Medical Principles and Practice Journal Impact Factor & Information

Publisher: Karger

Journal description

Medical Principles and Practiceí is a general medical journal that focuses on recent advances made in basic medical sciences and clinical practice. It reflects the broad spectrum of work conducted by scientists and physicians from around the world at the Kuwait University faculty of medicine since its foundation in 1976. The international character of their contributions has resulted in the journal attracting original papers, reviews, reports and short communications not only from Kuwait and the Middle East, but also from the international scientific and medical communities as a whole.

Current impact factor: 1.34

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.34
2013 Impact Factor 1.113
2012 Impact Factor 0.963
2011 Impact Factor 0.887
2010 Impact Factor 1.069
2009 Impact Factor 0.824
2008 Impact Factor 0.583
2007 Impact Factor 0.542
2006 Impact Factor 0.442
2005 Impact Factor 0.566
2004 Impact Factor 0.319
2003 Impact Factor 0.194
2002 Impact Factor 0.141
2001 Impact Factor 0.106
2000 Impact Factor 0.097
1999 Impact Factor 0.263
1998 Impact Factor 0.125

Impact factor over time

Impact factor

Additional details

5-year impact 1.12
Cited half-life 5.30
Immediacy index 0.17
Eigenfactor 0.00
Article influence 0.26
Website Medical Principles and Practice website
ISSN 1423-0151
OCLC 164576043
Material type Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • On author's personal website or institutional website
    • Server must be non-commercial
    • Publisher's version/PDF may be used
    • Published source must be acknowledged
    • Must link to publisher version
    • Creative Commons Attribution Non-Commercial License 3.0
    • All titles are open access journals
    • This policy is an exception to the default policies of 'Karger'
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective: The aim of this case report was to highlight the importance of ruling out pheochromocytoma in a patient with von Hippel-Lindau disease and cardiovascular manifestations. Clinical presentation and intervention: A 22-year-old woman with type IIb Von Hippel Lindau disease, presented with signs and symptoms of acute decompensated heart failure. Transthoracic echocardiography showed a dilated left ventricle with severely depressed ejection fraction, confirmed by magnetic resonance imaging. Urinary cathecolamines and metanepfhrines tests had elevated levels and an abdominal MRI was performed, that showed the presence of two cystic masses located at the left hypochondrium. Surgical resection of both masses was performed, confirming the diagnosis of pheochromocytoma and clear cell renal carcinoma on histology. The six month echocardiography showed a left ventricle with normal diameters and preserved ejection fraction. Genetic analysis revealed a germline mutation (exon 3 deletion of VHL). No family history of VHL, hence it was denovo mutation. Conclusion: This case report showed an atypical manifestation in a patient with von Hippel-Lindau disease and the importance of screening for pheochromocytoma in such a patient.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442525
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    ABSTRACT: Screening mammography offers the possibility of discovering malignant diseases at an early stage, consequently treated early thereby could reduce the mortality rate. However, ionizing radiation as used in low-dose X-ray mammography may be associated with a risk of radiation-induced carcinogenesis. In the context of the harmful effects of ionizing radiation, this article reviewed novel radiobiological data and provided a simulation of the relative incidence of radiation- induced breast cancer due to screening against a background baseline incidence in a population of 100.000 individuals. The use of modern digital mammographic technology was assumed, giving rise to a glandular dose of 2.5 mGy from a two-view per breast image. Assuming no latency time, this lead to a ratio induced incidence rate over baseline incidence rate of about 1.6 pro mille for biennial screening in women aged 50-74 years, although it cannot be excluded that the dose dose-rate effectiveness factor (DDREF) values relying on new radiobiological insights may lower this number to about 0.7 pro mille. This carcinogenic risk is considered small in relation to the potential beneficial effects of screening, especially as latency time was not taken into consideration. However, individuals who are known to be carriers of risk- increasing genetic variations and/or have an inherited disposition of breast cancer should avoid ionizing radiation as much as possible and should be referred to ultrasound or magnetic resonance imaging. In addition, a significant, but difficult to quantify, risk of cancer is present for individuals who suffer from hypersusceptibility to ionizing radiation.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442442
