American Journal of Alzheimer s Disease and Other Dementias

Publisher: SAGE Publications


The American Journal of Alzheimer's Disease and Other Dementias (AJADD) is for and by professionals on the frontlines of Alzheimer's care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, healthcare administrators, and other related healthcare specialists who deal with patients having dementias and families everyday. In every issue, you will find down-to-earth clinical information on: Practical medical, psychiatric, and nursing issues such as assessment and management of problem behaviors, communication difficulties, dealing with delusions and other psychotic features, apathy, effects of physical activity, integrated treatment approaches, new and changing pharmacotherapies, orientation behaviors, and hospice use. AJADD also includes information on management of concurrent medical issues in the patient with dementia; New and forthcoming diagnostic tools such as computerized testing for mild cognitive impairment and other aspects of cognitive testing, as well as high technology resources for sophisticated disease characterization. AJADD also provides information on the clinical features and management of non-Alzheimer's dementias; Psychosocial issues such as dealing with staff caregivers' distress, improving caregivers' communication skills, helping patients and families to deal with a diagnosis of Alzheimer's disease or another dementia, and patients' perceptions and preferences; Practice-oriented clinical research from the frontiers of neurology and genetics, including sleep-wake states, targeting glutamate excitotoxicity, cholesterol and apolipoprotein E, and other aspects of the underlying biology that causes the symptoms of dementia. AJADD also reports on the latest clinical trials that focus on medications for the symptoms of dementia and the disease process; Administrative and legal issues such as coding, consumer evaluation of adult day-care services, cost-effectiveness of special care units, dangerous wandering, end-stage dementia, informed consent, Medicare coverage for cognitively impaired residents, supervision of high-risk fall dementia patients, and vulnerable populations and avoidable hospitalizations.

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  • Website
    American Journal of Alzheimer's Disease and Other Dementias website
  • Other titles
    American journal of Alzheimer's disease and other dementias (Online), American journal of Alzheimer's disease and other dementias, American journal of Alzheimer's disease and other dementias
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  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

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SAGE Publications

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    • Author can archive a pre-print version
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    • Author can archive a post-print version
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    • Authors retain copyright
    • Pre-print on any website
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    • On other repositories including PubMed Central after 12 months embargo
    • Publisher copyright and source must be acknowledged
    • Publisher's version/PDF cannot be used
    • Post-print version with changes from referees comments can be used
    • "as published" final version with layout and copy-editing changes cannot be archived but can be used on secure institutional intranet
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    ​ green

