Nature reviews. Immunology (NAT REV IMMUNOL)

Publisher: Nature Publishing Group

Journal description

Current impact factor: 34.99

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 34.985
2013 Impact Factor 33.836
2012 Impact Factor 33.129
2011 Impact Factor 33.287
2010 Impact Factor 35.196
2009 Impact Factor 32.245
2008 Impact Factor 30.006
2007 Impact Factor 28.3
2006 Impact Factor 28.697
2005 Impact Factor 30.458
2004 Impact Factor 32.695
2003 Impact Factor 26.957
2002 Impact Factor 14.059

Impact factor over time

Impact factor

Additional details

5-year impact 37.32
Cited half-life 6.40
Immediacy index 5.78
Eigenfactor 0.10
Article influence 17.47
Website Nature Reviews Immunology website
Other titles Immunology
ISSN 1474-1733
OCLC 48623854
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Nature Publishing Group

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 6 months embargo
  • Conditions
    • Authors retain copyright
    • Author's pre-print on arXiv or bioRXiv
    • Author's post-print on author's personal website, institutional repository, PubMed Central or funding body's archive
    • Published source must be acknowledged
    • Must link to publisher version with DOI
    • Publisher's version/PDF cannot be used
  • Classification
    ​ yellow

Publications in this journal

  • Nature reviews. Immunology 09/2015; 15(10):599-614. DOI:10.1038/nri3901
  • Nature reviews. Immunology 07/2015; 15(8). DOI:10.1038/nri3888
  • [Show abstract] [Hide abstract]
    ABSTRACT: Improved treatments are needed for nearly all forms of Mycobacterium tuberculosis infection. Adjunctive host-directed therapies have the potential to shorten tuberculosis treatment duration, prevent resistance and reduce lung injury by promoting autophagy, antimicrobial peptide production and other macrophage effector mechanisms, as well as by modifying specific mechanisms that cause lung inflammation and matrix destruction. The range of candidates is broad, including several agents approved for other clinical indications that are ready for evaluation in Phase II clinical trials. The promise of new and existing host-directed therapies that could accelerate response and improve tuberculosis treatment outcomes is discussed in this Opinion article.
    Nature reviews. Immunology 03/2015; 15(4). DOI:10.1038/nri3813
  • Nature reviews. Immunology 03/2015; 15(4). DOI:10.1038/nri3835
  • Nature reviews. Immunology 03/2015; 15(4). DOI:10.1038/nri3833
  • Nature reviews. Immunology 03/2015; 15(4). DOI:10.1038/nri3832
  • [Show abstract] [Hide abstract]
    ABSTRACT: Antigenic peptide-loaded MHC class II molecules (peptide-MHC class II) are constitutively expressed on the surface of professional antigen-presenting cells (APCs), including dendritic cells, B cells, macrophages and thymic epithelial cells, and are presented to antigen-specific CD4(+) T cells. The mechanisms of antigen uptake, the nature of the antigen processing compartments and the lifetime of cell surface peptide-MHC class II complexes can vary depending on the type of APC. It is likely that these differences are important for the function of each distinct APC subset in the generation of effective adaptive immune responses. In this Review, we describe our current knowledge of the mechanisms of uptake and processing of antigens, the intracellular formation of peptide-MHC class II complexes, the intracellular trafficking of peptide-MHC class II complexes to the APC plasma membrane and their ultimate degradation.
    Nature reviews. Immunology 02/2015; 15(4). DOI:10.1038/nri3818
  • [Show abstract] [Hide abstract]
    ABSTRACT: Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity antibodies and are also the origin of most human B cell lymphomas. Recent progress has been made in identifying the functionally relevant stages of the GC and the complex trafficking mechanisms of B cells within the GC. These studies have identified transcription factors and signalling pathways that regulate distinct phases of GC development. Notably, these factors and pathways are hijacked during tumorigenesis, as revealed by analyses of the genetic lesions associated with various types of B cell lymphomas. This Review focuses on recent insights into the mechanisms that regulate GC development and that are relevant for human B cell lymphomagenesis.
    Nature reviews. Immunology 02/2015; 15(3):172-84. DOI:10.1038/nri3814
  • Nature reviews. Immunology 02/2015; 15(3). DOI:10.1038/nri3828
  • Nature reviews. Immunology 02/2015; 15(3). DOI:10.1038/nri3825
  • Nature reviews. Immunology 02/2015; 15(3). DOI:10.1038/nri3827
  • Nature reviews. Immunology 02/2015; 15(3). DOI:10.1038/nri3829
  • Nature reviews. Immunology 02/2015; 15(3). DOI:10.1038/nri3826
  • [Show abstract] [Hide abstract]
    ABSTRACT: The immune system can remember a previously experienced pathogen and can evoke an enhanced response to reinfection that depends on memory lymphocyte populations. Recent advances in tracking antigen-experienced memory B cells have revealed the existence of distinct classes of cells that have considerable functional differences. Some of these differences seem to be determined by the stimulation history during memory cell formation. To induce rapid recall antibody responses, the contributions of other types of cells, such as memory T follicular helper cells, have also now begun to be appreciated. In this Review, we discuss these and other recent advances in our understanding of memory B cells, focusing on the underlying mechanisms that are required for rapid and effective recall antibody responses.
    Nature reviews. Immunology 02/2015; 15(3). DOI:10.1038/nri3802
  • [Show abstract] [Hide abstract]
    ABSTRACT: In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4(+) T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (TFH) cells, which are the specialized providers of help to B cells.
    Nature reviews. Immunology 02/2015; 15(3). DOI:10.1038/nri3803
  • Nature reviews. Immunology 02/2015; 15(3). DOI:10.1038/nri3822