Tissue Antigens (Tissue Antigens)

Publications in this journal

• Article: Nomenclature for factors of the HLA system, update January 2013.

  Steven G E Marsh
  Tissue Antigens 06/2013; 81(6):471-3.
• Article: Peptide-binding motifs and characteristics for HLA -B*13:01 molecule.

  J Zhang, H Yang, H Li, F Liu, Q Jia, H Duan, Y Niu, P Bin, Y Zheng, Y Dai
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  ABSTRACT: Trichloroethylene (TCE)-induced hypersensitivity dermatitis is one of the critical occupational diseases among workers in China. Our previous studies have identified a strong linkage between the disease and the HLA-B*13:01 allele. In this study, we searched for peptides bound to the HLA-B*13:01 molecule; 57 HLA-B*13:01-bound peptides in total were identified and 54 peptides were used to calculate frequency of amino acid residues to obtain binding motifs of HLA-B*13:01 molecule. The results showed P2, P3, and P9 were the primary binding anchor positions with the dominant anchor motifs of L, Q at P2, L at P9, D at P3. HLA-B*13:01-bound peptides were identified for the first time in our research, the results of which could contribute to the human leukocyte antigen (HLA)-binding peptides database.
  Tissue Antigens 06/2013; 81(6):442-8.
• Article: A novel HLA-A null allele (A*02:395N) with stop codon in exon 2 generated by single nucleotide exchange.

  P Jindra, P Venigová, L Houdová, K Steinerová
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  ABSTRACT: The new HLA-A*02:395N allele differs from A*02:01:01 at one nucleotide position in the exon 2.
  Tissue Antigens 06/2013; 81(6):451-2.
• Article: The novel allele HLA-DQB1*06:01:04 differs from HLA-DQB1*06:01:01 by a single synonymous nucleotide exchange.

  K Y Zhang, Z X Zhang, L Ni, L Wang, X Y Shan
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  ABSTRACT: HLA-DQB1*06:01:04 differs from HLA-DQB1*06:01:01 by the nucleotide exchange at position 156 (G >C) without an amino exchange.
  Tissue Antigens 06/2013; 81(6):468-9.
• Article: Nomenclature for factors of the HLA system, update February 2013.

  Steven G E Marsh
  Tissue Antigens 06/2013; 81(6):474-9.
• Article: Identification of the novel HLA-B*50:18 allele variant in an Italian unrelated bone marrow donor.

  R Azzarone, A Canossi, C Cervelli, M Scimitarra, F Papola
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  ABSTRACT: The HLA-B*50:18 allele differs from the closest related B*50:01:01 by one nucleotide substitution at position 454 in exon 3.
  Tissue Antigens 06/2013; 81(6):466-8.
• Article: The novel allele HLA-A*02:145 differs from HLA-A*02:01:01 by a single amino acid exchange at position 153 from alanine to valine.

  K Y Zhang, Z X Zhang, N Liu, L Ni, X Y Shan
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  ABSTRACT: HLA-A*02:145 differs from HLA-A*02:02:01:01 by the amino acid exchange at position 153 Ala changes to Val.
  Tissue Antigens 06/2013; 81(6):449-50.
• Article: A novel HLA-A*02 allele, HLA-A*02:129.

  K Y Zhang, Z X Zhang, L J Wang, N Liu, X Y Shan
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  ABSTRACT: HLA-A*02:129 differs from HLA-A*02:87 exon 2 at nt 25, nt 29, nt 167 T, nt 184 and nt 192.
  Tissue Antigens 06/2013; 81(6):450-1.
• Article: A novel HLA-A allele, A*66:17 was revealed in a family of a leukemia patient during high-resolution HLA typing.

  K Witter, M Kutsch, M Spannagl, A Dick
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  ABSTRACT: HLA -A*66:17, presented here, shows a single-nucleotide polymorphism in exon 4 in comparison to A*66:01.
  Tissue Antigens 06/2013; 81(6):456-7.
• Article: Correlation between Luminex donor-specific crossmatches and levels of donor-specific antibodies in pretransplantation screening.