Publications in this journal

  • American Journal of Alzheimer s Disease and Other Dementias 12/2014; 29(8):660-666.
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    ABSTRACT: Although often cast as a disease of later life, a growing number of people are being diagnosed with Alzheimer’s disease in their 50s and 60s. Early-onset Alzheimer’s disease (EOAD) poses special challenges and needs for individuals and their caregivers, such as employment and access to services. In this cross-sectional study, the researchers surveyed 81 (N= 81) family caregivers to individuals with EOAD to identify service and support usage and need. Descriptive analyses revealed that families utilized a range of formal services (eg, adult day) and informal support from family and friends. In terms of challenges and needs, participants indicated that they struggled most with employment, benefits, and financial issues. Although most caregivers felt that they were coping well, they also indicated that their needs were not well understood by service providers and the public. These findings highlight the need to better understand and respond to the specific issues surrounding EOAD.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014; 29(7):596-600.
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    ABSTRACT: The possible roles played by growth arrest and DNA damage-inducible gene 34 (GADD34) in Alzheimer's disease (AD) are so far less understood. In this study, we found that GADD34 was increased in the brains of AD transgenic J20 mice. The deposition of β-amyloid (Aβ) peptide is the main component of neurotic plaques in AD brain. Thus, we examined the effect of Aβ in the expression of GADD34 in human SH-SY5Y cells in vitro. Amyloid β (Aβ1-42) treatment led to increased expression of GADD34. Pretreatment with 50 nmol/L of c-Jun N-terminal kinases (JNK) inhibitor SP600125 abolished the upregulation of GADD34. c-Jun silencing by transfection with c-Jun small-interfering RNA abolished the effects of Aβ1-42 on the expression of GADD34. Importantly, chromatin immunoprecipitation studies verified the ability of c-Jun to bind to the GADD34 promoter, and this ability was increased more than 3-fold by Aβ1-42. These data suggest that the induction of GADD34 by Aβ is mediated by JNK/c-Jun pathway. Finally, depletion of GADD34 significantly rescued Aβ-induced cell apoptosis as evidenced by a marked decrease in the number of terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells. Consistently, knockdown of GADD34 attenuated caspase 3 activation induced by Aβ1-42.
    American Journal of Alzheimer s Disease and Other Dementias 09/2014;
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    ABSTRACT: This study examined whether seniors' exposure to direct-to-consumer advertising (DTCA) for Alzheimer's disease (AD) medicine contributes to his or her subjective and objective knowledge of AD.
    American Journal of Alzheimer s Disease and Other Dementias 09/2014;
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    ABSTRACT: To compare periodontal health status in individuals with and without Alzheimer's disease (AD).
    American Journal of Alzheimer s Disease and Other Dementias 09/2014; 29(6):498-502.
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    ABSTRACT: An experimental study using a pre-posttest control group design was conducted to assess the effects of a person-centered care-based psychoeducational intervention on direct care workers' stress, burnout, and job satisfaction. The intervention aimed to develop person-centered care competences and tools for stress management. Four aged care facilities were randomly assigned to a psychoeducational or an education-only intervention (control). Data were collected from 56 direct care workers (female, mean age 44.72 ± 9.02) through measurements of burnout (Maslach Burnout Inventory), job satisfaction (Minnesota Satisfaction Questionnaire-short form), and stress (Perceived Stress Scale) and focus-group interviews. Results showed significant positive effects in emotional exhaustion (P = .029) and positive but no significant effects in stress and job satisfaction. According to qualitative data, the experimental group perceived enhanced group cohesion, emotional management, and self-care awareness. Psychoeducational interventions may contribute to reduce direct care workers' burnout. Further work is needed to determine the extent of its benefits.
    American Journal of Alzheimer s Disease and Other Dementias 08/2014; In Press.
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    ABSTRACT: On the first few days after admission to the Geriatric-Internal Medicine department, the suffering level of patients with advanced dementia (Mini-Mental State Examination 0 of 30) was evaluated according to the Mini-Suffering State Examination (MSSE). During hospitalization, 14.8% (27 of 183) of patients with advanced dementia were died with a mean survival rate of 19.86 + 26.9 days. The MSSE scale score of died patients was 7.56+1.71 during the first few days of admission which indicates high suffering levels. The MSSE scale score of survived patients with advanced dementia was 3.99 + 2.10 which confirms their low level of suffering. There was a significant difference (P < .001) between the groups. Patients with dementia who died and were diagnosed as having Aminoff suffering syndrome during the first few days of admission had a high suffering level and short-survival time. Keywords: advanced dementia, end of life, Aminoff suffering syndrome, survival prognosis, relief of suffering units, palliative care
    American Journal of Alzheimer s Disease and Other Dementias 06/2014;