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    ABSTRACT: Objective: The aim of this study was to compare the health effects of shisha smoking with cigarette smoking among male college students in Kuwait. Subjects and methods: This cross-sectional study was conducted among 525 male students of Kuwait from September to October 2013. A pretested questionnaire was used for information on demographics and health complaints. Peak expiratory flow rate (PEFR) was measured using a portable peak flow meter. The outcome variables of health status were compared between smoking shisha, cigarette, or both and nonsmoking. Results: The prevalence of current smokers was 243/525 (46%): 52 (10%) were shisha smokers, 69 (13%) cigarette smokers, and 122 (23%) were both shisha and cigarette smokers. Symptoms of persistent cough (4%, 2/52 vs. 13%, 15/69, p = 0.007), chest pain (4%, 2/52 vs. 23% 16/69, p = 0.004), and rapid heart rate (12%, 6/52 vs. 28%, 19/69, p = 0.04) were significantly lower among shisha smokers compared with cigarette smokers. Other complaints, including asthma, respiratory infections, shortness of breath, high blood pressure, increased blood sugar, and sleep disturbances were similar in between the two groups. Values of PEFR were not significantly different between shisha smokers and cigarette smokers. Conclusion: This study demonstrated evidence suggesting that shisha smoking was not safer than cigarette smoking except a few complaints, such as cough, chest pain, and rapid heart rate, and that the people who smoked both had worse health effects in terms of frequent symptoms of respiratory infections, persistent cough, rapid heartbeats, and sleep disturbances.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442417
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    ABSTRACT: Objectives: The purpose of this study was to assess the pattern of third molar impaction and associated symptoms in Central Anatolian Turkish population. Material and methods: Total of 2133 impacted third molar teeth of 705 panoramic radiographs were reviewed. The positions of impacted third molar teeth on panoramic radiographs were documented according to the classifications of Pell and Gregory, and Winter. Presence of related symptoms including; pain, pericoronitis, lymphadenopathy and trismus was noted for every patient. Distributions of obtained values were compared using Pearson chi-square test. Non-parametric values were analyzed using Mann-Whitney U test and Kruskal Wallis Test. Results: The mean age of subjects was (30.58 ± 11.98 years) range: (19-73) were reviewed of the 2133 impacted third molar teeth, the most common angulation of impaction in both maxillaries was vertical 1177 (55%). Level B impaction was the most common in maxilla 425/1037(39%) while the Level C impaction was the most common in mandible 635/1096 (61%). Pain 272/705 (39%) and pericoronitis 188/705 (27%) were found to be the most common complications of impaction. Among 705 patients (335 males, 370 females), pericoronitis were more prevalent in males 101 (30%) and usually related with lower third molars 236 (22%). The retromolar space was significantly smaller in females (p<0.05). Moreover there was a significant difference in retromolar space for area of jaw (maxillar: 11.3 mm, mandibular: 14.2 mm) and impaction level (A:14.7 mm, B: 11,1mm, C: 10,3mm) (p<0.05). Conclusion: The pattern of third molar impaction in Central Anatolian Turkish population was characterized by a high prevalence rate of Level C impaction with vertical position. Pain and pericoronitis were the most common symptoms usually associated with Level A impaction and vertical position.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442416
