Angewandte Chemie International Edition (ANGEW CHEM INT EDIT )

Publisher: Gesellschaft Deutscher Chemiker, John Wiley & Sons

Description

Angewandte Chemie is one of the prime chemistry journals in the world with an ISI-measured Impact Factor higher than those of comparable journals (1999: 7.996). Moreover it is the only journal in the field to have a stimulating mixture of review articles highlights and short communications. The "reviews" written by leading experts summarize the important results of recent research on topical subjects in all branches of chemistry point to unresolved problems and discuss possible developments. The "highlights" provide concise evaluations of current trends in chemical research. The communications are critically selected and report on the latest research results making the journal indispensable to the chemist who wants to stay well informed. Angewandte Chemie also regularly publishes Nobel lectures in chemistry and related fields. Kurztext Auch die internationale Ausgabe der Angewandten Chemie zählt zu den führenden bedeutenden Chemiezeitschrifent weltweit. Chemiker wissen daß sie hier das Neueste aus der Chemie bestens aufbereitet vorfinden. Society Affiliation German Chemical Society ( Gesellschaft Deutscher Chemiker ) Readers Chemists of all disciplines

  • Impact factor
    11.34
    Show impact factor history
     
    Impact factor
  • 5-year impact
    13.56
  • Cited half-life
    5.50
  • Immediacy index
    2.96
  • Eigenfactor
    0.54
  • Article influence
    3.50
  • Website
    Angewandte Chemie International Edition website
  • Other titles
    Angewandte Chemie (International ed. in English), Angewandte Chemie. International edition in English, Angewandte Chemie international edition,, Advanced materials (Deerfield Beach, Fla.), Chembiochem., Chemphyschem
  • ISSN
    1433-7851
  • OCLC
    1481137
  • Material type
    Periodical, Internet resource
  • Document type
    Journal / Magazine / Newspaper, Internet Resource

Publisher details

John Wiley & Sons

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • See Wiley-Blackwell entry for articles after February 2007
    • On personal web site or secure external website at authors institution
    • Not allowed on institutional repository
    • JASIST authors may deposit in an institutional repository
    • Non-commercial
    • Pre-print must be accompanied with set phrase (see individual journal copyright transfer agreements)
    • Published source must be acknowledged with set phrase (see individual journal copyright transfer agreements)
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • 'John Wiley and Sons' is an imprint of 'Wiley-Blackwell'
  • Classification
    ​ green

