalez, Declan McGuone
  New England Journal of Medicine 06/2013; 368(24):2304-12.
• Article: Daily chlorhexidine bathing and hospital-acquired infection.

  Martin Wolkewitz, Stephan Harbarth, Jan Beyersmann
  New England Journal of Medicine 06/2013; 368(24):2330.
• Article: Daily chlorhexidine bathing and hospital-acquired infection.

  Michael W Climo, Edward S Wong
  New England Journal of Medicine 06/2013; 368(24):2332.
• Article: Nonheparin anticoagulants for heparin-induced thrombocytopenia.

  Vijaya R Bhatt, Madan R Aryal, James O Armitage
  New England Journal of Medicine 06/2013; 368(24):2333-4.
• Article: Nonheparin anticoagulants for heparin-induced thrombocytopenia.

  Ian Jenkins, Doug Humber
  New England Journal of Medicine 06/2013; 368(24):2333.
• Article: Daily chlorhexidine bathing and hospital-acquired infection.

  Ben Cooper, Christian Brun-Buisson, Marc Bonten
  New England Journal of Medicine 06/2013; 368(24):2330-1.
• Article: Daily chlorhexidine bathing and hospital-acquired infection.

  Jean-Jacques Parienti, Vincent Cattoir
  New England Journal of Medicine 06/2013; 368(24):2331.
• Article: Treating iron overload.

  Clara Camaschella
  New England Journal of Medicine 06/2013; 368(24):2325-7.
• Article: Racemic adrenaline and inhalation strategies in acute bronchiolitis.

  Håvard Ove Skjerven, Jon Olav Gjengstø Hunderi, Sabine Kristin Brügmann-Pieper, Anne Charlotte Brun, Hanne Engen, Leif Eskedal, Marius Haavaldsen, Bente Kvenshagen, Jon Lunde, Leif Bjarte Rolfsjord, Christian Siva, Truls Vikin, Petter Mowinckel, Kai-Håkon Carlsen, Karin C Lødrup Carlsen
  [show abstract] [hide abstract]
  ABSTRACT: Acute bronchiolitis in infants frequently results in hospitalization, but there is no established consensus on inhalation therapy--either the type of medication or the frequency of administration--that may be of value. We aimed to assess the effectiveness of inhaled racemic adrenaline as compared with inhaled saline and the strategy for frequency of inhalation (on demand vs. fixed schedule) in infants hospitalized with acute bronchiolitis. In this eight-center, randomized, double-blind trial with a 2-by-2 factorial design, we compared inhaled racemic adrenaline with inhaled saline and on-demand inhalation with fixed-schedule inhalation (up to every 2 hours) in infants (<12 months of age) with moderate-to-severe acute bronchiolitis. An overall clinical score of 4 or higher (on a scale of 0 to 10, with higher scores indicating more severe illness) was required for study inclusion. Any use of oxygen therapy, nasogastric-tube feeding, or ventilatory support was recorded. The primary outcome was the length of the hospital stay, with analyses conducted according to the intention-to-treat principle. The mean age of the 404 infants included in the study was 4.2 months, and 59.4% were boys. Length of stay, use of oxygen supplementation, nasogastric-tube feeding, ventilatory support, and relative improvement in the clinical score from baseline (preinhalation) were similar in the infants treated with inhaled racemic adrenaline and those treated with inhaled saline (P>0.1 for all comparisons). On-demand inhalation, as compared with fixed-schedule inhalation, was associated with a significantly shorter estimated mean length of stay--47.6 hours (95% confidence interval [CI], 30.6 to 64.6) versus 61.3 hours (95% CI, 45.4 to 77.2; P=0.01) - as well as less use of oxygen supplementation (in 38.3% of infants vs. 48.7%, P=0.04), less use of ventilatory support (in 4.0% vs. 10.8%, P=0.01), and fewer inhalation treatments (12.0 vs. 17.0, P<0.001). In the treatment of acute bronchiolitis in infants, inhaled racemic adrenaline is not more effective than inhaled saline. However, the strategy of inhalation on demand appears to be superior to that of inhalation on a fixed schedule. (Funded by Medicines for Children; ClinicalTrials.gov number, NCT00817466; EudraCT number, 2009-012667-34.).
  New England Journal of Medicine 06/2013; 368(24):2286-93.
• Article: How point-of-care testing could drive innovation in global health.

  Ilesh V Jani, Trevor F Peter
  New England Journal of Medicine 06/2013; 368(24):2319-24.
• Article: Sall4 in "stemness"-driven hepatocarcinogenesis.

  Jens U Marquardt, Snorri S Thorgeirsson
  New England Journal of Medicine 06/2013; 368(24):2316-8.
• Article: Anti-Ro antibodies and reversible atrioventricular block.

  Irene Santos-Pardo, Melania Martínez-Morillo, Roger Villuendas, Antoni Bayes-Genis
  New England Journal of Medicine 06/2013; 368(24):2335-7.