Angewandte Chemie International Edition Journal Impact Factor & Information

Publisher: Gesellschaft Deutscher Chemiker, Wiley-VCH Verlag

Journal description

Angewandte Chemie is one of the prime chemistry journals in the world with an ISI-measured Impact Factor higher than those of comparable journals (1999: 7.996). Moreover it is the only journal in the field to have a stimulating mixture of review articles highlights and short communications. The "reviews" written by leading experts summarize the important results of recent research on topical subjects in all branches of chemistry point to unresolved problems and discuss possible developments. The "highlights" provide concise evaluations of current trends in chemical research. The communications are critically selected and report on the latest research results making the journal indispensable to the chemist who wants to stay well informed. Angewandte Chemie also regularly publishes Nobel lectures in chemistry and related fields. Kurztext Auch die internationale Ausgabe der Angewandten Chemie zählt zu den führenden bedeutenden Chemiezeitschrifent weltweit. Chemiker wissen daß sie hier das Neueste aus der Chemie bestens aufbereitet vorfinden. Society Affiliation German Chemical Society ( Gesellschaft Deutscher Chemiker ) Readers Chemists of all disciplines

Current impact factor: 11.26

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 11.261
2013 Impact Factor 11.336
2012 Impact Factor 13.734
2011 Impact Factor 13.455
2010 Impact Factor 12.73
2009 Impact Factor 11.829
2008 Impact Factor 10.879
2007 Impact Factor 10.031
2006 Impact Factor 10.232
2005 Impact Factor 9.596
2004 Impact Factor 9.161
2003 Impact Factor 8.427
2002 Impact Factor 7.671
2001 Impact Factor 8.255
2000 Impact Factor 8.547
1999 Impact Factor 7.996
1998 Impact Factor 8.029
1997 Impact Factor 8.56
1996 Impact Factor 8.184
1995 Impact Factor 6.983
1994 Impact Factor 6.327
1993 Impact Factor 6.168
1992 Impact Factor 5.974

Impact factor over time

Impact factor

Additional details

5-year impact 12.06
Cited half-life 5.80
Immediacy index 2.61
Eigenfactor 0.53
Article influence 3.39
Website Angewandte Chemie International Edition website
Other titles Angewandte Chemie (International ed. in English), Angewandte Chemie. International edition in English, Angewandte Chemie international edition,, Advanced materials (Deerfield Beach, Fla.), Chembiochem., Chemphyschem
ISSN 1433-7851
OCLC 1481137
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Wiley-VCH Verlag

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  • Post-print
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  • Restrictions
    • Upon funder agreement with publisher
  • Conditions
    • Pre-print may be deposited on personal intranet or institutional intranet repository, but not on a public repository
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    • Publisher's version/PDF cannot be used
    • Some journal exceptions-check individual homepages
  • Classification
    ​ white

