Chemistry - A European Journal (Chem Eur J )

Publisher: Gesellschaft Deutscher Chemiker; Koninklijke Nederlandse Chemische Vereniging; Société royale de chimie (Belgium); Koninklijke Vlaamse Chemische Vereniging; Società chimica italiana; All authors, John Wiley and Sons

Description

Since 1995 Chemistry - A European Journal is the new international forum based in Europe for the publication of outstanding Full Papers from all areas of chemistry and related fields. Chemistry increases the visibility of European chemistry and attracts authors and readers worldwide under the motto "Made in Europe for the World". It appears bimonthly and has established itself as a truly international journal with top quality contributions from Europe the US and Japan. All manuscripts are peer-reviewed and electronic processing ensures accurate reproduction of text and data and short publication times. An additional "Concepts" section in Chemistry provides the nonspecialist reader with a useful conceptual guide to unfamiliar areas and the expert with new angles on familiar problems. For information about the European Journals see Editorial . Society Affiliations 14 European Chemical Societies Kurztext Chemistry - A European Journal publiziert seit 1995 "Full Papers" aus allen Gebieten der Chemie einschließlich ihrer Grenzbereiche. Sie erscheint zweimal monatlich. Als europäisches Forum für ausführliche Originalpublikationen zieht sie Beiträge von international bekannten Autoren aus der ganzen Welt an und ist daher für jeden Chemiker unverzichtbar. Die Rubrik "Concepts" führt Nicht-Spezialisten in neue Gebiete ein und stellt Spezialisten bekannte Probleme aus einem neuen Blickwinkel vor. Informationen über die "European Journals" siehe: Editorial . Readers Chemists of all disciplines

  • Impact factor
    5.93
  • 5-year impact
    5.87
  • Cited half-life
    3.90
  • Immediacy index
    1.29
  • Eigenfactor
    0.17
  • Article influence
    1.53
  • Website
    Chemistry - A European Journal website
  • Other titles
    Chemistry (Weinheim an der Bergstrasse, Germany: Online), Chemistry, Angewandte Chemie (International ed. in English: Online), Angewandte Chemie (Weinheim an der Bergstrasse, Germany: Online), Chembiochem (Online), Chemphyschem (Online)
  • ISSN
    1521-3765
  • OCLC
    42084594
  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

John Wiley and Sons

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • See Wiley-Blackwell entry for articles after February 2007
    • On personal web site or secure external website at authors institution
    • Deposit in institutional repositories is not allowed
    • JASIST authors may deposit in an institutional repository
    • Non-commercial
    • Pre-print must be accompanied with set phrase (see individual journal copyright transfer agreements)
    • Published source must be acknowledged with set phrase (see individual journal copyright transfer agreements)
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • 'John Wiley and Sons' is an imprint of 'Wiley'
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The synthesis and photochemical study of novel nonsymmetrical 1,2-dithienylethenes (DTEs) with a maleimide bridge have been carried out. The synthetic approach to the DTEs was based on selective and successive palladium-catalyzed cross-coupling reactions of 5-susbtituted-2-methyl-3-thiophenyl indium reagents with a 3,4-dichloromaleimide. The required organoindium reagents were prepared from 2-methyl-3,5-dibromothiophene by a selective coupling reaction with other triorganoindium compounds (R3In) at C-5 and subsequent metal-halogen exchange. The coupling reactions usually gave good yields and have a high atom economy with substoichiometric amounts of R3In. The results of photochemical studies show that these novel dithienylmaleimides undergo a photocyclization reaction upon irradiation in the UV region and a photocycloreversion after excitation in the visible region, thus allowing their use as photochemical switches. On-off operations can be repeated in successive cycles without appreciable loss of effectiveness in the process.
