Chemistry - A European Journal (Chem Eur J)

Publisher: Gesellschaft Deutscher Chemiker; Koninklijke Nederlandse Chemische Vereniging; Société royale de chimie (Belgium); Koninklijke Vlaamse Chemische Vereniging; Società chimica italiana; All authors, Wiley-VCH Verlag

Journal description

Since 1995 Chemistry - A European Journal is the new international forum based in Europe for the publication of outstanding Full Papers from all areas of chemistry and related fields. Chemistry increases the visibility of European chemistry and attracts authors and readers worldwide under the motto "Made in Europe for the World". It appears bimonthly and has established itself as a truly international journal with top quality contributions from Europe the US and Japan. All manuscripts are peer-reviewed and electronic processing ensures accurate reproduction of text and data and short publication times. An additional "Concepts" section in Chemistry provides the nonspecialist reader with a useful conceptual guide to unfamiliar areas and the expert with new angles on familiar problems. For information about the European Journals see Editorial . Society Affiliations 14 European Chemical Societies Kurztext Chemistry - A European Journal publiziert seit 1995 "Full Papers" aus allen Gebieten der Chemie einschließlich ihrer Grenzbereiche. Sie erscheint zweimal monatlich. Als europäisches Forum für ausführliche Originalpublikationen zieht sie Beiträge von international bekannten Autoren aus der ganzen Welt an und ist daher für jeden Chemiker unverzichtbar. Die Rubrik "Concepts" führt Nicht-Spezialisten in neue Gebiete ein und stellt Spezialisten bekannte Probleme aus einem neuen Blickwinkel vor. Informationen über die "European Journals" siehe: Editorial . Readers Chemists of all disciplines

Current impact factor: 5.73

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 5.731
2013 Impact Factor 5.696
2012 Impact Factor 5.831
2011 Impact Factor 5.925
2010 Impact Factor 5.476
2009 Impact Factor 5.382
2008 Impact Factor 5.454
2007 Impact Factor 5.33
2006 Impact Factor 5.015
2005 Impact Factor 4.907
2004 Impact Factor 4.517
2003 Impact Factor 4.353
2002 Impact Factor 4.238
2001 Impact Factor 4.614
2000 Impact Factor 4.698
1999 Impact Factor 4.814
1998 Impact Factor 5.153
1997 Impact Factor 4.828
1996 Impact Factor 4.814

Impact factor over time

Impact factor

Additional details

5-year impact 5.64
Cited half-life 4.40
Immediacy index 1.26
Eigenfactor 0.20
Article influence 1.44
Website Chemistry - A European Journal website
Other titles Chemistry (Weinheim an der Bergstrasse, Germany: Online), Chemistry, Angewandte Chemie (International ed. in English: Online), Angewandte Chemie (Weinheim an der Bergstrasse, Germany: Online), Chembiochem (Online), Chemphyschem (Online)
ISSN 1521-3765
OCLC 42084594
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Wiley-VCH Verlag

  • Pre-print
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  • Post-print
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  • Conditions
    • Pre-print may be deposited on personal intranet or institutional intranet repository, but not on a public repository
    • Pre-print must not updates with future versions
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    • Publisher's version/PDF cannot be used
    • Some journal exceptions-check individual homepages
  • Classification
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Publications in this journal

