Biomarkers (Biomarkers)

Publisher: Informa Healthcare

Journal description

Biomarkers is an exciting new journal which brings together work on all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source.

Current impact factor: 2.52

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.522
2012 Impact Factor 1.879
2011 Impact Factor 2.215
2010 Impact Factor 2.09
2009 Impact Factor 1.608
2008 Impact Factor 1.728
2007 Impact Factor 1.978
2006 Impact Factor 2.203
2005 Impact Factor 1.662
2004 Impact Factor 2.384
2003 Impact Factor 1.605
2002 Impact Factor 0.929
2001 Impact Factor 1.118
2000 Impact Factor 0.987
1999 Impact Factor 1.427
1998 Impact Factor 1.554
1997 Impact Factor 1.303

Impact factor over time

Impact factor

Additional details

5-year impact 2.23
Cited half-life 4.70
Immediacy index 0.40
Eigenfactor 0.00
Article influence 0.61
Website Biomarkers website
Other titles Biomarkers (Online)
ISSN 1366-5804
OCLC 38266024
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Informa Healthcare

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • On author's personal website or institution website
    • Publisher copyright and source must be acknowledged
    • On a non-profit server
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • NIH funded authors may post articles to PubMed Central for release 12 months after publication
    • Wellcome Trust authors may deposit in Europe PMC after 6 months
  • Classification
    ​ yellow