  N Guillaume, H Mazouz, V Piot, C Presne, P-F Westeel
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  ABSTRACT: Before kidney transplantation, recipients are routinely screened for preformed antibodies and prospective crossmatches. In this study, we compared prospective Luminex donor-specific crossmatches (LumXm) with the levels of identified, donor-specific antibodies (DSAs). LumXm was performed for 108 patient sera, 84 of which were positive for preformed antibodies and 24 of which were negative. Although LumXm can detect class I DSAs (anti-A and anti-B) with a mean fluorescence intensity (MFI) as low as 2300, the assay has a 'grey zone' for MFIs up to 4000 with a sensitivity of 54% and a specificity of 100%. LumXm can detect a class II DSA (anti-DRB1) with an MFI as low as 1300 and a sensitivity of 93% and a specificity of 99%. However, these correlations were obtained with two precautions: autocrossmatching and single-antigen bead assay with denaturing buffer were performed in discordant cases. Moreover, LumXm failed to detect anti-Cw and anti-DP in the 10 cases studied. LumXm, therefore, displays certain discrepancies with respect to single-bead assays - especially for antibodies with a low MFI. Unfortunately, LumXm has a low sensitivity for anti-A and anti-B class I antibodies.
  Tissue Antigens 04/2013;
• Article: Characterization of a novel allele, HLA-DQB1*06:47.

  J-J He, W Zhang, J He, F-M Zhu, H-J Lv
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  ABSTRACT: HLA-DQB1*06:47 has one base substitution at position 618C>A in exon 3 from HLA-DQB1*06:02:01.
  Tissue Antigens 04/2013;
• Article: Identification of two new HLA class II alleles: DRB1*01:50 and DQB1*05:18.

  W T N Swelsen, K S Hartog, N M Lardy
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  ABSTRACT: Two new human leukocyte antigen (HLA) class II alleles were identified during routine sequence-based typing.
  Tissue Antigens 04/2013;
• Article: The functional MICA-129 polymorphism is associated with skin but not joint manifestations of psoriatic disease independently of HLA-B and HLA-C.

  R A Pollock, V Chandran, F J Pellett, A Thavaneswaran, L Eder, J Barrett, P Rahman, V Farewell, D D Gladman
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  ABSTRACT: A methionine/valine polymorphism at amino acid 129 of the major histocompatibility complex class I chain-related gene A (MICA-129) categorizes alleles into strong and weak binders of the natural killer (NK) and T-cell receptor NKG2D. We investigated whether MICA-129 is differentially associated with skin and joint manifestations of psoriatic disease (PsD) independently of human leukocyte antigen (HLA)-C and HLA-B in patients and controls from Toronto and St. John's. The MICA-129 methionine (Met) allele, particularly Met/Met homozygosity, was strongly associated with both cutaneous psoriasis (PsC) and psoriatic arthritis (PsA) independently of HLA-B and HLA-C in Toronto patients, and was also associated with PsA in St. John's patients, but with no additional effect of Met/Met homozygosity. No association remained after adjustment for HLA alleles in St. John's patients. MICA-129 was not associated with PsA when compared with PsC. We conclude that MICA-129 is a marker of skin manifestations of PsD that is independent of HLA class I in Toronto patients.
  Tissue Antigens 04/2013;
• Article: HLA associations with tubulointerstitial nephritis with or without uveitis in Finnish pediatric population: a nation-wide study.

  J Peräsaari, V Saarela, J Nikkilä, M Ala-Houhala, P Arikoski, J Kataja, K Rönnholm, J Merenmies, M Nuutinen, T Jahnukainen
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  ABSTRACT: The human leukocyte antigen (HLA) genotype has been shown to associate with tubulointerstitial nephritis (TIN) and tubulointerstitial nephritis with uveitis syndrome (TINU). The association of HLA genes with TIN was examined in this nation-wide study. HLA genotyping was performed in 31 pediatric patients with biopsy-proven TIN. All patients were examined by an ophthalmologist to diagnose possible uveitis. Class II HLA genotypes of TIN patients were compared with the Finnish reference population. We found a significant association between the HLA alleles DQA1*04:01 [risk ratio (RR) 5.0, 95% confidence interval (CI) 2.0-11.2], DQB1*04:02 (RR 2.7, 95% CI 1.4-5.3), and DRB1*08 (RR 3.8, 95% CI 1.5-8.4) and TIN. Uveitis was found in 20/31 (64.5%) patients. HLA genotyping of the TINU patients showed additional risk HLA alleles: DQA1*01:04 (RR 6.1, 95% CI 1.5-17.8), and DRB1*14 (RR 8.2, 95% CI 2.2-22.1). The alleles DQA1*01:04 (RR 8.8, 95% CI 2.2-26.5), DQA1*04:01 (RR 3.2, 95% CI 1.2-7.3), and DRB1*14 (RR 12.0, 95% CI 3.2-33.0) were more frequent in patients with TIN and chronic uveitis than in reference population. The HLA class II haplotype DQA1*04:01/DQB1:04:02/DRB1*08 was the most common combination in our study population (58.1%). None of the patients had haplotype DQA1*04:01/DQB1*06:02/DRB1*15, which is common in Finland. HLA genotype did not predict the renal outcome. We found a strong association between certain HLA genotypes both in TIN and TINU patients. The TIN/TINU-associated HLA alleles appear to vary depending on study population.
  Tissue Antigens 04/2013;
• Article: Characterization of the novel HLA-DPA1*02:02:04 allele.

