Interdisciplinary toxicology (Interdiscip Toxicol )

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  • ISSN
    1337-9569

Publications in this journal

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    ABSTRACT: This work describes that cyto-toxicity of lead chloride and lead acetate to in vitro cultured lymphocytes from human umbilical cord blood, using four monitoring methods namely, trypan blue staining, acridine orange/ ethidium bromide staining, 3-[4, 5- dimethylthiazol-2-yl] 2,5-diphenyl tetrazolium bromide (MTT) and neutral red uptake assays; lead geno-toxicity to lymphocytes was monitored by comet assay. The MIC value in each method was invariably 300 mg/L for PbCl2. Lethal concentration25 (LC25) values were almost in an agreeable range: 691.83 to 831.76 mg/L; LC50 values in each method were almost in the range: 1174.9 to 1348.9 mg/L; LC100 values were in the range: 3000 to 3300 mg/L, for lead chloride. Similarly, The MIC value in each method were invariably 150 mg/L; LC25 values were almost in the range: 295.12 to 371.53 mg/L; LC50 values were in the range: 501.18 to 588.84 mg/L; LC100 value was 1500 mg/L in all assays, for lead acetate. The comet assay also indicated that the LC100 values were 3300 mg/L lead chloride and 1500 mg/L lead acetate. Thus, both cyto-toxicity and geno-toxicity were recorded at 3300 mg/L lead chloride and 1500 mg/L lead acetate with lymphocytes.
    Interdisciplinary toxicology 12/2014;
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    ABSTRACT: Catalytic ozone decomposition is of great significance because ozone is a toxic substance commonly found or generated in human environments (aircraft cabins, offices with photocopiers, laser printers, sterilizers). Considerable work has been done on ozone decomposition reported in the literature. This review provides a comprehensive summary of the literature, concentrating on analysis of the physico-chemical properties, synthesis and catalytic decomposition of ozone. This is supplemented by a review on kinetics and catalyst characterization which ties together the previously reported results. Noble metals and oxides of transition metals have been found to be the most active substances for ozone decomposition. The high price of precious metals stimulated the use of metal oxide catalysts and particularly the catalysts based on manganese oxide. It has been determined that the kinetics of ozone decomposition is of first order importance. A mechanism of the reaction of catalytic ozone decomposition is discussed, based on detailed spectroscopic investigations of the catalytic surface, showing the existence of peroxide and superoxide surface intermediates. Download at : file:///C:/Users/BAN/Downloads/intox-2014-0008.pdf
    Interdisciplinary toxicology 10/2014; 7(2):47-59.
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    ABSTRACT: Activated neutrophils represent the main source of myeloperoxidase (MPO), superoxide (SO) and subsequently derived oxygen metabolites. They have important microbicidal activities, however in inflammatory conditions they may secondarily attack surrounding tissues. Overproduction of reactive oxygen species, prolonged or excessive liberation of MPO and other effective yet also toxic substances from neutrophils may participate in disturbed apoptosis, intensify the inflammatory processes and result in serious human diseases. The inhibitory effect of quercetin on PMA stimulated SO generation in isolated human neutrophils was found to be dose-dependent, without affecting the activity of intact isolated neutrophils. At comparable conditions, quercetin was more potent in inhibiting MPO release than SO generation. Our results indicate that quercetin could support resolution of inflammation through decreased activity of neutrophils, i.e. respiratory burst and degranulation.
    Interdisciplinary toxicology 06/2012; 5(2):81-3.
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    ABSTRACT: Approximately 50% of publications in English peer reviewed journals are contributed by non-native speakers (NNS) of the language. Basic thought processes are considered to be universal yet there are differences in thought patterns and particularly in discourse management of writers with different linguistic and cultural backgrounds. The study highlights some areas of potential incompatibility in native and NNS processing of English scientific papers. Principles and conventions in generating academic discourse are considered in terms of frequently occurring failures of NNS to meet expectations of editors, reviewers, and readers. Major problem areas concern organization and flow of information, principles of cohesion and clarity, cultural constraints, especially those of politeness and negotiability of ideas, and the complicated area of English modality pragmatics. The aim of the paper is to sensitize NN authors of English academic reports to problem areas of discourse processing which are stumbling blocks, often affecting acceptance of manuscripts. The problems discussed are essential for acquiring pragmalinguistic and sociocultural competence in producing effective communication.
    Interdisciplinary toxicology 06/2012; 5(2):105-15.
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    ABSTRACT: The pomegranate, Punica granatum L., has been the subject of current interest as a medicinal agent with wide-ranging therapeutic indications. In the present study, pomegranate ethanolic seed and hull extracts were tested, in comparison with a commercial sample, for the inhibition of aldose reductase, an enzyme involved in the etiology of diabetic complications. In vitro inhibition of rat lens aldose reductase was determined by a conventional method. Pomegranate ethanolic hull extract and commercial pomegranate hull extract exhibited similar aldose reductase inhibitory activity characterized by IC(50) values ranging from 3 to 33.3 μg/ml. They were more effective than pomegranate ethanolic seed extract with IC(50) ranging from 33.3 to 333 μg/ml. Antioxidant action of the novel compounds was documented in a DPPH test and in a liposomal membrane model, oxidatively stressed by peroxyl radicals. All the plant extracts showed considerable antioxidant potential in the DPPH assay. Pomegranate ethanolic hull extract and commercial pomegranate hull extract executed similar protective effects on peroxidatively damaged liposomal membranes characterized by 10<IC(50)<100 μg/ml. Pomegranate ethanolic seed extract showed significantly lower antioxidant activity compared to both hull extracts studied. Pomegranate extracts are thus presented as bifunctional agents combining aldose reductase inhibitory action with antioxidant activity and with potential therapeutic use in prevention of diabetic complications.
    Interdisciplinary toxicology 03/2012; 5(1):15-20.