American Journal of Alzheimer s Disease and Other Dementias

Publisher: SAGE Publications

Journal description

The American Journal of Alzheimer's Disease and Other Dementias (AJADD) is for and by professionals on the frontlines of Alzheimer's care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, healthcare administrators, and other related healthcare specialists who deal with patients having dementias and families everyday. In every issue, you will find down-to-earth clinical information on: Practical medical, psychiatric, and nursing issues such as assessment and management of problem behaviors, communication difficulties, dealing with delusions and other psychotic features, apathy, effects of physical activity, integrated treatment approaches, new and changing pharmacotherapies, orientation behaviors, and hospice use. AJADD also includes information on management of concurrent medical issues in the patient with dementia; New and forthcoming diagnostic tools such as computerized testing for mild cognitive impairment and other aspects of cognitive testing, as well as high technology resources for sophisticated disease characterization. AJADD also provides information on the clinical features and management of non-Alzheimer's dementias; Psychosocial issues such as dealing with staff caregivers' distress, improving caregivers' communication skills, helping patients and families to deal with a diagnosis of Alzheimer's disease or another dementia, and patients' perceptions and preferences; Practice-oriented clinical research from the frontiers of neurology and genetics, including sleep-wake states, targeting glutamate excitotoxicity, cholesterol and apolipoprotein E, and other aspects of the underlying biology that causes the symptoms of dementia. AJADD also reports on the latest clinical trials that focus on medications for the symptoms of dementia and the disease process; Administrative and legal issues such as coding, consumer evaluation of adult day-care services, cost-effectiveness of special care units, dangerous wandering, end-stage dementia, informed consent, Medicare coverage for cognitively impaired residents, supervision of high-risk fall dementia patients, and vulnerable populations and avoidable hospitalizations.

Current impact factor: 1.43

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013/2014 Impact Factor 1.426
2012 Impact Factor 1.518
2011 Impact Factor 1.453
2010 Impact Factor 1.774

Impact factor over time

Impact factor
Year

Additional details

5-year impact 0.00
Cited half-life 5.30
Immediacy index 0.20
Eigenfactor 0.00
Article influence 0.00
Website American Journal of Alzheimer's Disease and Other Dementias website
Other titles American journal of Alzheimer's disease and other dementias (Online), American journal of Alzheimer's disease and other dementias, American journal of Alzheimer's disease and other dementias
ISSN 1533-3175
OCLC 71196303
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

