European Journal of Clinical Investigation (Eur J Clin Investig)

Publisher: European Society for Clinical Investigation, Wiley

Journal description

The Journal of the European Society for Clinical Investigation. The European Journal of Clinical Investigation publishes papers in the field of clinical investigation, provided they contribute to the advancement of knowledge in this field. The term 'clinical investigation' is interpreted widely and includes studies relevant to humans in health or disease, including such studies that may have taken place with animals.

Current impact factor: 2.83

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.834
2012 Impact Factor 3.365
2011 Impact Factor 3.018
2010 Impact Factor 2.736
2009 Impact Factor 2.643
2008 Impact Factor 2.784
2007 Impact Factor 2.701
2006 Impact Factor 2.847
2005 Impact Factor 2.684
2004 Impact Factor 2.53
2003 Impact Factor 2.346
2002 Impact Factor 2.193
2001 Impact Factor 2.255
2000 Impact Factor 2.071
1999 Impact Factor 1.922
1998 Impact Factor 1.907
1997 Impact Factor 1.693
1996 Impact Factor 2.15
1995 Impact Factor 2.174
1994 Impact Factor 2.224
1993 Impact Factor 2.349
1992 Impact Factor 1.99

Impact factor over time

Impact factor
Year

Additional details

5-year impact 3.05
Cited half-life 8.00
Immediacy index 0.70
Eigenfactor 0.01
Article influence 0.90
Website European Journal of Clinical Investigation website
Other titles European journal of clinical investigation (Online)
ISSN 1365-2362
OCLC 46653881
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Wiley

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • Some journals have separate policies, please check with each journal directly
    • On author's personal website, institutional repositories, arXiv, AgEcon, PhilPapers, PubMed Central, RePEc or Social Science Research Network
    • Author's pre-print may not be updated with Publisher's Version/PDF
    • Author's pre-print must acknowledge acceptance for publication
    • On a non-profit server
    • Publisher's version/PDF cannot be used
    • Publisher source must be acknowledged with citation
    • Must link to publisher version with set statement (see policy)
    • If OnlineOpen is available, BBSRC, EPSRC, MRC, NERC and STFC authors, may self-archive after 12 months
    • If OnlineOpen is available, AHRC and ESRC authors, may self-archive after 24 months
    • Publisher last contacted on 07/08/2014
    • This policy is an exception to the default policies of 'Wiley'
  • Classification
    ​ yellow