  • Anand Acharya · S Vijay Kumar · Hiriyakkanavar Ila
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    ABSTRACT: An efficient, high yielding route to multisubstituted benzo[b]thiophenes has been developed through palladium-catalyzed intramolecular oxidative CH functionalization-arylthiolation of enethiolate salts of α-aryl-β-(het)aryl/alkyl-β-mercaptoacrylonitriles/acrylates or acrylophenones. The overall strategy involves a one-pot, two-step process in which enethiolate salts [generated in situ through base-mediated condensation of substituted arylacetonitriles, deoxybenzoins, or arylacetates with (het)aryl (or alkyl) dithioates] are subjected to intramolecular CH functionalization-arylthiolation under the influence of a palladium acetate (or palladium chloride)/cupric acetate catalytic system and tetrabutylammonium bromide as additive in N,N-dimethylformamide (DMF) as solvent. In a few cases, the yields of benzo[b]thiophenes were better in a two-step process by employing the corresponding enethiols as substrates. In a few examples, Pd(OAc)2 (or PdCl2 ) catalyst in the presence of oxygen was found to be more efficient than cupric acetate as reoxidant, furnishing benzothiophenes in improved yields by avoiding formation of side products. The method is compatible with a diverse range of substituents on the aryl ring as well as on the 2- and 3-positions of the benzothiophene scaffold. The protocol could also be extended to the synthesis of a raloxifene precursor and a tubulin polymerization inhibitor in good yields. The versatility of this newly developed method was further demonstrated by elaborating it for the synthesis of substituted thieno-fused heterocycles such as thieno[2,3-b]thiophenes, thieno[2,3-b]indoles, thieno[3,2-c]pyrazole, and thieno[2,3-b]pyridines in high yields. A probable mechanism involving intramolecular electrophilic arylthiolation via either a Pd-S adduct or palladacycle intermediate has been proposed on the basis of experimental studies.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201501828
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    ABSTRACT: With a view to addressing the shortcomings of traditional catalysts, a new generation of outstanding N- heterocyclic carbene platinum(0) complexes for the hydrosilylation of unsaturated carbon–carbon bonds is reported. Their discovery and application to the stereoselective addition of various silanes to silylated alkynes, terminal acetylenes, and olefins is presented. Insights into the catalytic cycle and the origin of the stereoselectivity are also discussed.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201502643
  • Emilie Delahaye · Robinson Moulin · Merwen Aouadi · Virgile Trannoy · Patricia Beaunier · Giulia Fornasieri · Anne Bleuzen
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    ABSTRACT: Mesoporous silica monoliths with various ordered nanostructures containing transition metal M(2+) cations in variable amounts were elaborated and studied. A phase diagram depicting the different phases as a function of the M(2+) salt/tetramethyl orthosilicate (TMOS) and surfactant P123/TMOS ratios was established. Thermal treatment resulted in mesoporous monoliths containing isolated, accessible M(2+) species or condensed metal oxides, hydroxides, and salts, depending on the strength of the interactions between the metal species and the ethylene oxide units of P123. The ordered mesoporosity of the monoliths containing accessible M(2+) ions was used as a nanoreactor for the elaboration of various transition metal compounds (Prussian blue analogues, Hofmann compounds, metal-organic frameworks), and this opens the way to the elaboration of a large range of nanoparticles of multifunctional materials.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201501918
  • Qilin Li · Hongbin Zhang
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    ABSTRACT: In this paper, a new strategy towards the synthesis of codeine and morphine is reported. This new approach features a cascade cyclization to construct the dihydrofuran ring, and an intramolecular palladium catalyzed CH olefination of unactivated aliphatic alkene to install the morphinan ring system.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201503594
  • Kevin Chan · Clive Yik-Sham Chung · Vivian Wing-Wah Yam
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    ABSTRACT: Water-soluble cationic alkynylplatinum(II) 2,6-bis(benzimidazol-2'-yl)pyridine (bzimpy) complexes have been demonstrated to undergo supramolecular assembly with anionic polyelectrolytes in aqueous buffer solution. Metal-metal-to-ligand charge transfer (MMLCT) absorptions and triplet MMLCT ((3) MMLCT) emissions have been found in UV/Vis absorption and emission spectra of the electrostatic assembly of the complexes with non-conjugated polyelectrolytes, driven by Pt⋅⋅⋅Pt and π-π interactions among the complex molecules. Interestingly, the two-component ensemble formed by [Pt(bzimpy-Et){CCC6 H4 (CH2 NMe3 -4)}]Cl2 (1) with para-linked conjugated polyelectrolyte (CPE), PPE-SO3 (-) , shows significantly different photophysical properties from that of the ensemble formed by 1 with meta-linked