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Developing a material that can combat antibioticresistant bacteria is an urgent requirement to the global fight against a major health threat. To tackle this challenge, we synthesized a multifunctional subphthalocyanine (SubPc) polymer nanosphere that has the ability to target, label, and photoinactivate antibiotic-resistant bacteria in a single treatment with more than 99% efficiency even with a dose as low as 4.2 J/cm2 and a loading concentration of 10 nM. The positively charged nanosphere shell composed of covalently-linked SubPc units can increase the local concentration of photosensitizers at therapeutic sites. The nanosphere shows superior performance compared to corresponding monomers presumably due to their enhanced water-dispersbility, higher singlet oxygen generation efficiency and phototoxicity. In addition, this material is useful in fluorescence labeling of living cells and shows promise in in vivo photoacoustic imaging of bacteria.
    Angewandte Chemie International Edition 10/2015; DOI:10.1002/anie.201507140R1
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    ABSTRACT: Recognition of chemical modifications in canonical nucleobases of nucleic acids is of key importance since such modified variants act as different genetic encoders, introducing variability in the biological information contained in DNA. Herein, we demonstrate the feasibility of direct SERS in combination with chemometrics and microfluidics for the identification and relative quantification of 4 different cytosine modifications in both single- and double-stranded DNA. The minute amount of DNA required per measurement, in the sub-nanogram regime, removes the necessity of pre-amplification or enrichment steps (which are also potential sources of artificial DNA damages). These findings show great potentials for the development of fast, low-cost and high-throughput screening analytical devices capable of detecting known and unknown modifications in nucleic acids (DNA and RNA) opening new windows of activity in several fields such as biology, medicine and forensic sciences.
    Angewandte Chemie International Edition 10/2015; DOI:10.1002/anie.201507682
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    ABSTRACT: A novel chemoenzymatic approach for simple and fast site-specific protein labeling is reported. Recombinant tubulin tyrosine ligase (TTL) was repurposed to attach various unnatural tyrosine derivatives as small bioorthogonal handles to proteins containing a short tubulin-derived recognition sequence (Tub-tag). This novel strategy enables a broad range of high-yielding and fast chemoselective C-terminal protein modifications on isolated proteins or in cell lysates for applications in biochemistry, cell biology, and beyond, as demonstrated by the site-specific labeling of nanobodies, GFP, and ubiquitin.
    Angewandte Chemie International Edition 09/2015; DOI:10.1002/anie.201505456
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    ABSTRACT: Although the deleterious effects of ozone on the human respiratory system are well-known, many of the precise chemical mechanisms that both cause damage and afford protection in the pulmonary epithelial lining fluid are poorly understood. As a key first step to elucidating the intrinsic reactivity of ozone with proteins, its reactions with deprotonated cysteine [Cys−H]− are examined in the gas phase. Reaction proceeds at near the collision limit to give a rich set of products including 1) sequential oxygen atom abstraction reactions to yield cysteine sulfenate, sulfinate and sulfonate anions, and significantly 2) sulfenate radical anions formed by ejection of a hydroperoxy radical. The free-radical pathway occurs only when both thiol and carboxylate moieties are available, implicating electron-transfer as a key step in this reaction. This novel and facile reaction is also observed in small cys-containing peptides indicating a possible role for this chemistry in protein ozonolysis.
    Angewandte Chemie International Edition 09/2015; DOI:10.1002/anie.201506019
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    ABSTRACT: Despite the unique chemical properties of selenocysteine (Sec), ligation at Sec is an under-utilized methodology for protein synthesis. We describe herein an unprecedented protocol for the conversion of Sec to serine (Ser) in a single, high-yielding step. When coupled with ligation at Sec, this transformation provides a new approach to programmed ligations at Ser residues. This new reaction is compatible with a wide range of functionality, including the presence of unprotected amino acid side chains and appended glycans. The utility of the methodology is demonstrated in the rapid synthesis of complex glycopeptide fragments of the epithelial glycoproteins MUC5AC and MUC4 and through the total synthesis of the structured, cysteine (Cys)-free protein eglin C.
    Angewandte Chemie International Edition 09/2015; DOI:10.1002/anie.201504639R1
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    ABSTRACT: The synthesis of polynuclear clusters with control over size and cluster geometry remains an unsolved challenge. Herein, we report the synthesis and characterization of open-shell octairon clusters supported by two heptaamine ligands [o-H2 NC6 H4 NH(CH2 )2 ]3 N ((tren) LH9 ). The crystal structure of the all-ferrous species ([(tren) L)2 Fe8 (PMe2 Ph)2 ] (1) displays a bicapped octahedral geometry with FeFe distances ranging from 2.4071(6) to 2.8236(5) Å, where the ligand amine units are formally in amine, amide, and imide oxidation states. Several redox states of the octairon cluster are accessible, as ascertained using cyclic voltammetry. The one-electron-reduced clusters [M](+) [((tren) L)2 Fe8 (PMe2 Ph)2 ](-) (M=Bu4 N (2 a); (15-crown-5)Na(thf) (2 b)) were isolated and characterized. Variable-temperature magnetic susceptibility data indicates that the exchange coupling within the [Fe8 ] core is antiferromagnetic which is attenuated upon reduction to the mixed valent anion. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 08/2015; 54(41):12009–13. DOI:10.1002/anie.201505671
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    ABSTRACT: A series of glycoconjugates with defined connectivity were synthesized to investigate the impact of coupling Salmonella Typhimurium O-antigen to different amino acids of CRM197 protein carrier. In particular, two novel methods for site selective glycan-conjugation were developed to obtain conjugates with single attachment site on the protein, based on disulfide bond chemical modification and pH controlled-transglutaminase catalyzed modification of lysine, respectively. Importantly, conjugation at the C186-201 bond resulted in significantly higher anti O-antigen bactericidal antibody titers than coupling to K37/39, and in comparable titers to conjugates bearing a larger number of saccharides. This study demonstrates that the conjugation site plays a role in determining the immunogenicity in mice and one single attachment point may be sufficient to induce high levels of bactericidal antibodies.
    Angewandte Chemie International Edition 07/2015; DOI:10.1002/anie.201506112R1
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    ABSTRACT: Cyclic homologated amino acids are important building blocks for the construction of helical foldamers. N-aminoazetidine-2-carboxylic acid (AAzC), an aza analogue of trans-2-aminocyclobutanecarboxylic acid (tACBC), displays a strong hydrazino turn conformational feature, which is proposed to act as an 8-helix primer. tACBC oligomers bearing a single N-terminal AAzC residue were studied to evaluate the ability of AAzC to induce and support an 8-helix along the oligopeptide length. While tACBC homooligomers assume a dominant 12-helix conformation, the aza-primed oligomers preferentially adopt a stabilized 8-helix conformation for an oligomer length up to 6 residues. The (formal) single-atom exchange at the N terminus of a tACBC oligomer thus contributes to the sustainability of the 8-helix, which resists the switch to a 12-helix. This effect illustrates atomic-level programmable design for fine tuning of peptide foldamer architectures. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 07/2015; 54(37):10807-10810. DOI:10.1002/anie.201504126
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    ABSTRACT: Chirality is a property of asymmetry important to both physical and abstract systems. Understanding how molecular systems respond to perturbations in their chiral building blocks can provide insight into diverse areas such as biomolecular self-assembly, protein folding, drug design, materials, and catalysis. Despite the fundamental importance of stereochemical preorganization in nature and designed materials, the ramifications of replacing chiral centers with stereodynamic atomic mimics in the context of biomolecular systems is unknown. Herein, we demonstrate that replacement of a single amino acid stereocenter with a stereodynamic nitrogen atom has profound consequences on the self-assembly of a biomolecular system. Our results provide insight into how the fundamental biopolymers of life would behave if their chiral centers were not configurationally stable, highlighting the vital importance of stereochemistry as a pre-organizing element in biomolecular folding and assembly events. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Angewandte Chemie International Edition 07/2015; 127(37). DOI:10.1002/anie.201504459