Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

Publisher: Elsevier

Current impact factor: 1.97

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.966
2013 Impact Factor 2.371
2012 Impact Factor 2.167
2011 Impact Factor 2.235
2010 Impact Factor 2.134
2009 Impact Factor 2.196
2008 Impact Factor 1.709
2007 Impact Factor 1.863
2006 Impact Factor 1.553
2005 Impact Factor 1.351
2004 Impact Factor 1.635
2003 Impact Factor 1.556
2002 Impact Factor 1.274
2001 Impact Factor 1.026
2000 Impact Factor 0.883
1999 Impact Factor 0.916
1998 Impact Factor 0.645
1997 Impact Factor 0.748
1996 Impact Factor 0.618
1995 Impact Factor 0.531
1994 Impact Factor 0.64
1993 Impact Factor 0.619
1992 Impact Factor 0.623

Impact factor over time

Impact factor

Additional details

5-year impact 2.26
Cited half-life >10.0
Immediacy index 0.51
Eigenfactor 0.01
Article influence 0.66
Other titles Comparative biochemistry and physiology., Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Comparative biochemistry and physiology., Molecular and integrative physiology, Molecular & integrative physiology, Comp. biochem. physiol., CBP., Comparative biochemistry and physiology
ISSN 1531-4332
OCLC 41929819
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details


