Asian Pacific journal of cancer prevention: APJCP (ASIAN PAC J CANCER P)
Current impact factor: 1.50
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Asian Pacific Journal of Cancer Prevention: APJCP website
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Publications in this journal
Objectives: Cancer loci comprises of heterogeneous cell populations besides their diverse cellular secretions. Therefore disseminating cancer-specific or cancer-associated protein antigens from tissue lysates could only be marginally correct, if otherwise not validated against known standards. Methods: In this study, 2DE proteomic profiles were examined from lysates of 13 lung-adenocarcinoma tissue samples and matched against A549 proteome. A549 matched-cancer-specific hits were analyzed and characterized by MALDI-TOF/MS. Results: Comparative analysis of 2DE from tissue lysates against A549 proteome identified a total of 13 protein spots of differential expression. These proteins were found to be involved in critical cellular functions regulating pyrimidine metabolism, pentose phosphate pathway and integrin signaling. Gene ontology based analysis classified majority of protein hits responsible for metabolic processes. Among these, only single non-predictive protein spot was found to be a cancer cell specific hit, identified as Armadillo repeat-containing protein 8 (ARMC8). Pathway reconstruction studies showed that ARMC8 lies at the centre of cancer metabolic pathways Conclusion: The findings in this report are suggestive of regulatory roles of ARMC8 in control of proliferation and differentiation in lung cancers.
Asian Pacific journal of cancer prevention: APJCP 02/2016; 16. DOI:10.7314/APJCP.2015.16.xx
Asian Pacific journal of cancer prevention: APJCP 03/2015; 16(5):1945-1952.
Background: Early diagnosis of hepatocellular carcinoma (HCC) is the most important step in successful
treatment. However, it is usually rare due to the lack of a highly sensitive specific biomarker so that the HCC
is usually fatal within few months after diagnosis. The aim of this work was to study the role of plasma nuclear
factor kappa B (NF-ĸB) and serum peroxiredoxin 3 (PRDX3) as diagnostic biomarkers for early detection of
HCC in a high-risk population. Materials and Methods: Plasma nuclear factor kappa B level (NF-ĸB) and serum
peroxiredoxin 3 (PRDX3) levels were measured using enzyme linked immunosorbent assay (ELISA), in addition
to alpha-fetoprotein (AFP) in 72 cirrhotic patients, 64 patients with HCC and 29 healthy controls. Results:
NF-ĸB and PRDX3 were significantly elevated in the HCC group in relation to the others. Higher area under
curve (AUC) of 0.854 (for PRDX3) and 0.825 (for NF-ĸB) with sensitivity of 86.3% and 84.4% and specificity of
75.8% and 75.4% respectively, were found compared to AUC of alpha-fetoprotein (AFP) (0.65) with sensitivity
of 72.4% and specificity of 64.3%. Conclusions: NF-ĸB and PRDX3 may serve as early and sensitive biomarkers
for early detection of HCC facilitating improved management. The role of nuclear factor kappa B (NF-ĸB) as
a target for treatment of liver fibrosis and HCC must be widely evaluated.
Asian Pacific journal of cancer prevention: APJCP 03/2015; 16(4):1657-1663.
Asian Pacific journal of cancer prevention: APJCP 03/2015;
Associations of GSTT1, GSTM1 and CYP1A1 gene variants with risk of developing oral cancer were evaluated
in this study. A case-control study was conducted in Pashtun population of Khyber Pakhtunkhwa province of
Pakistan in which 200 hospital based oral cancer cases and 151 population based healthy controls exposed to
similar environmental conditions were included. Sociodemographic data were obtained and blood samples were
collected with informed consent for analysis. GSTM1 and GSTT1 were analysed through conventional PCR
method while specific RT-PCR method was used to detect CYP1A1 polymorphisms. Results were analyzed for
conditional logistic regression model by SPSS version 20. The study shows that patients with either GSTM1 or
GSTT1 null genotypes have significantly higher risk of oral cancer (adjusted odds (OR): (3.019 (1.861-4.898)
and 3.011(1.865-4.862), respectively), which further increased when either one or both null genes were present in
combination (adjusted odds (OR): (3.627 (1.981-6.642 and 9.261 (4.495-19.079), respectively). CYP1A1 rs4646903
gene variants individually showed weak association OR: 1.121 (0.717-1.752); however, in the presence of GSTM1
and/or GSTT1 null genotypes further increasing the association (adjusted odds (ORs): 4.576 (2.038-10.273), 5.593
(2.530-12.362) and 16.10 (3.854-67.260 for GSTM/GSTT null and CYP1A1 wild type, GSTM/GSTT either null
and CYP1A1 variant alleles, and all 3 gene polymorphisms combinations, respectively). Our findings suggest
that presence of GSTM1 and/or GSTT1 null genotypes along with variant alleles of CYP1A1 may be the risk
alleles for oral cancer susceptibility in Pashtun population.
Asian Pacific journal of cancer prevention: APJCP 03/2015; 16(3):1145-1150.
Asian Pacific journal of cancer prevention: APJCP 03/2015;
Breast cancer is the leading cause of morbidity and mortality globally but has an even more significant impact in developing countries. Pakistan has the highest prevalence among Asian countries. A general lack of public awareness regarding the disease often results in late diagnosis and poor treatment outcomes. The literacy rate of the Southern Punjab (Pakistan) is low compared to its Northern part. It is therefore vital that university students and especially medical students develop a sound knowledge about the disease so that they can spread awareness to others who may be less educated. This study therefore considers current knowledge and understanding about the early signs of breast cancer amongst a study group of medical and non-medical university students of the Southern Punjab, Pakistan. A cross-sectional descriptive analysis of the university students was carried out using a self-administered questionnaire to assess their awareness of breast cancer from March to May 2014. A total of 566 students participated in this study, out of which 326 were non-medical and 240 were from a medical discipline. Statistical analysis was carried out using Graph Pad Prism Version 5 with a significance level set at p<0.05. The mean age of the non medical and medical participants was 23 (SD 2.1) and 22 (SD 1.3) years, respectively. Less than 35% students were aware of the early warning signs of the breast cancer development. Knowledge of medical students about risk factors was significantly better than the non medical ones, but on the whole was insufficient. Our study indicated that knowledge regarding breast cancer was generally insufficient amongst the majority of the university students (75% non-medical and 55% medical) of Southern Punjab, Pakistan. This study highlights the need to formulate an awareness campaign and to organize conferences to promote breast cancer awareness among students in this region
Asian Pacific journal of cancer prevention: APJCP 03/2015; 16(3):979-84.
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