Research in Veterinary Science (RES VET SCI )

Publisher: British Veterinary Association, Elsevier


Research in Veterinary Science is an international journal publishing original articles, topical reviews and short communications of a high scientific and ethical standard in the veterinary sciences. Topics covered include, but are not limited to: anaesthesia, anatomy, avian disease bacteriology, behaviour, biochemistry, cardiology, clinical chemistry, cytogenetics, cytology, dermatology, endocrinology, epidemiology, ethology, genetics, haematology, histochemistry, histology, immunology, microbiology, molecular biology mycology, neurology, nutrition, ophthalmology, parasitology,pathology, pharmacokinetics, pharmacology, physiology, surgery, toxicology, urology, virology and welfare. Papers on every species of animal will be considered for publication.

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  • Other titles
    Research in veterinary science
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  • Document type
    Journal / Magazine / Newspaper, Internet Resource

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  • Pre-print
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    • Pre-print allowed on any website or open access repository
    • Voluntary deposit by author of authors post-print allowed on authors' personal website, or institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate
    • Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists.
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months .
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    • Articles in some journals can be made Open Access on payment of additional charge
    • NIH Authors articles will be submitted to PubMed Central after 12 months
    • Publisher last contacted on 18/10/2013
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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Leaves of Ocimum sanctum have been traditionally used for various ethno-veterinary practices as well as medicinal purpose. In vitro ovicidal and larvicidal potential of crude aqueous and hydro-alcoholic extracts of the bulb of Ocimum sanctum was investigated. Alkaloids, carbohydrates, steroids and tannins were identified in phytochemical analyses. The various blood parameters coupled marker enzymes and anti oxidant status, were also evaluated during in vivo trial. Aqueous extract showed better EC50 and EC99 values in comparison with methanolic extract in egg hatch assay and larval development test, respectively. However, in larval paralysis test, both aqueous and methanolic extracts showed almost similar efficacy. A 77.64 % reduction in faecal egg output was observed on day 14. No deleterious ill effect was found in any of the haematological and biochemical parameters suggesting that the plant could be safer for use in sheep.
    Research in Veterinary Science 01/2015;
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    ABSTRACT: We explored observed risk factors and drivers of infection possibly associated with African swine fever (ASF) epidemiology in Uganda. Representative sub-populations of pig farms and statistics were used in a case-control model. Indiscriminate disposal of pig viscera and waste materials after slaughter, including on open refuse dumps, farm-gate buyers collecting pigs and pig products from within a farm, and retention of survivor pigs were plausible risk factors. Wire mesh-protected windows in pig houses were found to be protective against ASF infection. Sighting engorged ticks on pigs, the presence of a lock for each pig pen and/or a gate at the farm entrance were significantly associated with infection/noninfection; possible explanations were offered. Strict adherence to planned within-farm and community based biosecurity, and avoidance of identified risk factors is recommended to reduce infection. Training for small-scale and emerging farmers should involve multidimensional and multidisciplinary approaches to reduce human-related risky behaviours driving infection.
    Research in Veterinary Science 10/2014; 97:218–225.
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    ABSTRACT: Besides enzymatic inactivation, catecholamines bind non-enzymatically and irreversible to proteins. The physiological impact of these catecholamine adducts is still unclear. We therefore collected basic data about the distribution of catecholamine adducts in the rat after repeated intravenous administration of 3H-adrenaline and 3H-noradrenaline. In all animals radioactivity in blood increased until the last injection on Day 7 and decreased then slowly close to background values (plasma) or remained higher (erythrocytes). In all sampled tissues radioactivity could be found, but only in hair high amounts remained present even after 3 weeks. Half-life of rat serum albumin loaded with 3H-adrenaline or 3H-noradrenaline was not altered. This study provides basic knowledge about the distribution of catecholamines or their adducts, but physiological effects could not be demonstrated. However, for the first time deposition and accumulation of catecholamines (adducts) in the hair could be proven, suggesting that hair might be used for evaluating long term stress.
    Research in Veterinary Science 10/2014; 97:204-210.
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    ABSTRACT: The locomotor pattern alterations produced after the administration of a sublingual detomidine gel was measured by an accelerometric method in horses. Using a randomized two-way crossover design, all animals (n=6) randomly received either detomidine gel or a placebo administered sublingually. A triaxial accelerometric device was used for gait assessment 15 minutes before (baseline) and every 10 minutes after each treatment for a period of 180 minutes. Eight different parameters were calculated, including speed, stride frequency, stride length, regularity, dorsoventral, propulsion, mediolateral, and total power. Force of acceleration and the three components of power were also calculated. Significant statistical differences were observed between groups in all the parameters but stride length. The majority of significant changes started between 30 and 70 minutes after drug administration and lasted for 160 minutes. This route of administration is definitely useful in horses in which a prolonged sedation is required being stability a major concern.
