Angewandte Chemie International Edition (Angew Chem Int Ed)

Publisher: Gesellschaft Deutscher Chemiker, Wiley-VCH Verlag

Journal description

Angewandte Chemie is one of the prime chemistry journals in the world with an ISI-measured Impact Factor higher than those of comparable journals (1999: 7.996). Moreover it is the only journal in the field to have a stimulating mixture of review articles highlights and short communications. The "reviews" written by leading experts summarize the important results of recent research on topical subjects in all branches of chemistry point to unresolved problems and discuss possible developments. The "highlights" provide concise evaluations of current trends in chemical research. The communications are critically selected and report on the latest research results making the journal indispensable to the chemist who wants to stay well informed. Angewandte Chemie also regularly publishes Nobel lectures in chemistry and related fields. Kurztext Auch die internationale Ausgabe der Angewandten Chemie zählt zu den führenden bedeutenden Chemiezeitschrifent weltweit. Chemiker wissen daß sie hier das Neueste aus der Chemie bestens aufbereitet vorfinden. Society Affiliation German Chemical Society ( Gesellschaft Deutscher Chemiker ) Readers Chemists of all disciplines

Current impact factor: 11.34

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2011 Impact Factor 13.455

Additional details

5-year impact 13.56
Cited half-life 5.50
Immediacy index 2.96
Eigenfactor 0.54
Article influence 3.50
Website Angewandte Chemie International Edition website
Other titles Angewandte Chemie (International ed. in English: Online), Angewandte Chemie, Angewandte Chemie international edition in English, Angewandte Chemie international edition
ISSN 1521-3773
OCLC 43968233
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Wiley-VCH Verlag

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  • Classification
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Publications in this journal