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Congenital Factor X (FX) deficiency is a rare bleeding disorder inherited as an autosomal recessive trait with an incidence of 1:500,000-1,000,000. A total or partial deficiency of FX causes an impairment of clot formation, leading to a hemorrhagic disease, which manifests with bleeding symptoms of different severity, also unprovoked. We analyzed the clinical manifestations, laboratory phenotype and genotype in 12 patients from Turkey affected with severe FX deficiency. Prothrombin time (PT), activated partial thromboplastin time (APTT), FX activity (FX:C) and FX antigen level (FX:Ag) were measured and mutation analysis was performed for all patients. Results The most frequent bleeding episodes in patients were epistaxis and easy bruising (11/12, 91%), followed by hemarthroses (10/12, 83%). FX:C was <1% in eleven patients, and 4% in one. FX:Ag was reduced in all patients, consistent with type II deficiency. Direct sequencing of the factor X gene (F10) identified two different mutations: the novel 33 bp in frame deletion p.Thr176_Gln186, c.526_558del, which seems to be associated with milder bleeding symptoms and the c.785G>A, p.Gly262Asp missense mutation (previously reported as Gly222Asp), which is associated with severe bleeding symptoms. The p.Gly262Asp missense mutation was identified in eleven of the 12 patients in the current study. Previously published cases on the same p.Gly262Asp mutation were Iranian patients originating from the border between Turkey and Iran suggesting that this mutation may be candidate as a good tool for mutational screening analysis in this area. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12511
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    ABSTRACT: Obesity is a risk factor for both vitamin D deficiency and cardiovascular disease. Alinkbetween vitamin D status optimisation and improvedcardiometabolic profileamong adults with obesity could inform public health initiatives. PubMed, Embase and Web of Science were searched for interventional studies examiningthe effects of vitamin D status improvement on cardiovascular risk factors(anthropometric measures, lipid profile,blood pressure, glucose tolerance) among nondiabeticadults with obesity. eventeenpublications reporting results from 11different studies were included. Number of participants ranged from 34 to 1179 subjects. Duration was between six weeks and four years. Vitamin D was administered as a supplementin ten studies (1,000 IU dailyto 120,000 IU fortnightly). In one study participants were advised to increase sunlight exposure and dietary vitamin D intake. The random and fixed effectsmeta-analysis showed that vitamin D significantly increased systolic blood pressureand LDL-c levels.The fixed effects model also indicated a significant decrease of triglyceride levels, which was not evident using the random effects model. Caution should be given to these results given the small number of studies used and the high heterogeneity between studies for the two latter outcomes. Additionally, a subset of eligible studies with compatible data presentation was included in the meta-analysis. his systematic review highlights a paucity of interventional studies examining the effects of vitamin D status improvement on cardiovascular risk factors among otherwise healthy adults with obesity.Large-scale studies at pharmacologically relevant doses and with sufficient duration are warranted. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12510
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    ABSTRACT: Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP) enzymes to vasoactive metabolites (mainly epoxyeicosatrienoic acids) which are known to play a protective role against damaging processes that may occur after re-oxygenation of the graft. We aimed to investigate whether the presence of functional polymorphisms along these metabolic routes may play a role in the outcome of renal transplantation. One-hundred-and-forty Caucasian renal transplant recipients and 137 donors were included. We determined the presence of seven common functional polymorphisms in the five genes governing the CYP-mediated AA metabolic pathway (CYP2C8, CYP2C9, CYP2J2, CYP4A11 and CYP4F2). Associations with parameters and events related to graft function and survival were retrospectively investigated throughout the first year after grafting. The CYP2J2*7 allele of the donor was significantly associated with higher risk for delayed graft function [OR=4.40 (1.45-13.37), p<0.01] and lower death-censored graft survival [107.90 (84.19-131.62) vs. 176.89 (166.47-187.32) months for CYP2J2*1/*1 grafts; log-rank p=0.015]. In addition, patients whose donors carried the CYP4A11 434S variant of the F434S polymorphism displayed impaired creatinine clearance, with statistically significant differences vs. 434FF subjects throughout the whole period of study (p<0.05, p<0.01, p<0.001 and p<0.05 for one week, one month, five months and one year after grafting, respectively). Taken together, these results indicate that variability in the CYP450 genes involved in the synthesis of eicosanoids from AA may have a significant impact on graft function and survival in renal transplantation. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12507