    Chemistry - A European Journal 12/2015;
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    ABSTRACT: A photoreactive molecular dye targeting the G-quadruplex nucleic acid (G4) of the human telomeric sequence Tel22, and several mutated analogues, was activated by green light (λ=532 nm). Highly selective covalent modification of G4 versus single-stranded and double-stranded DNA was achieved with efficiency up to 64 %. The phenoxyl radical was generated and detected by laser-flash photolysis as a reactive intermediate that targeted loop thymine residues. These insights may suggest a non-invasive tool for selective nucleic acid tagging and “pull-down” cellular applications.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: The development of two-dimensional nanomaterials has expedited the growth of advanced technological applications. PbI2 is a layered inorganic solid with important and unique properties suitable for applications in the detection of electromagnetic radiation. While the optical and electrical properties of layered PbI2 have been generally established, its electrochemistry has remained largely unexplored. In this work, we examine the inherent electrochemistry of PbI2 in relation to its morphological and structural properties. A direct comparison between commercially available and solution-grown PbI2 showed high similarity in properties based on characterizations by X-ray photoelectron spectroscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The respective layered PbI2 materials also exhibited similar inherent electrochemistry. Electrochemical potential cycling of PbI2 in phosphate buffer resulted in the dissolution of iodide ions from PbI2 to form complex lead-phosphate-chloride with the oxygen groups of the phosphate ions while retaining the hexagonal structure. In the case of KCl solution, the formation of PbO2 was observed.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Selective enzyme-catalysed biotransformations offer great potential in organic chemistry. However, special requirements are needed to achieve optimum enzyme activity and stability. A bicontinuous microemulsion is proposed as reaction medium because of its large connected interface between oil and water domains at which a lipase can adsorb and convert substrates in the oil phase of the microemulsion. Herein, a microemulsion consisting of buffer–n-octane–nonionic surfactant CiEj was used to investigate the key factors that determine hydrolyses of p-nitrophenyl esters catalysed by the lipase B from Candida antarctica (CalB). The highest CalB activity was found around 44 °C in the absence of NaCl and substrates with larger alkyl chains were better hydrolysed than their short-chained homologues. The CalB activity was determined using two different co-surfactants, namely the phospholipid 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and the sugar surfactant decyl β-D-glucopyranoside (β-C10G1). The results show the CalB activity as linear function of both enzyme and substrate concentration with an enhanced activity when the sugar surfactant is used as co-surfactant.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Two novel cyclic azobenzenophanes (SC, RC) with functional handles have been synthesized efficiently by a Glaser coupling reaction. Through a Suzuki coupling reaction, alternating ring/linear polymers with rigid (conjugated)/flexible (unconjugated) bridges were obtained from the resultant cyclic azobenzenophanes. The optical activities of linear, cyclic, and macromolecular binaphethyl–azobenzene derivatives were investigated by UV/Vis and circular dichroism (CD) spectra and the time-dependent (TD)-DFT method. Experimental results and theoretical analyses indicated that the cyclic configurations exhibited better chiroptical features than the others, and the reverse conformation and difference of dextro-/levo-rotation of azobenzenophanes were detected by comparing linear and cyclic structures, which provides an opportunity for the optical-rotation-controlled “smart” materials systems in future.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: New stimuli-responsive nanomaterials, made up of host–guest lipidic cubic phases (LCPs) are presented. These biocompatible, stable, transparent and water-insoluble LCPs are composed of monoolein (MO) as a neutral host, and small amounts of one of three judiciously designed and synthesized designer lipids as guest that preserve the structure and stability of LCPs, but render them specific functionalities. Efficient pH- and light-induced binding, release and sequestration of hydrophilic dyes are demonstrated. Significantly, these processes can be performed sequentially, thereby achieving both temporal and dosage control, opening up the possibility of using such LCPs as effective carriers to be used in drug delivery applications. Specifically, because of the inherent optical transparency and molecular isotropy of LCPs they can be envisaged as light-induced drug carriers in ophthalmology. The results presented here demonstrate the potential of molecular design in creating new functional materials with predicted operating mode.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: There are only a few systematic rules about how to selectively control the formation of DNA-templated metal nanoparticles (NPs) by varying sequence combinations of double-stranded DNA (dsDNA), although many attempts have been made. Herein, we develop a facile method for sequence-dependent formation of fluorescent CuNPs by using dsDNA as templates. Compared with random sequences, AT sequences are better templates for highly fluorescent CuNPs. Other specific sequences, for example, GC sequences, do not induce the formation of CuNPs. These results shed light on directed DNA metallization in a sequence-specific manner. Significantly, both the fluorescence intensity and the fluorescence lifetime of CuNPs can be tuned by the length or the sequence of dsDNA. In order to demonstrate the promising practicality of our findings, a sensitive and label-free fluorescence nuclease assay is proposed.