Angewandte Chemie International Edition (ANGEW CHEM INT EDIT )

Publisher: Gesellschaft Deutscher Chemiker, Wiley-VCH Verlag

Description

Angewandte Chemie is one of the prime chemistry journals in the world with an ISI-measured Impact Factor higher than those of comparable journals (1999: 7.996). Moreover it is the only journal in the field to have a stimulating mixture of review articles highlights and short communications. The "reviews" written by leading experts summarize the important results of recent research on topical subjects in all branches of chemistry point to unresolved problems and discuss possible developments. The "highlights" provide concise evaluations of current trends in chemical research. The communications are critically selected and report on the latest research results making the journal indispensable to the chemist who wants to stay well informed. Angewandte Chemie also regularly publishes Nobel lectures in chemistry and related fields. Kurztext Auch die internationale Ausgabe der Angewandten Chemie zählt zu den führenden bedeutenden Chemiezeitschrifent weltweit. Chemiker wissen daß sie hier das Neueste aus der Chemie bestens aufbereitet vorfinden. Society Affiliation German Chemical Society ( Gesellschaft Deutscher Chemiker ) Readers Chemists of all disciplines

  • Impact factor
    11.34
    Show impact factor history
     
    Impact factor
  • 5-year impact
    13.56
  • Cited half-life
    5.50
  • Immediacy index
    2.96
  • Eigenfactor
    0.54
  • Article influence
    3.50
  • Website
    Angewandte Chemie International Edition website
  • Other titles
    Angewandte Chemie (International ed. in English), Angewandte Chemie. International edition in English, Angewandte Chemie international edition,, Advanced materials (Deerfield Beach, Fla.), Chembiochem., Chemphyschem
  • ISSN
    1433-7851
  • OCLC
    1481137
  • Material type
    Periodical, Internet resource
  • Document type
    Journal / Magazine / Newspaper, Internet Resource

Publisher details

Wiley-VCH Verlag

  • Pre-print
    • Author cannot archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • Upon funder agreement with publisher
  • Conditions
    • Pre-print may be deposited on personal intranet or institutional intranet repository, but not on a public repository
    • Pre-print must not updates with future versions
    • Published source must be acknowledged with set phrases (See policy)
    • Must link to publisher's site: http://www.interscience.wiley.com/
    • Publisher's version/PDF cannot be used
    • Some journal exceptions-check individual homepages
  • Classification
    ​ white

