Angewandte Chemie International Edition (Angew Chem Int Ed)

Description

Angewandte Chemie is one of the prime chemistry journals in the world with an ISI-measured Impact Factor higher than those of comparable journals (1999: 7.996). Moreover it is the only journal in the field to have a stimulating mixture of review articles highlights and short communications. The "reviews" written by leading experts summarize the important results of recent research on topical subjects in all branches of chemistry point to unresolved problems and discuss possible developments. The "highlights" provide concise evaluations of current trends in chemical research. The communications are critically selected and report on the latest research results making the journal indispensable to the chemist who wants to stay well informed. Angewandte Chemie also regularly publishes Nobel lectures in chemistry and related fields. Kurztext Auch die internationale Ausgabe der Angewandten Chemie zählt zu den führenden bedeutenden Chemiezeitschrifent weltweit. Chemiker wissen daß sie hier das Neueste aus der Chemie bestens aufbereitet vorfinden. Society Affiliation German Chemical Society ( Gesellschaft Deutscher Chemiker ) Readers Chemists of all disciplines

Publisher details

John Wiley & Sons

Publications in this journal

• Artificial Egg Stalks Made of a Recombinantly Produced Lacewing Silk Protein.

  Authors: Felix Bauer, Thomas Scheibel

  Angewandte Chemie (International ed. in English).

  Rigid threads: Lacewings protect their eggs from predators on small stalks. The stalks have good mechanical properties and, unlike most other silks, a cross β structure. An artificial egg stalk wasRigid threads: Lacewings protect their eggs from predators on small stalks. The stalks have good mechanical properties and, unlike most other silks, a cross β structure. An artificial egg stalk was produced using a designed recombinant variant of a sequenced lacewing egg stalk protein, and it attained 90 % of the tensile strength of a natural egg stalk.

• A Mild Benzannulation through Directed Cycloaddition Reactions.

  Authors: James D Kirkham, Roger J Butlin, Joseph P A Harrity

  Angewandte Chemie (International ed. in English).

  Simple as ABC: Alkynyl borane cycloadditions can be substrate-directed to assemble aromatic difluoroboranes within an extremely mild and efficient reaction manifold compared to that of traditionalSimple as ABC: Alkynyl borane cycloadditions can be substrate-directed to assemble aromatic difluoroboranes within an extremely mild and efficient reaction manifold compared to that of traditional methods. The aromatic boranes are readily transformed into a range of useful products.

• Linking Photo- and Redoxactive Phthalocyanines Covalently to Graphene.

  Authors: Maria-Eleni Ragoussi, Jenny Malig, Georgios Katsukis, Benjamin Butz, Erdmann Spiecker, Gema de la Torre, Tomás Torres, Dirk M Guldi

  Angewandte Chemie (International ed. in English).

  "Green" graphene: For the first time the covalent attachment of a light-harvesting and electron-donating phthalocyanine to the basal plane of few-layer graphene is reported. Physico-chemical"Green" graphene: For the first time the covalent attachment of a light-harvesting and electron-donating phthalocyanine to the basal plane of few-layer graphene is reported. Physico-chemical characterizations reveal an ultrafast charge separation from the photoexcited phthalocyanine to few-layer graphene followed by a slower charge recombination.

• Consequences of Cooperativity in Racemizing Supramolecular Systems.

  Authors: Seda Cantekin, Huub M M Ten Eikelder, Albert J Markvoort, Martijn A J Veld, Peter A Korevaar, Mark M Green, Anja R A Palmans, E W Meijer

  Angewandte Chemie (International ed. in English).

  Saluting the sergeant: Phg-BTA cooperatively self-assembles into helical aggregates and shows unprecedented racemization behavior in the presence of base. In thermodynamically controlled conditions,Saluting the sergeant: Phg-BTA cooperatively self-assembles into helical aggregates and shows unprecedented racemization behavior in the presence of base. In thermodynamically controlled conditions, the addition of a small amount of chiral auxiliary to this mixture results in a deracemization reaction and a final enantiomeric excess of 32 %. A theoretical model is presented to understand in detail the results obtained.

• Gold-Catalyzed Cascade Cyclizations of 1,6-Diynyl Carbonates to Benzo[b]fluorenes Involving Arylation of Oxocarbenium Ion Intermediates and Decarboxylative Etherification.

  Authors: Yifeng Chen, Ming Chen, Yuanhong Liu

  Angewandte Chemie (International ed. in English).

