Cardiovascular Drug Reviews (Cardiovasc Drug Rev)

Publications in this journal

• Article: Challenges for Cardiovascular Drug Research

  Alexander Scriabine
  Cardiovascular Drug Reviews 10/2007; 25(3):205 - 209.
• Article: Therapeutic Potential of VIVIT, a Selective Peptide Inhibitor of Nuclear Factor of Activated T cells, in Cardiovascular Disorders

  Haixiang Yu, Theo J.C. Van Berkel, Erik A.L. Biessen
  [show abstract] [hide abstract]
  ABSTRACT: Cardiovascular disease is the major cause of death in industrialized nations. Targeted intervention in calcineurin, a calmodulin-dependent, calcium-activated phosphatase and its substrate, nuclear factor of activated T cells (NFAT), was demonstrated to be effective in the treatment of cardiovascular diseases. Although effective in the disruption of calcineurin phosphatase activity, cyclosporin A (CsA) and FK506 also resulted in undesired side effects and toxicity, prompting the discovery of VIVIT, a novel peptide inhibitor. VIVIT selectively and potently inhibits calcineurin/NFAT interaction, but does not compromise calcineurin phosphatase activity and non-NFAT-mediated signaling. VIVIT displays a favorable therapeutic profile as a potential drug candidate and constitutes a useful tool in exploring calcineurin-NFAT functionality. This review describes the development of VIVIT peptide as a selective NFAT inhibitor and its application as a therapeutic agent in cardiovascular disorders including cardiac hypertrophy, restenosis, atherosclerosis, and angiogenesis.
  Cardiovascular Drug Reviews 05/2007; 25(2):175 - 187.
• Article: Ticlopidine

  John J. Bruno, Basil A. Molony
  Cardiovascular Drug Reviews 04/2007; 1(1):295 - 316.
• Article: Cibenzoline

  Kenneth H. Dangman, Dennis S. Miura
  Cardiovascular Drug Reviews 04/2007; 4(1):107 - 128.
• Article: Anagrelide

  J. S. Fleming, J. P. Buyniski
  Cardiovascular Drug Reviews 04/2007; 1(1):277 - 294.
• Article: Lovastatin

  A. W. Alberts, J. S. MacDonald, A. E. Till, J. A. Tobert
  Cardiovascular Drug Reviews 04/2007; 7(2):89 - 109.
• Article: Inotropic Effects of DN‐9693: A Selective Cyclic AMP Phosphodiesterase Inhibitor

  Tadashi Tanaka, Makoto Kawai, Satoshi Kurihara
  Cardiovascular Drug Reviews 04/2007; 14(3):246 - 255.
• Article: PD‐156707: A Selective Endothelin‐A Receptor Antagonist

  Andrew C. G. Uprichard, Alan L. Metz, Hussein Hallak, Stephen J. Haleen
  Cardiovascular Drug Reviews 04/2007; 16(2):89 - 104.
• Article: Bethanidine Sulfate as an Antifibrillatory Drug

  Marvin B. Bacaner
  Cardiovascular Drug Reviews 04/2007; 1(1):69 - 92.
• Article: Falipamil (AQ‐A 39) and UL‐FS 49

  Walter Kobinger, Christian Lillie
  Cardiovascular Drug Reviews 04/2007; 6(1):35 - 53.
• Article: Isradipine—A Review of Its Antihypertensive and Other Properties

  D. Holmes, R. P. Hof, P. C. Rüegg, H. Schön
  Cardiovascular Drug Reviews 04/2007; 10(1):3 - 25.
• Article: Tetrandrine

  Yi-Tsau Huang, Chuang-Ye Hong
  Cardiovascular Drug Reviews 04/2007; 16(1):1 - 15.
• Article: PAF Antagonists as Potential Therapeutic Agents in Cardiac Anaphylaxis and Myocardial Ischemia

  Matyas Koltai, Arpad Tosaki, Jean‐Michel Guillon, David Hosford, Pierre Braquet
  Cardiovascular Drug Reviews 04/2007; 7(3):177 - 198.
• Article: Dopropidil, A Novel Antianginal Calcium Modulating Agent

  J. Planellas, Ph Coudray, E. Winslow, R. Massingham
  Cardiovascular Drug Reviews 04/2007; 12(3):208 - 224.
• Article: Trimetazidine, A Cellular Anti‐ischemic Agent

  Catherine Harpey, Pascale Clauser, Claude Labrid, Jean‐Louis Freyria, Jean‐Pierre Poirier
  Cardiovascular Drug Reviews 04/2007; 6(4):292 - 312.
• Article: Imazodan (CI‐914)

  Robert P. Steffen, Ronald E. Weishaar, Dale B. Evans, Harvey R. Kaplan
  Cardiovascular Drug Reviews 04/2007; 4(1):81 - 105.
• Article: Amosulalol

  Toichi Takenaka
  Cardiovascular Drug Reviews 04/2007; 5(1):117 - 134.
• Article: Esmolol

  Richard J. Gorczynski, Check Y. Quon, Richard W. Krasula, W. Lesley Matier
  Cardiovascular Drug Reviews 04/2007; 3(1):99 - 119.
• Article: OPC‐13340, a New Potent and Long‐Acting Dihydropyridine Calcium Antagonist

  Natsuki Nakayama, Katsumi Ikezono, Naoki Fujio, Hiroyuki Sasabe, Keisuke Kitaura, Shigeharu Tamada, Toshinobu Shirafuji, Youichi Yabuuchi
  Cardiovascular Drug Reviews 04/2007; 9(2):147 - 157.
• Article: Delapril

  Yoshikazu Oka, Kohei Nishikawa, Go Kito, Hiroshi Mayahara, Shigeharu Tanayama, Hiroshi Muto, Kentaro Hiraga
  Cardiovascular Drug Reviews 04/2007; 6(3):192 - 205.