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    ABSTRACT: Objective: The purpose of this study was to evaluate the effect of atorvastatin consumption on amiodarone-induced pulmonary fibrosis in the rats. Materials and methods: Thirty six (36) male Wistar rats were randomly divided into four groups: control group (CTL): received 0.3 ml of distilled water intratracheally on days 0 and 2 and also 0.5 ml orally from day 0 for three weeks; atorvastatin group (AT): in addition to intratracheal distilled water, received atorvastatin 1mg/kg orally from day 0 for three weeks; amiodarone group (AMI): received two intratracheal instillation amiodarone (6.25 mg/ kg, in 0.3 ml of water) on days 0 and 2 and also 0.5 ml of distilled water, similar to CTL group.AMI+AT: amiodarone+ atorvastatin group (AMI+AT): received both amiodarone and atorvastatin in the same doses and methods used in AMI and AT groups. After 28 days, the rate of lung fibrosis was estimated according to pathological criteria of lung sections and measurement of hydroxyproline in pieces of left lung tissue. Results: Lung hydroxyproline content was higher in treated groups (CTL: 0.35±0.017; AT: 0.38±0.012; AMI: 0.375±0.018: AMI+AT: 0.38±0.012 unit/mg protein), however did not reached to significant level when compared with CTL group (p=0.56). Amiodarone significantly increased the score of pulmonary fibrosis (0.5) in comparison with AT (0.125) and CTL (0) groups (p<0.5). Combination of amiodarone and atorvastatin exacerbated the pulmonary fibrosis (1.5) (p<0.01 compared with the amiodarone group (0.5) and p<0.001versus AT (0.125) and CTL (0) groups). Conclusion: In this study the concomitant administration of amiodarone and atorvastatin increased the pulmonary fibrosis in rat.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442202
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    ABSTRACT: Objective: The aim of this study was to determine if the ratio of the Macruz index (P/P-R segment) can predict the severity of valvular involvement and the success of percutaneous mitral balloon valvuloplasty (PMBV) in patients with mitral stenosis (MS). Subjects and methods: Sixty-one (61) patients with MS eligible for PMBV and 72 healthy subjects (61 females, 11 males) with sinus rhythm were enrolled in this study. The PMBV was performed in all patients using a percutaneous trans-septal antegrade approach and a multitrack balloon technique. The ratio of the P/P-R segment and echocardiographic variables were measured before and 48-72 hours after the procedure. The optimal cut-off points for the differences in the Macruz index to determine clinical success was evaluated by receiver operator characteristic analysis by calculating the area under the curve (AUC) as giving the maximum sum of sensitivity and specificity for the significant test. Results: In the patient group (the mean age was 42.9±11.1 years), the pre-procedural Macruz index was significantly higher than the control group (2.79±1.03 vs. 1.29±0.11; p<0.001). In the successful procedure group (n=53), mean post-index values were significantly lower (2.12±0.71 vs. 2.81±1.0, p=0.020) and the decrease in Macruz index was significantly higher than the unsuccessful procedure group (p=0.007). An index decrease of 0.105 was the best cutoff value to distinguish the successful and unsuccessful PMBV group (AUC =0.888, 95% confidence interval 0.788-0.988, p<0.001). Conclusion: The Macruz index was significantly higher in patients with MS compared to healthy subjects. A greater decrease in Macruz index was associated successful PMBV. .
    Medical Principles and Practice 11/2015; DOI:10.1159/000442201
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    ABSTRACT: Objective: The aim of this study was to investigate the role of the clinical course and prognosis of serum levels of β-defensin-2 (BD-2) in patients with Crimean-Congo hemorrhagic fever (CCHF). Subjects and methods: Patients who were hospitalized in the Department of Infectious Diseases and Clinical Microbiology of Ataturk University Faculty of Medicine were considered for inclusion in the study. The patients with positive real time reverse transcription polymerase chain reaction (RT-PCR) and/or enzyme- linked immune-sorbent assay (ELISA) results of the CCHF virus.. There were 60 patients with CCHF in the study group and 25 healthy participants in the control group. Serum BD-2 levels were measured using an ELISA. Data were analyzed with the student t test or the Mann-Whitney U test. Results: Of the 60 patients, 6 (10%) died, and 54 (90%) were discharged following their recovery. The mean BD-2 levels of the patient group were significantly higher (4180.30±3944.19 pg/mL) than those of the control group (964.45±266.07 pg/mL (p=0.001). The serum BD-2 levels of the fatal (1529.81 ± 1028.14) and nonfatal patients(4474.80 ± 4041.58) differed, but this difference showed only borderline significance (p=0.055). The mean BD-2 level of the severe group was 5507.45±4327.06 pg/mL, while in the mild/moderate group was 3611.52±3676.73 pg/mL and both were significantly higher than that of the control group (p=0.001). Conclusion: In this study the expression of serum BD-2 level was high in patients with CCHF and this increase may be helpful in survival. Studies with a larger sample size are needed to confirm the association of serum BD-2 with CCHF prognosis. .