SAGE Publications

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Authors retain copyright
    • Pre-print on any website
    • Author's post-print on author's personal website, departmental website, institutional website or institutional repository
    • On other repositories including PubMed Central after 12 months embargo
    • Publisher copyright and source must be acknowledged
    • Publisher's version/PDF cannot be used
    • Post-print version with changes from referees comments can be used
    • "as published" final version with layout and copy-editing changes cannot be archived but can be used on secure institutional intranet
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: A Language-Enriched Exercise Plus Socialization (LEEPS) Program for older adults with Alzheimer's disease and related disorders (ADRD) was implemented in rural Wisconsin communities. Patterned after a university-based research intervention, (1) the LEEPS protocol entailed ongoing weekly to biweekly sessions with a trained volunteer and an individual with dementia, with exercise and language stimulation sessions interspersed with social or volunteer outings. Of 64 persons with ADRD who enrolled, 29 completed an initial follow-up assessment at an average of 10.65 months, and 8 completed a second follow-up at an average of 20.55 months. Results generally show stability in cognition, mood, and physical performance. Improvement was noted at the initial retest on 1 of the 3 physical fitness measures (arm curls; t = 2.61, P = .015), but self-rated quality of life declined slightly from baseline to the first retest (t = -2.09, P = .048). Change in the Mini-Mental State Examination at the first and second follow-ups (mean = +0.18 and -1.0, respectively) was negligible. The maintenance of function observed with LEEPS is an encouraging outcome, given the progressive nature of ADRD, but controlled investigations are needed to establish the efficacy of LEEPS. Barriers to implementation of an intensive activities-focused intervention in rural communities are discussed. © The Author(s) 2015.
    American Journal of Alzheimer s Disease and Other Dementias 02/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: The prevalence of Alzheimer's disease (AD) is projected to grow dramatically, but efforts to treat its progression have been unsuccessful. Fear of AD among older persons is greater than fear of cancer, and lingering worries about developing AD can be detrimental to well-being. Yet, much remains to be known about such worries and their precursors. This study, based on data from the Health and Retirement Survey, examines correlates of worry. Results of multivariate analyses show the following to be independent and significant correlates: present memory ratings, perceived changes in memory, personal familiarity with AD, belief that being a first-degree relative of someone with AD heightens the chance of developing AD, and age. Interaction analyses show that memory ratings and perceived changes in memory functioning are associated with worry regardless of personal familiarity. These findings will enable practitioners to identify patients and clients at risk of being worried about getting AD. © The Author(s) 2015.
    American Journal of Alzheimer s Disease and Other Dementias 02/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Amyloid β25-35 (Aβ25-35) represents a neurotoxic fragment of Aβ1 - 40 or Aβ1 - 42, and is implicated in the progressive neurodegeneration in cases of the Alzheimer disease (AD). Amyloid β25-35 was shown to lyse rat erythrocytes (RBCs) of all ages, and the extent of the RBC toxicity is directly correlated with Aβ25-35 concentration and cell age. Activities of glycolytic, antioxidant, and Na(+)/K(+)-adenosine triphosphatase (ATPase) enzymes, in vivo, are significantly decreased in older RBCs as compared to the young RBCs. In vitro, Aβ25-35 reduced activities of hexokinase, phosphofructokinase, pyruvate kinase, glutathione peroxidase, and glutathione transferase and increased Na(+)/K(+)-ATPase activity; these effects are significantly greater in aged RBCs as compared to those of the younger cells. The diminution in activity of certain enzymes may determine the life span of the RBCs in vivo and may be relevant to the human AD; higher sensitivity of older RBCs to Aβ25-35 toxicity may contribute to the ultimate death of the RBCs in patients with AD.
    American Journal of Alzheimer s Disease and Other Dementias 12/2014; 29(8):685-695.
  • American Journal of Alzheimer s Disease and Other Dementias 12/2014; 29(8):660-666.
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of the current study was to investigate whether an informative Web site is effective at producing higher scores for an individual's knowledge of Alzheimer's disease (AD) relative to those who do not visit a Web site. A total of 552 participants completed the study on Amazon's Mechanical Turk; half were randomly assigned to visit alz.org, while a control group did not. Both groups were given the AD Knowledge Scale (ADKS) to assess their knowledge of AD. Participants who visited alz.org scored significantly higher on the ADKS than those in the control group. Participants who were health care workers demonstrated higher scores than others in the experimental condition. Findings indicate that the Alzheimer's Association Web site is effective at producing higher scores for AD knowledge relative to no Web site at all and that it is especially helpful for health care workers compared to those who are not health care workers. © The Author(s) 2014.