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    ABSTRACT: A drop in postural blood pressure(BP) may contribute to falls, while antihypertensives have been considered to induce postural drop or orthostatic hypotension (OH) and falls among older people. However, this relationship between antihypertensives, postural BP and the risk of falls has never been evaluated in a single study. To examine the association of postural BP changes and BP therapy with the risk of falls among community-dwelling older people in a case-control manner. Cases(n=202) included participants aged ≥65years with two falls or one injurious fall while controls(n=156) included participants ≥65years with no falls in the preceding 12months. Antihypertensives usage and medical history were recorded. Supine blood pressure measurements were obtained at 10minutes' rest and at 1,2 and 3 minutes after standing. Orthostatic hypotension was defined as a reduction in BP of 20mmHg/10mmHg within 3 minutes of standing. Individual antihypertensive classes were not associated with falls. Minimal standing systolic BP(SBP) was significantly lower among fallers [128(±27.3)vs.135.7(±24.7)mmHg;p=0.01], but fallers were not more likely to fulfil the diagnostic criteria for OH. Diuretics were associated with OH and α-blockers were associated with minimal standing SBP. The use of ≥2 antihypertensives was significantly associated with recurrent and injurious falls [OR,1.97;CI,1.2-3.1], which was not attenuated by adjustment for either OH or minimal standing SBP, but was no longer significant after adjustment for age and number of comorbidities [OR, 1.6; CI, 0.95-2.6]. Minimal standing SBP or a lower SBP at 2 or 3 minutes standing was associated with falls rather than OH using consensus definition, while the association between ≥2 antihypertensives and falls was attenuated by age and comorbidities but not by OH or minimal standing SBP, challenging previous assumptions that antihypertensives are associated with OH related falls. Future studies should now seek to link these findings prospectively with falls in order to guide decision-making for BP lowering therapy among older patients. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12508
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    ABSTRACT: A suboptimal ventricular-arterial (VA) interaction may have a prolonged depressing effect on the failing heart after functional reserves forced to their limits under stress conditions such as exercise. The continuation of excessive load in the post-exercise period may be more important than the load during exercise, because the sum of post-exercise periods generally exceeds exercise time itself. We sought that exercise-induced changes in post-exercise VA coupling and pulsatile efficiency in patients with heart failure (HF). Thirty consecutive HF with reduced ejection fraction (EF) and thirty age-, sex- and peak VO2 -matched subjects with preserved EF were enrolled. Pre- and post-exercise echocardiographic and tonometric measurements were taken to calculate left ventricular and arterial elastances, arterial compliance and wave reflections, and steady and pulsatile power. VA coupling significantly deteriorated in HF group (from 1.50 ± 0.47 to 2.00 ± 0.75 mmHg.mL(-1) , P<0.01), but control group maintained basal favorable coupling status after exercise (from 1.04 ± 0.29 to 1.03 ± 0.24 mmHg.mL(-1) , P=0.77). Pulsatile percentage of total power significantly increased with exercise in HF group, whereas it showed a significant decrease in control group. The change in pulsatile power fraction was correlated with the change in augmentation pressure (r=0.41, ß=3.00, P<0.01) and inversely correlated with the change in total arterial compliance (r= -0.29, ß = -8.52, P=0.02). Our data indicates that exercise-induced VA decoupling and pulsatile inefficiency extend into post-exercise phase in patients with systolic dysfunction. The exact duration of these derangements requires further studies. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12504
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    ABSTRACT: Right ventricular (RV) dysfunction in heart failure (HF) with reduced left ventricular ejection fraction (LVEF) is associated with a poorer prognosis. No studies to date have investigated the prognostic utility of RV isovolumic acceleration (IVA) measured at tissue Doppler imaging (TDI) in HF. RV strain instead has been already correlated to a poorer prognosis in these patients. We aimed to assess the predictive value of both parameters in this context. 60 patients enrolled, NYHA II-III. Everyone underwent echocardiographic examination including TDI and strain analysis. Adverse event was defined as cardiovascular death or re-hospitalization. Follow-up was 32±13 months. 