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.
    Angewandte Chemie International Edition 10/2014;
  • Angewandte Chemie International Edition 10/2014; 53(41).
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    ABSTRACT: The easy and effective separation of proteins from a mixture is crucial in proteomics. A supramolecular method is described to selectively capture and precipitate one protein from a protein mixture upon application of a magnetic field. A multivalent complex self-assembles in a dilute aqueous solution of three components: magnetic nanoparticles capped with cyclodextrin, non-covalent cross-linkers with an adamantane and a carbohydrate moiety, and lectins. The self-assembled ternary complex is precipitated in a magnetic field and readily redispersed with the aid of a non-ionic surfactant and competitive binding agents. This strategy to purify proteins by supramolecular magnetic precipitation is highly selective and efficient.
    Angewandte Chemie International Edition 09/2014;
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    ABSTRACT: Luminescent europium complexes are used in a broad range of applications as a result of their particular emissive properties. The synthesis and application of bright, highly water-soluble, and negatively charged sulfonic- or carboxylic acid derivatives of para-substituted aryl–alkynyl triazacyclononane complexes are described. Introduction of the charged solubilizing moieties suppresses cellular uptake or adsorption to living cells making them applicable for labeling and performing assays on membrane receptors. These europium complexes are applied to monitor fluorescent ligand binding on cell-surface proteins with time-resolved Förster resonance energy transfer (TR-FRET) assays in plate-based format and using TR-FRET microscopy.
    Angewandte Chemie International Edition 08/2014;
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    ABSTRACT: The first demonstration of the hydrogenation of sulfoxides under atmospheric H2 pressure is reported. The highly efficient reaction is facilitated by a heterogeneous Ru nanoparticle catalyst. The mild reaction conditions enable the selective hydrogenation of a wide range of functionalized sulfoxides to the corresponding sulfides. The high redox ability of RuOx nanoparticles plays a key role in the hydrogenation. Ru nanoparticles supported on TiO2 promote the selective hydrogenation of various functionalized sulfoxides at atmospheric H2 pressure. The corresponding sulfides are obtained in excellent yields. The redox ability of Ru nanoparticles plays a crucial role in this hydrogenation reaction.
    Angewandte Chemie International Edition 08/2014; 53(32).
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    ABSTRACT: The CAAC [CAAC=cyclic (alkyl)(amino)carbene] family of carbene ligands have shown promise in stabilizing unusually low‐coordination number transition‐metal complexes in low formal oxidation states. Here we extend this narrative by demonstrating their utility in affording access to the first examples of two‐coordinate formal Fe0 and Co0 [(CAAC)2M] complexes, prepared by reduction of their corresponding two‐coordinate cationic FeI and CoI precursors. The stability of these species arises from the strong σ‐donating and π‐accepting properties of the supporting CAAC ligands, in addition to steric protection. A delightfully lack of coordination: The CAAC [CAAC=cyclic (alkyl)(amino)carbene] family of carbene ligands allow access to the first examples of two‐coordinate formal Fe0 and Co0 [M(CAAC)2] complexes. These compounds are prepared by reduction of their corresponding two‐coordinate cationic FeI and CoI precursors. Their stability arises from the strong σ‐donating and π‐accepting properties of the supporting CAAC ligands, as well as steric protection.
    Angewandte Chemie International Edition 08/2014; 53(32).
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    ABSTRACT: While single-molecule sensing offers the ultimate detection limit, its throughput is often restricted as sensing events are carried out one at a time in most cases. 2D and 3D DNA origami nanostructures are used as expanded single-molecule platforms in a new mechanochemical sensing strategy. As a proof of concept, six sensing probes are incorporated in a 7-tile DNA origami nanoassembly, wherein binding of a target molecule to any of these probes leads to mechanochemical rearrangement of the origami nanostructure, which is monitored in real time by optical tweezers. Using these platforms, 10 pM platelet-derived growth factor (PDGF) are detected within 10 minutes, while demonstrating multiplex sensing of the PDGF and a target DNA in the same solution. By tapping into the rapid development of versatile DNA origami nanostructures, this mechanochemical platform is anticipated to offer a long sought solution for single-molecule sensing with improved throughput.
    Angewandte Chemie International Edition 05/2014; 53(31):8137-8141.
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    ABSTRACT: We developed a novel method to design various helical tubular structures using the DNA origami method. The size-controlled tubular structures which have 192, 256, and 320 base pairs for one turn of the tube were designed and prepared. We observed the formation of the expected short tubes and unexpected long ones. Detailed analyses of the surface patterns of the tubes showed that the short tubes had mainly a lefthanded helical structure. The long tubes mainly formed a righthanded helical structure and extended to the directions of the double helical axes as structural isomers of the short tubes. The folding pathways of the tubes were estimated by analyzing the proportions of short and long tubes obtained at different annealing conditions. Depending on the number of base pairs involved in one turn of the tube, the population of left-/righthanded and short/long tubes changed. The bending stress caused by the stiffness of the bundled double helices and the non-natural helical pitch determine the structural variety of the tubes.
    Angewandte Chemie International Edition 05/2014; 53(29):7484-7490.
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    ABSTRACT: Thiamine diphosphate dependent enzymes are well known for catalyzing the asymmetric synthesis of chiral α-hydroxy ketones from simple prochiral substrates. The steric and chemical properties of the enzyme active site define the product spectrum. Enzymes catalyzing the carboligation of aromatic aldehydes to (S)-benzoins have not so far been identified. We were able to close this gap by constructing a chimeric enzyme, which catalyzes the synthesis of various (S)-benzoins with excellent enantiomeric excess (>99 %) and very good conversion.
    Angewandte Chemie International Edition 05/2014; accepted.
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    ABSTRACT: Graphitic carbon nitride has been predicted to be structurally analogous to carbon-only graphite, yet with an inherent bandgap. We have grown, for the first time, macroscopically large crystalline thin films of triazine-based, graphitic carbon nitride (TGCN) using an ionothermal, interfacial reaction starting with the abundant monomer dicyandiamide. The films consist of stacked, two-dimensional (2D) crystals between a few and several hundreds of atomic layers in thickness. Scanning force and transmission electron microscopy show long-range, in-plane order, while optical spectroscopy, X-ray photoelectron spectroscopy, and density functional theory calculations corroborate a direct bandgap between 1.6 and 2.0 eV. Thus TGCN is of interest for electronic devices, such as field-effect transistors and light-emitting diodes.
    Angewandte Chemie International Edition 05/2014; 53:7450-7455.
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    ABSTRACT: In regard to earth‐abundant cobalt water oxidation catalysts, very recent findings show the reorganization of the materials to amorphous active phases under catalytic conditions. To further understand this concept, a unique cobalt‐substituted crystalline zinc oxide (Co:ZnO) precatalyst has been synthesized by low‐temperature solvolysis of molecular heterobimetallic Co4−x Znx O4 (x=1–3) precursors in benzylamine. Its electrophoretic deposition onto fluorinated tin oxide electrodes leads after oxidative conditioning to an amorphous self‐supported water‐oxidation electrocatalyst, which was observed by HR‐TEM on FIB lamellas of the EPD layers. The Co‐rich hydroxide‐oxidic electrocatalyst performs at very low overpotentials (512 mV at pH 7; 330 mV at pH 12), while chronoamperometry shows a stable catalytic current over several hours. To be self‐made: A cobalt‐substituted zinc oxide (Co:ZnO) precatalyst was synthesized by low‐temperature solvolysis of molecular heterobimetallic Co4−x Znx O4 (x=1–3) precursors. Electrophoretic deposition onto fluorinated tin oxide (FTO) electrodes leads, after oxidative conditioning, to an amorphous self‐supported water‐oxidation electrocatalyst that performs at very low overpotentials and with high current density for several hours.
    Angewandte Chemie International Edition 05/2014; 53(20).
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    ABSTRACT: Probing interactions of biological systems at the molecular level is of great importance to fundamental biology, diagnosis, and drug discovery. A rational bioassay design of lithographically integrating individual point scattering sites into electrical circuits is capable of realizing real‐time, label‐free biodetection of influenza H1N1 viruses with single‐molecule sensitivity and high selectivity by using silicon nanowires as local reporters in combination with microfluidics. This nanocircuit‐based architecture is complementary to more conventional optical techniques, but has the advantages of no bleaching problems and no fluorescent labeling. These advantages offer a promising platform for exploring dynamics of stochastic processes in biological systems and gaining information from genomics to proteomics to improve accurate molecular and even point‐of‐care clinical diagnosis. A bioassay design involving lithographically integrating point scattering sites into electrical circuits is capable of realizing real‐time, label‐free biodetection of H1N1 viruses with single‐molecule sensitivity and high selectivity by using Si nanowires as local reporters in combination with microfluidics. This architecture is complementary to conventional optical techniques but has the advantages of no bleaching or fluorescent labeling.
    Angewandte Chemie International Edition 05/2014; 53(20).