    Medical Principles and Practice 11/2015; DOI:10.1159/000442177
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    ABSTRACT: Objective: The purpose of this study was to determine the efficacy of the Lidopat® 5% skin patch in relieving rib fracture pain. Subjects and methods: From June 2009 to May 2011, 44 trauma patients with isolated rib fractures were enrolled in this study and randomized in a double-blind method into 2 groups. The experimental group (group E: 27 patients) used a Lidopat® 5% skin patch at the trauma site and took an oral analgesic drug for pain relief. The placebo group (group P: 17 patients) used a placebo vehicle patch and an oral analgesic drug. Results: The mean age, weight and hospital stay of patients were 56.8 ± 13.8 years, 67.4 ± 12.6 kg and 6.34 ± 1.3 days, respectively. In the first 4 days, there were no significant differences in pain scores between the groups (p > 0.05). After the 5th day, the average pain score was significantly less in group E (mean 1.5) than in group P (mean 3.10; p < 0.05). There was no significant difference in the number of fractured ribs between groups (p = 0.904). The use of meperidine and the length of hospital stay (6.0 vs. 6.9 days) were both significantly less in group E (p = 0.043 and 0.009, respectively). Conclusion: In this study, the use of the Lidopat® 5% skin patch in patients with isolated rib fractures alleviated pain and shortened the hospital stay, and a lower dose of pain-relieving medication was used.
    Medical Principles and Practice 11/2015; DOI:10.1159/000441002
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    ABSTRACT: Objective: To assess the utility of visual electrophysiological methods, visual evoked potentials (VEPs) and pattern electroretinograms (PERGs) were recorded for the detection of subclinical optic nerve and retinal involvement in patients with diabetes mellitus. Subjects and methods: The data of 63 patients (126 eyes) with no vascular retinopathy or optic neuropathy were retrospectively analyzed. The patients were divided into polyneuropathic/non-polyneuropathic groups to differentiate between early and late subclinical stages. The recorded parameters were compared with local reference values. Results: 116 eyes (92%) had VEP and 76 (60%) had PERG abnormalities. The most frequent alteration was latency delay, but waveform and amplitude irregularities were also observed. The simultaneous use of the two methods allowed us to differentiate abnormal VEPs of purely optic nerve origin from those reflecting retinal involvement. Conclusions: We suggest that regular electrophysiological screening should receive more attention in the ophthalmological care of diabetic patients.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442163
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    ABSTRACT: Objective: To determine the role of glutathione S-transferase (GST) isoenzyme polymorphisms as susceptibility factors in a Turkish cohort of patients with psoriasis. Subjects and methods: This was a case-control study in which 105 patients with plaque-type psoriasis and 102 healthy controls were recruited from Dermatology Outpatient Clinics of two university hospitals. Genomic DNA was extracted from whole blood using a DZ DNA isolation kit. Multiplex PCR method was used to determine the GSTM1 and GSTT1 polymorphism in the isolated DNAs. Results: Of the 150 patients with psoriasis, 83 (79%) were identified with GSTT1 genotype, and 22 (21%) with the null genotype. Of the 102 patients in the control group, 69 (67.6%) subjects were identified with the GSTT1 genotype, and 33 (32.4%) with the null genotype. There was no significant difference between the patient and control groups (p=0.063). Regarding the GSTM1 polymorphism, 54 (51.4%) patients were identified with this genotype, and 51(48.6%) with the null genotype, in the control group, 50(49%) were identified with this genotype, and 52(51%) with the null genotype. Again there was no statistically significant difference between the groups (p=0.957). Conclusion: In this Turkish cohort of patients with psoriasis, neither GSTT1 nor GSTM1 polymorphisms was associated as the disease susceptibility factor. Larger studies with a wider range of GST isoenzyme could be needed.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442165
