Publisher: Springer Verlag


Die Zeitschrift HNO berichtet über aktuelle wissenschaftliche Ergebnisse aus Klinik und Forschung. Die Herausgeber sind bemüht bei der Auswahl der Beiträge auch die Interessen des in der Praxis tätigen HNO-Arztes zu berücksichtigen. Zugleich wird in diagnostischen und therapeutischen Fragen des Fachgebietes eine kontinuierliche Fortbildung vermittelt. Über wichtige Kongresse und Symposien wird zusammenfassend in kurzen Berichten informiert. Zur Publikation eingereichte Manuskripte müssen bei Untersuchungen an Probanden oder Patienten die Erklärung enthalten daß das Versuchsprotokoll von einer Ethikkomission begutachtet wurde und somit den ethischen Standards der Deklaration von Helsinki 1964 in der jeweils gültigen Fassung (Pharm. Ind. Nr. 12/1990 sowie Bundesanzeiger Nr. 243a vom 29.12.1989) entspricht. Gleichzeitig ist die Einwilligung der Versuchsperson nach Aufklärung im Text des Manuskriptes zu fixieren. Hinweise die auf die Identität der Versuchsperson schließen lassen sind zu vermeiden. Tierversuchsprogramme müssen den Passus enthalten daß die "Principles of laboratory animal care" (NIH publication No. 86-23 revised 1985) eingehalten wurden soweit nicht zusätzlich besondere nationale Regelungen zu beachten sind (für die Bundesrepublik Deutschland ist dies das Tierschutzgesetz in aktueller Fassung). Die Herausgeber behalten sich deshalb das Recht vor Manuskripte abzulehnen die den o.g. Anforderungen nicht entsprechen. Der Autor haftet bei Verstoß gegen die o.g. Anforderungen oder bei falschen Angaben.

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  • Other titles
    HNO (Online), Hals- Nasen- Ohrenheilkunde
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Springer Verlag

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Publications in this journal

  • L E Walther, R Hülse, K Lauer, A Wenzel
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    ABSTRACT: Ototoxicity describes reversible or irreversible disorders of inner ear functions due to the influence of chemical, biological, or physical substances. Ototoxicity should be kept in mind during differential diagnosis of hearing loss, tinnitus, dizziness, and vertigo. In clinical practice, drug-induced ototoxic effects play a major role. The otorhinolaryngologist should also be involved in interdisciplinary cooperation, e.g., during treatment with antineoplastic chemotherapeutic agents with potential ototoxic side effects. In clinical practice, multimedication and interactions between different agents can complicate precise correlation in individual cases. Recent studies also show that noncellular components, such as otoconia, are extremely sensitive to chemical attacks.
    HNO 01/2015;
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    ABSTRACT: The desire for authenticity is often cited as a motive for making use of plastic surgery. This article aims to elaborate on the meaning of this particular authenticity. At the same time, it discusses reasons that justify or forbid a plastic surgery intervention in the light of ethics. For this purpose, a distinction is made between "objective body" (Körper) and "subjective body" (Leib), and the objectives of medical actions are questioned. Through the terminological differentiation between integrity (Integrität), prosperity (Wohlergehen), and well-being (Wohlbefinden), these objectives are qualified and the limits of medical actions are determined.
    HNO 01/2015; 63(1):6-9.
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    ABSTRACT: Developments in surgical procedures have led to improved results in the field of reconstructive nasal surgery. In this article, the authors focus on the forehead flap technique in one of its smallest forms to cover three-layered alar defects. The example of a complete nasal reconstruction shows how, despite the use of a proven surgical concept, serious complications could occur. In the case shown, a satisfactory outcome was achieved by starting anew with the forehead flap in one of the largest forms-the expanded lateral forehead flap. The authors ascribe particular importance to preoperative analysis with standardized series of photographs. Such series should be made before each surgical step. These are indispensable for structured planning and, thus, are prerequisite for an excellent outcome.
    HNO 01/2015; 63(1):10-21.
  • HNO 07/2014; 2014(62):596-598.
  • HNO 07/2014;
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    ABSTRACT: By virtue of direct bone conduction, percutaneous bone-anchored hearing implants offer a high level of wearing comfort, as well as audiologically superior signal transmission due to less dampening. Over the years, titanium implants have been optimized and the surgical technique developed into a minimally invasive intervention without soft tissue reduction. This study aims to investigate the success rates of the various percutaneous implant systems.
    HNO 06/2014;
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    ABSTRACT: Alongside improvements in hearing and communication skills, the rehabilitation of children, adolescents and adults with a cochlear implant (CI) in recent years has increasingly taken into account mental health and quality of life issues. In the context of the programs offered, this study assesses the significance of dance for the mental health of adult clients with a CI.