  Rearranged: The described gold-catalyzed cycloisomerizations give access to highly substituted benzo[b]fluorenes under mild reaction conditions. Experimental results indicate that the in situ formedRearranged: The described gold-catalyzed cycloisomerizations give access to highly substituted benzo[b]fluorenes under mild reaction conditions. Experimental results indicate that the in situ formed oxocarbenium ion intermediates, derived from gold-catalyzed 3,3-rearrangement and 6-endo-dig cyclization, undergo intramolecular arylation and subsequent decarboxylative etherification to furnish the final ether products.

• Real-Time Quantitative Monitoring of Specific Peptide Cleavage by a Proteinase for Cancer Diagnosis.

  Authors: Gyudo Lee, Kilho Eom, Joseph Park, Jaemoon Yang, Seungjoo Haam, Yong-Min Huh, Joo Kyung Ryu, Nam Hee Kim, Jong In Yook, Sang Woo Lee, Dae Sung Yoon, Taeyun Kwon

  Angewandte Chemie (International ed. in English).

  Good vibrations: A bioassay using a resonant peptide-functionalized microcantilever enables the quantitative characterization of the proteolytic activity of membrane type-1 matrix metalloproteinaseGood vibrations: A bioassay using a resonant peptide-functionalized microcantilever enables the quantitative characterization of the proteolytic activity of membrane type-1 matrix metalloproteinase (MT1-MMP). In this assay, shifts in the frequency of the cantilever after specific proteolytic cleavage of the target peptides by MT1-MMP are measured.

• A Dipeptide-Based Multicolored-Switching Luminescent Solid Material: When Molecular Assemblies Meet Mechanochemical Reaction.

  Authors: Ming-Jun Teng, Xin-Ru Jia, Xiao-Fang Chen, Yen Wei

  Angewandte Chemie (International ed. in English).

  Color schemes: A mechanochromic material composed of two types of peptides bearing a pyrene group and rhodamine B moieties, respectively, displays multiluminescent colors, such as blue, green, andColor schemes: A mechanochromic material composed of two types of peptides bearing a pyrene group and rhodamine B moieties, respectively, displays multiluminescent colors, such as blue, green, and reddish in one sample. The mechanochromic behavior is based on a combined switching of molecular assemblies and chemical structure.

• Synthesis of Eight-Membered Lactones: Intermolecular [6+2] Cyclization of Amphoteric Molecules with Siloxy Alkynes.

  Authors: Wanxiang Zhao, Zhaobin Wang, Jianwei Sun

  Angewandte Chemie (International ed. in English).

  That's about the size of it: The title molecules react with siloxy alkynes in the presence of a Brønsted acid to deliver medium-sized lactones through a [6+2] cyclization (see scheme;That's about the size of it: The title molecules react with siloxy alkynes in the presence of a Brønsted acid to deliver medium-sized lactones through a [6+2] cyclization (see scheme; TIPS=triisopropylsilyl). This process is the first intermolecular synthesis of such lactones and involves a sequence of several selective ring-opening/ring-closing events.

• Functional Organic Materials Based on Polymerized Liquid-Crystal Monomers: Supramolecular Hydrogen-Bonded Systems.

  Authors: Dirk J Broer, Cees M W Bastiaansen, Michael G Debije, Albertus P H J Schenning

  Angewandte Chemie (International ed. in English).

  Functional organic materials are of great interest for a variety of applications. To obtain precise functional properties, well-defined hierarchically ordered supramolecular materials are crucial.Functional organic materials are of great interest for a variety of applications. To obtain precise functional properties, well-defined hierarchically ordered supramolecular materials are crucial. The self-assembly of liquid crystals has proven to be an extremely useful tool in the development of well-defined nanostructured materials. We have chosen the illustrative example of photopolymerizable hydrogen-bonding mesogens to show that a wide variety of functional materials can be made from a relatively simple set of building blocks. Upon mixing these compounds with other reactive mesogens, nematic, chiral nematic, and smectic or columnar liquid-crystalline phases can be formed that can be applied as actuators, sensors and responsive reflectors, and nanoporous membranes, respectively.

• The Subtle Art of Bimetallic Activation: Juggling Carbenes, Hydrocarbons, and Hydride Ligands Between Metals.

  Authors: Guy Lavigne

  Angewandte Chemie (International ed. in English).

  The selective redistribution of hydrocarbon chains C((n)) on a polyhydrido triruthenium cyclopentadienyl complex (see scheme; Ru red spheres) involves a repeated sequence of face-to-face CH groupThe selective redistribution of hydrocarbon chains C((n)) on a polyhydrido triruthenium cyclopentadienyl complex (see scheme; Ru red spheres) involves a repeated sequence of face-to-face CH group transfers (A to C) through the open cluster B, followed by individual concerted skeletal re-arrangements on the two faces (C to A'). This process is just one of several spectacular examples illustrating the power of a molecular polymetallic system.