    Research in Veterinary Science 09/2014;
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    ABSTRACT: Six Beagles were used in this prospective randomised crossover experimental study. Dexmedetomidine was administered at 0, 1 or 2 µg/kg IV for group C, LDA and HDA, respectively. Animals were induced and maintained with alfaxalone at 0.07 mg/kg/min with a CRI dexmedetomidine dose of 0, 0.5 or 1 µg/kg/h for group C, LDA and HDA, respectively. Cardiorespiratory variables, arterial blood gases and depth of anaesthesia were recorded. The recovery times and quality of recovery were scored. Group HDA produced a greater increase in the depth of anaesthesia than LDA. However, with both protocols, CI was halved compared to normal values in dogs. The use of oxygen before and during the anaesthetic maintenance is advisable, mainly if dexmedetomidine is going to be use as a pre-medicant and maintenance agent. The quality of recovery was better in groups receiving dexmedetomidine, without causing an increase in recovery time.
    Research in Veterinary Science 08/2014;
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    ABSTRACT: Pharmacokinetic and pharmacodynamic of IV enalapril at 0.50 mg/kg, PO placebo and PO enalapril at three different doses (0.50, 1.00 and 2.00 mg/kg) were analyzed in 7 healthy horses. Serum concentrations of enalapril and enalaprilat were determined for pharmacokinetic analysis. Angiotensin-converting enzyme (ACE) activity, serum ureic nitrogen (SUN), creatinine and electrolytes were measured, and blood pressure was monitored for pharmacodynamic analysis. The elimination half-lives of enalapril and enalaprilat were 0.67 and 2.76 h respectively after IV enalapril. Enalapril concentrations after PO administrations were below the limit of quantification (10 ng/mL) in all horses and enalaprilat concentrations were below the limit of quantification in 4 of the 7 horses. Maximum mean ACE inhibitions from baseline were 88.38, 3.24, 21.69, 26.11 and 30.19% for IV enalapril at 0.50 mg/kg, placebo and PO enalapril at 0.50, 1.00 and 2.00 mg/kg, respectively. Blood pressures, SUN, creatinine and electrolytes remained unchanged during the experiments.
    Research in Veterinary Science 08/2014;
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    ABSTRACT: The effects of two diets supplemented with flaxseed oil (FO) or vitamin E (VE) were studied in sheep infected with Fasciola hepatica. The control group (CO), not supplemented, had higher weight gain and faecal egg count (P<0.05) at the end of the study. At necropsy, the number (71.2 ±26.5) and size of flukes were lower in the FO group (P<0.01), probably due to the higher levels of white blood cells and lymphocytes (P<0.01). This group also had higher red blood cell and haematocrit values (P<0.01). The CO group had more severe hypoproteinaemia and hypoalbuminaemia, due to having the highest fluke burden (123.0 ±35.2), and also the highest IgG1 titre (P<0.01). The diet did not affect production or gene expression levels of IFN-γ and IL-4. On the other hand, the supplementation with VE led to a reduction in adult fluke burden (97.7 ±39.9) and lower lipid oxidation in the liver (P<0.001).
    Research in Veterinary Science 06/2014;
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    ABSTRACT: Cyclooxygenase-2 (COX-2) is a potential target for chemoprevention and cancer therapy. Celecoxib, a selective COX-2 inhibitor, inhibits cell growth of various types of human cancer including malignant melanoma. In dogs, oral malignant melanoma represents the most common oral tumor and is often a fatal disease. Therefore, there is a desperate need to develop additional therapeutic strategies. The purpose of this study was to investigate the anticancer effects of celecoxib on canine malignant melanoma cell lines that express varying levels of COX-2. Celecoxib induced a significant anti-proliferative effect in both LMeC and CMeC-1 cells. In the CMeC cells, treatment of 50 μM celecoxib caused an increase in cells in the G0/G1 and a decreased proportion of cells in G-2 phase. In the LMeC cells, 50 μM of celecoxib led to an increase in the percentage of cells in the sub-G1 phase and a significant activation of caspase-3 when compared to CMeC-1 cells. In conclusion, these results demonstrate that celecoxib exhibits antitumor effects on canine melanoma LMeC and CMeC-1 cells by induction of G1-S cell cycle arrest and apoptosis. Our data suggest that celecoxib might be effective as a chemotherapeutic agent against canine malignant melanoma.
