Angewandte Chemie International Edition (Angew Chem Int Ed)

Publisher: Gesellschaft Deutscher Chemiker, Wiley-VCH Verlag

Journal description

Angewandte Chemie is one of the prime chemistry journals in the world with an ISI-measured Impact Factor higher than those of comparable journals (1999: 7.996). Moreover it is the only journal in the field to have a stimulating mixture of review articles highlights and short communications. The "reviews" written by leading experts summarize the important results of recent research on topical subjects in all branches of chemistry point to unresolved problems and discuss possible developments. The "highlights" provide concise evaluations of current trends in chemical research. The communications are critically selected and report on the latest research results making the journal indispensable to the chemist who wants to stay well informed. Angewandte Chemie also regularly publishes Nobel lectures in chemistry and related fields. Kurztext Auch die internationale Ausgabe der Angewandten Chemie zählt zu den führenden bedeutenden Chemiezeitschrifent weltweit. Chemiker wissen daß sie hier das Neueste aus der Chemie bestens aufbereitet vorfinden. Society Affiliation German Chemical Society ( Gesellschaft Deutscher Chemiker ) Readers Chemists of all disciplines

Current impact factor: 11.34

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2011 Impact Factor 13.455

Additional details

5-year impact 13.56
Cited half-life 5.50
Immediacy index 2.96
Eigenfactor 0.54
Article influence 3.50
Website Angewandte Chemie International Edition website
Other titles Angewandte Chemie (International ed. in English: Online), Angewandte Chemie, Angewandte Chemie international edition in English, Angewandte Chemie international edition
ISSN 1521-3773
OCLC 43968233
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Wiley-VCH Verlag