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: This review considers adipokines as predictive biomarkers for early onset post-traumatic knee osteoarthritis (KOA). Serum concentrations of leptin and resistin can predict radiographic changes and are elevated in early KOA, with higher leptin concentrations independently associated with more severe knee changes. Plasma concentrations of resistin are chronically elevated after injury. Leptin, resistin, chemerin and vistfatin induce catabolic enzymes associated with cartilage degeneration. Available literature on adipokines in post-traumatic KOA pathogenesis suggests that they could contribute to risk prediction of early onset post-traumatic KOA. Further research is needed to further understand the association between adipokines, synovitis and long-term outcomes in this population.
    Biomarkers 05/2015; DOI:10.3109/1354750X.2014.948914
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    ABSTRACT: Assessing a diverse biomarker panel (NT-proBNP, TNF-α, galectin-3, IL-6, Troponin I, ST2 and sFlt-1) to detect subclinical cardiotoxicity after treatment with anthracyclines. Of 55 breast cancer patients biomarkers were assessed and echocardiography was performed one year after treatment with anthracyclines. 29.1% of patients showed abnormal biomarker levels: NT-proBNP in 18.2%, TNF-α and Galectin-3 in 7.3%. IL-6, troponin I, ST2 and sFlt-1 were normal in all patients. A correlation between left ventricular ejection fraction (LVEF) and NT-proBNP was observed (r = -0.564, p ≤ 0.01). The evaluated biomarkers do not contribute to early detection. Future research should focus on NT-proBNP.
    Biomarkers 05/2015; DOI:10.3109/1354750X.2015.1040839
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    ABSTRACT: Aims: We examined the prognostic performance of measurements of cTnT concentrations at admission compared to discharge, in predicting major cardiovascular events during hospital admission and at six months follow-up. Methods and Results: The study population comprised 1351 patients with AMI and a mean age of 57.5 ± 11.4 years, of whom 66% were males. Cardiac TnT was measured on admission, 24 hours, and at discharge using the Elecsys 2010 [Roche Diagnostics]. No significant difference was found in patients who were cTnT negative on admission [n=345 (26%)] compared to the cTnT positive group [n=1006 (74%)], with respect to baseline characteristics, infarct pattern, biochemical data, and major cardiac events. In 475 patients [35%], serum cTnT levels were found to be higher on discharge from the CCU compared to admission/24 hour levels. A significantly greater proportion of patients had hypertension [63% vs. 50%, p< 0.001], higher systolic blood pressures [133, IQR 115 -154 vs. 127, IQR 111 -147, p< 0.001], history of previous AMI [17% vs. 9%, p< 0.001], and previous angina [17% vs. 9%, p= 0.001] if the discharge cTnT levels exceeded the admission/24 hour levels. A total of 120 deaths occurred during the study period with a significantly greater number of deaths recorded in patients whose discharge cTnT levels were higher than the admission/24 hour values [54(11%) vs. 66 (8%); p= 0.02, respectively]. Multivariable analysis using logistic regression showed that cardiogenic shock [ OR 5.92 {95% CI 2.86 - 12.28}; p< 0.001], cardiac failure [ OR 4.80 {95% CI 2.61 – 8.82}; p< 0.001], cerebrovascular accident [ OR 3.95 {95% CI 1.48 – 10.58}; p= 0.01], complete heart block [ OR 3.50 { 95% CI 1.22 – 10.09}; p= 0.02], increasing age [ OR 1.04 {95% CI 1.02 – 1.01}; p< 0.001], and a greater discharge cTnT value [ OR 1.61 (95%CI 1.01 - 2.56); p=0.04] conferred a significantly higher odds of mortality. Conclusions: This study shows that, in addition to cardiogenic shock, cardiac failure, cerebrovascular accident, complete heart block, and increasing age, higher cTnT level at discharge is an important independent predictor of mortality in patients with AMI, and could further improve the prognostic accuracy of admission values of cTnT, based on relevant patents.
    Biomarkers 04/2015;
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    ABSTRACT: Possession of the apolipoprotein E (APOE) ϵ4 genotype is a major predictor of progression to Alzheimer’s disease (AD), particularly in patients with mild cognitive impairment (MCI). However, the use of APOE genotyping in the diagnosis of MCI is limited due to its low sensitivity and specificity, which often results in a high false-positive rate. In this study, we found that there was a significant decrease in serum BDNF and notable increase in urine AD7c-NTP in MCI patients who harbored the APOE ϵ4 allele. Both serum BDNF and urine AD7c-NTP had higher positive predictive values and were more sensitive biomarkers of MCI. Additionally, a testing strategy employing serum BDNF and urine AD7c-NTP revealed increases in sensitivity, positive and negative predictive values, and predictive ability compared with the use of either biomarker alone, suggested that combinatorial detection might have great potential for translation to the clinic.
    Biomarkers 12/2014; 20(1). DOI:10.3109/1354750X.2014.994036
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    ABSTRACT: Infliximab (IFX) is widely used in ulcerative colitis and in Crohn’s disease treatment. Both diseases are characterised by increased oxidative stress, which may affect albumin oxidation. In order to test this hypothesis, the effect of IFX on colitis induced by dextran sulphate sodium (DSS) in rats was evaluated by measuring the Disease Activity Index, biochemical parameters, serum albumin oxidation and colonic mucosa oxidation. Rats with colitis showed an increase in oxidised serum albumin levels and in the oxidation of colon mucous cells. Both decreased after IFX treatment. This suggests that oxidised albumin could be a useful biomarker for monitoring inflammatory bowel disease.
    Biomarkers 11/2014; DOI:10.3109/1354750X.2014.982189
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    ABSTRACT: Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly decreased compared with 252 healthy controls. Receiver operating characteristic analysis showed that the biomarker panel including C16:1, C18:3, C18:2, C20:4, and C22:6 presents a high diagnostic ability to differentiate early-stage GC patients from healthy controls plus BGD patients, with a sensitivity of 80.6% and a specificity of 72.7%.
    Biomarkers 10/2014; DOI:10.3109/1354750X.2014.977951
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    ABSTRACT: Context: A proteomic analysis has proposed fetuin-A (alpha-2-HS-glycoprotein) as a new potential marker for pancreatic cancer (PC). Objective: Circulating fetuin-A levels in patients with PC. Methods: Serum fetuin-A was measured in 81 cases with PC and 81 matched controls before the initiation of any treatment. Results: Serum fetuin-A was not independently associated with the presence of PC. Although there was a trend with higher fetuin-A levels across PC stages, comparisons of fetuin-A in patients within different PC prognostic stages revealed no differences. Conclusions: Circulating fetuin-A was similar between patients and controls and was not associated with the disease severity.
    Biomarkers 10/2014; DOI:10.3109/1354750X.2014.974071
