Angewandte Chemie International Edition (Angew Chem Int Ed)

Publications in this journal

• Article: LovG: The Thioesterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover in Lovastatin Biosynthesis.

  Wei Xu, Yit-Heng Chooi, Jin W Choi, Shuang Li, John C Vederas, Nancy A Da Silva, Yi Tang
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  ABSTRACT: No Lov lost: The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme). LovG also helped improve the turnover of LovB through hydrolysis of incorrectly made intermediates, freeing LovB for another round of catalysis.
  Angewandte Chemie International Edition 05/2013;
• Article: Stereoselective Rearrangements with Chiral Hypervalent Iodine Reagents.

  Umar Farid, Florence Malmedy, Romain Claveau, Lena Albers, Thomas Wirth
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  ABSTRACT: I likes rearrangements: Hypervalent iodine compounds can be used as environmentally friendly, mild, and selective reagents for highly enantioselective rearrangements of alkenes. For the first time, rearrangements to α-arylated ketones can be performed enantioselectively using lactic acid-based iodine(III) reagents.
  Angewandte Chemie International Edition 05/2013;
• Article: Rapidly Reversible Manipulation of Molecular Activity with Dual Chemical Dimerizers.

  Yu-Chun Lin, Yuta Nihongaki, Tzu-Yu Liu, Shiva Razavi, Moritoshi Sato, Takanari Inoue
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  ABSTRACT: Tell it where to go: Rapamycin induced the relocation of an FRB-fused protein of interest (POI) to the plasma membrane (labeled with the fusion protein GAIs-FKBP-C2(LACT)) to activate a signaling event. Subsequent treatment with a gibberellic acid ester led to the relocation of the whole GAIs-FKBP-C2(LACT)/rapamycin/FRB-POI complex to the Tom20-GID1-labeled mitochondria with the termination of POI-dependent signaling.
  Angewandte Chemie International Edition 05/2013;
• Article: A Tetrapositive Metal Ion in the Gas Phase: Thorium(IV) Coordinated by Neutral Tridentate Ligands.

  Yu Gong, Han-Shi Hu, Guoxin Tian, Linfeng Rao, Jun Li, John K Gibson
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  ABSTRACT: Sheltering thorium ions: A Th(4+) ion supported by three neutral tetramethyl-3-oxaglutaramide ligands (L=TMOGA) is produced in the gas phase by electrospray ionization. The thorium in chiral Th(L)3 (4+) is coordinated by nine oxygen atoms (see picture; O red, N blue, C gray). Quantum chemical studies revealed a decrease in ThO binding energies and bond orders and an increase in bond lengths, as the number of coordinating ligands increases.
  Angewandte Chemie International Edition 05/2013;
• Article: Computational Studies and Experimental Results-An Example of Excellent Teamwork in Studying Carbocyclization.

  Indre Thiel, Marko Hapke
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  ABSTRACT: In silico veritas? Maybe not the whole truth, but very helpful suggestions and guidelines for the experimental work can be deduced from computational studies on Rh-catalyzed [3+2+1] cycloaddition reactions for the construction of cis-fused bicyclohexenones from alkylidenecyclopropanes and carbon monoxide.
  Angewandte Chemie International Edition 05/2013;
• Article: Isoprenoid Biosynthesis: Ferraoxetane or Allyl Anion Mechanism for IspH Catalysis?

  Jikun Li, Ke Wang, Tatyana I Smirnova, Rahul L Khade, Yong Zhang, Eric Oldfield
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  ABSTRACT: The catalytic mechanism of the enzyme IspH, involved in formation of isopentenyl diphosphate and dimethylallyl diphosphate, was investigated by using HYSCORE spectroscopy combined with DFT. The results indicate the formation of an allyl anion bound to a HiPIP-like oxidized 4Fe-4S cluster, rather than formation of a cyclic, ferraoxetane intermediate, as has been proposed elsewhere.
  Angewandte Chemie International Edition 05/2013;
• Article: Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability.

  Yanfeng Zhang, Qian Yin, Lichen Yin, Liang Ma, Li Tang, Jianjun Cheng
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  ABSTRACT: Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy.
  Angewandte Chemie International Edition 05/2013;
• Article: Accurate Control of Multishelled Co3 O4 Hollow Microspheres as High-Performance Anode Materials in Lithium-Ion Batteries.

  Jiangyan Wang, Nailiang Yang, Hongjie Tang, Zhenghong Dong, Quan Jin, Mei Yang, David Kisailus, Huijun Zhao, Zhiyong Tang, Dan Wang
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  ABSTRACT: More than just an empty shell: Multishelled Co3 O4 microspheres were synthesized as anode materials for lithium-ion batteries in high yield and purity. As their porous hollow multishell structure guarantees a shorter Li(+) diffusion length and sufficient void space to buffer the volume expansion, their rate capacity, cycling performance, and specific capacity were excellent (1615.8 mA h g(-1) in the 30th cycle for triple-shelled Co3 O4 ; see graph).
  Angewandte Chemie International Edition 05/2013;
• Article: Hybrid Nanoscale Organic Molecular Crystals Assembly as a Photon-Controlled Actuator.