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    ABSTRACT: The aim of this study was to determine whether an egocentric topographical working memory (WM) deficit is present in the early stages of Alzheimer's disease (AD) with respect to other forms of visuospatial WM. Further, we would investigate whether this deficit could be present in patients having AD without topographical disorientation (TD) signs in everyday life assessed through an informal interview to caregivers. Seven patients with AD and 20 healthy participants performed the Walking Corsi Test and the Corsi Block-Tapping Test. The former test requires memorizing a sequence of places by following a path and the latter is a well-known visuospatial memory task. Patients with AD also performed a verbal WM test to exclude the presence of general WM impairments. Preliminary results suggest that egocentric topographical WM is selectively impaired, with respect to visuospatial and verbal WM, even without TD suggesting an important role of this memory in the early stages of AD.
    American Journal of Alzheimer s Disease and Other Dementias 06/2014;
  • American Journal of Alzheimer s Disease and Other Dementias 01/2014;
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    ABSTRACT: We aimed to determine whether there is an association between teaching and the development of progressive speech and language disorders (SLDs). Occupation was compared between 100 patients with a progressive SLD, 404 patients with Alzheimer’s dementia, and the 2008 US census. In SLDs, the most common occupation was teacher (22%) versus 8% in Alzheimer’s dementia. The odds ratio (OR) of being a teacher in SLDs compared to Alzheimer’s dementia was 3.4 (95% confidence interval [CI] = 1.87-6.17). No differences were observed in the frequency of other occupations. The frequency of teachers was higher in SLDs compared to the US census, OR of 6.9 (95% CI = 4.3-11.1). Farming, forestry, and fishing occupations were more frequent in SLDs compared to the US census. We identified an association between progressive SLDs and the occupation of teaching. Since teaching is a communication demanding occupation, teachers may be more sensitive to the development of speech and language impairments.
    American Journal of Alzheimer s Disease and Other Dementias 09/2013; 28(6):612-616.
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    ABSTRACT: Background: Restless legs syndrome (RLS) is a neurological disorder characterized by the urge to move the legs associated with peculiar unpleasant sensations during periods of rest and inactivity that are relieved by movement. A few studies analyzed RLS in neurodegenerative diseases such as Alzheimer's Disease (AD). The aim of our study was to assess the prevalence and the clinical characteristics of RLS in a cohort of AD patients. Methods: Three hundred and thirty-nine subjects with a diagnosis of AD were recruited. Cognitive, functional, and neuropsychiatric measures were collected at baseline and six-monthly for a 2-years follow-up Results: Fourteen subjects met the RLS criteria. RLS subjects were more frequently male (p:0,006) and younger than AD subject without RLS (p:0,029). MMSE, ADL and IADL were not significantly different. NPI total scores did not differ significantly, however, AD patients with RLS were found to be more apathetic (p:0,001) than AD subjects without RLS. Conclusion: RLS prevalence in our AD cohort was estimated to be about 4%. RLS appeared to be associated with neuropsychiatric symptoms such as apathy. RLS and apathy might share a common pathophysiological basis represented by a dysfunction of the central dopaminergic system
    American Journal of Alzheimer s Disease and Other Dementias 03/2013; 28(2):165-170.
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    ABSTRACT: Background: Behavioral disturbances of dementia, such as repetitive and stereotypic phenomena, can be distressing to caregivers and may lead to early institutionalization of the patient. Objective: The purpose of this article is to examine the phenomenon of repetitive phenomena in patients with dementia. Methods: We searched the PubMed electronic databases for original research and review articles on repetitive phenomena in patients with dementia using the search terms "repetitive behavior, stereotypic behavior, dementia, Alzheimer's disease, Frontotemporal dementia." Results: Repetitive and stereotypic phenomena are common problems in dementia, which may reflect a disruption of coordinated function within the basal ganglia or corticostriatal structures. Conclusions: There are no systematic studies concerning repetitive phenomena in patients with dementia, and very little is known about the treatment. Further studies are needed to determine the specific phenomena.
    American Journal of Alzheimer s Disease and Other Dementias 01/2013;
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    ABSTRACT: The aims were to assess dysautonomia in Alzheimer’s Disease (AD), clinically and electrophysiologically, using sympathetic skin response (SSR) test and R-R interval variation (RRIV) test and to analyze the relationship between symptoms of dysautonomia and SSR/RRIV results. A tota of 54 patients with AD and 37 controls were evaluated using Autonomic Symptoms Questionnaire and SSR/RRIV test. Clinical dysautonomia was observed in 66% of patients (eg, orthostatic hypotension in 34.5%, constipation in 17.2%, urinary incontinence in 13.8%). The SSR test was abnormal in 26%, but the RRIV test was abnormal in 97.7% of cases; there was significant difference in RRIV test results between AD and controls (R mean 8.05% and 14.6%, respectively). In AD, clinical dysautonomia occurs at a various degree, and the abnormal SSR and RRIV test results were not always related to the presence of clinical dysautonomia; this observation points that the tests could be used as a useful tool in the assessment of subclinical dysautonomia.