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    ABSTRACT: Context/objective: To clarify ambiguous published data, we determined whether standardized nutrient intake influences serum copeptin concentrations. Materials/methods: Thirty healthy volunteers underwent oral glucose tolerance testing (OGTT) and mixed-meal tolerance testing (MMTT), respectively drinking 300 ml/237 ml of glucose-containing or fat/protein/carbohydrate-containing fluid. Copeptin was measured 30 min pre-(“baseline”)–180 min post-fluid intake. Results: Median [25th–75th percentile] copeptin fell from 4.9 [3.6–8.3]/4.9 [3.6–7.1] pmol/l at OGTT/MMTT baselines to 3.2 (2.8–5.9)/4.1 (2.7–6.1) pmol/l at post-OGTT/post-MMTT nadirs (150 min/120 min; p < 0.001, linear mixed-effect modeling). Discussion/conclusions: Regardless of nutrient type ingested, copeptin did not increase, suggesting values can be interpreted independently of prandial status.
    Biomarkers 09/2014; 19(7). DOI:10.3109/1354750X.2014.940504
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    ABSTRACT: Context: The definitive standard for the diagnosis of nonalcoholic fatty liver disease (NAFLD) is clinico-pathological correlation, but frequently the only laboratory abnormality is an elevation of serum aminotransferases. Objective: This has resulted in the search for more specific laboratory biomarkers. Methods: The literature was searched for novel plasma/serum markers of NAFLD. Results: Studies reviewed here included histologically-confirmed patients presenting some stage of NAFLD and monitored one or more novel serum/plasma biomarkers. Conclusion: The most promising application of some of these novel biomarkers for the detection and quantification of NAFLD and particularly NASH appears to be in the combination of several into diagnostic panels.
    Biomarkers 09/2014; 19(7). DOI:10.3109/1354750X.2014.958535
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    ABSTRACT: Atrial fibrillation (AF) is a highly prevalent arrhythmia with pronounced morbidity and mortality. Genetics analysis has established electrophysiological substrates, which determine individual vulnerability to AF occurrence and maintenance. MicroRNAs (miRNAs) found in virtually all organisms function as negative regulators of protein-coding genes. Several studies have suggested a role for miRNAs in the regulation of cardiac excitability and arrhythmogenesis. This review is based on 18 studies conducted between 2009 and 2013 to investigate the association of miRNAs with AF. miRNAs are discussed here as candidate biomarkers for AF in blood and cardiac tissues and as potential targets for AF therapy.
    Biomarkers 08/2014; 19(8). DOI:10.3109/1354750X.2014.954001
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    ABSTRACT: Podocyte damage and loss together have an important role in the pathogenesis and progression of glomerulonephritis. Glomerulonephritis patients and healthy controls were enrolled in this study. Biochemical, clinical and experimental procedures included measurement of total urinary protein, renal biopsy and gene expression analysis of the receptor activator of NF-kappaB (RANK). The urinary mRNA levels of RANK were significantly higher in the glomerulonephritis group compared to the controls. The urinary RANK level of glomerular subtypes was correlated significantly with proteinuria. The calculated area of RANK mRNA levels under the curve was 0.61 for minimal change disease (MCD), 0.97 for membranous nephropathy (MN), 0.65 for IgA nephropathy (IgAN), 0.70 for lupus nephritis (LN) and 0.70 for focal segmental glomerulosclerosis (FSGS). The urinary mRNA of RANK might be used to differentiate histologic subtypes of glomerulonephritis, particularly between MCD and MN.
    Biomarkers 08/2014; 19(7). DOI:10.3109/1354750X.2014.956148
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    ABSTRACT: We developed a high-performance ELISA assay and measured serum BHMT levels in healthy individuals and patients with acute liver injury (ALI). The detection range of this ELISA assay was from 1.56 to 100 ng/ml. BHMT levels are significantly higher in ALI groups. In the healthy group (n = 244), the median value (interquartile range, IQR 0–56.40) was 1.83 ng/ml. In the ALI group (n = 42), the median value of BHMT was 748.48 ng/ml (IQR, 0–51095.92). ROC curve analysis demonstrated good sensitivity (0.86) and specificity (0.98). In addition, in five ALI cases with time course samples available, BHMT and ALT both followed the “rise and fall” temporal pattern with the disease progression. However, the slopes of BHMT curves were steeper than ALT curves. And in three out of the five cases, BHMT levels peaked 1 day earlier than ALT levels be a sensitive marker with good prognostic value.
    Biomarkers 08/2014; 19(7). DOI:10.3109/1354750X.2014.951880
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    ABSTRACT: The cerebrospinal fluid (CSF) used for identification of molecular biomarkers in amyotrophic lateral sclerosis (ALS) is mainly obtained from lumbar puncture (LP) performed to exclude other causes of motor neuron damage. Aim: The aim of the study was to analyze whether CSF of ALS patients obtained for diagnostic purposes is suitable for biomarker studies in the entire ALS population. Material and methods: We analyzed the medical data, LP frequency and CSF parameters in 568 ALS patients. Results: LP was performed in 34% of cases. Patients who underwent LP were significantly younger and more frequently presented limb onset ALS, there were no differences in the clinical phenotypes. Conclusion: CSF obtained for diagnostic purposes can be used for biomarkers studies in ALS.
    Biomarkers 08/2014; 19(7). DOI:10.3109/1354750X.2014.949867
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    ABSTRACT: Context: Ureteropelvic junction obstruction (UPJO) constitutes a predominant cause of obstructive hydronephrosis. Fundamental questions regarding the assessment and treatment of infants and children with obstructive nephropathy remain unanswered. Objective: Several studies have investigated the usefulness of substances that could serve as potential diagnostic and prognostic biomarkers in children with UPJO. Aim of the present study is to systematically review the literature on biomarkers that have been studied to date in patients with UPJO. Methods: The main search was conducted in the electronic databases MEDLINE and Cochrane Central Register of Controlled Trials (CENTRAL) from inception through March 2014 using various combinations of Medical Subject Headings (MeSH). Results: The 14 included studies reported data on 380 UPJO patients who underwent surgery, 174 who were treated conservatively and 213 controls. Conclusion: Some biomarkers offer promising results however more multicenter, prospective carefully designed studies are needed to evaluate their diagnostic and prognostic value.
    Biomarkers 08/2014; 19(7). DOI:10.3109/1354750X.2014.943292
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    ABSTRACT: Mild injury of the exocrine pancreas is often asymptomatic and can be under- or mis-diagnosed. The pancreas-enriched microRNAs miR-216a and miR-217 were evaluated as potential serum biomarkers of exocrine pancreas injury in rodent models of acute pancreatitis induced by caerulein, l-arginine, and pancreatic duct ligation. Both microRNAs showed time- and dose- relevant responses to pancreatic injury and wider dynamic ranges of response than serum amylase or lipase. Pancreas-selective microRNAs were found to be relatively sensitive serum biomarkers of pancreatic injury in rodents with potentially greater specificity than the current standard assays.
    Biomarkers 07/2014; 19(6). DOI:10.3109/1354750X.2014.944217