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Three stereoselective syntheses and the physicochemical properties of trans,trans-5-(4-ethoxy-2,3-difluorophenyl)-2-(4-propylcyclohexyl)tetrahydropyran, which is an important liquid-crystal compound with a large negative dielectric anisotropy (Δε=−7.3), are described. The key step in the construction of the trans-2,5-disubstituted tetrahydropyran ring in the first approach involved a benzylic cation mediated intramolecular olefin cyclization of a 2-allyloxy-1-arylethanol derivative. The second method included the Et2Zn-induced 1,2-aryl shift of a bromohydrin obtained from a hetero-Diels–Alder reaction, followed by stereoselective bromination. The third approach utilized the hetero-Diels–Alder reaction of trans-4-propylcyclohexanecarboxaldehyde and a 2-aryl-3-(trimethylsilyl)oxy-1,3-butadiene, followed by stereoselective protonation. From results obtained by using a quantum chemical calculation method, the reason why the target compound shows a large negative Δε value is discussed.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Even though the Dewar–Chatt–Duncanson model has been successfully used by chemists since the 1950s, no experimental methodology is yet known to unambiguously estimate the constituents (donation and back-donation) of a metal–ligand interaction. It is demonstrated here that one of these components, the metal-to-ligand π back-donation, can be effectively probed by NMR measurements aimed at determining the rotational barrier of a CN bond (ΔHr≠) of a nitrogen acyclic carbene ligand. A large series of gold(I) complexes have been synthesized and analyzed, and it was found that the above experimental observables show an accurate correlation with back-donation, as defined theoretically by the appropriate charge displacement originated upon bond formation. The proposed method is potentially of wide applicability for analyzing the ligand effect in metal catalysts and guiding their design.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Although the content of Mg2+ in hard tissues is very low (typically ≤1.5 wt %), its incorporation into synthetic hydroxyapatite (HAp) particles and its role in the mineral’s properties are still subject of intensive debate. A combined experimental–computational approach is used to answer many of the open questions. Mg2+-enriched HAp particles are prepared using different synthetic approaches and considering different concentrations of Mg2+ in the reaction medium. The composition, morphology and structure of the resulting particles are investigated using X-ray photoelectron spectroscopy, energy dispersive X-ray spectroscopy, scanning and transmission electron microscopies, FTIR, and wide-angle X-ray diffraction. After this scrutiny, the role of the Mg2+ in the first nucleation stages, before HAp formation, is investigated using atomistic molecular dynamics simulations. Saturated solutions are simulated with and without the presence of DNA, which has been recently used as a soft template in the biomineralization process. This synergistic investigation provides a complete picture of how Mg2+ ions affect the mineralization from the first stages onwards.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Two, symmetrical, mixed-valence (MV), complex cations—{[Mo2(DAniF)3]2(μ-oxamidate)}+ (1+) and {Mo2(DAniF)3]2(μ-dithiooxamidate)}+ (2+; DAniF=N,N′-di(p-anisyl)formamidinate)—are significantly differentiated in terms of electronic coupling between the two [Mo2] units. For 1+ the intervalence (IV) charge-transfer band in the near-IR spectrum is truncated in half on the low-energy side as predicted for MV compounds at the Class II–III limit (2Hab/λ=1; for which Hab=electronic coupling matrix element and λ=reorganization energy). In contrast, the very strongly coupled analogue 2+, as indicated by 2Hab/λ=3.5 (> >1), exhibits a higher energy and more symmetrical IV band. As rare examples, this pair of MV species shows distinct optical behaviors for MV systems crossing the Class III region. Optical analysis and DFT calculations are carried out to elucidate the transformation from vibronic to electronic vertical transition.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Taking inspiration from yeast alcohol dehydrogenase (yADH), a benzimidazolium (BI+) organic hydride-acceptor domain has been coupled with a 1,10-phenanthroline (phen) metal-binding domain to afford a novel multifunctional ligand (LBI+) with hydride-carrier capacity (LBI++H−⇌LBIH). Complexes of the type [Cp*M(LBI)Cl][PF6]2 (M=Rh, Ir) have been made and fully characterised by cyclic voltammetry, UV/Vis spectroelectrochemistry, and, for the IrIII congener, X-ray crystallography. [Cp*Rh(LBI)Cl][PF6]2 catalyses the transfer hydrogenation of imines by formate ion in very goods yield under conditions where the corresponding [Cp*Ir(LBI)Cl][PF6] and [Cp*M(phen)Cl][PF6] (M=Rh, Ir) complexes are almost inert as catalysts. Possible alternatives for the catalysis pathway are canvassed, and the free energies of intermediates and transition states determined by DFT calculations. The DFT study supports a mechanism involving formate-driven RhH formation (90 kJ mol−1 free-energy barrier), transfer of hydride between the Rh and BI+ centres to generate a tethered benzimidazoline (BIH) hydride donor, binding of imine substrate at Rh, back-transfer of hydride from the BIH organic hydride donor to the Rh-activated imine substrate (89 kJ mol−1 barrier), and exergonic protonation of the metal-bound amide by formic acid with release of amine product to close the catalytic cycle. Parallels with the mechanism of biological hydride transfer in yADH are discussed.