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  • Classification
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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: ATP analogues have been powerful compounds for the study of kinase-catalyzed phosphorylation. However, the cell impermeability of ATP analogues has largely limited their use to in vitro lysate-based experiments. Herein, we report the first cell-permeable ATP analogue, ATP–polyamine–biotin (APB). APB is shown to promote biotin labeling of kinase substrates in live cells and has future applications in phosphoprotein purification and analysis. More generally, these studies provide a foundation for the development of additional cell-permeable ATP analogues for cell-signaling research.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201503041
  • Albert Paparo, Jared S Silvia, Christos E Kefalidis, Thomas P Spaniol, Laurent Maron, Jun Okuda, Christopher C Cummins
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    ABSTRACT: We describe the stable and isolable dimetalloxycarbene [(TiX3 )2 (μ2 -CO2 -κ(2) C,O:κO')] 5, where X=N-(tert-butyl)-3,5-dimethylanilide, which is stabilized by fluctuating μ2 -κ(2) C,O:κ(1) O' coordination of the carbene carbon to both titanium centers of the dinuclear complex 5, as shown by variable-temperature NMR studies. Quantum chemical calculations on the unmodified molecule indicated a higher energy of only +10.5 kJ mol(-1) for the μ2 -κ(1) O:κ(1) O' bonding mode of the free dimetalloxycarbene compared to the μ2 -κ(2) C,O:κ(1) O' bonding mode of the masked dimetalloxycarbene. The parent cationic bridging formate complex [(TiX3 )2 (μ2 -OCHO-κO:κO')][B(C6 F5 )4 ], 4[B(C6 F5 )4 ], was simply deprotonated with the strong base K(N(SiMe3 )2 ) to give 5. Complex 5 reacts smoothly with CO2 to generate the bridging oxalate complex [(TiX3 )2 (μ2 -C2 O4 -κO:κO'')], 6, in a CC bond formation reaction commonly anticipated for oxalate formation by reductive coupling of CO2 on low-valent transition-metal complexes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201502532
  • Wei Zheng, Bei-Bei Wang, Cheng-Hui Li, Jing-Xuan Zhang, Cheng-Zhang Wan, Jia-Hao Huang, Jian Liu, Zhen Shen, Xiao-Zeng You
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    ABSTRACT: Novel aza-diisoindolylmethene and their BF2 -chelating complexes (benzo-fused aza-BODIPYs) were synthesized on a large scale and in a facile manner from phthalonitrile in tBuOK-DMF solution. The unique asymmetric donor-π-acceptor structure facilitates BN bond detachment in the presence of trifluoroacetic acid (TFA) in dichloromethane, resulting in sharp color change from red to colorless, with over 250 nm hypsochromic shift in the absorption maximum. This colorimetric process can be reversed by adding a very small amount of proton-accepting solvents or compounds. A (1) H and (11) B NMR spectroscopy study and also density functional theory (DFT) calculations suggest that TFA-induced BN bond cleavage may disrupt the whole π-conjugation of the BODIPY molecule, resulting in significant colorimetric behavior. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201501984
  • Martin R Kotyrba, Eduardo Cuervo-Reyes, Reinhard Nesper
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    ABSTRACT: YAlC was prepared by a flux method. It crystallizes as a partially filled-up TlI structure, showing remarkable structural aspects at the border between Zintl phases and intermetallics. This novel ternary aluminide-carbide exhibits a unique one-dimensional multi-center bond and a polyacetylene-related aluminum carbide substructure. The different functionalities of aluminum and of yttrium are quite remarkable. While the latter behaves more like a trivalent ion, aluminum contributes considerably to covalent bonding with carbon. Still yttrium d states contribute, but hardly in a directed manner. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201501356
  • Yibo Dou, Ting Pan, Simin Xu, Hong Yan, Jingbin Han, Min Wei, David G Evans, Xue Duan
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    ABSTRACT: Transparent and flexible gas-barrier materials have shown broad applications in electronics, food, and pharmaceutical preservation. Herein, we report ultrahigh-gas-barrier films with a brick-mortar-sand structure fabricated by layer-by-layer (LBL) assembly of XAl-layered double hydroxide (LDH, X=Mg, Ni, Zn, Co) nanoplatelets and polyacrylic acid (PAA) followed by CO2 infilling, denoted as (XAl-LDH/PAA)n -CO2 . The near-perfectly parallel orientation of the LDH "brick" creates a long diffusion length to hinder the transmission of gas molecules in the PAA "mortar". Most significantly, both the experimental studies and theoretical simulations reveal that the chemically adsorbed CO2 acts like "sand" to fill the free volume at the organic-inorganic interface, which further depresses the diffusion of permeating gas. The strategy presented here provides a new insight into the perception of barrier mechanism, and the (XAl-LDH/PAA)n -CO2 film is among the best gas barrier films ever reported. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201503797
  • Martin Quernheim, Florian E Golling, Wen Zhang, Manfred Wagner, Hans-Joachim Räder, Tomohiko Nishiuchi, Klaus Müllen
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    ABSTRACT: The longitudinal extension of cycloparaphenylenes (CPP) towards ultrashort carbon nanotubes (CNTs) is essential for the solution based bottom-up synthesis of CNTs. Herein, the longitudinal extension of the CPP skeleton by the introduction of hexaphenylbenzene units towards polyarylated [n]CPPs is described. Further, the applicability of the Scholl reaction to selectively form graphenic sidewalls is demonstrated. The ring size and substitution patterns of the polyarylated [n]CPPs were varied to overcome strain-induced side reactions during the oxidative cyclodehydrogenation and cyclic para-hexa-peri-hexabenzocoronene trimers ([3]CHBCs) were selectively obtained. This concept is envisioned as an access to ultrashort carbon nanotubes subject to the condition that further benzene rings with the right connectivity will be inserted. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201500392
  • Olga García Mancheño, Sören Asmus, Mercedes Zurro, Theresa Fischer