    American Journal of Alzheimer s Disease and Other Dementias 12/2012; 27(8):592-599.
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    ABSTRACT: Growing evidence suggests that healthy behaviors such as being physically active, having a heart healthy diet, and being socially involved may promote cognitive health. The United States has recently begun encouraging such behaviors for that purpose. To help evaluate the diffusion of this policy, we sought to measure a baseline of activity in this area. We examined Web sites of 156 large health care systems, the health departments of all 50 states and the 20 largest US cities, and 181 nationally accredited senior centers, to identify information, products, programs, or services recommended for cognitive health. Among health care systems, 40% promoted cognitive health: 24% recommended mental activity, 20% healthy diets, 20% physical activity, and 16% social involvement. Among health departments, 30% promoted cognitive health in the same ways. Among senior centers, 21% offered strategies, primarily mental activity. Results suggest emerging activity in this area and opportunities for continued development.
    American Journal of Alzheimer s Disease and Other Dementias 12/2012; 27(8):600-608.
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    ABSTRACT: The Questionnaire on Palliative Care for Advanced Dementia (qPAD) is a 2-part instrument that measures long-term care staff knowledge, and beliefs, perceptions, and attitudes about palliative and end-of-life care for persons with advanced dementia. Factor analyses of the Knowledge Test (coefficient α = .81) produced 3 factors: Anticipating Needs, Preventing Negative Outcomes, and Insight and Intuition (coefficient α = .75, .73, and .58, respectively), explaining 67% of the total variance. Factor analyses of the Attitude Scale (coefficient α = .83) produced 3 factors: Job Satisfaction, Perceptions and Beliefs, and Work Setting Support of Families (coefficient α = .90, .64, and .67, respectively), explaining 68% of the total variance. These initial findings hold promise for an instrument that measures both knowledge and attitudes of long-term care staff in the care of persons with advanced dementia.
    American Journal of Alzheimer s Disease and Other Dementias 11/2012; 27(7):537-543.
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    ABSTRACT: Reliable assessment of change from previous cognitive functioning is a prerequisite for determining the possible presence of neurodegenerative diseases such as Alzheimer's disease (AD). We investigated whether standardized change scores on the German version of the Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery (CERAD-NAB) could be used for early diagnosis of AD and whether change scores on the CERAD-NAB are superior in this respect to scores recorded on 1 occasion only. Three hundred seventy-four normal control subjects were assessed twice. Data from 95 patients with mostly mild probable AD were collected at their first entry to a memory clinic and an average of 1.1 +/- 0.24 years later. It is concluded that repeated testing with the CERAD-NAB does not generally add to improved diagnostic accuracy for mild and very mild AD and cannot, therefore, be recommended as a routine clinical procedure.
    American Journal of Alzheimer s Disease and Other Dementias 01/2010; 22(5):416-26.
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    ABSTRACT: During clinical practice, degenerative diseases in some patients appear after exposure to a severe psychological stress. Several studies have suggested that the duration of exposure to corticosteroids or stress, the dose of corticosteroids and the vulnerability of the hippocampus, amygdala and prefrontal cortex areas targeted by elevated stress hormones, mediate the damaging effects of elevated corticosteroids. Although understanding what triggers the transition from adaptive plasticity to the maladaptive effects of stress in the elderly is important, one of the great challenges is to determine individual differences in vulnerability to stress-induced events in both animal and human populations, and to devise strategies that may help protecting the brain from permanent damage. This review provides the basis for creating interventions and educational programs during midlife in order to prevent dementia or other neurodegenerative diseases or to halt the progress of neurodegeneration in the early stages.
    American Journal of Alzheimer s Disease and Other Dementias 03/2009; 24(2):85-94.
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    ABSTRACT: Dementia of Lewy body disease is the second most common degenerative cause of dementia after Alzheimer's disease, among all the dementias. The core features are a progressive dementia, fluctuations in cognitive functions, visual hallucinations, and spontaneous parkinsonism. Rapid eye movement sleep behavior disorder, severe neuroleptic sensitivity, and low dopamine transporter uptake in basal ganglia are other suggestive features. Behavioral abnormalities are commonly present in the form of aggressive behavior, irritability, and uninhibited behaviors. These are mostly seen in the advanced stages of dementia. However, inappropriate sexual behavior is uncommonly seen in such cases. Three types of inappropriate sexual behaviors commonly found in cases of dementia are sex talks, sexual acts, and implied sexual acts. Such inappropriate sexual behaviors have not been described adequately in dementia of Lewy body disease. We report inappropriate sexual behaviors in a case of dementia of Lewy body disease, which improved rapidly after treatment with quetiapine.
    American Journal of Alzheimer s Disease and Other Dementias 02/2009; 24(2):136-40.