• Strong and Selective Binding of Amiloride to an Abasic Site in RNA Duplexes: Thermodynamic Characterization and MicroRNA Detection.

  Authors: Yusuke Sato, Toshiki Ichihashi, Seiichi Nishizawa, Norio Teramae

  Angewandte Chemie (International ed. in English).

  Firmly tied: The binding affinity of amiloride for an abasic (AP) site-containing RNA duplex is two orders of magnitude superior to the affinity of the corresponding AP site-containing DNA duplex.Firmly tied: The binding affinity of amiloride for an abasic (AP) site-containing RNA duplex is two orders of magnitude superior to the affinity of the corresponding AP site-containing DNA duplex. The observed high binding affinity for the RNA duplex arises from a favorable enthalpy gain. The binding-induced fluorescence response of amiloride is applicable to microRNA detection.

• Decoupling Two-Dimensional NMR Spectroscopy in Both Dimensions: Pure Shift NOESY and COSY.

  Authors: Juan A Aguilar, Adam A Colbourne, Julia Cassani, Mathias Nilsson, Gareth A Morris

  Angewandte Chemie (International ed. in English).

  An increase in the resolving power in 2D NMR spectra is obtained by collapsing 2D signals with multiplet structure into 2D singlets. This resolution gain is achieved by combining 2D experiments withAn increase in the resolving power in 2D NMR spectra is obtained by collapsing 2D signals with multiplet structure into 2D singlets. This resolution gain is achieved by combining 2D experiments with pure shift techniques and covariance processing. The method should be of value in both manual and automated structure determination.

• Dynamic Electrochemistry in Flame Plasma Electrolyte.

  Authors: Atif Elahi, Toks Fowowe, Daren J Caruana

  Angewandte Chemie (International ed. in English).

  Chemistry in flames: Dynamic electrochemistry in the gas phase is described by considering the ionized medium of a flame as an electrolyte. This study opens up the possibility of accessing redoxChemistry in flames: Dynamic electrochemistry in the gas phase is described by considering the ionized medium of a flame as an electrolyte. This study opens up the possibility of accessing redox reactions which are outside the potential limits set by the solvent in conventional liquid-phase electrochemistry.

• Ruthenium-Catalyzed Redox Isomerization of Trifluoromethylated Allylic Alcohols: Mechanistic Evidence for an Enantiospecific Pathway.

  Authors: Vincent Bizet, Xavier Pannecoucke, Jean-Luc Renaud, Dominique Cahard

  Angewandte Chemie (International ed. in English).

  Transfer news: A synthetic approach to chiral β-CF(3) -substituted saturated carbonyl compounds has been developed in which ruthenium complexes efficiently catalyze the redox isomerization of CF(3)Transfer news: A synthetic approach to chiral β-CF(3) -substituted saturated carbonyl compounds has been developed in which ruthenium complexes efficiently catalyze the redox isomerization of CF(3) -bearing allylic alcohols by an intramolecular suprafacial enantiospecific 1,3-hydrogen transfer. This method was used for the enantioselective synthesis of (S)-CF(3) -citronellol.

• Boronic Acid Catalysis as a Mild and Versatile Strategy for Direct Carbo- and Heterocyclizations of Free Allylic Alcohols.

  Authors: Hongchao Zheng, Sina Ghanbari, Shinji Nakamura, Dennis G Hall

  Angewandte Chemie (International ed. in English).

  BAC to the future: Boronic acid catalysis (BAC) was applied to the direct activation of alcohols leading to the preparation of carbocycles, benzofurans, tetrahydrofurans, pyrrolidines, pyrans,BAC to the future: Boronic acid catalysis (BAC) was applied to the direct activation of alcohols leading to the preparation of carbocycles, benzofurans, tetrahydrofurans, pyrrolidines, pyrans, piperidines, and various polycyclic compounds. The reactions proceed under mild conditions that circumvent the use of reactive leaving groups like halides.

• Polymer/Boron Nitride Nanocomposite Materials for Superior Thermal Transport Performance.

  Authors: Wei-Li Song, Ping Wang, Li Cao, Ankoma Anderson, Mohammed J Meziani, Andrew J Farr, Ya-Ping Sun

  Angewandte Chemie (International ed. in English).