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: In the United States half of the 15 million informal caregivers of persons with Alzheimer's disease or a related dementia (PWDs) do not live with the PWD. This paper compares the sleep quality and health of 59 community-dwelling caregivers living with the PWD and 21 living apart from the PWD. Variables of interest were caregiving experience (hours caregiving, problematic behaviors of the PWD, caregivers' perception of dementia severity), sleep quality, and health (perceived health, stress, and depressive symptoms). Parametric unpaired t tests were used to calculate the differences between key variables. Multiple regression models were constructed, controlling for age, gender, behavior index, and dementia severity to examine the variance explained by living arrangements on sleep quality and health. Caregivers living apart from the PWD experienced the same level of poor sleep quality as did caregivers living with the PWD. The living arrangements of the caregiver did not make a unique contribution to sleep quality or health variables except for reports of unhealthy days. Given the importance of good quality sleep for health, the findings highlight the importance of evaluating caregivers living apart from the PWD for sleep problems with the same level of concern as one would have for those living with the PWD. © The Author(s) 2014.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Millions face the challenges of caregiving for a loved one with dementia. A classic Glaserian grounded theory methodology was used to discover the problem that caregivers of individuals with dementia face at the end of life and how they attempt to resolve that problem. Data were collected from a theoretical sample of 101 participants through in-person interviews, online interviews, book and blog memoirs of caregivers, and participant observation. Constant comparative method revealed a basic social psychological problem of role entrapment. Caregivers attempt to resolve this problem through a 5-stage basic social psychological process of rediscovering including missing the past, sacrificing self, yearning for escape, reclaiming identity, and finding joy. Health care professionals can support caregivers through this journey by validating, preparing caregivers for future stages, and encouraging natural coping strategies identified in this process. This study provides a substantive theory that may serve as a framework for future studies. © The Author(s) 2014.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study investigated the effects of testosterone (T) treatment on cognition, mood, and quality of life in men with mild cognitive impairment (MCI) and low serum T levels.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Adherence to cholinesterase inhibitor (ChEI) is associated with treatment effectiveness in the treatment of Alzheimer's disease (AD). We investigated the clinical adherence to donepezil in Taiwan.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized by irreversible decline of mental faculties, emotional and behavioral changes, loss of motor skills, and dysfunction of autonomic nervous system and disruption of circadian rhythms (CRs). We attempted to describe the morphological findings of the hypothalamus in early cases of AD, focusing our study mostly on the suprachiasmatic nucleus (SCN), the supraoptic nucleus (SON), and the paraventricular nucleus (PVN). Samples were processed for electron microscopy and silver impregnation techniques. The hypothalamic nuclei demonstrated a substantial decrease in the neuronal population, which was particularly prominent in the SCN. Marked abbreviation of dendritic arborization, in association with spinal pathology, was also seen. The SON and PVN demonstrated a substantial number of dystrophic axons and abnormal spines. Alzheimer’s pathology, such as deposits of amyloid-β peptide and neurofibrillary degeneration, was minimal. Electron microscopy revealed mitochondrial alterations in the cell body and the dendritic branches. The morphological alterations of the hypothalamic nuclei in early cases of AD may be related to the gradual alteration of CRs and the instability of autonomic regulation.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dementia is an age-related disorder associated with elderly population, resulting from interaction of lifestyle risk factors with genetic, vascular, and other risk factors to affect risk of disease. Alzheimer's disease (AD) is the most common form of dementia, estimated to be affecting 4.4% of the population older than 65 years of age. Apolipoprotein E (ApoE) ε4 allele is a known genetic risk factor for AD, which not only predisposes and influences the severity of pathological changes in the brain, thereby modifying the age at onset, but also promotes cognitive decline early in nondemented older people. To review the published evidence on ApoE polymorphism with the susceptibility to AD and frequency of ApoE ε4 genotype (ε4/-) and homozygotes (ε4/4) among patients diagnosed with AD as compared to controls in Indian Population. In the present study, MEDLINE was reviewed for articles published till June 2013 supplemented by citation analysis from retrieved articles to select case-control studies. A meta-analysis was performed to demonstrate the association of ApoE gene with vascular dementia by random effects to demonstrate models. The association was assessed by odds ratio (OR) with 95% confidence intervals (CIs). Case-control studies, using clinical criteria for AD with ApoE polymorphism determined for allele and genotype in both cases and controls. A meta-analysis was performed to demonstrate the association of ApoE gene with AD by random effects to demonstrate models. The association was assessed by OR with 95% CIs. We also looked for publication bias and performed sensitivity analysis to investigate the influence of each individual study. A total of 7 studies representing data from 417 patients with AD and 651 controls in the Indian population were eligible. The ApoE ε2/4, ε3/4, and ε4/4 genotypes (OR = 3.93, 95% CI: 1.60-9.68; OR = 4.18, 95% CI: 2.54-6.87; OR = 4.81, 95% CI: 1.95-11.86, respectively) as well as ApoE ε4 allele (OR = 5.90, 95% CI: 3.44-10.13) were associated with an increased risk of AD, whereas ApoE ε2/3, ε3/3 genotypes (OR = 0.52, 95% CI: 0.32-0.83; OR = 0.28, 95% CI: 0.19-0.42), and ApoE ε3 allele (OR = 0.29, 95% CI: 0.17-0.50) were found to be marginally significant protective factors for AD. There was no significant difference in ApoE ε2/2 genotype and ApoE ε2 allele frequency (OR = 0.42; 95% CI: 0.11-1.68; OR = 0.69, 95% CI: 0.37-1.31, respectively) in patients with AD and controls. These results indicate that all genotypes of ApoE ε4 allele, that is, ε2/4, ε3/4, and ε4/4, are associated with an increased risk of AD, whereas ApoE ε2/2, ε2/3, and ε3/3 are protective for AD.