  Tian Lan, Wei Chen
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  ABSTRACT: Molecule deformation to macroactuation: In a novel hybrid assembly photoisomerization causes microscale deformation of molecules that is amplified to macroscale bending of a composite membrane. The nanoscale molecular crystals, which are unevenly distributed in a functional polymer matrix, provide a new strategy for designing higher performance actuators that combine the advantages of both molecular crystals and liquid crystal elastomers.
  Angewandte Chemie International Edition 05/2013;
• Article: Multimodal Magnetic Core-Shell Nanoparticles for Effective Stem-Cell Differentiation and Imaging.

  Birju Shah, Perry T Yin, Shraboni Ghoshal, Ki-Bum Lee
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  ABSTRACT: Special delivery! The title system, composed of a highly magnetic core surrounded by a thin uniform gold shell, has been synthesized and applied to the magnetically facilitated delivery of genetic material (siRNA or plasmid DNA) into neural stem cells (NSCs) for controlling their neural differentiation in a spatiotemporally controlled, biocompatible manner.
  Angewandte Chemie International Edition 05/2013;
• Article: Tetrameric Cyclic Double Helicates as a Scaffold for a Molecular Solomon Link.

  Jonathon E Beves, Christopher J Campbell, David A Leigh, Robin G Pritchard
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  ABSTRACT: Let's twist again: The one-pot synthesis of a molecular Solomon link assembles four iron(II) cations, four bis(aldehyde) molecules, and four bis(amine) building blocks. The process generates two interwoven 68-membered-ring macrocycles, which feature four crossing points, in 75 % yield.
  Angewandte Chemie International Edition 05/2013;
• Article: Oxidation of Water under Visible-Light Irradiation over Modified BaTaO2 N Photocatalysts Promoted by Tungsten Species.

  Kazuhiko Maeda, Daling Lu, Kazunari Domen
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  ABSTRACT: Water splitting: In heterogeneous photocatalysis, it has been believed that doping transition-metal cations having partly filled d orbitals into semiconductor photocatalysts results in a significant drop in photocatalytic activity. Nevertheless, it was found that the activity for the water oxidation of BaTaO2 N could be improved by seven times upon modification by pentavalent W species.
  Angewandte Chemie International Edition 05/2013;
• Article: An Atom-Economical Approach to Functionalized Single-Walled Carbon Nanotubes: Reaction with Disulfides.

  Zois Syrgiannis, Valeria La Parola, Caroline Hadad, Maribel Lucío, Ester Vázquez, Francesco Giacalone, Maurizio Prato
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  ABSTRACT: Simple and effective exterior decorating: Single-walled carbon nanotubes were functionalized with disulfides, including cystamine-core polyamidoamine dendrimers, simply upon heating in toluene. One advantage of this method is that any unreacted disulfide can be recovered by filtration.
  Angewandte Chemie International Edition 05/2013;
• Article: The Electrophilic α-Amination of α-Alkyl-β-Ketoesters with In Situ Generated Nitrosoformates.

  Philipp Selig
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  ABSTRACT: Lewis acid and oxidation catalysis are merged in the reaction discussed here, which provides access to diversely substituted N-hydroxycarbamates. This reaction highlights the potential of nitrosoformates as electrophilic amination reagents as well as the benefits of aerobic oxidation for the formation of highly reactive species.
  Angewandte Chemie International Edition 05/2013;
• Article: A Brief History of G-Protein Coupled Receptors (Nobel Lecture).

  Robert J Lefkowitz
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  ABSTRACT: The idea of receptors has fascinated scientists for more than a century. Today it is known that the G-protein coupled receptors (GPCRs) represent by far the largest, most versatile and most ubiquitous of the several families of plasma membrane receptors. The Nobel Prize for Chemistry 2012 was awarded for studies on GPCRs.
  Angewandte Chemie International Edition 05/2013;
• Article: Biarylphosphonite Gold(I) Complexes as Superior Catalysts for Oxidative Cyclization of Propynyl Arenes into Indan-2-ones.

  Guilhem Henrion, Thomas E J Chavas, Xavier Le Goff, Fabien Gagosz
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  ABSTRACT: Striking gold: A series of variously functionalized propynyl arenes was smoothly converted into indan-2-ones by a new gold(I)-catalyzed oxidative cyclization process. [LAu]NTf2 (Tf=trifluoromethanesulfonyl) is a superior catalyst both in terms of yield and kinetics for the present transformation.
  Angewandte Chemie International Edition 05/2013;
• Article: Two Isostructural Explosive Cocrystals with Significantly Different Thermodynamic Stabilities.

  Kira B Landenberger, Onas Bolton, Adam J Matzger
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  ABSTRACT: Irreconcilable differences: Electron-rich diacetone diperoxide is paired with the electron-deficient rings of trichloro- and tribromotrinitrobenzene to form energetic cocrystals by design. Though the two cocrystals are isostructural, the former is very stable while the later exhibits a rare metastability and favors separation.
  Angewandte Chemie International Edition 05/2013;
• Article: Total Synthesis of (-)-Rhizopodin.

  Stephen M Dalby, Jake Goodwin-Tindall, Ian Paterson
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  ABSTRACT: Core assembly: The total synthesis of the myxobacterial metabolite rhizopodin, a potent actin-binding anticancer agent, has been achieved. The modular synthesis utilizes a common C1-C22 monomeric unit to assemble the dimeric 38-membered macrodiolide core, which was elaborated by a bidirectional boron-mediated aldol reaction to install the characteristic side-chains. The final global deprotection was critically dependent on the correct choice of silyl protecting groups at C16/C16'.
  Angewandte Chemie International Edition 05/2013;