    Research in Veterinary Science 06/2014;
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    ABSTRACT: The microbiota of the intestinal tract plays important roles in the overall health, productivity and well-being of the animals. We have characterized the intestinal microbiota of the ferret because its human cohabitation may increase the possibility of new zoonosis. The presence of anaerobic- and microaerophilic-bacteria has been evaluated in fresh fecal specimens of forty ferrets in apparently good health. The bacteria most frequently isolated were Clostridium acetobutylicum (25/40 samples, 62.5%; 95% confidence interval [CI]: 45.81– 76.83%) and Helicobacter spp. (16/40 samples, 40.0%; 95% CI: 25.28-56.61%), as anaerobic- and microaerophilic-bacteria, respectively. The Kirby-Bauer disc-diffusion method showed penicillin, streptomycin and vancomycin resistances in high percentages (>80%) of the bacterial isolates, both in anaerobic and microaerophilic groups. Furthermore, the microaerophilic-bacteria group exhibited a significantly higher antibiotic-resistance profile compared to that of anaerobic-bacteria group. The presence of antibiotic-resistant microorganisms in the microbiota of the ferret gastro-intestinal tract is a great concern for public health.
    Research in Veterinary Science 06/2014;
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    ABSTRACT: Bovine neonatal pancytopenia (BNP) is a haemorrhagic disease of new-born calves elicited by colostrum from specific cows. Two studies have indicated that BNP-inducing colostrum might be associated with alloantibodies directed against MHC class I in response to vaccination with a distinct inactivated Bovine Viral Diarrhoea Virus (BVDV) vaccine. However, the proportion of alloantibody-producing individuals by far exceeds the proportion of clinical BNP cases in the vaccinated population. This raises the question about the incidence of subclinical, unrecognised cases and also suggests further factors involved in BNP pathogenesis, e.g., genetic predisposition. Our results on neonatal calves from a closely monitored resource population confirmed the hypothesis of a genetic predisposition for clinical BNP and suggest that the predisposition is also involved in subclinical BNP-cases. No indication was obtained for a higher frequency of subclinical BNP-cases compared to clinical cases. Neither time point nor frequency of vaccination was a relevant factor for BNP in our resource population.
    Research in Veterinary Science 06/2014;
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    ABSTRACT: The effects of steroid hormone implants containing trenbolone alone (Finaplix-H), combined with 17β-oestradiol (17β-E; Revalor-H), or with 17β-E and dexamethasone (Revalor-H plus dexamethasone per os) on the bovine muscle transcriptome were examined by DNA-microarray. Overall, large sets of genes were shown to be modulated by the different growth promoters (GPs) and the regulated pathways and biological processes were mostly shared among the treatment groups. Using the Prediction Analysis of Microarray program, GP-treated animals were accurately identified by a small number of predictive genes. A meta-analysis approach was also carried out for the Revalor group to potentially increase the robustness of class prediction analysis. After data pre-processing, a high level of accuracy (90%) was obtained in the classification of samples, using 105 predictive gene markers. Transcriptomics could thus help in the identification of indirect biomarkers for anabolic treatment in beef cattle to be applied for the screening of muscle samples collected after slaughtering.
    Research in Veterinary Science 06/2014;
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    ABSTRACT: The present study was carried out in order to assess the possible alterations in purines levels of brain, associated neuronal lesions in gerbils experimentally infected with N. caninum. For that, gerbils (Meriones unguiculatus) were inoculated with Nc-1 strain of N. caninum, composing two different experiments: Experiment I (EI) and experiment II (EII), where purine levels were measured along with the histopathologic study, on days 7 (EI), 15 and 30 (EII), post-infection (PI). As results, it was possible to observe that purines levels (ATP, ADP, AMP, adenosine, inosine and xanthine) in brain in EI significantly reduced (P < 0.05), while in EII we faced with a different pattern, since in their majority the purine levels were significantly increased (P<0.05) on day 15 (ATP, AMP, adenosine, hypoxanthine and xanthine) and 30 PI (ATP, ADP, AMP, adenosine, and uric acid). Results of brain histopathology did not show histological lesion in animals of EI; however, in gerbils of EII it was possible to verify that the alterations (lesions) were more pronounced in gerbils evaluated on day 30 PI when compared to day 15 PI. Therefore, it was possible to conclude that the purine levels in brain were altered in both experiments, concomitant with the histopathological injuries observed in EII.