    HNO 06/2014;
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    ABSTRACT: Nanomaterials are not just used in various areas of scientific research, but are increasingly found in consumer products. Particularly the cosmetic and textile industries, as well as the medical branch benefit from the specific chemical and physical properties of nanoparticles (NPs). However, the knowledge base concerning the potential health hazards that nanomaterials hold for humans is far from complete. NPs mainly enter the organism via the lungs or the gastrointestinal tract, where they can accumulate. Transcutaneous penetration is most unlikely in the case of healthy skin. Chronic inflammatory reactions of the airways are particularly relevant in the context of potential risks to human health. Evidence for a geno- and cytotoxic potential of some of the most frequently used NPs is available from cell culture and animal experiments. Therefore, the risk of NP-induced cancerogenesis cannot be ruled out. Currently available nanotoxicological data is partly contradictory, due to differing characteristics of the tested substances and variable experimental settings. Long-term studies using continuous NP exposure in consumer-relevant dosages are needed. Additionally, the molecular mechanisms of NP-induced toxicity have to be elucidated in detail.
    HNO 06/2014; 62(6):432-8.
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    ABSTRACT: Due to the enormous expansion of knowledge in the fields of stem cell research and biomaterials, skeletal muscle tissue engineering represents a rapidly developing field of biomedical research. This article provides a general overview of skeletal muscle tissue engineering, including a discussion of recent findings and future research perspectives. Additionally, the results of myogenic differentiation of human mesenchymal stem cells and satellite cells are presented.
    HNO 06/2014; 62(6):415-22.
  • HNO 05/2014;
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    ABSTRACT: The upper esophageal sphincter (UES) forms a barrier between the pharynx and the esophagus. When closed, the barrier function serves to prevent reflux and aerophagia; when open, swallowing, belching and vomiting are possible. The closing muscles include caudal parts of the inferior pharyngeal sphincter and cranial parts of the upper esophagus musculature. Sphincter opening is achieved by muscles that insert from the outside to connect to the larynx and pharynx in the sphincter region. The closing muscles are innervated by branches of the glossopharyngeal and vagal nerves, and central control is probably mediated by several reflexes. This article presents an overview of the current understanding of the complex UES anatomy.
    HNO 05/2014; 62(5):385-94.
  • HNO 04/2014;
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    ABSTRACT: Dysphagias, together with the diseases resulting therefrom, severely reduce patients' quality of life and substantially increase the costs of public health, making efficient therapy a prime concern. Among pathophysiologically oriented diagnostic procedures, the endoscopic examination of swallowing has emerged within the past 20 years as an indispensable standard examination with high sensitivity and specificity. Thus, every ears, nose, and throat (ENT) physician and phoniatric specialist should be familiar with this procedure, in order to ensure widest possible access to it, not only in hospitals but also in outpatient settings and in healthcare establishments. In this article, the preconditions, execution, and evaluation of the endoscopic examination are described and its relevance for immediate or long-term therapeutic treatment is discussed.
    HNO 04/2014;
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    ABSTRACT: The aim of palliative care is to improve the quality of life (QOL) of patients with a limited life expectancy in a comprehensive multidisciplinary approach. It encompasses consideration of medical, physical, psychosocial and spiritual problems, including treatment and help from a team of various professionals. Palliative care often extents to the patient's families and may continue after the death of the patient. Half of all head and neck cancer patients will die of their malignancy within 5 years of diagnosis. The primary medical issues affecting QOL at the end of life are communication problems due to laryngectomy or tracheostomy, disturbed eating and drinking due to surgery and radiotherapy, edematous changes of the face and neck with resultant functional and cosmetic consequences, as well as strong-smelling ulcerated wounds, which often lead to social isolation. General symptoms occurring at the end of life include pain, anxiety, different types of dyspnea and acute bleeding. All therapeutic approaches applied during the last phase of life must be questioned regarding their real efficacy and side effects. Consideration of the patient's wishes is of the highest priority.
    HNO 04/2014;
  • HNO 04/2014; 62(4):307-8.
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    ABSTRACT: In principle, a child can seemingly easily acquire any given language. First language acquisition follows a certain pattern which to some extent is found to be language independent. Since time immemorial, it has been of interest why children are able to acquire language so easily. Different disciplinary and methodological orientations addressing this question can be identified. A selective literature search in PubMed and Scopus was carried out and relevant monographies were considered. Different, partially overlapping phases can be distinguished in language acquisition research: whereas in ancient times, deprivation experiments were carried out to discover the "original human language", the era of diary studies began in the mid-19th century. From the mid-1920s onwards, behaviouristic paradigms dominated this field of research; interests were focussed on the determination of normal, average language acquisition. The subsequent linguistic period was strongly influenced by the nativist view of Chomsky and the constructivist concepts of Piaget. Speech comprehension, the role of speech input and the relevance of genetic disposition became the centre of attention. The interactionist concept led to a revival of the convergence theory according to Stern. Each of these four major theories-behaviourism, cognitivism, interactionism and nativism-have given valuable and unique impulses, but no single theory is universally accepted to provide an explanation of all aspects of language acquisition. Moreover, it can be critically questioned whether clinicians consciously refer to one of these theories in daily routine work and whether therapies are then based on this concept. It remains to be seen whether or not new theories of grammar, such as the so-called construction grammar (CxG), will eventually change the general concept of language acquisition.