Publications in this journal

  • Quan Chen, Thierry León, Paul Knochel
    [Show abstract] [Hide abstract]
    ABSTRACT: We report a BF3‐mediated direct alkynylation of pyridines at C(2) by using a variety of alkynyllithium reagents (oxidative cross‐coupling). Moreover, we have developed a novel transition‐metal‐free cross‐coupling method between alkylmagnesium reagents and 4‐substituted pyridines, such as isonicotinonitrile and 4‐chloropyridine, by employing BF3⋅OEt2 as a promoter. The combination of these methods enabled us to efficiently prepare a range of di‐, tri‐, and tetrasubstituted pyridines. Oxidative or non‐oxidative—That is the question! Pyridines bearing a substituent at position 4 readily undergo a BF3‐mediated oxidative coupling at position 2 with a wide range of alkynyllithium compounds. In contrast, 4‐cyano‐ or 4‐chloropyridines undergo a novel BF3‐mediated cross‐coupling at position 4 with alkylmagnesium reagents. The combination of the two transition‐metal‐free procedures allows the preparation of a broad range of pyridines.
    Angewandte Chemie International Edition 08/2014; 53(33).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Nitidasin is a pentacyclic sesterterpenoid with a rare 5‐8‐6‐5 carbon skeleton that was isolated from the Peruvian folk medicine “Hercampuri”. It belongs to a small class of sesterterpenoids that feature an isopropyl trans‐hydrindane moiety fused to a variety of other ring systems. As a first installment of our general approach toward these natural products, we report the total synthesis of the title compound. Our stereoselective, convergent route involves the addition of a complex alkenyl lithium compound to a trans‐hydrindanone, followed by chemoselective epoxidation, ring‐closing olefin metathesis, and redox adjustment. Put a ring on it: The first total synthesis of nitidasin, a complex sesterterpenoid with a 5‐8‐6‐5 skeleton, is reported. It involves the addition of a tetrasubstituted alkenyl lithium compound to a trans‐hydrindanone and an olefin metathesis to form a highly substituted eight‐membered ring at an unexpected site. The absolute configuration of nitidasin was established with our highly stereoselective and convergent synthesis.
    Angewandte Chemie International Edition 08/2014; 53(32).
  • [Show abstract] [Hide abstract]
    ABSTRACT: The CAAC [CAAC=cyclic (alkyl)(amino)carbene] family of carbene ligands have shown promise in stabilizing unusually low‐coordination number transition‐metal complexes in low formal oxidation states. Here we extend this narrative by demonstrating their utility in affording access to the first examples of two‐coordinate formal Fe0 and Co0 [(CAAC)2M] complexes, prepared by reduction of their corresponding two‐coordinate cationic FeI and CoI precursors. The stability of these species arises from the strong σ‐donating and π‐accepting properties of the supporting CAAC ligands, in addition to steric protection. A delightfully lack of coordination: The CAAC [CAAC=cyclic (alkyl)(amino)carbene] family of carbene ligands allow access to the first examples of two‐coordinate formal Fe0 and Co0 [M(CAAC)2] complexes. These compounds are prepared by reduction of their corresponding two‐coordinate cationic FeI and CoI precursors. Their stability arises from the strong σ‐donating and π‐accepting properties of the supporting CAAC ligands, as well as steric protection.
    Angewandte Chemie International Edition 08/2014; 53(32).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Overhauser–DNP‐enhanced homonuclear 2D 19F correlation spectroscopy with diagonal suppression is presented for small molecules in the solution state at moderate fields. Multi‐frequency, multi‐radical studies demonstrate that these relatively low‐field experiments may be operated with sensitivity rivalling that of standard 200–1000 MHz NMR spectroscopy. Structural information is accessible without a sensitivity penalty, and diagonal suppressed 2D NMR correlations emerge despite the general lack of multiplet resolution in the 1D ODNP spectra. This powerful general approach avoids the rather stiff excitation, detection, and other special requirements of high‐field 19F NMR spectroscopy. Overhauser–DNP‐enhanced homonuclear 2D 19F correlation spectroscopy with diagonal suppression is presented for small molecules in solution at moderate fields (13.5–135 MHz; DNP=dynamic nuclear polarization). At these relatively low fields, structural information is nevertheless accessible without a sensitivity penalty. This powerful general approach avoids the special requirements of high‐field 19F NMR spectroscopy.
    Angewandte Chemie International Edition 08/2014; 53(32).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Simon & Schuster, New York, 2014. 448 pp., hardcover, $ 30.00.—ISBN 978‐1451655667
    Angewandte Chemie International Edition 08/2014; 53(32).
  • [Show abstract] [Hide abstract]
    ABSTRACT: In press
    Angewandte Chemie International Edition 08/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: The first demonstration of the hydrogenation of sulfoxides under atmospheric H2 pressure is reported. The highly efficient reaction is facilitated by a heterogeneous Ru nanoparticle catalyst. The mild reaction conditions enable the selective hydrogenation of a wide range of functionalized sulfoxides to the corresponding sulfides. The high redox ability of RuOx nanoparticles plays a key role in the hydrogenation. Ru nanoparticles supported on TiO2 promote the selective hydrogenation of various functionalized sulfoxides at atmospheric H2 pressure. The corresponding sulfides are obtained in excellent yields. The redox ability of Ru nanoparticles plays a crucial role in this hydrogenation reaction.
    Angewandte Chemie International Edition 08/2014; 53(32).
  • [Show abstract] [Hide abstract]
    ABSTRACT: While single-molecule sensing offers the ultimate detection limit, its throughput is often restricted as sensing events are carried out one at a time in most cases. 2D and 3D DNA origami nanostructures are used as expanded single-molecule platforms in a new mechanochemical sensing strategy. As a proof of concept, six sensing probes are incorporated in a 7-tile DNA origami nanoassembly, wherein binding of a target molecule to any of these probes leads to mechanochemical rearrangement of the origami nanostructure, which is monitored in real time by optical tweezers. Using these platforms, 10 pM platelet-derived growth factor (PDGF) are detected within 10 minutes, while demonstrating multiplex sensing of the PDGF and a target DNA in the same solution. By tapping into the rapid development of versatile DNA origami nanostructures, this mechanochemical platform is anticipated to offer a long sought solution for single-molecule sensing with improved throughput.
