Electrophoresis (Electrophoresis )

Publisher: Electrophoresis Society; International Electrophoresis Society, John Wiley & Sons

Description

Attracting high-quality papers from the world's leading laboratories ELECTROPHORESIS has proved itself indispensable in the life sciences where electrophoresis is the most widely used method. ELECTROPHORESIS is the foremost journal for new analytical and preparative methods and for innovative applications on all aspects of electrophoresis. It has an international scope and publishes original papers short communications and review articles in the following areas: biochemistry molecular and cell biochemistry genetics immunology microbiology clinical chemistry forensics food science and many more. Special Issues Paper Symposium issues devoted to new developments prepared by an expert Guest Editor are published regularly with special emphasis on capillary electrophoresis (2-3 issues per year)and proteomics. The journal also publishes proceedings of international and national electrophoresis meetings.

  • Impact factor
    3.26
  • 5-year impact
    2.87
  • Cited half-life
    7.10
  • Immediacy index
    0.48
  • Eigenfactor
    0.03
  • Article influence
    0.63
  • Website
    Electrophoresis website
  • Other titles
    Electrophoresis (Online), Electrophoresis, Proteomics reviews
  • ISSN
    1522-2683
  • OCLC
    43388561
  • Material type
    Periodical, Program, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

John Wiley & Sons

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • See Wiley-Blackwell entry for articles after February 2007
    • On personal web site or secure external website at authors institution
    • Not allowed on institutional repository
    • JASIST authors may deposit in an institutional repository
    • Non-commercial
    • Pre-print must be accompanied with set phrase (see individual journal copyright transfer agreements)
    • Published source must be acknowledged with set phrase (see individual journal copyright transfer agreements)
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • 'John Wiley and Sons' is an imprint of 'Wiley-Blackwell'
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The ability to determine the tissue source of biological materials from evidence samples can be highly informative for interpreting forensic data. In this study, a previously published capillary electrophoresis (CE)-based method to probe locus-specific DNA methylation was modified to accommodate detection using next-generation sequencing (NGS) to perform tissue source attribution. DNA samples (1 ng) from each of four different tissue types were digested with the methylation sensitive restriction endonuclease Hha1 and polymerase chain reaction (PCR) was used to amplify an optimized subset of ten methylated loci, including positive and negative control loci. The products were prepared as NGS libraries, pooled in a multiplex assay with sample specific barcodes, sequenced with an Illumina MiSeq, and analyzed using a k-Nearest Neighbor algorithm. With this initial effort a concordance rate of 15/16 was demonstrated from samples of varying types: semen, saliva, skin epidermis, and blood. This method also was designed to be compatible with the workflows published to date for NGS of short tandem repeats (STRs). Thus, the methylation approach described here is highly accurate and upon further validation and testing may be potentially used in practice as a confirmatory test in conjunction with other NGS protocols used in forensic laboratories. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: The formation process of polyoxometalates [PMo12 O40 ](3-) and [PMo12-x Vx O40 ](3-) has been studied in aqueous solutions of 0.1 M malonate buffer at pH 2.8-3.0 using capillary zone electrophoresis. Two different approaches, pre-capillary and in-capillary, were examined and compared. In pre-capillary mode the reaction mixture of the reactants and reaction products was injected into the capillary followed by the separation procedure. In in-capillary mode the sequential input of the reagents and running electrolyte into the capillary and the species separation occurs simultaneously. The optimal parameters of in-capillary separation were established as functions of applied voltage and the length of the intermediate buffer zone between the reagents in the capillary. As a result the best-compromise conditions for the separation of the mixtures containing the reactants, intermediates and reaction products to achieve the best effectiveness, symmetry, and peak areas were achieved at -18 kV and at the input parameter of 900 mbar·s. It was also shown that in-capillary mode is more informative than pre-capillary one for the study of the complex compounds formation process. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: Molecular crowding is a new approach to enhance the retention properties and selectivity of molecularly imprinted polymers. In this work, this concept was firstly applied to chiral capillary electrophoresis (CE) to enhance its enantioselectivity. A model system, enantioseparation of salbutamol using hydroxypropyl-beta- cyclodextrin as chiral selector in the presence of dextran or dextrin as crowding-inducing agents, was chosen to demonstrate its potency. Some parameters, especially the concentration of crowding-inducing agents and cyclodextrins were investigated intensively. Moreover, based on fluorescence spectroscopy and affinity capillary electrophoresis, it was found that the presence of crowding-inducing agents could promote the association of enantiomers with cyclodextrins and intensify the interacting differences of two enantiomers with cyclodextrins. As a result, the essential concentration of cyclodextrins to make the enantiomers reach baseline separation was significantly decreased with the aid of molecular crowding. This study shows that molecular crowding is an effective strategy to enhance the enantioselectivity of cyclodextrin in chiral CE. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: This report provides a comparison of multiple gel formats to study myosin heavy chain (MHC) isoforms that are expressed in reptilian skeletal and cardiac muscles of five turtle species, water monitor, and prehensile tailed skink. Three gel formats were tested. The results identify one format that is superior, for the overall extent of electrophoretic separation and for the assessment of the number of MHC isoforms in reptilian striated muscles. The same format was shown previously to separate MHC isoforms that are expressed in American alligator. The results also show that another gel format reveals the distinct electrophoretic mobility of MHC isoforms in cardiac ventricular and jaw adductor samples, compared to those expressed in skeletal muscles in the limbs and elsewhere in the body. In addition, the results reveal that the electrophoretic mobility of specific MHC isoforms, relative to other isoforms, depends on the gel format, as shown previously for mammalian and avian species. The discovery of the expression of masticatory MHC, which is abundantly expressed in jaw adductors of members of Carnivora and several other vertebrate orders, in the homologous muscles of prehensile tailed skink, an herbivore, and the carnivorous water monitor, was made during the course of this study. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: A generic chiral separation strategy for the analysis of acidic compounds in capillary electrochromatography (CEC) is proposed in completion of an earlier defined strategy for non-acidic compounds. The screening step of this strategy uses a 45 mM ammonium formate, pH 2.9/ACN, 35/65 (v/v) mobile phase, a temperature of 25°C and an applied voltage of 15 kV. To update the screening step, eight chiral stationary phases, which all possessed chlorinated and non-chlorinated polysaccharide-based chiral selectors were evaluated using the earlier defined screening conditions. A combination of the two types polysaccharide-based chiral phases proved to have the highest cumulative success rate. In the updated screening step, amylose tris (3,5-dimethylphenylcarbamate) (ADH), cellulose tris (4-methylbenzoate) (OJH), cellulose tris (3,5-dichlorophenylcarbamate) (SP5) and cellulose tris (3,5-dimethylphenylcarbamate) (ODRH) were included as selectors and their preferred screening sequence was determined as ADH > OJH > SP5 > ODRH. New optimisation steps were also defined for SP5 by investigating the influences of different parameters on the separation outcome using an experimental design approach. After application of the updated strategy, already 15 out of 17 acidic pharmaceuticals were separated at screening conditions, of which nine were baseline resolved. When the optimization steps were applied, another three compounds were baseline separated, while the total number of separations was increased by one, which brings the total number of separations to 16 out of 17 with 12 baseline separated compounds. This reflects the successful performance of the updated strategy on acidic compounds. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: In this paper, we numerically explore the possibility of separating two groups of deformable cells, by a very small dielectrophoretic (DEP) microchip with the characteristic length of several cell diameters. A 2D two-fluid model is developed to describe the separation process, where three types of forces are considered, the aggregation force for cell-cell interaction, the deformation force for cell deformation, and the DEP force for cell dielectrophoresis. As a model validation, we calculate the levitation height of a cell subject to DEP force, and compare it with the experimental data. After that, we simulate the separation of two groups of cells with different dielectric properties at high and low frequencies, respectively. The simulation results show that the deformable cells can be separated successfully by a very small DEP microchip, according to not only their different permittivities at the high frequency, but also their different conductivities at the low frequency. In addition, both two groups of cells have a shape deformation from an original shape to a lopsided slipper shape during the separation process. It is found that the cell motion is mainly determined by the DEP force arising from the electric field, causing the cells to deviate from the centerline of microchannel. However, the cell deformation is mainly determined by the deformation force arising from the fluid flow, causing the deviated cells to undergo an asymmetric motion with the deformation of slipper shape. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: Inherited arrhythmogenic disorders is a relatively common cause of cardiac sudden death in young people. Diagnosis has been difficult so far due to the genetic heterogeneity of the disease. Next Generation Sequencing (NGS) is offering a new scenario for diagnosis. The purpose of our study was to validate Next Generation Sequencing (NGS) for the analysis of twenty-eight genes known to be associated with inherited arrhythmogenic disorders and therefore with Sudden cardiac death (SCD). SureSelect hybridization was used to enrich DNA from 53 samples, prior to be sequenced with the SOLID(TM) System of Life Technologies. Depth of coverage, consistency of coverage across samples, and location of variants identified were assessed. All the samples showed a depth of coverage over 200x, except one of them discarded because of its coverage below 30x. Average percent of target bp covered at least 20x was 96.45%. In the remaining samples, following a prioritization process 46 possible variants in 31 samples were found, of which 45 were confirmed by Sanger sequencing. After filtering variants according to their MAF in the Exome Sequencing Project (ESP) 27 putative pathogenic variants in 20 samples remained. With the use of in silico tools, 13 variants in 11 samples were classified as likely pathogenic. In conclusion, NGS allowed us to accurately detect arrhythmogenic disease causing mutations in a fast and cost-efficient manner that is suitable for daily clinical of forensic practice of genetic testing of this type of disorders. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: An analytical study is presented for the transient electrophoretic response of a circular cylindrical particle to the step application of an electric field. The electric double layer adjacent to the particle surface is thin but finite compared with the radius of the particle. The time-evolving electroosmotic velocity at the outer boundary of the double layer is utilized as a slip condition so that the transient momentum conservation equation for the bulk fluid flow is solved. Explicit formulas for the unsteady electrophoretic velocity of the particle are obtained for both axially and transversely applied electric fields, and can be linearly superimposed for an arbitrarily-oriented applied field. If the cylindrical particle is neutrally buoyant in the suspending fluid, the transient electrophoretic velocity is independent of the orientation of the particle relative to the applied electric field and will be in the direction of the applied field. If the particle is different in density from the fluid, then the direction of electrophoresis will not coincide with that of the applied field until the steady state is attained. The growth of the electrophoretic mobility with the elapsed time for a cylindrical particle is substantially slower than for a spherical particle. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: It has been twenty years since Luire et al. first published their model of electromigration of an analyte under simultaneous interaction with two cyclodextrins as chiral selectors. Since then, the theory of (enantio) separation in dual and complex mixtures of (chiral) selectors is well understood. In spite of this, a trial-and-error approach still prevails in analytical practice. Such a situation is likely caused by the fact that the entire theory is spread over numerous papersand the relations between various models are not always clear. The present review condenses the theory for the first time. Available mathematical models and feasible practical approaches are summarised and their advantages and limitations discussed. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: A novel 3-hydroxypropyl (propanol) bonded silica phase has been prepared by hydrosilylation of allyl alcohol on a hydride silica intermediate, in the presence of platinum (0)-divinyltetramethyldisiloxane (Karstedt's catalyst). The regio-selectivity of this synthetic approach had been correctly predicted by previous reports involving octakis(dimethylsiloxy)octasilsesquioxane (Q8 M8 (H) ) and hydrogen silsesquioxane (T8 H8 ), as molecular analogs of hydride amorphous silica. Thus, C-silylation predominated (∼ 94%) over O-silylation, and high surface coverages of propanol groups (5±1 μmol/m(2) ) were typically obtained in this work. The propanol-bonded phase was characterized by spectroscopic (IR and solid state NMR on silica microparticles), contact angle (on fused-silica wafers) and CE (on fused-silica tubes) techniques. CE studies of the migration behavior of pyridine, caffeine, tris(2,2'-bipyridine)Ru(II) chloride and lysozyme on propanol-modified capillaries were carried out. The adsorption properties of these select silanol-sensitive solutes were compared to those on the unmodified and hydride-modified tubes. It was found that hydrolysis of the SiH species underlying the immobilized propanol moieties leads mainly to strong ion-exchange based interactions with the basic solutes at pH 4, particularly with lysozyme. Interestingly, and in agreement with water contact angle and electroosmotic mobility figures, the silanol-probe interactions on the buffer-exposed (hydrolyzed) hydride surface are quite different from those of the original unmodified tube. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: The forensic utility of an insect can depend in part on its population structure. Although some native North American species have been characterized in this fashion, information is lacking for species that were introduced from elsewhere and that might have lower genetic diversity and less geographic differentiation. We surveyed Chrysomya megacephala, an Asian fly present in the continental USA since the 1980s. Amplified Fragment Length Polymorphism profiles were generated from adult insects collected across Florida and in Mobile, Alabama. Analysis of Molecular Variance on 151 polymorphic loci found significant but very small variation among samples. STRUCTURE and principle coordinate analyses produced the same two clusters in the population, consistent with C. megacephala in Florida having originated from two separate source populations. A weak negative correlation between genetic and geographic distances probably reflected the geographic arrangement of the genetic clusters. A positive relative relatedness coefficient for each sample indicated that flies arriving at a bait within a short time were likely to be close relatives, consistent with the earlier results for native North American carrion flies. However, genetic diversity estimated for the introduced Florida C. megacephala was lower than for native species or for published data on Malaysian C. megacephala, perhaps reflecting the genetic effects of being introduced to a new geographic region. Genetic assignment, a method that has been proposed as a way to infer corpse postmortem relocation, was much less successful for C. megacephala compared to the native species, possibly reflecting a history of admixture. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: We numerically investigated the dynamics of short double-stranded DNA molecules moving through a deep-shallow alternating nanofilter, by utilizing Brownian dynamics simulation. We propose a novel mechanism for high-throughput DNA separation with a high electric field, which was originally predicted by Laachi et al. (Physical Review Letters, 2007, 98). In this work, we show that DNA molecules deterministically move along different electrophoretic streamlines according to their length, owing to geometric constraint at the exit of the shallow region. Consequently, it is more probable that long DNA molecules pass over a deep well region without significant lateral migration toward the bottom of the deep well, which is in contrast to the long dwelling time for short DNA molecules. We investigated the dynamics of DNA passage through a nanofilter facilitating electrophoretic field kinematics. The statistical distribution of the DNA molecules according to their size clearly corroborates our assumption. On the other hand, it was also found that the tapering angle between the shallow and deep regions significantly affects the DNA separation performance. The current results show that the non-uniform field effect combined with geometric constraint plays a key role in nanofilter-based DNA separation. We expect that our results will be helpful in designing and operating nanofluidics-based DNA separation devices and in understanding the polymer dynamics in confined geometries. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: The illicit drug market of psychoactive substances for human abuse is continuously expanding and developing. Besides already known substance classes like cathinones, amphetamines or synthetic cannabinoids, further derivatives such as benzofurys, thiophenes and structural analogues of methylphenidate entered the global market recently. As many of these new compounds contain a stereogenic centre it is supposed that their isomers may differ in their pharmacological effects as it is the case with amphetamines or several chiral active pharmaceutical ingredients, for instance. In the course of this study, a method for the chiral separation of a set of 16 recreational drugs by capillary electrophoresis was developed. The aim was to separate the analytes into their enantiomers at equal conditions within short time. Sulfobutylether ß-cyclodextrin served as chiral selector in an aqueous ammonium acetate solution containing acetonitrile. For method optimization, methedrone and ethylphenidate were used as model compounds to find the appropriate concentration of chiral selector. Moreover, the influence of the pH value on enantioseparation was tested. 14 or 16 mM sulfobutylether β-cyclodextrin, 50 mM ammonium acetate solution (pH 4.5) with 10% acetonitrile were found to be optimal for enantioseparation of seven benzofurys, four cathinones, two diphenidines, ethylphenidate, methiopropamine and thiothinone. Most of them were baseline resolved at migration times below 25 min. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: Here we describe an improved high-speed CE system using a short capillary and translational spontaneous sample injection. Several important factors for consideration in system design as well as various factors influencing the performance of the HSCE system were investigated in detail. The performance of this HSCE system was demonstrated in electrophoretic separation of FITC-labeled amino acids. Under optimized conditions, baseline separation of eight amino acids and FITC were achieved in 21 s with the plate heights ranging from 0.20 to 0.31 μm, corresponding to a separation rate up to 20,700 theoretical plates per second. The separation speed and efficiency of the optimized high speed CE system are comparable to or even better than those reported in microchip-based CE systems. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: Chiral capillary electrophoresis method has been developed for quantitative determination of D-amino acid modulators of NMDA glutamate receptor; D-serine and D-aspartate along with L-glutamate and L-aspartate in biological samples. These ligands are suggested to be involved in regulation of NMDA receptor related brain functions, such as neurogenesis, neuronal plasticity and memory formation. For sensitive determination of the amino acids LIF detection was chosen, and a fluorogenic reagent, 7-fluoro-4-nitro-2,1,3-benzoxadiazole was used for derivatization. An amino-modified β-cyclodextrin, 6-monodeoxy-6-mono(3-hydroxy)propylamino-β-CD (HPA-β-CD) was applied as chiral selector. Determinations were accomplished in a polyacrylamide coated capillary and reverse polarity was used for the analysis of the negatively charged analytes. The method was optimized and validated; 6 mM HPA-β-CD in 50 mM HEPES buffer, pH 7 was appropriate to achieve baseline separation of the analytes. The limit of quantification with acceptable accuracy is 0.05 μM for both D-amino acids. The method was used for the determination of D-aspartate and D-serine content in various brain regions of adult mice. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: Current methods for determination of impurities with different charge-to-volume ratio are limited especially in terms of sensitivity and precision. The main goal of this research was to establish a quantitative method for determination of impurities with charges differing from that of recombinant human granulocyte colony-stimulating factor (rhG-CSF, filgrastim) with superior precision and sensitivity compared to existing methods. A capillary zone electrophoresis (CZE) method has been developed, optimized and validated for a purity assessment of filgrastim in liquid pharmaceutical formulations. Optimal separation of filgrastim from the related impurities with different charges was achieved on a 50 μm i.d. fused-silica capillary of a total length of 80.5 cm. A background electrolyte that contains 100 mM phosphoric acid adjusted to pH 7.0 with triethanolamine was used. The applied voltage was 20 kV while the temperature was maintained at 25 ºC. UV detection was set to 200 nm. Method was validated in terms of selectivity/specificity, linearity, precision, limit of detection, limit of quantification, stability and robustness. Linearity was observed in the concentration range of 6- 600 μg/ml and the limit of quantification was determined to be 0.3% relative to the concentration of filgrastim of 0.6 mg/ml. Other validation parameters were also found to be acceptable; thus the method was successfully applied for a quantitative purity assessment of filgrastim in a finished drug product. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
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    ABSTRACT: The focus of this study is to evaluate the application of epigenetic markers as a forensic tool for the determination of semen present in sexual assault cases. A series of genetic loci were screened in order to identify certain epigenetic markers displaying differential methylation that can allow semen to be differentiated from blood, buccal cells, skin epidermis, and vaginal epithelial cells. Of the different loci tested, a panel of six markers, DACT1, USP49, DDX4, Hs_INSL6_03, Hs_ZC3H12D_05, and B_SPTB_03 were identified to contain tissue specific differential methylation. Samples ranging from 9 - 21 for each tissue type were collected and subjected to bisulfite modification. The bisulfite modified DNA was amplified by Polymerase Chain Reaction (PCR), and analyzed by pyrosequencing to quantitate the level of methylation at each marker. All six markers successfully differentiated semen samples from the other four tissue types analyzed. Sperm DNA was hypomethylated in all but one marker, B_SPTB_03, where this marker showed hypermethylation. Mean methylation percentages for semen samples were statistically significant from mean methylation percentages of the other four tissues studied (p<0.01). The results of this study demonstrate the applicability of epigenetic markers as a novel tool for determination of spermatozoa and to identify the tissue source of origin of a DNA sample. This article is protected by copyright. All rights reserved.
    Electrophoresis 06/2014;
  • Electrophoresis 06/2014; 35(11):1517-8.
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    ABSTRACT: The field of research and development of forensic short tandem repeat genotyping remains active, innovative and focused on continuous improvements. A series of recent developments including the introduction of a sixth dye have brought expanded STR multiplex sizes while maintaining sensitivity to typical forensic DNA. New supplementary kits complimenting the core STRs have also helped improve analysis of challenging identification cases such as distant pairwise relationships in deficient pedigrees. This article gives an overview of several recent key developments in forensic STR analysis: availability of expanded core STR kits and supplementary STRs; short-amplicon Mini-STRs offering practical options for highly degraded DNA; Y-STR enhancements made from the identification of rapidly-mutating loci, and enhanced analysis of genetic ancestry by analysing 32-STR profiles with a Bayesian forensic classifier originally developed for SNP population data. As well as providing scope for genotyping larger numbers of STRs optimised for forensic applications, the launch of compact next generation sequencing systems provides considerable potential for genotyping the sizeable proportion of nucleotide variation existing in forensic STRs which currently escapes detection with capillary electrophoresis. This article is protected by copyright. All rights reserved.
    Electrophoresis 05/2014;
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    ABSTRACT: Standardization of protein extracts for clinical purposes represents an important task in order to maintain adequate reactivity, presence of the relevant allergens and safety among other factors. The main objective of this work was to explore the potential use of a chip-based automated capillary electrophoresis system commercially available to analyze several of the most common forms of allergenic extracts from olive pollen used in allergy clinics. These include experimental extracts prepared from olive pollens, in-house reference extracts, extracts designed for skin prick test assays, and a panel of vaccine variants aimed to specific immunotherapy. As a major conclusion of the study, chip-based capillary electrophoresis allowed in all cases to determine accurate protein profiles with different degrees of sensitivity, where several allergens (particularly the major olive pollen allergen Ole e 1) were easily recognized. Moreover, several purified allergens were also analyzed by this method, and proposed as specific standards for different purposes. In the present condition, the method can only provide the protein profile of the extracts respect to a pre-established standard extract, but not allergen identification. However, these and other future developments and applications are discussed. This article is protected by copyright. All rights reserved.
    Electrophoresis 05/2014;

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