    HNO 04/2014; 62(4):242-8.
  • HNO 04/2014; 62(4):241.
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    ABSTRACT: During first language acquisition (L1), children need to gather knowledge about the speech sounds and grammar of their mother tongue. Furthermore, communication skills require an adequate vocabulary. Individual profiles of vocabulary acquisition can vary considerably. However, actively using around 50 words by the age of 24 months is considered a milestone in first language acquisition. This is usually followed by the so-called vocabulary spurt, a rapid increase in lexical knowledge. This article provides an overview of the theories of lexical development and discusses how the acquisition of vocabulary may be explained. A selective literature search was conducted in PubMed and Scopus. Current textbooks were also considered. In order to acquire new words, a child has to identify what the new string of speech sounds refers to. The child has to construct a valid concept of the word and subsequently store both word and concept into long-term memory. Several theories have been put forward to explain lexicon organization, the acquisition of concepts and the mechanisms underlying the so-called fast mapping phenomenon in particular. All of these attempt to explain the phenomenon of lexicon acquisition in terms of a model scheme. In the context of the fast mapping mechanism, constraints and assumptions, cognitive, intentionalist and emergence-based theories are discussed. Knowledge of the different theories of vocabulary acquisition is mandatory to understand the construction of the tests used to assess vocabulary skills in clinical practice and to apply these appropriately.
    HNO 03/2014;
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    ABSTRACT: Hintergrund Nach dem operativen Verschluss der Lippen-Kiefer-Gaumen(LKG)-Spalten stellen Hörvermögen und Sprachentwicklung der betroffenen Kinder und Jugendlichen einen Untersuchungsschwerpunkt in der ärztlichen Sprechstunde dar. Die Diagnostik soll durch das selbst entwickelte PEAKS (Programm für die Evaluation und Analyse kindlicher Sprechstörungen) verkürzt werden, das die Sprechverständlichkeit automatisch analysiert. PEAKS basiert auf einem Spracherkenner und wurde um ein Sprechermodell erweitert. PEAKS wurde in dieser Arbeit anhand isolierter Gaumenspalten validiert. Methode 99 Wortproduktionen von jedem der untersuchten 39 Kinder und Jugendlichen mit isolierter Gaumenspalte (3;1–14;5 Jahre) wurden digital aufgenommen und analysiert, einmal „subjektiv“ von 5 Experten und 5 Laien, einmal „objektiv“ mittels PEAKS. Ergebnisse Die automatische Spracherkennung und die Experten kommen zu einem ähnlichen Ergebnis bei der Analyse der Sprechverständlichkeit. Die Urteile der Experten und Laien weichen signifikant voneinander ab. Innerhalb der Laiengruppe zeigt eine schwache Interraterreliabilität die Unsicherheit der Beurteilung. Schlussfolgerungen PEAKS liefert repräsentative und zuverlässige Ergebnisse bei der Messung der Sprechverständlichkeit von Kindern und Jugendlichen mit isolierter Gaumenspalte. Die automatisierte Messung der Sprechverständlichkeit von Kindern und Jugendlichen mit isolierter Gaumenspalte ist möglich. Abstract Background Following surgical repair of cleft lip and palate, hearing and speech and language development are important issues for the continued care of affected childhood and adolescent patients. Therefore, PEAKS (Program for Evaluation and Analysis of all Kinds of Speech Disorders) was developed in order to rate speech intelligibility automatically and reduce the time required for diagnostics. PEAKS is based on a speech recognition system and was extended to incorporate a speaker model. This investigation validated PEAKS for isolated cleft palate. Methods From each of the 39 children with isolated cleft palate (3.1–14.5years), 99 word productions were recorded digitally and analyzed—once “subjectively” by five experts and five nonexperts; once “objectively” using PEAKS. Results The automatic speech recognition system and the experts arrive at similar results with regard to speech intelligibility. The expert and nonexpert ratings differ significantly from each other. Within the group of nonexperts, a weak interrater reliability demonstrates the uncertainty associated with their ratings. Conclusion PEAKS delivers reliable and representative results with regard to speech intelligibility among children and adolescents with isolated cleft palate. The automatic measurement of speech quality in children and adolescents with isolated cleft palate is possible.
    HNO 03/2014;