  Boron nitride nanosheets were dispersed in polymers to give composite films with excellent thermal transport performances approaching the record values found in polymer/graphene nanocomposites.Boron nitride nanosheets were dispersed in polymers to give composite films with excellent thermal transport performances approaching the record values found in polymer/graphene nanocomposites. Similarly high performance at lower BN loadings was achieved by aligning the nanosheets in poly(vinyl alcohol) matrix by simple mechanical stretching.

• Catalytic CH Amination with Aromatic Amines.

  Authors: Raymond T Gephart, Daria L Huang, Mae Joanne B Aguila, Graham Schmidt, Andi Shahu, Timothy H Warren

  Angewandte Chemie (International ed. in English).

  Aniline joins the club: A β-diketiminato copper(I) catalyst enables CH amination of anilines employing low catalyst loadings to preclude oxidation to the diazene ArNNAr. Electron-poor anilines areAniline joins the club: A β-diketiminato copper(I) catalyst enables CH amination of anilines employing low catalyst loadings to preclude oxidation to the diazene ArNNAr. Electron-poor anilines are particularly resistant towards diazene formation and participate in the amination of strong and unactivated CH bonds. N-alkyl anilines also take part in CH amination.

• Synthesis of Dual-Mesoporous Silica Using Non-Ionic Diblock Copolymer and Cationic Surfactant as Co-Templates.

  Authors: Jing Wei, Qin Yue, Zhenkun Sun, Yonghui Deng, Dongyuan Zhao

  Angewandte Chemie (International ed. in English).

  It takes two: Ordered dual-mesoporous silica with two sets of well-configured pores can be synthesized by evaporation-induced step-by-step aggregating assembly in which the non-ionic block copolymerIt takes two: Ordered dual-mesoporous silica with two sets of well-configured pores can be synthesized by evaporation-induced step-by-step aggregating assembly in which the non-ionic block copolymer PEO-b-PMMA (red spheres) and the cationic surfactant alkyltrimethyl ammonium bromide (yellow rods) serve as co-templates in an acidic THF/H(2) O solution containing tetraethyl orthosilicate as the silica source (SiO(2) oligomers shown as green balls in the picture).

• Refining of Plant Oils to Chemicals by Olefin Metathesis.

  Authors: Samir Chikkali, Stefan Mecking

  Angewandte Chemie (International ed. in English).

  Plant oils are attractive substrates for the chemical industry. Their scope for the production of chemicals can be expanded by sophisticated catalytic conversions. Olefin metathesis is an example,Plant oils are attractive substrates for the chemical industry. Their scope for the production of chemicals can be expanded by sophisticated catalytic conversions. Olefin metathesis is an example, which also illustrates generic issues of "biorefining" to chemicals. Utilization on a large scale requires high catalyst activities, which influences the choice of the metathesis reaction. The mixture of different fatty acids composing a technical-grade plant oil substrate gives rise to a range of products. This decisively determines possible process schemes, and potentially provides novel chemicals and intermediates not employed to date.

• Facile Preparation of Indoles and 1,2-Benzothiazine 1,1-Dioxides: Nucleophilic Addition of Sulfonamides to Bromoacetylenes and Subsequent Palladium-Catalyzed Cyclization.

  Authors: Masahito Yamagishi, Ken Nishigai, Azusa Ishii, Takeshi Hata, Hirokazu Urabe

  Angewandte Chemie (International ed. in English).

  Bromine as a double agent: The bromine atom in 1-bromo-1-alkynes works as an electron-withdrawing group to effect the nucleophilic addition of sulfonamides. It again plays a pivotal role in theBromine as a double agent: The bromine atom in 1-bromo-1-alkynes works as an electron-withdrawing group to effect the nucleophilic addition of sulfonamides. It again plays a pivotal role in the palladium-catalyzed cyclization of the resultant (Z)-2-(sulfonylamino)-1-bromoalkenes into nitrogen heterocycles.

• Isolation of the Magic-Size CdSe Nanoclusters [(CdSe)(13) (n-octylamine)(13) ] and [(CdSe)(13) (oleylamine)(13) ].

  Authors: Yuanyuan Wang, Yi-Hsin Liu, Ying Zhang, Fudong Wang, Paul J Kowalski, Henry W Rohrs, Richard A Loomis, Michael L Gross, William E Buhro

  Angewandte Chemie (International ed. in English).