    Angewandte Chemie International Edition 05/2014; 53(31):8137-8141.
  • [Show abstract] [Hide abstract]
    ABSTRACT: We developed a novel method to design various helical tubular structures using the DNA origami method. The size-controlled tubular structures which have 192, 256, and 320 base pairs for one turn of the tube were designed and prepared. We observed the formation of the expected short tubes and unexpected long ones. Detailed analyses of the surface patterns of the tubes showed that the short tubes had mainly a lefthanded helical structure. The long tubes mainly formed a righthanded helical structure and extended to the directions of the double helical axes as structural isomers of the short tubes. The folding pathways of the tubes were estimated by analyzing the proportions of short and long tubes obtained at different annealing conditions. Depending on the number of base pairs involved in one turn of the tube, the population of left-/righthanded and short/long tubes changed. The bending stress caused by the stiffness of the bundled double helices and the non-natural helical pitch determine the structural variety of the tubes.
    Angewandte Chemie International Edition 05/2014; 53(29):7484-7490.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Thiamine diphosphate dependent enzymes are well known for catalyzing the asymmetric synthesis of chiral α-hydroxy ketones from simple prochiral substrates. The steric and chemical properties of the enzyme active site define the product spectrum. Enzymes catalyzing the carboligation of aromatic aldehydes to (S)-benzoins have not so far been identified. We were able to close this gap by constructing a chimeric enzyme, which catalyzes the synthesis of various (S)-benzoins with excellent enantiomeric excess (>99 %) and very good conversion.
    Angewandte Chemie International Edition 05/2014; accepted.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Graphitic carbon nitride has been predicted to be structurally analogous to carbon-only graphite, yet with an inherent bandgap. We have grown, for the first time, macroscopically large crystalline thin films of triazine-based, graphitic carbon nitride (TGCN) using an ionothermal, interfacial reaction starting with the abundant monomer dicyandiamide. The films consist of stacked, two-dimensional (2D) crystals between a few and several hundreds of atomic layers in thickness. Scanning force and transmission electron microscopy show long-range, in-plane order, while optical spectroscopy, X-ray photoelectron spectroscopy, and density functional theory calculations corroborate a direct bandgap between 1.6 and 2.0 eV. Thus TGCN is of interest for electronic devices, such as field-effect transistors and light-emitting diodes.
    Angewandte Chemie International Edition 05/2014; 53:7450-7455.
  • [Show abstract] [Hide abstract]
    ABSTRACT: In regard to earth‐abundant cobalt water oxidation catalysts, very recent findings show the reorganization of the materials to amorphous active phases under catalytic conditions. To further understand this concept, a unique cobalt‐substituted crystalline zinc oxide (Co:ZnO) precatalyst has been synthesized by low‐temperature solvolysis of molecular heterobimetallic Co4−x Znx O4 (x=1–3) precursors in benzylamine. Its electrophoretic deposition onto fluorinated tin oxide electrodes leads after oxidative conditioning to an amorphous self‐supported water‐oxidation electrocatalyst, which was observed by HR‐TEM on FIB lamellas of the EPD layers. The Co‐rich hydroxide‐oxidic electrocatalyst performs at very low overpotentials (512 mV at pH 7; 330 mV at pH 12), while chronoamperometry shows a stable catalytic current over several hours. To be self‐made: A cobalt‐substituted zinc oxide (Co:ZnO) precatalyst was synthesized by low‐temperature solvolysis of molecular heterobimetallic Co4−x Znx O4 (x=1–3) precursors. Electrophoretic deposition onto fluorinated tin oxide (FTO) electrodes leads, after oxidative conditioning, to an amorphous self‐supported water‐oxidation electrocatalyst that performs at very low overpotentials and with high current density for several hours.
    Angewandte Chemie International Edition 05/2014; 53(20).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Probing interactions of biological systems at the molecular level is of great importance to fundamental biology, diagnosis, and drug discovery. A rational bioassay design of lithographically integrating individual point scattering sites into electrical circuits is capable of realizing real‐time, label‐free biodetection of influenza H1N1 viruses with single‐molecule sensitivity and high selectivity by using silicon nanowires as local reporters in combination with microfluidics. This nanocircuit‐based architecture is complementary to more conventional optical techniques, but has the advantages of no bleaching problems and no fluorescent labeling. These advantages offer a promising platform for exploring dynamics of stochastic processes in biological systems and gaining information from genomics to proteomics to improve accurate molecular and even point‐of‐care clinical diagnosis. A bioassay design involving lithographically integrating point scattering sites into electrical circuits is capable of realizing real‐time, label‐free biodetection of H1N1 viruses with single‐molecule sensitivity and high selectivity by using Si nanowires as local reporters in combination with microfluidics. This architecture is complementary to conventional optical techniques but has the advantages of no bleaching or fluorescent labeling.
    Angewandte Chemie International Edition 05/2014; 53(20).
  • [Show abstract] [Hide abstract]
    ABSTRACT: Low extracellular electron transfer performance is often a bottleneck in developing high-performance bioelectrochemical systems. Herein, we show that the self-assembly of graphene oxide and Shewanella oneidensis MR-1 formed an electroactive, reduced-graphene-oxide-hybridized, three-dimensional macroporous biofilm, which enabled highly efficient bidirectional electron transfers between Shewanella and electrodes owing to high biomass incorporation and enhanced direct contact-based extracellular electron transfer. This 3D electroactive biofilm delivered a 25-fold increase in the outward current (oxidation current, electron flux from bacteria to electrodes) and 74-fold increase in the inward current (reduction current, electron flux from electrodes to bacteria) over that of the naturally occurring biofilms.
    Angewandte Chemie International Edition 03/2014; 53:4480-4483.

Related Journals