CPE, mPPE-Ala. The helical conformation of mPPE-Ala allows the formation of strong mPPE-Ala-1 aggregates with Pt⋅⋅⋅Pt, electrostatic, and π-π interactions, as revealed by the large Stern-Volmer constant at low concentrations of 1. Together with the reasonably large Förster radius, large HOMO-LUMO gap and high triplet state energy of mPPE-Ala to minimize both photo-induced charge transfer (PCT) and Dexter triplet energy back-transfer (TEBT) quenching of the emission of 1, efficient Förster resonance energy transfer (FRET) from mPPE-Ala to aggregated 1 molecules and strong (3) MMLCT emission have been found, while the less strong PPE-SO3 (-) -1 aggregates and probably more efficient PCT and Dexter TEBT quenching would account for the lack of (3) MMLCT emission in the PPE-SO3 (-) -1 ensemble.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201501804
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    ABSTRACT: Novel ordered lamellar mesostructure pZrPS-2 was hydrothermally prepared by using zirconium propoxide and 4-(EtO)2OPC6H4Si(OEt)3 (pPPS-E), which was hydrolyzed to organic building units substituted with both siliconate and phosphonate groups, in the presence of CnTAB and TMAOH. The pZrPS-2 materials were obtained at a Zr/PPS ratio of 2 or higher and the basal spacing was increased by using a longer-chain surfactant (n=12–18). Removal of the occluded surfactants at 300 °C resulted in retention of the lamellar structure with negligible shrinkage of the interlayer distance. Nitrogen adsorption studies revealed the ordered mesoporous nature of pZrPS-2 with a pore diameter of approximately 2 to 3 nm. The lamellar structure is assumed to be composed of layers that include zirconia-based crystalline nanodomains and interlayer pillars mainly based on PPS units. Although lamellar structures with the same crystalline phase also formed when no surfactant was added or when the meta isomer of PPS was used, no mesoporous materials were obtained except pZrPS-2. A possible schematic model to elucidate these results is also proposed.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201502353
  • Jan Paczesny · Małgorzata Wolska-Pietkiewicz · Ilona Binkiewicz · Zbigniew Wróbel · Monika Wadowska · Kinga Matuła · Igor Dzięcielewski · Damian Pociecha · Julita Smalc-Koziorowska · Janusz Lewiński · Robert Hołyst
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    ABSTRACT: The ability to self-assemble nanosized ligand-stabilized metal oxide or semiconductor materials offers an intriguing route to engineer nanomaterials with new tailored properties from the disparate components. We describe a novel one-pot two-step organometallic approach to prepare ZnO nanocrystals (NCs) coated with deprotonated 4-(dodecyloxy)benzoic acid (i.e., an X-type liquid-crystalline ligand) as a model LC system (termed ZnO-LC1 NCs). Langmuir and Langmuir-Blodgett films of the resulting hybrids are investigated. The observed behavior of the ZnO NCs at the air/water interface is rationalized by invoking a ZnO-interdigitation process mediated by the anchored liquid-crystalline shell. The ordered superstructures form according to mechanism based on a ZnO-interdigitation process mediated by liquid crystals (termed ZIP-LC). The external and directed force applied upon compression at the air/water interface and the packing of the ligands that stabilize the ZnO cores drives the formation of nanorods of ordered internal structure. To study the process in detail, we follow a nontraditional protocol of thin-film investigation. We collect the films from the air/water interface in powder form (ZnO-LC1 LB), resuspend the powder in organic solvents and utilize otherwise unavailable experimental techniques. The structural and physical properties of the resulting superlattices were studied by using electron microscopy, atomic force microscopy, X-ray studies, dynamic light scattering, thermogravimetric analysis, UV/Vis absorption, and photoluminescence spectroscopy.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201502714
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    ABSTRACT: The effect of carbenes as Lewis donor groups on the homoaromaticity of mono- and bicyclic organic molecules is surveyed. The search for viable carbene-stabilised homoaromatics resulted in a large amount of rejected candidates as well as nine promising candidates that are further analysed for their homoaromaticity by using a number of metrics. Of these, five appeared to show modest homoaromaticity, whereas another compound showed a level of homoaromaticity comparable with the homotropylium cation benchmark compound. Isoelectronic analogues and constitutional isomers of the lead compound were investigated, however, none of these showed comparable homoaromaticity. The implications of these calculations on the design of donor-stabilised homoaromatics are discussed.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201501948