  S-K Lai, C-C Chu, M Lin
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  ABSTRACT: HLA-DPA1*02:02:04 is identical to DPA1*02:02:03 except for a synonymous change at nucleotide position 138 (C to G) in exon 2.
  Tissue Antigens 04/2013;
• Article: Identification of two novel HLA-B*54 alleles, B*54:01:03 and B*54:01:04 by polymerase chain reaction sequence-based typing.

  Y-M He, W Wang, J He, F-M Zhu, H-J Lv
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  ABSTRACT: HLA-B*54:01:03 and HLA-B*54:01:04 show one nucleotide change compared to HLA-B*54:01:01.
  Tissue Antigens 04/2013;
• Article: Identification of a novel HLA-B allele, B*07:162, in a Taiwanese individual.

  P-L Chen, S-K Lai, W-S Yang, T-C Chang, C-C Chu
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  ABSTRACT: The new allele, HLA-B*07:162, is identical to HLA-B*07:12 in exon 2 but has a non-synonymous substitution at position 419 (A to C) in exon 3.
  Tissue Antigens 04/2013;
• Article: Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.

  R Yamada, A Takahashi, T Torigoe, R Morita, Y Tamura, T Tsukahara, T Kanaseki, T Kubo, K Watarai, T Kondo, Y Hirohashi, N Sato
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  ABSTRACT: Cancer/testis (CT) antigens encoded by CT genes are immunogenic antigens, and the expression of CT gene is strictly restricted to only the testis among mature organs. Therefore, CT antigens are promising candidates for cancer immunotherapy. In a previous study, we identified a novel CT antigen, DNAJB8. DNAJB8 was found to be preferentially expressed in cancer stem-like cells (CSCs)/cancer-initiating cells (CICs), and it is thus a novel CSC antigen. In this study, we hypothesized that CT genes are preferentially expressed in CSCs/CICs rather than in non-CSCs/-CICs and we examined the expression of CT genes in CSCs/CICs. The expression of 74 CT genes was evaluated in side population (SP) cells (=CSC) and main population (MP) cells (=non-CSC) derived from LHK2 lung adenocarcinoma cells, SW480 colon adenocarcinoma cells and MCF7 breast adenocarcinoma cells by RT-PCR and real-time PCR. Eighteen genes (MAGEA2, MAGEA3, MAGEA4, MAGEA6, MAGEA12, MAGEB2, GAGE1, GAGE8, SPANXA1, SPANXB1, SPANXC, XAGE2, SPA17, BORIS, PLU-1, SGY-1, TEX15 and CT45A1) showed higher expression levels in SP cells than in MP cells, whereas 10 genes (BAGE1, BAGE2, BAGE4, BAGE5, XAGE1, LIP1, D40, HCA661, TDRD1 and TPTE) showed similar expression levels in SP cells and MP cells. Thus, considerable numbers of CT genes showed preferential expression in CSCs/CICs. We therefore propose a novel sub-category of CT genes in this report: cancer/testis/stem (CTS) genes.
  Tissue Antigens 04/2013;
• Article: Characterization of a novel HLA-DQB1*06 allele, HLA-DQB1*06:04:04.

  E Cosentini, M Andreani, G Ciardiello, A Di Luzio, M Testi
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  ABSTRACT: The novel allele human leukocyte antigen(HLA)-DQB1*06:04:04 differs from HLA-DQB1*06:04:01 by a silent nucleotide substitution at codon 75 (TTG → CTG).
  Tissue Antigens 04/2013;