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    • Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
    • Publisher last reviewed on 03/06/2015
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: In developing avian embryos, the right and left ductus arteriosi (DA) allow for a shunt of systemic venous return away from the lungs to the body and chorioallantoic membrane (CAM). Unlike in mammals where the transition from placental respiration to lung respiration is instantaneous, in birds the transition from embryonic CAM respiration to lung respiration can take over 24h. To understand the physiological consequences of this long transition we examined changes and DA morphological changes during hatching in the emu (Dromaius novaehollandiae), a primitive ratite bird. By tracking microspheres injected into a CAM vein, we observed no change in DA blood flow between the pre-pipped to internally pipped stages. Two hours after external pipping, however, a significant decrease in DA blood flow occurred, evident from a decreased systemic blood flow and subsequent increased lung blood flow. Upon hatching, the right-to-left shunt disappeared. These physiological changes in DA blood flow correspond with a large decrease in DA lumen diameter from the pre-pipped stages to Day 1 hatchlings. Upon hatching, the right-to-left shunt disappeared and, at the same time apoptosis of smooth muscle cells began remodeling the DA for permanent closure. After the initial smooth muscle contraction, the lumen disappeared as intimal cushioning formed, the internal elastic lamina degenerated, and numerous cells underwent regulated apoptosis. The DA closed rapidly between the initiation of external pipping and hatching, resulting in circulatory patterns similar to the adult. This response is most likely produced by increased DA constriction in response to increased arterial oxygen levels and the initiation of vessel remodeling.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 11/2015; 191. DOI:10.1016/j.cbpa.2015.11.006
  • [Show abstract] [Hide abstract]
    ABSTRACT: Alterations to natural habitats are becoming more common due to changes in anthropogenic land use. As such, there is increasing interest in determining how wild animals adapt and respond to environmental stressors. The glucocorticoid (GC) stress response enables animals to react appropriately to environmental challenges but can be affected by many factors, two of which are habitat quality and time of year (i.e., season). This study tested whether baseline and maximum (stress-induced) whole-body cortisol concentrations varied in relation to habitat quality and season using wild central mudminnows (Umbra limi) collected from two connected streams differing in habitat quality in each of four seasons. Overall, baseline and maximum cortisol levels did not differ significantly between the two systems but there was evidence of a seasonal effect. Baseline cortisol levels in the fall and summer were significantly (P<0.01) lower than those in winter and spring and maximum cortisol levels in the summer were significantly lower (P<0.01) than those in the spring. Inconsistent with the prevailing paradigm, our results indicate that habitat quality does not always influence baseline GCs or the stress response. In contrast, baseline and maximum GCs in this species do vary seasonally. As such, seasonality should be considered in the interpretation of stress response data especially when using small-bodied stream fish as biological indicators.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 11/2015; 192. DOI:10.1016/j.cbpa.2015.10.027
  • [Show abstract] [Hide abstract]
    ABSTRACT: Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide that in mammalian testis is involved in the control of testosterone and 17β-estradiol synthesis. A similar involvement was recently postulated in the testis of a nonmammalian vertebrate, the wall lizard Podarcis sicula. Indeed, we reported the presence of PACAP and its receptors throughout the reproductive cycle within both germ and somatic cells. Now, we investigated the effects of PACAP on steroidogenesis in significant periods of Podarcis reproductive cycle: winter stasis, reproductive period and summer stasis. Using different in vitro treatments, in the absence or presence of receptor antagonists, we demonstrated that in P. sicula testis PACAP is involved in the control of testosterone and 17β-estradiol production. In particular we demonstrated that treatment with PACAP induced a testosterone increase only in stasis periods (winter and summer stasis); differently they induced a 17β-estradiol production in all periods analyzed (summer stasis, winter stasis and reproductive period).
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 10/2015; 191. DOI:10.1016/j.cbpa.2015.10.022
  • [Show abstract] [Hide abstract]
    ABSTRACT: In mammalian tissues under hypoxic conditions, ATP degradation results in accumulation of purine metabolites. During exercise, muscle energetic demand increases and oxygen consumption can exceed its supply. During breath-hold diving, oxygen supply is reduced and, although oxygen utilization is regulated by bradycardia (low heart rate) and peripheral vasoconstriction, tissues with low blood flow (ischemia) may become hypoxic. The goal of this study was to evaluate potential differences in the circulating levels of purine metabolism components between diving and exercise in bottlenose dolphins (Tursiops truncatus). Blood samples were taken from captive dolphins following a swimming routine (n=8) and after a 2min dive (n=8). Activity of enzymes involved in purine metabolism (hypoxanthine-guanine phosphoribosyl transferase (HGPRT), inosine monophosphate deshydrogenase (IMPDH), xanthine oxidase (XO), purine nucleoside phosphorylase (PNP)), and purine metabolite (hypoxanthine (HX), xanthine (X), uric acid (AU), inosine monophosphate (IMP), inosine, nicotinamide adenine dinucleotide (NAD(+)), adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), ATP, guanosine diphosphate (GDP), guanosine triphosphate (GTP)) concentrations were quantified in erythrocyte and plasma samples. Enzymatic activity and purine metabolite concentrations involved in purine synthesis and degradation, were not significantly different between diving and exercise. Plasma adenosine concentration was higher after diving than exercise (p=0.03); this may be related to dive-induced ischemia. In erythrocytes, HGPRT activity was higher after diving than exercise (p=0.007), suggesting an increased capacity for purine recycling and ATP synthesis from IMP in ischemic tissues of bottlenose dolphins during diving. Purine recycling and physiological adaptations, may maintain the ATP concentrations in bottlenose dolphins after diving and exercise.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 10/2015; 191. DOI:10.1016/j.cbpa.2015.10.021