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    ABSTRACT: The total synthesis of (-)-isoschizogamine was accomplished, featuring the construction of the quaternary carbon center by the modified Johnson-Claisen rearrangement in basic media and the facile assembly of the key tetracyclic quinolone intermediate through a cascade cyclization. The characteristic cyclic aminal was constructed by late-stage CH functionalization at the position adjacent to the lactam nitrogen using a combination of CrO3 and nBu4 NIO4 and subsequent Bi(OTf)3 -mediated cyclization.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201503606
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    ABSTRACT: The total synthesis of the marine fungus-derived natural product ascospiroketal is described. This concise synthesis relies on a unique Ag(I) -promoted tandem cascade cyclization that provides direct access to the correctly configured tricyclic core of the natural product from a linear precursor. The synthesis of candidate stereostructures of ascospiroketal A allowed for the confident assignment of both the relative and absolute stereochemistry of this unusual octaketide.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201502754
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    ABSTRACT: The first example of efficient asymmetric hydrogenation of challenging β-aryloxyacrylic acids was realized using a Rh(I) -complex based on the heterocombination of a readily available chiral monodentate secondary phosphine oxide (SPO) and an achiral monodentate phosphine ligand as the catalyst. Excellent enantioselectivities (92->99 % ee) were achieved for a wide variety of chiral β-aryloxypropionic acids with minor aryloxy elimination in most cases. The resultant products were readily transformed into biologically active compounds through simple synthetic manipulations.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201503229
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    ABSTRACT: Activation of CO2 by the bis(amidinato)silylene 1 and the analogous bis(guanidinato)silylene 2 leads to the structurally analogous six-coordinate silicon(IV) complexes 4 (previous work) and 8, respectively, the first silicon compounds with a chelating carbonato ligand. Likewise, CS2 activation by silylene 1 affords the analogous six-coordinate silicon(IV) complex 10, the first silicon compound with a chelating trithiocarbonato ligand. CS2 activation by silylene 2, however, yields the five-coordinate silicon(IV) complex 13 with a carbon-bound CS2 (2-) ligand, which also represents an unprecedented coordination mode in silicon coordination chemistry. Treatment of the dinuclear silicon(IV) complexes 5 and 6 with CO2 also affords the six-coordinate carbonatosilicon(IV) complexes 4 and 8, respectively.
    Chemistry - A European Journal 10/2015; DOI:10.1002/chem.201501788
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    ABSTRACT: A series of phenylene vinylene macrocycles (PVMs) bearing substituents with various sizes and electronic properties have been synthesized through a one-step acyclic diene metathesis macrocyclization approach and their aggregation behaviors have been investigated. In great contrast to the aggregation of the analogous phenylene ethynylene macrocycles, which aggregate only when substituted with electron-withdrawing groups, these PVMs undergo exceptionally strong aggregation, regardless of the electron-donating or -withdrawing characters of the substituents. The unusual aggregation behavior of the PVMs is further investigated with thermodynamic and computer modeling studies, which show a good agreement with the recently proposed direct through-space interaction model, rather than the polar/π model. The high aggregation tendency of PVMs suggests the great potential of this novel class of shape-persistent macrocycles in a variety of applications, such as ion channels, host-guest recognition, and catalysis.
    Chemistry - A European Journal 09/2015; DOI:10.1002/chem.201502848
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    ABSTRACT: Three different tetraphenylalanine (FFFF) based peptides that differ at the N- and C-termini have been synthesized by using standard procedures to study their ability to form different nanoassemblies under a variety of conditions. The FFFF peptide assembles into nanotubes that show more structural imperfections at the surface than those formed by the diphenylalanine (FF) peptide under the same conditions. Periodic DFT calculations (M06L functional) were used to propose a model that consists of three FFFF molecules defining a ring through head-to-tail NH3 (+) ⋅⋅⋅(-) OOC interactions, which in turn stack to produce deformed channels with internal diameters between 12 and 16 Å. Depending on the experimental conditions used for the peptide incubation, N-fluorenylmethoxycarbonyl (Fmoc) protected FFFF self-assembles into a variety of polymorphs: ultra-thin nanoplates, fibrils, and star-like submicrometric aggregates. DFT calculations indicate that Fmoc-FFFF prefers a parallel rather than an antiparallel β-sheet assembly. Finally, coexisting multiple assemblies (up to three) were observed for Fmoc-FFFF-OBzl (OBzl = benzyl ester), which incorporates aromatic protecting groups at the two peptide terminals. This unusual and noticeable feature is attributed to the fact that the assemblies obtained by combining the Fmoc and OBzl groups contained in the peptide are isoenergetic.