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Metal–organic frameworks (MOFs) are among the most attractive porous materials available today. They have garnered much attention for their potential utility in many different areas such as gas storage, separation, catalysis, and biomedicine. However, very little is known about the possible health or environmental risks of these materials. Here, the results of toxicity studies on sixteen representative uncoated MOF nanoparticles (nanoMOFs), which were assessed for cytotoxicity to HepG2 and MCF7 cells in vitro, and for toxicity to zebrafish embryos in vivo, are reported. Interestingly, there is a strong correlation between their in vitro toxicity and their in vivo toxicity. NanoMOFs were ranked according to their respective in vivo toxicity (in terms of the amount and severity of phenotypic changes observed in the treated zebrafish embryos), which varied widely. Altogether these results show different levels of toxicity of these materials; however, leaching of solubilized metal ions plays a main role.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: A pH-responsive free-blockage release system was achieved through controlling the hydrophobic/hydrophilic conversion of mesoporous silica nanopores. This system further presented pulsatile release with changing pH values between 4.0 and 7.0 for several cycles. This free-blockage release system could also release antitumor agents to induce cell death after infecting tumor cells and could have the ability of continuous infection to tumor cells with high drug-delivery efficiency and few side effects.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: An enantioselective [3+2] cycloaddition of vinyl cyclopropane derived from 1,3-indanedione with nitroalkenes catalyzed by palladium(0) with a chiral bis(tert-amine) ligand was developed in high yields with good diastereoselectivities and excellent enantioselectivities. The resulting bis(tert-amine)–palladium complex proved to be a highly efficient catalyst for this cycloaddition.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Foldamers offer an attractive opportunity for the design of novel molecules that mimic the structures and functions of proteins and enzymes including biocatalysis and biomolecular recognition. Herein we report a new class of nonnatural helical sulfono-γ-AApeptide foldamers of varying lengths. The crystal structure of the sulfono-γ-AApeptide monomer S6 illustrates the intrinsic folding propensity of sulfono-γ-AApeptides, which likely originates from the bulkiness of tertiary sulfonamide moiety. The two-dimensional solution NMR spectroscopy data for the longest sequence S1 demonstrates a 10/16 right-handed helical structure. Optical analysis using circular dichroism further supports well- defined helical conformation of sulfono-γ-AApeptides in solution containing as few as five building blocks. Future development of sulfono-γ-AApeptides may lead to new foldamers with discrete functions, enabling expanded application in chemical biology and biomedical sciences.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: To improve the radical-trapping capacity of the natural antioxidants, alkylthio-, alkylseleno-, and alkyltelluro groups were introduced into all vacant aromatic positions in β-, γ- and δ-tocopherol. Reaction of the tocopherols with electrophilic chalcogen reagents generated by persulfate oxidation of dialkyl dichalcogenides provided convenient but low-yielding access to many sulfur and selenium derivatives, but failed in the case of tellurium. An approach based on lithiation of the appropriate bromo-tocopherol, insertion of chalcogen into the carbon-lithium bond, air-oxidation to a dichalcogenide, and final borohydride reduction/alkylation turned out to be generally applicable to the synthesis of all chalcogen derivatives. Whereas alkylthio- and alkylseleno analogues were generally poorer quenchers of lipid peroxyl radicals than the corresponding parents, all tellurium compounds showed a substantially improved radical-trapping activity. Introduction of alkyltelluro groups into the tocopherol scaffold also caused a dramatic increase in the regenerability of the antioxidant. In a two-phase lipid peroxidation system containing N-acetylcysteine as a water-soluble co-antioxidant the inhibition time was up to six-fold higher than that recorded for the natural antioxidants.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: A new series of neutral isocyanoborato rhenium(I) diimine complexes [Re(CO)3(N^N)(CNBR3)], where N^N=bpy, 4,4′-Me2bpy, phen, 4,7-Me2phen, 2,9-Me2phen, 3,4,7,8-Me4phen; R=C6F5, C6H5, Cl, 4-ClC6H4, 3,5-(CF3)2C6H3, with various isocyanoborate and diimine ligands of diverse electronic and steric nature have been synthesized and characterized. The X-ray crystal structures of six complexes have also been determined. These complexes displayed intense bluish green to yellow phosphorescence at room temperature in dichloromethane solution. The photophysical and electrochemical properties of these complexes had been investigated. To elucidate the electronic structures and transitions of these complexes, DFT and TD-DFT calculations have been performed, which revealed that the lowest-energy electronic transition associated with these complexes originates from a mixture of MLCT [dπ(Re)π*(N^N)] and LLCT [π(CNBR3)π*(N^N)] transitions.
    Chemistry - A European Journal 12/2014;
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    ABSTRACT: Facile growth of CuS nanowires through self-assembly and their application as building blocks for near-infrared light-responsive functional films have been demonstrated. It is found that DNA is a key factor in preparing the CuS material with defined nanostructure. An exclusive oriented self-aggregate growth mechanism is proposed for the growth of the nanowires, which might have important implications for preparing advanced, sophisticated nanostructures based on DNA nanotechnology. By employing the hydrophilic CuS nanowire as an optical absorber and thermosensitive nanogel as guest reservoir inside alginate film, a new platform for the release of functional molecules has been set up. In vitro studies have shown that the hybrid film possesses excellent biocompatibility and the release rate of chemical molecules from the film could be controlled with high spatial and temporal precision. Our novel approach and the resulting outstanding combination of properties may advance both the fields of DNA nanotechnology and light-responsive devices.
    Chemistry - A European Journal 12/2014;