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    ABSTRACT: Objectives: To evaluate the level of knowledge regarding the relationships between, oral health, diabetes, body mass index (BMI) (obesity) and lifestyle among students of the Health Science Center (HSC), and to explore any possible correlation between students' oral health knowledge, BMI and lifestyle choices. Subjects and methods: A stratified random sample was proportionally selected according to the size of each faculty from the 1,799 students. Questionnaires were divided into three sections: demographics evaluation of oral health knowledge in relation to diabetes and lifestyle were distributed to 532 students. Oral health knowledge was categorized into: limited, reasonable and knowledgeable categories. Lifestyle was divided into healthy and non-healthy. The BMI was calculated as weight (kg) divided by height (m2). ANOVA and chi-square tests were used to test for differences between independent variables. A Pearson correlation coefficient test was used to assess correlations. p values < 0.05 were considered to be significant. Results: Of the 532 questionnaires, 498 (93.6%) were completed. The mean score of knowledge was 47.7 ± 25.2; Of the 498 students 235 (47.3%) were within the normal range of BMI:, 184 (37.0%) pre-obese, and 67 (13.5%) were obese. Of the 498 students, 244 (49%) had a healthy lifestyle. There wasn't any correlation between oral health knowledge and other variables; however, there was a correlation between lifestyle and obesity. Conclusion: In this study, the majority of the students had limited knowledge of oral health in association with diabetes and lifestyle. More than half of the students fall in pre-obese/ obese range.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442162
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    ABSTRACT: Objective: To evaluate the effect of N-benzyl-4-bromobenzamide (NBBA) on Lipopolysaccharide (LPS)-induced IL-6 and prostaglandin E2 (PGE2) production in human gingival fibroblasts (HGFs). Material and methods: The benzamide compound was synthesized. The condition for IL-6 production of HGFs after induced with LPS was optimized. The HGFs were incubated with benzamide compound NBBA (10 µg/ml) for 30 min before LPS (1 g/ml) was added. After 24 h of incubation time, the culture media were harvested and determined for IL-6 and PGE2 contents using an enzyme-linked immunosorbent assay (ELISA) method. Prednisolone (PDS) and NS-398 were used as a positive drugs. Statistical analysis of the IL-6 and PGE2 contents was performed using the ANOVA test followed by Tukey multiple comparison tests to compare replicate means; p < 0.001 was considered statistically significant. Results: The maximum IL-6 production was achieved when exposed to 1 g/ml of LPS for 24 h, which was inhibited by the IL-6 immunosuppressant PDS. The benzamide compound, NBBA, exhibited a potent anti-IL-6 activity with % inhibition of 35.6 + 0.5, significantly different from the LPS-induced HGFs (p < 0.001). In addition, it inhibited 75.6 + 0.52% PGE2 production. Cell viability was not significantly affected in the treatment of NBBA at a concentration < 10 µg/ml (p < 0.001). Conclusions: The NBBA exhibited an inhibitory effect on the production of IL-6 and PGE2 from LPS-induced HGFs. It could serve as a compound with inhibiting inflammatory activity in periodontal disease.
    Medical Principles and Practice 11/2015; DOI:10.1159/000442164
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    ABSTRACT: Objective: To analyze the intracapsular pressure of the hip joint following femoral neck fracture and its relationship to the position of the hip or to traction and to evaluate the blood supply of the femoral head, using super-selective arteriography, and the influence of traction and hip position on blood supply. Subjects and methods: Twenty six (26) cases of fresh Garden type I to type III femoral neck fractures were enrolled. After being placed in neutral position, in internal rotation, with traction of 3kg and 5kg respectively, the intracapsular manometric changes in 26 cases were measured. Eight (8) of them underwent super-selective arteriography of the medial circumflex femoral artery and of its branches under the manometric changes of the hip joint capsule. Results: Twenty four (24) to 48 hours after injury, the intracapsular pressure was significantly higher on the fractured side than on the normal side. In fully extended hips in neutral position the mean pressure was 28.41 ± 9.339mmHg, in internally rotated hips it was 79.92 ± 12.80mmHg, in hips with 3kg traction it was 51.39 ± 15.41mmHg and in hips with 5Kg traction it was 64.81 ± 13.56mmHg. The arteriographic findings revealed that traction and internal rotation reduced the perfusion of the femoral head by the medial circumflex femoral artery and its branches and negatively influenced venous reflux. Conclusion: Traction and internal rotation both caused the intracapsular pressure of the hip joint to rise considerably, which reduced the femoral head perfusion and impeded venous reflux. This could lead to avascular necrosis of the femoral head.