16 patients (26.7%) had an adverse event. IVA and RV strain were significantly lower in these patients. At logistic regression they were both related to adverse event and their receiver-operating characteristic (ROC) curve predictive (area under ROC 0.916 and 0.952, respectively). Kaplan-Meier survival curves were significantly worse for both parameters inferior to their respective means (p<0.001 for both). Univariate and multivariate analyses confirmed their better utility than tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC) or S' at TDI. our study demonstrated a useful prognostic role of RV strain and IVA, which are parameters of subclinical RV impairment. Patients with low values may benefit from a more aggressive therapy and a closer follow-up. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12505
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    ABSTRACT: Erythropoietic protoporphyria and X-Linked protoporphyria are genetic abnormalities of heme synthesis that result in excess production of protoporphyrin and that manifest as severe photosensitivity. These disorders are often associated with iron deficiency anemia [IDA]. Our aim was to determine whether hepcidin is increased in EPP/XLPP patients, resulting in decreased enteral iron absorption and IDA. Eight subjects with EPP, 1 with XLPP, and 9 controls had baseline blood and urine samples collected, and thereafter were given oral ferrous sulfate [660 mg]. Post-iron blood and urine samples were collected at 2, 4, 6, and 8 hours. Blood counts, serum cytokines, ferritin, and iron studies were analyzed at baseline. Serum iron studies, serum and urine hepcidin, and erythropoietin were analyzed at baseline and subsequent time points. At baseline, EPP-XLPP subjects had lower mean blood hemoglobin (13.9/15.3 g/dL) and serum ferritin (31.6/115 ng/mL) than controls. Serum iron levels increased markedly in both cohorts. Mean serum and urine hepcidin levels were significantly lower in the EPP-XLPP group at 4 and 8 h post-iron (serum-4 h, 3.79/26.6, 8 h, 5.79/34.6 nM; urine-4 h, 0.85/2.50, 8 h, 1.44/6.63 nmol/mmol creatinine). Serum cytokines and erythropoietin were normal and not different between groups. We conclude that serum and urine hepcidin are not inappropriately increased in EPP/XLPP subjects at baseline and do not increase over time as serum iron increases after oral ferrous sulfate. Levels of serum cytokines and Epo are normal in EPP/XLPP. The molecular basis for the iron-deficient phenotype in EPP/XLPP remains unknown. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12503
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    ABSTRACT: The purpose of this study was to evaluate the effects of multiple sclerosis (MS) on the risk of venous thromboembolism (VTE) development. We identified patients diagnosed with MS in Taiwan between 1998 and 2010 by using the National Health Insurance Research Database and the Catastrophic Illness Patient Database (RCIPD). Each MS patient was frequency-matched to 4 controls according to age, sex, and the year of MS registration to the RCIPD. Patients with a history of VTE and incomplete information of age and sex were excluded. All patients were followed up from the index year until VTE diagnosis, loss to follow up, or the end of 2010. We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) of VTE in the MS and comparison cohorts by using Cox proportional hazards regression models. We followed up 1238 MS patients and 4952 comparison patients for approximately 6437 and 27 595 person-years, respectively. After adjusting for age, sex, and comorbidities, the MS patients exhibited a 6.87-fold increased risk of VTE compared with the control patients. Women with MS were associated with an 11.1-fold increased risk of VTE development compared with the non-MS women (95% CI: 2.70-45.5). The MS patients aged < 50 years exhibited a 14.8-fold increased risk of developing VTE compared with age-matched patients in the comparison cohort (95% CI: 2.99-73.4). The risk of VTE development increased with the duration of hospitalization stay. MS patients are associated with significantly greater risk of developing VTE compared with non-MS patients. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12502
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    ABSTRACT: In 2013 we reported in this journal the absence of a relation between plasma ferritin and adiponectin levels in patients with manifest vascular disease[1]. Since then no studies have investigated this relation in this specific and important population. Research in the general population, including some patients with vascular disease, has again proven the inverse relation between plasma ferritin and adiponectin levels and also found a relation with adipose tissue insulin resistance[2, 3]. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12499