    Research in Veterinary Science 06/2014;
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    ABSTRACT: This study aimed to examine the Doppler velocimetric pattern of the testicular artery of small dogs in two different locations. Testes of 21 dogs were evaluated by two-dimensional ultrasonography to measure testicular volume and by Doppler ultrasonography to record the velocimetric patterns of the testicular artery in the spermatic cord and marginal location. The volume of left testes (4.70 ± 1.22 cm3) was significantly higher than the volume of the right testes (4.45 ± 1.17 cm3). Peak systolic velocity (PSV) of the left spermatic cord was significantly higher than the right side. End-diastolic velocity was significantly higher in the marginal artery than the spermatic cord on both sides; however, resistance and pulsatility indexes were significantly lower in the marginal artery. Results demonstrate the viability of Doppler ultrasonography for characterization of the testicular artery in small dogs and Doppler velocimetric values vary according to the location of measurement along the artery.
    Research in Veterinary Science 06/2014;
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    ABSTRACT: Enolases are glycolytic enzymes in the glycolytic pathway which catalyzes the reversible conversion of D-2-phosphoglycerate into phosphoenol- pyruvate in the second half of the glycolytic pathway. Our previous studies demonstrated that the relative expression levels ofα-enolase (ENO1) in the ovaries of laying geese increased by 2.34 ± 0.67 fold compared with those of pre-laying geese. In order to evaluate the effect of ENO1 on follicle-stimulating hormone receptor (FSHR) mRNA and Luteinizing Hormone Receptor (LHR) mRNA of primary granular cell from goose F1 follicles, the recombinant plasmid adenovirus carrying ENO1 (pAd-CMV-ENO1) were constructed and infected the primary culture granular cells. The granular cells were randomly divided into three groups: recombinant adenovirus pAd-CMV-ENO1 infected (pAd-CMV-ENO1), empty vector Ad-CMV-Null infected (pAd-CMV-Null) and no virus (Mock control). The expression levels of FSHR mRNA and LHR mRNA of granular cell were examined by quantitative real-time PCR (qRT-PCR). The results showed that the group pAd-CMV-ENO1 had significantly higher FSHR mRNA expression levels than other two groups (P < 0.05), but the group pAd-CMV- ENO1 had significantly lower LHR mRNA expression levels than other two groups (P < 0.05). There were no significant differences in FSHR or LHR mRNA between the group pAd-CMV-Null and group mock control. The results suggested that ENO1 could improve the combination rate between FSH and FSHR to accelerate the proliferation and differentiation and steroidogenesis in poultry gonadal tissues. The study provided a better understanding of the functional action of ENO1 with regard to the processes of goose ovary development and egg laying.
    Research in Veterinary Science 06/2014;
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    ABSTRACT: A total of 13 serotype O and 5 serotype A FMD Ethiopian isolates and some isolates from other countries (six for serotype A and four for serotype O) were sequenced on the structural protein (P1) coding region. The deduced amino acid sequences were aligned and investigated in an attempt to determine the amino acid variation. Differences were observed at 115 (15.6%) and 119 (16.1%) amino acid positions for serotype O and serotype A, respectively. The variation in the derived amino acid sequences is the highest in VP1, while VP4 was highly conserved in both serotypes A and O. In all isolates, hypervariable regions were located at regions corresponding to the highly immunogenic sites, the G–H loop (133–158) and the C-terminus (194–213) of the VP1 gene. The RGD cell attachment site within the G–H loop of the gene was conserved in all isolates. The study revealed the presence of significant amino acid variation at VP2 and VP3 in addition to known VP1 coding region. Hence, determination of amino acid sequence of the whole P1 region provides more information on antigenic variability of FMD virus and could be used in vaccine strain selection in parallel with serological vaccine matching assays.
    Research in Veterinary Science 06/2014;
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    ABSTRACT: Spoligotyping is the most widely used method for genotyping Mycobacterium bovis (M. bovis). However, its discriminatory power varies widely between countries. MIRU-VNTR typing could be a promising alternative, although it generally requires the time consuming and laborious simplex PCR assays using standard agarose gel electrophoresis. The accuracy of this approach depends on good standardization and a certain degree of expertise. This study presents a version of MIRU-VNTR based on three triplex PCRs with automatic allelic assignation of the products analyzed in capillary electrophoresis. The technique was prospectively applied to 44 M. bovis and two Mycobacterium caprae (M. caprae) isolates, and 22 different MIRU-VNTRtypes were obtained; with spoligotyping, only 14 different types were obtained. The proposal makes it possible to shorten response times, automate procedures, and increase accuracy, thus minimizing errors in assigning genotypes. It would enable the switch from a standard limited method of genotyping M. bovis to a high-throughput discriminatory fingerprinting approach.
    Research in Veterinary Science 06/2014;