    Medical Principles and Practice 10/2015; DOI:10.1159/000442019
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    ABSTRACT: Objective: To assess the impact of resveratrol on oxidative stress induced by methotrexate in rat ileum tissue. Materials and methods: Twenty four rats were divided into 4 groups, 6 in each group. Each rat was given the following orally every day for 30 days; Group 1 (MTXG): methotrexate (MTX)(5 mg/kg); Group 2 (RMTXG): MTX(5 mg/kg) plus resveratrol (RST)(25mg/kg/day); Group 3 (RSTG): RST(25mg/kg/day)alone ; and Group 4 (control) distilled water. After sacrifing the rat, , the ileums were removed for the assessment of malondialdehyde (MDA), total glutathione (tGSH) and glutathione peroxidase (GSH-Px). Gene expression analyses for interleukin-1ß (IL-1ß), tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO) were also performed. Haematoxylin-eosin stained paraffin embedded sections of the ileum were analyzed under light microscope and the findings were recorded. Statistical analyses of the data were done using the one-way ANOVA. Results: Administration of MTX in group 1 yielded higher level of MDA(8.33±2.5, p < 0.001) and lower levels of tGSH(0.97±0.29) and GSH-Px(5.22±0.35, p < 0.001) compared to other groups. The MTX also increased IL-1ß(40.33±5.43), TNF-α(6.08±0.59) and MPO gene expression(9±1.41) in group 1 compared to controls(11.33±2.07, 2.15±0.33 and 3.43±0.48, p < 0.001). The impact of RST on IL-1ß, TNF-α and MPO gene expression induced by MTX were observed as a reversal of these findings(p < 0.05). Severe inflammation, damage to the villus epithelium and crypt necrosis were observed histopathologically in MTXG group, whereas only a mild inflammation was seen in the RMTXG group. Conclusion: In this study the ileal damage caused by MTX was inhibited by using RST.
    Medical Principles and Practice 10/2015; DOI:10.1159/000442020
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    ABSTRACT: Objectives: To investigate patients' satisfaction with nursing care by measuring the gap between patients' expectations of care and perceptions of the actual care provided and to identify the areas of nursing care that need improvement. Subjects and methods: A cross-sectional survey was conducted among patients who were admitted to the Departments of Medicine and Surgery at King Saud Medical City, Riyadh, Saudi Arabia. A modified Service Quality (SERVQUAL) instrument was adapted to collect information from a convenience sample of 432 patients from November 25, 2012, to February 3, 2013. The instrument comprised 22 pairs of questions assessing 5 dimensions of the nursing care provided to patients during hospitalizations. The mean patient expectations and perceptions as well as the gap score values for each dimension of nursing service were tested for differences between the mean scores of the sample at a level of significance of 0.05 using a t test. Results: The gap score for all of the 5 dimensions of nursing services were: responsiveness, -1.71; reliability, -1.48; tangibles, -1.36; assurance, -1.26, and empathy, -0.96. Service quality across the dimensions of responsiveness and reliability was statistically significant (p < 0.05). This result indicated that patients were not satisfied with the nursing service quality in relation to all dimensions. Conclusion: Our study showed negative gaps for the 5 nursing service quality dimensions evaluated. This could provide nurses with information about the aspects of nursing care that promote more positive patient outcomes and satisfaction.
    Medical Principles and Practice 10/2015; DOI:10.1159/000441000
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    ABSTRACT: Objective: The aim of this study was to evaluate the efficacy of tibial autogenous bone grafting in the treatment of patients with alveolar bone defects. Materials and methods: The study subjects consisted of 12 patients (10 male, 2 female, age: 19-51 years) who underwent reconstructive autogenous bone-grafting procedures. The medial approach to the tibial bone was used to harvest autogenous cancellous bone grafts in all the patients. Clinical parameters (complications at the donor and recipient sites, resorption and volume of the grafts) were evaluated retrospectively. Results: The mean age of the patients was 36.25 ± 0.9 years. Of the 12 patients, 5 (41.7%) received bone grafts for sinus augmentation, 3 (25%) for cyst cavity reconstruction and 4 (33.3%) for alveolar cleft reconstruction procedures. The average follow-up period was 28.4 months (range: 21-40 months). An average of 5.2 cm3 of cancellous bone was harvested for grafting procedures. All the grafting procedures were successful, and there were no surgical complications during the harvesting protocol. In all cases, pain and gait disturbance lasted less than 2 weeks. Conclusion: The results of this study suggest that the use of tibial autogenous bone graft harvested using a medial approach was a safe, simple and effective method for grafting various alveolar bone defects where high amounts of cancellous bone grafts were needed with low morbidity.