  • Angewandte Chemie International Edition 05/2015; DOI:10.1002/anie.201503763
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    ABSTRACT: Skeletal rearrangement of O-propargylic formaldoximes, in the presence of gold catalysts, afforded 4-methylene-2-isoxazolines in good to excellent yields by an intermolecular methylene transfer. In addition, the cascade reaction with maleimide in the presence of a gold catalyst afforded isoxazole derivatives by cyclization/methylene transfer and a subsequent ene reaction, whereas that using a copper catalyst gave oxazepines through a 2,3-rearrangement. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 05/2015; DOI:10.1002/anie.201501856
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    ABSTRACT: Ni,Fe-containing CO dehydrogenases (CODHs) use a [NiFe4 S4 ] cluster, termed cluster C, to reversibly reduce CO2 to CO with high turnover number. Binding to Ni and Fe activates CO2 , but current crystal structures have insufficient resolution to analyze the geometry of bound CO2 and reveal the extent and nature of its activation. The crystal structures of CODH in complex with CO2 and the isoelectronic inhibitor NCO(-) are reported at true atomic resolution (dmin ≤1.1 Å). Like CO2 , NCO(-) is a μ2 ,η(2) ligand of the cluster and acts as a mechanism-based inhibitor. While bound CO2 has the geometry of a carboxylate group, NCO(-) is transformed into a carbamoyl group, thus indicating that both molecules undergo a formal two-electron reduction after binding and are stabilized by substantial π backbonding. The structures reveal the combination of stable μ2 ,η(2) coordination by Ni and Fe2 with reductive activation as the basis for both the turnover of CO2 and inhibition by NCO(-) . © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201501778
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    ABSTRACT: A molecularly defined copper acetylide cluster with ancillary N-heterocyclic carbene (NHC) ligands was prepared under acidic reaction conditions. This cluster is the first molecular copper acetylide complex that features high activity in copper-catalyzed azide-alkyne cycloadditions (CuAAC) with added acetic acid even at -5 °C. Ethyl propiolate protonates the acetate ligands of the dinuclear precursor complex to release acetic acid and replaces one out of four ancillary ligands. Two copper(I) ions are thereby liberated to form the core of a yellow dicationic C2 -symmetric hexa-NHC octacopper hexaacetylide cluster. Coalescence phenomena in low-temperature NMR experiments reveal fluxionality that leads to the facile interconversion of all of the NHC and acetylide positions. Kinetic investigations provide insight into the influence of copper acetylide coordination modes and the acetic acid on catalytic activity. The interdependence of "click" activity and copper acetylide aggregation beyond dinuclear intermediates adds a new dimension of complexity to our mechanistic understanding of the CuAAC reaction. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502368
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    ABSTRACT: In solid-state science, most changing phenomena have been mysterious. Furthermore, the changes in chemical composition should be added to mere physical changes to also cover the chemical changes. Here, the first success in characterizing the nature of gas inclusion in a single crystal is reported. The gas inclusion process has been thoroughly investigated by in situ optical microscopy, single-crystal X-ray diffraction analyses, and gas adsorption measurements. The results demonstrated an inclusion action of a first-order transition behavior induced by a critical concentration on the phase boundary. The transfer of phase boundary and included gas are strongly related. This relationship can generate the dynamic features hidden in the inclusion phenomena, which can lead to the guest capturing and transfer mechanism that can apply to spatiotemporal inclusion applications by using host solids. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201500884
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    ABSTRACT: Development of a solar water splitting device requires design of a low-cost, efficient, and non-noble metal compound as alternative to noble metals. For the first time, we showed that CoSe2 can function as co-catalyst in phototoelectrochemical hydrogen production. We designed a heterostructure of p-Si and marcasite-type CoSe2 for solar-driven hydrogen production. CoSe2 successively coupled with p-Si can act as a superior photocathode in the solar-driven water splitting reaction. Photocurrents up to 9 mA cm(-2) were achieved at 0 V vs. reversible hydrogen electrode. Electrochemical impedance spectroscopy showed that the high photocurrents can be attributed to low charge transfer resistance between the Si and CoSe2 interfaces and that between the CoSe2 and electrolyte interfaces. Our results suggest that this CoSe2 is a promising alternative co-catalyst for hydrogen evolution. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502573
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    ABSTRACT: A novel in situ IR spectroscopic approach is demonstrated for the characterization of hydrogenase during catalytic turnover. E. coli hydrogenase 1 (Hyd-1) is adsorbed on a high surface-area carbon electrode and subjected to the same electrochemical control and efficient supply of substrate as in protein film electrochemistry during spectral acquisition. The spectra reveal that the active site state known as Ni-L, observed in other NiFe hydrogenases only under illumination or at cryogenic temperatures, can be generated reversibly in the dark at ambient temperature under both turnover and non-turnover conditions. The observation that Ni-L is present at all potentials during turnover under H2 suggests that the final steps in the catalytic cycle of H2 oxidation by Hyd-1 involve sequential proton and electron transfer via Ni-L. A broadly applicable IR spectroscopic technique is presented for addressing electrode-adsorbed redox enzymes under fast catalytic turnover. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502338
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    ABSTRACT: Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2 -symmetric marine-derived bis(lactone) disorazole C1 , a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201501922
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    ABSTRACT: Coherent light signals generated at the nanoscale are crucial to the realization of photonic integrated circuits. Self-assembled nanowires from organic dyes can provide both a gain medium and an effective resonant cavity, which have been utilized for fulfilling miniaturized lasers. Excited-state intramolecular proton transfer (ESIPT), a classical molecular photoisomerization process, can be used to build a typical four-level system, which is more favorable for population inversion. Low-power driven lasing in proton-transfer molecular nanowires with an optimized ESIPT energy-level process has been achieved. With high gain and low loss from the ESIPT, the wires can be applied as effective FP-type resonators, which generated single-mode lasing with a very low threshold. The lasing wavelength can be reversibly switched based on a conformation conversion of the excited keto form in the ESIPT process. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502684