    Chemistry - A European Journal 09/2015; DOI:10.1002/chem.201501793
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    ABSTRACT: The reaction of a Schiff base ligand (LH3 ) with lanthanide salts, pivalic acid and triethylamine in 1:1:1:3 and 4:5:8:20 stoichiometric ratios results in the formation of decanuclear Ln10 (Ln=Dy(1), Tb(2), and Gd (3)) and pentanuclear Ln5 complexes (Ln=Gd (4), Tb (5), and Dy (6)), respectively. The formation of Ln10 and Ln5 complexes are fully governed by the stoichiometry of the reagents used. Detailed magnetic studies on these complexes (1-6) have been carried out. Complex 1 shows a SMM behavior with an effective energy barrier for the reversal of the magnetization (Ueff )=16.12(8) K and relaxation time (τo )=3.3×10(-5) s under 4000 Oe direct current (dc) field. Complex 6 shows the frequency dependent maxima in the out-of-phase signal under zero dc field, without achieving maxima above 2 K. Complexes 3 and 4 show a large magnetocaloric effect with the following characteristic values: -ΔSm =26.6 J kg(-1) K(-1) at T=2.2 K for 3 and -ΔSm =27.1 J kg(-1) K(-1) at T=2.4 K for 4, both for an applied field change of 7 T.
    Chemistry - A European Journal 09/2015; DOI:10.1002/chem.201501992
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    ABSTRACT: A new nucleic acid detection method was developed for a rapid and cost-effective diagnosis of infectious disease. This approach relies on the three unique elements: 1) detection probes that regulate DNA polymerase activity in response to the complementary target DNA; 2) universal reporters conjugated with a single fluorophore; and 3) fluorescence polarization (FP) detection. As a proof-of-concept, the assay was used to detect and sub-type Salmonella bacteria with sensitivities down to a single bacterium in less than three hours.
    Chemistry - A European Journal 09/2015; DOI:10.1002/chem.201502934
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    ABSTRACT: Three diaceno[a,e]pentalene analogues with pendant sterically bulky di-tert-butylphenyl groups have been designed and synthesized. With the extension of the conjugated molecular framework, the molecular arrangement is apparently tuned by the balance between the π-extended surface and pendant alkyl or aryl substituents. Theoretical calculations of the morphologies were in good agreement with the experimental results. Ambient-stable field-effect transistors based on dianthraceno[a,e]pentalene (DAP) have been fabricated, which exhibited excellent hole mobilities (up to 6.55 cm(2) V(-1) s(-1) ). Thus, this study has shown that diaceno[a,e]pentalenes are stable even with an extraordinarily large π-surface area, and may thus serve as excellent molecular platforms for further exploring high-performance semiconducting materials.
    Chemistry - A European Journal 09/2015; DOI:10.1002/chem.201502184
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    ABSTRACT: The oxidative stress that arises from the catalytic reduction of dioxygen by Cu(II/I) -loaded amyloids is the major pathway for neuron death that occurs in Alzheimer's disease. In this work, we show that bis-8(aminoquinoline) ligands, copper(II) specific chelators, are able to catalytically extract Cu(II) from Cu-Aβ1-16 and then completely release Cu(I) in the presence of glutathione to provide a Cu(I) -glutathione complex, a biological intermediate that is able to deliver copper to apo forms of copper-protein complexes. These data demonstrate that bis-8(aminoquinolines) can perform the transfer of copper ions from the pathological Cu-amyloid complexes to regular copper-protein complexes. These copper-specific ligands assist GSH to recycle Cu(I) in an AD brain and consequently slow down oxidative damage that is due to copper dysregulation in Alzheimer's disease. Under the same conditions, we have shown that the copper complex of PBT2, a mono(8-hydroxyquinoline) previously used as a drug candidate, does not efficiently release copper in the presence of GSH. In addition, we report that GSH itself was unable to fully abstract copper ions from Cu-β-amyloid complexes.
    Chemistry - A European Journal 09/2015; DOI:10.1002/chem.201502824
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    ABSTRACT: The synthesis of five novel distyrylbenzene (DSB) derivatives, featuring a central tetraphenylbenzene core, is reported. The targets show aggregation-induced emission (AIE), which, however, is substituent-dependent. For the pure hydrocarbon and derivatives that do not carry (+M) or (-M) substituents, classic AIE behavior is observed, that is, the DSBs are non-fluorescent in solution, but are highly fluorescent in cold matrices, upon aggregate formation in poor solvents and in the solid, crystalline state. If aldehyde or dibutylamino groups are attached in the para-position of the DSB unit, non-classic AIE-phores result. These are fluorescent both in dilute solution as well as in the solid state. Prolonged irradiation of the targets leads to benzotetraphene derivatives by a double cyclization.
    Chemistry - A European Journal 09/2015; DOI:10.1002/chem.201502877