    Medical Principles and Practice 10/2015; DOI:10.1159/000440998
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    ABSTRACT: Castration-resistant prostate cancer (CRPC) progression after androgen deprivation therapy shows upregulated expression of androgen receptor (AR) splice variants, induced epithelial-to-mesenchymal transition phenotypes and enhanced stem cell characteristics, all of which are associated with resistance to enzalutamide. Since there is no curative treatment for CRPC, innovative treatments are urgently needed. In our recent study, we found that resistance to enzalutamide was partly due to deregulated expression of microRNAs such as miR-34a, miR-124, miR-27b, miR-320 and let-7, which play important roles in regulating AR and stem cell marker gene expression that appears to be linked with resistance to enzalutamide. Importantly, we found that BioResponse 3,3'-diindolylmethane (BR-DIM) treatment in vitro and in vivo caused downregulation in the expression of wild-type AR. The AR splice variants, Lin28B and EZH2, appear to be deregulated through the re-expression of let-7, miR-27b, miR-320 and miR-34a in human prostate cancer (PCa). BR-DIM administered in clinical trials was well tolerated, and 93% of patients had detectable prostatic DIM levels. The inhibitory effects of BR-DIM on AR and AR target gene such as prostate-specific antigen were also observed in the clinical trial. Our preclinical and clinical studies provide the scientific basis for a 'proof-of-concept' clinical trial in CRPC patients treated with enzalutamide in combination with BR-DIM. This strategy could be expanded in future clinical trials in patients with PCa to determine whether or not they could achieve a better treatment outcome which could be partly mediated by delaying or preventing the development of CRPC.
    Medical Principles and Practice 10/2015; DOI:10.1159/000439307
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    ABSTRACT: Cellular blebbing is a unique form of dynamic protrusions emanating from the plasma membrane which can be either apoptotic or non-apoptotic in nature. Blebs have been observed in a wide variety of cell types and in response to multiple mechanical and chemical stimuli. They have been linked to various physiological and pathological processes including tumor motility and invasion as well as in various immunological disorders. They can form and retract extremely rapidly in seconds or minutes, or slowly over hours or days. This review focuses on recent evidence regarding the role of blebbing in cell locomotion with particular emphasis on their role in tumor metastasis, indicating the role of specific causative molecules. The phenomenon of blebbing has been observed in endocrine resistant breast cancer cells in response to brief exposure to extracellular alkaline pH which leads to enhanced invasive capacity. Genetic or pharmacological targeting of cellular blebs could serve as a potential therapeutic option to control tumor metastasis.
    Medical Principles and Practice 10/2015; DOI:10.1159/000441848
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    ABSTRACT: Objective: To assess the value of neuroimaging studies in evaluating pediatric patients presenting with first attack of non-febrile seizure. Material and methods: Medical records of pediatric patients aged 28 days to 12 years who were admitted between January 1st and December 31st 2013 with first attack of unprovoked, afebrile seizure were reviewed. These patients had undergone neuroimaging studies. Exclusion criterium was patients with known predisposing conditions for seizure. Computed tomographic (CT) scan and magnetic resonance imaging (MRI) were either normal or abnormal, and the abnormal ones were further classified into clinically insignificant or significant. Descriptive analysis was performed to summarize the data. Results: Fifty (50) children were identified, mean age 5.2±3.8 years (28 days - 12 years). Of the 50 subjects, 29 (58.0%) were males and 21 (42.0%) were females. Of the 50 patients, 16 (32.0%) had abnormal neuroimaging studies (CT scan, MRI, or both); however, only one of them was considered to have clinically significant abnormality. later diagnosed with Moyamoya disease. Conclusion: In this study, the neuroimaging studies was not useful in evaluating pediatric patients presenting with first attack of unprovoked, non-febrile seizures among our patients. .
    Medical Principles and Practice 10/2015; DOI:10.1159/000441847