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    ABSTRACT: Reported is the design and modular synthesis of a dual metal-dual semiconductor heterostructure with control over the dimensions and placement of its individual components. Analogous to molecular synthesis, colloidal synthesis is now evolving into a series of sequential synthetic procedures with separately optimized steps. We detail the challenges and parameters that must be considered when assembling such a multicomponent nanoparticle, and their solutions. This multicomponent nanosystem, Ru-CdSe@CdS-Pt, was designed to achieve charge carrier separation and directional transfer across different interfaces toward two separate redox catalysts. This heterostructure may potentially serve as a nanometric closed circuit photoelectrochemical cell. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201411461
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    ABSTRACT: Preparation of porous materials from one-dimensional polymers is challenging because the packing of polymer chains results in a dense, non-porous arrangement. Herein, we demonstrate the remarkable adaptation of an amorphous, linear, non-porous, flexible organic polymer into a three-dimensional, highly porous, crystalline solid, as the organic component of a metal-organic framework (MOF). A polymer with aromatic dicarboxylic acids in the backbone functioned as a polymer ligand upon annealing with Zn(II) , generating a polymer-metal-organic framework (polyMOF). These materials break the dogma that MOFs must be prepared from small, rigid ligands. Similarly, polyMOFs contradict conventional polymer chemistry by demonstrating that linear and amorphous polymers can be readily coaxed into a highly crystalline, porous, three-dimensional structure by coordination chemistry. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502733
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    ABSTRACT: Cubic boron nitride (c-BN) is a super-hard material whose hardness increases dramatically with decreasing size. However, c-BN nanoparticles (NPs) with sizes less than 10 nm have never been obtained. Herein we report a simple strategy towards the synthesis of ultrafine c-BN NPs with an average size of 3.5 nm. The method, under ambient conditions, exploits a laser-induced photochemical effect and employs dioxane solution of ammonia borane (AB) as a liquid target. Meanwhile, total dehydrogenation of AB is realized by laser irradiation. Therefore, this approach shows great potential for the preparation of super-hard NPs as well as controllable dehydrogenation. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502023
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    ABSTRACT: The rhodium-catalyzed asymmetric N-selective coupling of pyrazole derivatives with terminal allenes gives access to enantioenriched secondary and tertiary allylic pyrazoles, which can be employed for the synthesis of medicinally important targets. The reaction tolerates a large variety of functional groups and labelling experiments gave insights into the reaction mechanism. This new methodology was further applied in a highly efficient synthesis of JAK 1/2 inhibitor (R)-ruxolitinib. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201501758
  • Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201501947
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    ABSTRACT: The objective of the study was to explore the potential of ring tension in cyclic disulfides for thiol-mediated cellular uptake. Fluorescent probes that cannot enter cells were equipped with cyclic disulfides of gradually increasing ring tension. As demonstrated by flow cytometry experiments, uptake into HeLa Kyoto cells increased with increasing tension. Differences in carbon-sulfur-sulfur-carbon (CSSC) dihedral angles as small as 8° caused significant changes in uptake efficiency. Uptake with high ring tension was better than with inactivated or activated linear disulfides or with thiols. Conversion of thiols on the cell surface into sulfides and disulfides decreased the uptake. Reduction of exofacial disulfides into thiols increased the uptake of transporters with disulfides and inactivated controls with thiols. These results confirm the occurrence of dynamic covalent disulfide-exchange chemistry on cell surfaces. Mechanistic and colocalization studies indicate that endocytosis does not fully account for this cellular uptake with ring tension. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502358
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    ABSTRACT: Described herein is the synthesis of BMS-986001 by employing two novel organocatalytic transformations: 1) a highly selective pyranose to furanose ring tautomerization to access an advanced intermediate, and 2) an unprecedented small-molecule-mediated dynamic kinetic resolution to access a variety of enantiopure pyranones, one of which served as a versatile building block for the multigram, stereoselective, and chromatography-free synthesis of BMS-986001. The synthesis required five chemical transformations and resulted in a 44 % overall yield. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502290
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    ABSTRACT: A novel white-light-emitting organic molecule, which consists of carbazolyl- and phenothiazinyl-substituted benzophenone (OPC) and exhibits aggregation-induced emission-delayed fluorescence (AIE-DF) and mechanofluorochromic properties was synthesized. The CIE color coordinates of OPC were directly measured with a non-doped powder, which presented white-emission coordinates (0.33, 0.33) at 244 K to 252 K and (0.35, 0.35) at 298 K. The asymmetric donor-acceptor-donor' (D-A-D') type of OPC exhibits an accurate inherited relationship from dicarbazolyl-substituted benzophenone (O2C, D-A-D) and diphenothiazinyl-substituted benzophenone (O2P, D'-A-D'). By purposefully selecting the two parent molecules, that is, O2C (blue) and O2P (yellow), the white-light emission of OPC can be achieved in a single molecule. This finding provides a feasible molecular strategy to design new AIE-DF white-light-emitting organic molecules. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201502180
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    ABSTRACT: We report the first fluorescence-based assay for the rapid determination of the ee value of amines, amino alcohols, and amino acid esters. The method uses the self-assembly of 2-formylphenylboronic acid with a chiral diol and a chiral amine or derivatives (of unknown chirality) to produce two diastereomeric iminoboronates that differ in their fluorescence intensity and polarization. The approach allows for the accurate determination of the ee value of chiral amines with errors of just 1-2 %. We believe that this application of orthogonal dynamic covalent self-assembly in the determination of the enantioselectivity will lead to the development of high-throughput procedures for the determination of chirality. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201501736
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    ABSTRACT: Anisotropic nanostructures provide an additional degree of freedom for tailoring the collective properties of their ensembles. Using Fe@SiO2 nanoellipsoids as anisotropic building blocks, herein we demonstrate a new class of magnetically responsive photonic structures whose photonic properties can be dynamically tuned by controlling the direction of the magnetic fields they are exposed to. These novel photonic structures diffract at a minimum wavelength when the field direction is perpendicular to the incident angle, and a maximum wavelength when the field is switched to parallel direction; and the diffraction intensity reaches maximum values when the fields are either parallel or perpendicular to the incident light, and decreases when the field direction is moved off-angle. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 04/2015; DOI:10.1002/anie.201501782