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    ABSTRACT: We read with interest the recent article entitled "Prevalence of normal TSH value among patients with autonomously functioning thyroid nodule" by Treglia et al. (1). Their meta-analysis showed approximately half of patients with autonomously functioning thyroid nodules (AFTN) demonstrated by thyroid scintigraphy to have TSH values within normal range. Herein, we report our investigation of AFTN cases with normal TSH levels treated with radioiodine therapy (RIT). This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12497
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    ABSTRACT: Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine tumors with a strong genetic background. We searched the PubMed database through February 2015 to identify studies characterizing metastatic PCs/PGLs as well as currently established and evolving therapies. Large size tumors (>5 cm), PASS score greater than 6, and Ki-67 labelling index > 3% are the most robust indices of metastatic PCs/PGLs albeit with great variability. Germline succinate dehydrogenase complex, subunit B (SDHB) mutation constitutes the main reliable molecular predictor of malignancy. Plasma and urinary methoxytyramine are the biochemical markers characterizing metastatic PCs/PGLs along with evolving molecular markers such as miRNAs and SNAIL. Conventional imaging is used for tumor localization whereas 18F-FDG-PET for staging of metastatic PCs/PGLs especially those related to SDHB gene mutations. In addition, 68Ga-DOTATATE PET/CT is emerging as a highly sensitive alternative. Surgery remains the gold standard treatment in reducing tumor bulk and/or controlling the clinical syndrome. Treatment with 131I-MIBG or radiolabeled somatostatin analogues is considered for un-resectable disease. Conventional chemotherapy is reserved for more advanced and refractory to other therapies disease although new schemes are currently evolving. Recent genetic studies have highlighted a number of pathways involved in PCs/PGLs pathogenesis directing towards the use of targeted therapies which have still to be validated in clinical practice. Metastatic PCs/PGLs remain an orphan disease that is only curable by surgery. However advances in genomic analyses have improved the pathogenesis of these tumors and may lead to effective and more personalized treatments in the near future. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12495
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    ABSTRACT: We have read with great interest the article entitled Prevalence of normal TSH value among patients with autonomously functioning thyroid nodule by Treglia et al (1). Autonomously functioning thyroid nodule (AFTN) are benign monoclonal tumors characterized by their capacity to grow and produce T4 and T3 independently of TSH regulation. AFTNs account for 5-10% of palpable nodules. Based on the assumption that normal TSH concentration rules out the presence of AFTNs, clinical guidelines on the management of thyroid nodules only recommend a thyroid scan if TSH concentration is subnormal. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12496
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    ABSTRACT: Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD) and has also been linked to co-morbidities often present in COPD. The aim of this study was to investigate whether vitamin D deficiency was related specifically to airflow limitation or whether vitamin D deficiency was determined by conditions that frequently co-exist with COPD: insulin resistance, hypertension, anemia, obesity, and hypercholesterolemia. For this cross-sectional analysis, we included 897 subjects from the Baltimore Longitudinal Study of Aging. Subjects taking vitamin D supplements were excluded. Airflow limitation was defined as FEV1 /FVC<lower limit of normal. Logistic regression was used to assess the association between vitamin D deficiency (25-hydroxy vitamin D<20 ng/mL) and possible determinants. Vitamin D deficiency was not specific for subjects with airflow limitation. Body mass index (BMI) (OR: 1.05, p<0.03) and obesity (BMI>30 kg/m(2) ) (OR: 1.9, p<0.002) were significantly associated with vitamin D deficiency in the adjusted multivariate regression analysis. Physical activity was associated with a decreased risk of vitamin D deficiency. Airflow limitation was not an independent determinant of vitamin D deficiency. The effect of weight loss and increased physical activity on vitamin D levels should be investigated further in intervention studies. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12498
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    ABSTRACT: Burnout represents a syndrome that is related to demanding job characteristics combined with the absence of resources or motivational job characteristics. The aim of this position paper is to present strategies that individuals use to minimize burnout and its unfavorable effects. The paper focuses explicitly on strategies that individuals use to (1) deal with diminished resources that come with burnout, (2) change their job characteristics such that the job becomes less demanding and more motivating, and (3) manage the interplay between the work and non-work domains. Individuals seem to use coping, recovery, and compensation strategies to reduce the impact of work stressors by changing the stressor or their responses to the stressor. Moreover, they use job crafting to alter the characteristics of the job such that it becomes less hindering and more motivating. Finally, individuals create boundaries between their work and non-work domains to experience less work-family and family-work conflicts by actively detaching from work. Finding bottom-up strategies that individuals use to minimize burnout or its unfavorable effects may be essential to complement the top-down interventions initiated by organizations. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12494