  Pure magic: CdSe nanoclusters with a magic size have previously been obtained only as mixtures. Two ligated forms of (CdSe)(13) have now been isolated by exfoliation of nanocluster-n-octylaminePure magic: CdSe nanoclusters with a magic size have previously been obtained only as mixtures. Two ligated forms of (CdSe)(13) have now been isolated by exfoliation of nanocluster-n-octylamine bilayer aggregates followed by release of [(CdSe)(13) (n-octylamine)(13) ] or freely soluble [(CdSe)(13) (oleylamine)(13) ] nanoclusters by ligand exchange.

• 6''-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes.

  Authors: Ido M Herzog, Keith D Green, Yifat Berkov-Zrihen, Mark Feldman, Roee R Vidavski, Anat Eldar-Boock, Ronit Satchi-Fainaro, Avigdor Eldar, Sylvie Garneau-Tsodikova, Micha Fridman

  Angewandte Chemie (International ed. in English).

  Amphiphilic aminoglycoside antibiotics kill bacteria by disruption of their highly negatively charged membrane. In their Communication (DOI:10.1002/anie.201200761), M. Fridman and co-workers reportAmphiphilic aminoglycoside antibiotics kill bacteria by disruption of their highly negatively charged membrane. In their Communication (DOI:10.1002/anie.201200761), M. Fridman and co-workers report the synthesis of 6''-thioether tobramycin derivatives and show that their aliphatic chain acts as a drill bit that can rupture bacterial cells. These potent compounds evade many of the common bacterial resistance mechanisms, thereby opening a new avenue for the discovery of membrane-targeting antibiotics.

• Phosphine Adducts of 1,2-Dibromo-1,2-dimesityldiborane(4): Between Bridging Halides and Rearrangement Processes.

  Authors: Holger Braunschweig, Alexander Damme, Jose O C Jimenez-Halla, Thomas Kupfer, Krzysztof Radacki

  Angewandte Chemie (International ed. in English).

  To bridge or not to bridge depends on the size of the Lewis base in mixed sp(2) -sp(3) phosphine adducts of Br(2) B(2) Mes(2) . Whereas reaction with bulky PMeCy(2) induced a 1,2-rearrangement toTo bridge or not to bridge depends on the size of the Lewis base in mixed sp(2) -sp(3) phosphine adducts of Br(2) B(2) Mes(2) . Whereas reaction with bulky PMeCy(2) induced a 1,2-rearrangement to afford the 1,1-dimesityl adduct as the major component, the "normal" 1,2-dimesityl adduct was favored for the smaller PEt(3) molecule. The latter contains an uncommon BBrB bridge and a rare dative BHal bonding interaction to the sp(2) boron center.

• Brønsted Acid Activation Strategy in Transition-Metal Catalyzed Asymmetric Hydrogenation of N-Unprotected Imines, Enamines, and N-Heteroaromatic Compounds.

  Authors: Zhengkun Yu, Weiwei Jin, Quanbin Jiang

  Angewandte Chemie (International ed. in English).

  Asymmetric hydrogenation plays an important role in organic synthesis, but that of the challenging substrates such as N-unprotected imines, enamines, and N-heteroaromatic compounds (1H-indoles,Asymmetric hydrogenation plays an important role in organic synthesis, but that of the challenging substrates such as N-unprotected imines, enamines, and N-heteroaromatic compounds (1H-indoles, 1H-pyrroles, pyridines, quinolines, and quinoxalines) has only received increased attention in the past three years. Considering the interaction modes of a Brønsted acid with a Lewis base, Brønsted acids may be used as the ideal activators of CN bonds. This Minireview summarizes the recent advances in transition-metal-catalyzed, Brønsted acid activated asymmetric hydrogenation of these challenging substrates, thus offering a promising substrate activation strategy for transformations involving CN bonds.

• An Unexpected and Significantly Lower Hydrogen-Bond-Donating Capacity of Fluorohydrins Compared to Nonfluorinated Alcohols.

  Authors: Jérôme Graton, Zhong Wang, Anne-Marie Brossard, Daniela Gonçalves Monteiro, Jean-Yves Le Questel, Bruno Linclau

  Angewandte Chemie (International ed. in English).

  Rewriting the rules as fluorination does not always increase hydrogen-bond acidity: while the strongly electron-withdrawing fluorine significantly enhances alcohol H-bond acidity in anti-vicinalRewriting the rules as fluorination does not always increase hydrogen-bond acidity: while the strongly electron-withdrawing fluorine significantly enhances alcohol H-bond acidity in anti-vicinal fluorohydrins, an intramolecular F⋅⋅⋅HO interaction overrules completely the inductive effect. This leads to an overall decrease in alcohol H-bond acidity, compared to the corresponding nonfluorinated alcohol.

Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.