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    ABSTRACT: The asymmetric dearomatization of N-heterocycles is an important synthetic method to gain bioactive and synthetically valuable chiral heterocycles. However, the catalytic enantio- and regioselective dearomatization of the simplest six-membered-ring N-heteroarenes, the pyridines, is still very challenging. The first anion-binding-catalyzed, highly enantioselective nucleophilic dearomatization of pyridines with triazole-based H-bond donor catalysts is presented. Contrary to other more common NH-based H-bond donors, this type of organocatalyst shows a prominent higher C2-regioselectivity and is able to promote high enantioinductions via formation of a close chiral anion-pair complex with a preformed N-acyl pyridinium ionic intermediate. This method offers a straightforward and useful synthetic approach to chiral N-heterocycles from abundant and readily available pyridines. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201502708
  • Yang Xu, Min Zhou, Xin Wang, Chengliang Wang, Liying Liang, Fabian Grote, Minghong Wu, Yan Mi, Yong Lei
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    ABSTRACT: The utilization of oxygen vacancies (OVs) in sodium ion batteries (SIBs) is expected to enhance performance, but as yet it has rarely been reported. Taking the MoO3-x nanosheet anode as an example, for the first time we demonstrate the benefits of OVs on SIB performance. Moreover, the benefits at deep-discharge conditions can be further promoted by an ultrathin Al2 O3 coating. A series of measurements show that the OVs increase the electric conductivity and Na-ion diffusion coefficient, and the promotion from ultrathin coating lies in the effective reduction of cycling-induced solid-electrolyte interphase. The coated nanosheets exhibited high reversible capacity and great rate capability with the capacities of 283.9 (50 mA g(-1) ) and 179.3 mAh g(-1) (1 A g(-1) ) after 100 cycles. This work may not only arouse future attention on OVs for sodium energy storage, but also open up new possibilities for designing strategies to utilize defects in other energy storage systems. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201503477
  • James M Hodges, Karel Kletetschka, Julie L Fenton, Carlos G Read, Raymond E Schaak
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    ABSTRACT: Ion exchange reactions of colloidal nanocrystals provide access to complex products that are synthetically challenging using traditional hot-injection methods. However, such reactions typically achieve only partial material transformations by employing either cation or anion exchange processes. It is now shown that anion and cation exchange reactions can be coupled together and applied sequentially in one integrated pathway that leads to complete material transformations of nanocrystal templates. Although the product nanocrystals do not contain any of the original constituent elements, the original morphology is retained, thereby fully decoupling morphology and composition control. The sequential anion/cation exchange process was applied to pseudo-spherical CdO nanocrystals and ZnO tetrapods, producing fully transformed and shape-controlled nanocrystals of copper and silver sulfides and selenides. Furthermore, hollow core-shell tetrapod ZnS@CdS heterostructures were readily accessible. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201504099
  • Dilong Liu, Fei Zhou, Cuncheng Li, Tao Zhang, Honghua Zhang, Weiping Cai, Yue Li
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    ABSTRACT: A facile approach for the fabrication of novel black plasmonic colloidosomes assembled from Au nanospheres is developed by an emulsion-templating strategy. This self-assembly process is based on a new reverse water-in-1-butanol emulsion system, in which the water emulsion droplets can dissolve into 1-butanol (oil) phase at an appropriate rate. These Au colloidosomes possess hexagonal close-packed multilayer shells and show a low reflectivity and intense broadband absorption owing to the strong interparticle plasmonic coupling, which is further investigated by a finite-difference time-domain method. This method is universal and is suitable for self-assembly of different noble-metal nanoparticles into different colloidosomes. These colloidosomes have important applications in photothermal therapy, biosensors, and drug delivery. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201503384
  • Fengcai Lei, Lei Zhang, Yongfu Sun, Liang Liang, Katong Liu, Jiaqi Xu, Qun Zhang, Bicai Pan, Yi Luo, Yi Xie
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    ABSTRACT: A model of doping confined in atomic layers is proposed for atomic-level insights into the effect of doping on photocatalysis. Co doping confined in three atomic layers of In2 S3 was implemented with a lamellar hybrid intermediate strategy. Density functional calculations reveal that the introduction of Co ions brings about several new energy levels and increased density of states at the conduction band minimum, leading to sharply increased visible-light absorption and three times higher carrier concentration. Ultrafast transient absorption spectroscopy reveals that the electron transfer time of about 1.6 ps from the valence band to newly formed localized states is due to Co doping. The 25-fold increase in average recovery lifetime is believed to be responsible for the increased of electron-hole separation. The synthesized Co-doped In2 S3 (three atomic layers) yield a photocurrent of 1.17 mA cm(-2) at 1.5 V vs. RHE, nearly 10 and 17 times higher than that of the perfect In2 S3 (three atomic layers) and the bulk counterpart, respectively. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201503410
  • Bardia Soltanzadeh, Arvind Jaganathan, Richard J Staples, Babak Borhan
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    ABSTRACT: An organocatalytic and highly regio-, diastereo-, and enantioselective intermolecular haloetherification and haloesterification reaction of allyl amides is reported. A variety of alkene substituents and substitution patterns are compatible with this chemistry. Notably, electronically unbiased alkene substrates exhibit exquisite regio- and diastereoselectivity for the title transformation. We also demonstrate that the same catalytic system can be used in both chlorination and bromination reactions of allyl amides with a variety of nucleophiles with little or no modification. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201502341