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014; 29(7):575-82.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Although often cast as a disease of later life, a growing number of people are being diagnosed with Alzheimer’s disease in their 50s and 60s. Early-onset Alzheimer’s disease (EOAD) poses special challenges and needs for individuals and their caregivers, such as employment and access to services. In this cross-sectional study, the researchers surveyed 81 (N= 81) family caregivers to individuals with EOAD to identify service and support usage and need. Descriptive analyses revealed that families utilized a range of formal services (eg, adult day) and informal support from family and friends. In terms of challenges and needs, participants indicated that they struggled most with employment, benefits, and financial issues. Although most caregivers felt that they were coping well, they also indicated that their needs were not well understood by service providers and the public. These findings highlight the need to better understand and respond to the specific issues surrounding EOAD.
    American Journal of Alzheimer s Disease and Other Dementias 11/2014; 29(7):596-600.
  • [Show abstract] [Hide abstract]
    ABSTRACT: In this case report, neuroleptic malignant syndrome (NMS) in an elderly patient with normal pressure hydrocephalus overlapping corticobasal degeneration was reported. The case highlights the need for clinicians to be cautious when using dopaminergic medication in the elderly patients, since these agents have risks for NMS which is a life-threatening complication. Additionally, co-occurrence of primary and secondary parkinsonian dementia syndromes should be kept in mind to avoid additional complications in the elderly patients.
    American Journal of Alzheimer s Disease and Other Dementias 10/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: The study was undertaken to evaluate the postganglionic sympathetic sudomotor function employing the quantitative sudomotor axon reflex test (QSART) in tauopathies Alzheimer's disease (AD) and behavioral variant of frontotemporal dementia (bvFTD).
    American Journal of Alzheimer s Disease and Other Dementias 10/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Recently, the Chinese Verbal Learning Test (ChVLT) was developed to assess episodic memory in Chinese speakers. The goal of this analysis was to determine whether memory consolidation as measured by the ChVLT was specifically associated with hippocampal volume in patients with cognitive impairment.
    American Journal of Alzheimer s Disease and Other Dementias 09/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Focusing on the understudied, increasing population of male Alzheimer's disease (AD) caregivers, the purpose of this study was to identify their likelihood of utilizing 3 coping strategies (task focused, emotion focused, and avoidance focused) and to examine the effects of each coping strategy on caregiving burden. Data were collected from 138 male AD caregivers in southern United States, including geographically proportional representation of African Americans in the sample. Stepwise regression revealed effects of each coping strategy on caregiving burden, controlling for demographics. The sample reported high burden. Task focused was the highest reported coping strategy. Yet, regression models indicated no significant effect of task-focused coping on burden outcomes. Emotion-focused and avoidance-focused coping each showed significant proportional effects on burden. Implications suggest that emotion- and avoidance-focused coping among male AD caregivers may be maladaptive, that is, reinforcing burden. Male AD caregivers may benefit from more task-focused coping, such as planning and active problem solving.
    American Journal of Alzheimer s Disease and Other Dementias 09/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dementia specific-case conferences with the Innovative dementia oriented assessment tool (CC-IdA) could be an important tool with which to analyze and manage challenging behavior. The study gives an insight into nursing staff' experiences using CC-IdA in dementia care.
    American Journal of Alzheimer s Disease and Other Dementias 09/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Management of nursing assistants' (NAs) emotional stress from relationship conflicts with residents, families, and coworkers is rarely the focus of educational programs. Our objective was to gather feedback from NAs and their nursing supervisors (NSs) about the utility of our e-learning program for managing relationship stress.
    American Journal of Alzheimer s Disease and Other Dementias 09/2014; 30(1).
  • [Show abstract] [Hide abstract]
    ABSTRACT: To describe the subjective experiences of older adults with early-stage Alzheimer's disease or related cognitive disorders (ADRDs) and their family caregivers who participated in an art museum engagement activity.
    American Journal of Alzheimer s Disease and Other Dementias 09/2014;