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    ABSTRACT: Arteriosclerosis is a pathological structural (media vascular calcification) and physiological (modified vascular smooth vessel cells; increased arterial stiffness) alteration of the vessel wall. Through improved assessment methods (functional and imaging) it has become a well-known phenomenon in recent decades. However, its clinical importance was underestimated until recently. The goal of the review is to summarize current data about conditions/diseases associated with arteriosclerosis, its clinical sequels, available diagnostic procedures and therapeutic modalities. Although arteriosclerosis showed an independent clinical impact on cardiovascular morbidity and mortality, especially in patients with chronic kidney disease/end-stage renal disease (CKD/ESRD) and diabetes mellitus, convincing clinical therapy concepts are not available up to now. The establishment of novel therapeutic strategies deriving from basic research is strongly needed. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12493
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    ABSTRACT: We thank Dr. Shen for his interest in, and favorable comments on, our article. [1] In the present study, our results demonstrated that an increased incidence of liver cirrhosis was observed among tuberculosis (TB) patients by significant higher risk of liver cirrhosis, and the overall incidence of liver cirrhosis was significantly higher in the TB than in controls. After controlling confounders for age, gender, and comorbidities, the risk was 1.79-fold (95% Confidence interval (CI) = 1.50-2.14) higher in the TB group than in the controls. Cox proportional hazard regression revealed that tuberculosis increased the risk of cirrhosis in patients with either hepatitis B (adjusted hazard ratio (HR) = 1.91; 95% CI = 1.05-3.47) or hepatitis C (adjusted HR = 2.56; 95% CI = 1.37-4.78). in Taiwan. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12489
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    ABSTRACT: I read with interest the recent article by Peng and colleagues on risk of liver cirrhosis after tuberculosis (TB).[1] In this matched cohort study, they found an increased incidence of cirrhosis in TB patients (adjusted hazard ratio 1.79, 95% confidence interval 1.50-2.14). However, the increased hazard may be explained by residual confounding, and by failure to account for surveillance bias and competing risk of death. Moreover, the risk estimate would not be valid if proportionality assumption is violated. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 07/2015; DOI:10.1111/eci.12488
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    ABSTRACT: To evaluate the genotype-driven effect of Haptoglobin (Hp) in patients with type 1 diabetes without clinical cardiovascular (CV) disease, considering endothelial dysfunction (ED) and arterial stiffness (AS). 137 patients with type 1 diabetes (duration ≥5years) and 68 age- and sex-matched controls were evaluated for: 1) smoking, alcohol intake, BMI, blood pressure, fasting plasma glucose, HbA1c and lipid profile, 2) microvascular complications, 3) serum markers of ED (ICAM-1, VCAM-1 and E-selectin), 4) AS, assessed as aortic pulse wave velocity (aPWV), and 5) Hp genotype. The prevalence of the 1/1, 2/1 and 2/2 Hp genotypes was 28.5, 46.7 and 24.8% in patients with type 1 diabetes and 20.9, 38.8 and 40.3% in controls, respectively. No differences were found in classical CV risk factors between patients homozygous for allele 2 and the remaining genotypes, both in patients with type 1 diabetes and controls. Patients with type 1 diabetes carrying the Hp2/2 genotype had higher concentrations of ICAM-1 (65.1(56.7-76.0) ng/ml vs. 59.0(51.7-69.3) ng/ml; p=0.033) and sVCAM-1 (1133.1(884.6-1458.6) ng/ml vs. 956.4(738.5-1206.1) ng/ml; p=0.040 than those without it. The Hp2/2 genotype remained independently associated with ED after adjusting for CV risk factors (p=0.038). No significant differences were found for aPWV between Hp genotypes. Endothelial dysfunction may be influenced by Hp2/2 genotype in patients with type 1 diabetes with independence of classical CV risk factors. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
    European Journal of Clinical Investigation 06/2015; DOI:10.1111/eci.12487
  • European Journal of Clinical Investigation 06/2015; DOI:10.1111/eci.12473