  • Nicholas P Calta, Jino Im, Alexandra P Rodriguez, Lei Fang, Daniel E Bugaris, Thomas C Chasapis, Arthur J Freeman, Mercouri G Kanatzidis
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    ABSTRACT: EuIr4 In2 Ge4 is a new intermetallic semiconductor that adopts a non-centrosymmetric structure in the tetragonal ${I\bar 42m}$ space group with unit cell parameters a=6.9016(5) Å and c=8.7153(9) Å. The compound features an indirect optical band gap Eg =0.26(2) eV, and electronic-structure calculations show that the energy gap originates primarily from hybridization of the Ir 5d orbitals, with small contributions from the Ge 4p and In 5p orbitals. The strong spin-orbit coupling arising from the Ir atoms, and the lack of inversion symmetry leads to significant spin splitting, which is described by the Dresselhaus term, at both the conduction- and valence-band edges. The magnetic Eu(2+) ions present in the structure, which do not play a role in gap formation, order antiferromagnetically at 2.5 K. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201504315
  • Lidong Zhang, Panče Naumov
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    ABSTRACT: A smart acidochromic agarose-based film with 1,4-bis(para-hydroxystyryl)benzene as the pH-responsive fluorophore was prepared. This film can simultaneously harness the chemical potential of light and aerial humidity gradients to convert them into mechanical work. The strong reversible hygroscopicity of the agarose matrix induces swift locomotion by mechanical deformation owing to exchange of water with the surroundings. Driven by humidity, a 20 mg composite film coupled to a piezoelectric bending transducer sensor generates a peak output of approximately 80 mV, which corresponds to a power density of 25 μW kg(-1) . Excitation with UV light triggers isomerization of the chromophore, which appears as reshaping by spiraling, bending, or twisting of the film. The material also responds to changes in the pH value by reversible protonation of the fluorophore with rapid changes in color and fluorescence. The threefold sensing capability of this smart material could be utilized for the fabrication of multiresponsive actuating dynamic elements in biomedicine and soft robotics. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201504153
  • Michael Neustetter, Julia Aysina, Filipe Ferreira da Silva, Stephan Denifl
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    ABSTRACT: The interaction of low-energy electrons with biomolecules plays an important role in the radiation-induced alteration of biological tissue at the molecular level. At electron energies below 15 eV, dissociative electron attachment is one of the most important processes in terms of the chemical transformation of molecules. So far, a common approach to study processes at the molecular level has been to carry out investigations with single biomolecular building blocks like pyrimidine as model molecules. Electron attachment to single pyrimidine, as well as to pure clusters and hydrated clusters, was investigated in this study. In striking contrast to the situation with isolated molecules and hydrated clusters, where no anionic monomer is detectable, we were able to observe the molecular anion for the pure clusters. Furthermore, there is evidence that solvation effectively prevents the ring fragmentation of pyrimidine after electron capture. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201503733
  • Piera Trinchera, Victoria B Corless, Andrei K Yudin
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    ABSTRACT: The photoredox-organocatalyzed α-alkylation of the α-MIDA boryl aldehyde with a range of α-bromoketones resulted in the first examples of boron-containing 1,4-dicarbonyl compounds. These novel trifunctional amphoteric molecules, which bear an additional, strategically placed electrophilic site compared to the starting amphoteric α-boryl aldehyde, were subjected to double-condensation reactions in the presence of various nucleophiles. As a result, a variety of synthetically challenging 3-borylated pyrroles and furans and 4-borylated pyridazines were generated. The borylated regioisomers accessible with this condensation-based strategy are distinctly different from those arising from the well-known lithiation and CH activation processes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201504271
  • Bruce Atwater, Nalin Chandrasoma, David Mitchell, Michael J Rodriguez, Matthew Pompeo, Robert D J Froese, Michael G Organ
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    ABSTRACT: The ability to cross-couple secondary alkyl centers is fraught with a number of problems, including difficult reductive elimination, which often leads to β-hydride elimination. Whereas catalysts have been reported that provide decent selectivity for the expected (non-rearranged) cross-coupled product with aryl or heteroaryl oxidative-addition partners, none have shown reliable selectivity with five-membered-ring heterocycles. In this report, a new, rationally designed catalyst, Pd-PEPPSI-IHept(Cl) , is demonstrated to be effective in selective cross-coupling reactions with secondary alkyl reagents across an impressive variety of furans, thiophenes, and benzo-fused derivatives (e.g., indoles, benzofurans), in most instances producing clean products with minimal, if any, migratory insertion for the first time. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201503941
  • Christian Merten, Corina H Pollok, Saihu Liao, Benjamin List
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    ABSTRACT: Ionic interactions are increasingly appreciated as a key, asymmetry-inducing factor in enantioselective catalytic transformations, including those involving Brønsted acid or base catalysis, phase-transfer catalysis, and related processes. However, a detailed understanding of these interactions is often lacking. Herein, we show how an enantiopure anion enforces a chiral conformation onto a catalytically relevant achiral cation. Specifically, we use vibrational circular dichroism (VCD) spectroscopy to monitor the transmission of stereochemical information from a chiral phosphate anion to a flexible manganese(III)-salen cation. We show that VCD can be used to study solvent effects and that the obtained chiroptical data directly and quantitatively correlate with the experimentally observed enantioselectivity in an asymmetric olefin epoxidation reaction. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 06/2015; DOI:10.1002/anie.201501271