  • [Show abstract] [Hide abstract]
    ABSTRACT: The main object of this study was to evaluate the impact of different levels of vitamin A (VA) and arachidonic acid (ARA) in relation to eicosapentaenoic acid (EPA) on mineralization and gene expression in Atlantic cod larvae (Gadus morhua). First-feeding larvae were fed enriched rotifers from start-feeding until 29 days post hatch (dph). Larvae in four tanks were fed one of the following diets: control (EPA/ARA ratio: 15.8, 0.9 μg VA g(-1)), control+VA (EPA/ARA ratio: 15.8, 7.8 μg VA g(-1)), High ARA (EPA/ARA ratio: 0.9, 1.5 μg VA g(-1)) or High ARA +VA (EPA/ARA ratio: 0.9, 12.0 μg VA g(-1)). Larvae fed High ARA+VA were shorter at 29 dph compared to the other groups and had significantly less mineralized bones when comparing larvae of similar size, showing interaction effects between VA and ARA. Although transcriptomic analysis did not reveal any interaction effects, a higher number of genes were differentially expressed in the high ARA fed larvae compared to control +VA fed larave. Furthermore, bglap1 , bglap2 and col10a1 were all down-regulated in larvae fed High ARA-diets and to a greater extent than larvae fed VA supplemented diet, indicating an additive effect on mineralization. In conclusion, this study showed that the dietary increase in ARA and VA altered the skeletal metabolism during larval development, most likely through signaling pathways specific for each nutrient rather than an interaction. The present study also demonstrates that VA could affect the larval response to ARA, even within the accepted non-toxic/non-deficient range.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 10/2015; 191. DOI:10.1016/j.cbpa.2015.10.011
  • [Show abstract] [Hide abstract]
    ABSTRACT: Whether passerines collectively have a higher mean mass-independent basal rate of metabolism than the mean of other birds has been controversial. The conclusion that no difference exists was based on phylogenetic analyses. Higher basal rates, however, have been repeatedly seen in passerines and demonstrated by ANCOVA analyses. Several studies indicated that the mean mass-independent basal rate of passerines is > 30% higher than the collective mean of other birds. Yet, at least three non-passerine orders of 25 have mean mass-independent basal rates equal to that of passerines. They are Anseriformes, Charadriiformes, and Procellariiformes, all characterized by an active lifestyle, including migratory and pelagic habits. In contrast, sedentary ducks endemic to islands have low basal rates. The high basal rates in temperate passerines correlate with migratory habits and life in cool to cold environments, the absence of these factors being partly responsible for the lower basal rates in most tropical passerines. The principal difference in energetics among non-passerines, between passerines and most non-passerines, and among passerines reflects the frequency of habits associated with high or low mass-independent energy expenditures, the habits correlating with body composition. The mean mass-independent basal rate in tropical passerines is slightly lower than in temperate passerines which implies that the collective mean in passerines would be somewhat lower if tropical passerines were included in proportion to their diversity. However, their inclusion will not eliminate the difference presently seen between passerines and other birds because the difference between tropical and temperate passerines is less than that between passerines and other birds.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 10/2015; 191. DOI:10.1016/j.cbpa.2015.10.005
  • [Show abstract] [Hide abstract]
    ABSTRACT: Tonic immobility (TI) is an innate characteristic of animals related to fear or stress response. Animals can be classified into long TI (LTI) and short TI (STI) phenotypes based on TI test duration. In this study, effect of TI phenotype, chronic corticosterone administration (CORT), and their interaction on cholesterol metabolism in liver was evaluated in broilers. LTI broilers showed higher level of cholesterol in liver compared to STI chickens (p<0.05), and CORT significantly increased hepatic cholesterol content (p<0.01). Real-time PCR results showed that both TI and CORT potentially altered ABCA1 and CYP7A1 gene expressions (0.05<p<0.1), while there was no significant interaction of CORT and TI on both gene expressions. CORT treatment significantly increased the level of SREBP2 (p=0.00), LDLR (p<0.05), GR (p<0.05) and 11β-HSD2 (p<0.05) protein abundance in liver. However, TI phenotype only affected hepatic HMGCR protein expression, and LTI broilers showed higher level of HMGCR protein expression in liver than STI (p<0.05). These results indicate that chronic CORT administration causes hepatic cholesterol accumulation in broiler chickens mainly by enhancing cholesterol synthesis and uptake into liver. LTI chickens had higher amount of total cholesterol in liver, which might be associated with an increase of hepatic HMGCR protein expression. However, there is no interaction between TI and CORT on cholesterol metabolism in liver of broilers.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 10/2015; 191. DOI:10.1016/j.cbpa.2015.09.020