Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo (ACTA DERMATOVENER CR )

Publisher: Hrvatsko dermatološko društvo


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  • [Show abstract] [Hide abstract]
    ABSTRACT: Pemphigus vulgaris (PV) is an infrequent autoimmune bullous disease involving the skin and mucous membranes, which is rare in pediatrics. Although the main therapy for childhood PV are steroids, immunosuppressive drugs are often needed to control the disease. We report the case of an 11-year-old Caucasian boy who presented with a 10 months history of PV unresponsive to steroids and to intravenous immunoglobulin. The therapeutic use of rituximab allowed a long-lasting and complete remission. According to a good safe profile and to our case report, as well as the literature, rituximab may be considered an safe and efficacious treatment for PV.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):288-290.
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    ABSTRACT: Dermatology is a specific branch of medicine which includes dermatologic manifestations of systemic underlying diseases as well as primary cutaneous diseases. In this study, specialists’ abilities of defining and diagnosing dermatologic diseases were assessed. 381 hospitalized patients who were referred to the Dermatology Clinic were reviewed via electronic medical charts. 121 of the clinicians (31.2%) made a dermatologic definition when referring their patients to dermatology. 136 of the the clinicians (35.1%) made a pre-diagnosis for their patients’ dermatologic condition of which 90 (66,2%) were correct and 46 (33,8%) were non-relevant. Internists wrote a definitive dermatologic examination note significantly more often than surgeons (P=0.03). However, there was not a significant difference between internists and surgeons when we compared the ratio of correct and complete dermatologic definitions of patient condition (P=0.503). There was also no difference between surgeons and internists in terms of making a pre-diagnosis, making a correct diagnosis, and making a wrong diagnosis (P>0.05 for each comparison). In conclusion, dermatologic consultations are crucial and necessary for the improvement of patient care and treatment. Specialists lack basic skills to recognize and define dermatologic conditions they are confronted with
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 09/2014; 22(22):259-263.
  • Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 06/2014; 8(2):119.
  • Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 03/2014;
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    ABSTRACT: Acute myeloid leukemia (AML) is a clonal expansion of myeloid blasts in peripheral blood, bone marrow, or other tissues. Cutaneous manifestations of leukemia are either specific or nonspecific. Specific lesions result from direct infiltration of the skin by leukemic cells. We present a case of myeloid leukemia cutis manifested by erythematous asymptomatic nodules and plaques distributed on the chest, abdomen and back. The clinical and histopathologic features of the cutaneous infiltrate were suggestive of hematolymphoid malignancy, more towards lymphoma. However, the immunohistochemical features were against the diagnosis of lymphoma and were highly suspicious of myeloid leukemia, which were concomitantly confirmed by bone marrow biopsy and blood smear. In any poorly differentiated malignant skin infiltrate of confirmed hematopoietic lineage, myeloid differentiation should be considered and excluded by an appropriate panel. CD56+ AML is a rare type of AML that has special features like the great liability of extramedullary involvement including skin, monocytic characteristic of leukemia cells, and absence of myeloperoxidase expression.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 09/2013; 21(3):189-192.
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    ABSTRACT: Abstract Background. Endothelin-1 (ET-1), expressed by keratinocytes, has paracrine effects on melanocytes. The endothelin 1-axis [ET-1, endothelin A receptor (ETAR) and endothelin B receptor (ETBR)] is thought to play a role in the depigmentation process occurring in vitiligo, with no studies on the cutaneous protein expression of this axis in the disease. Objectives. To compare the expression of ET-1 axis in lesional and perilesional normal epidermis of vitiligo patients. Methods. Ten patients with non-segmental stable vitiligo were included. Skin biopsies from all patients were studied immunohistochemically for ET-1, ETAR and ETBR expression. Results. There was no statistically significant difference between lesional vitiligo and perilesional normal epidermis regarding rates of expression of ET-1, ETAR and ETBR (P-value =0.82, 0.5 and ˃0.99 respectively). Semi quantitative analysis of ETAR revealed higher staining grades in lesional compared with perilesional normal epidermis but with a statistically significant difference (P-value =0.04). There was also no statistically significant difference between the two groups regarding the staining grades of ET-1 and ETBR (P-value>0.05 in both markers). A highly significant positive correlation was detected between ET-1 and ETAR (r =0.99, P-value <0.05) and between ET-1 and ETBR (r=0.87, P-value<0.05). Conclusion. This study shows unaltered expression of ET-1 axis in keratinocytes in lesional vitiligo and perilesional normal epidermis. Further studies on the differential expression of this axis in keratinocytes and melanocytes are therefore required.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 01/2013; 21(1):12-18.
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    ABSTRACT: Drug-induced pemphigus is a well-established variety of pemphigus, presenting with clinical and histopathologic features identical to idiopathic form. Medical history plays a fundamental role in the diagnosis of drug-induced pemphigus. A large variety of drugs have been implicated in its pathogenesis and they may induce acantholysis via biochemical and/or immune mechanism. We present a case of a 69-year-old woman affected by amoxicillin/clavulanic acid-induced pemphigus and discuss its pathogenetic mechanism.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 06/2012; 20(2):108-111.
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    ABSTRACT: On March 18, 2012, at the Annual Meeting Luncheon in Indigo Ballroom of Hilton Hotel in San Diego, WDS Awards delivery was successfully organized by Prof. Diane Berson, president of the Women's Dermatologic Society (WDS 2011-2012) Physicians Leaders Mentors. Awards were designated for particular areas of professional skill development and goal-oriented projects. Up to $10,000 were awarded! WDS Mission is to foster, promote and support women's issues in dermatology; to identify, train, and recognize women leaders in dermatology; to provide a forum for developing relationships through mentoring and building of coalitions; to provide a forum for the exchange of ideas and research relevant women's issues; to promote the highest possible standards of ethics, support of research, patient care, patient education and public education. The WDS Career and Community Advancement Award encourages projects and initiatives focusing on community service, career enhancement, and advancement of the specialty of dermatology. This year, the 2012 Rose Hirschler Award Recipient is Jean L. Bolognia, Professor of Dermatology at the Yale University School of Medicine, the author of over 180 articles and book chapters, especially as senior editor of the textbook Dermatology, which has been translated into four other languages. She is "walking encyclopedia"! Rose Hirschler Award is named in honor of Dr. Rose Hirschler, the first known female dermatologist in the United States. The Award is presented annually by the WDS to a physician chosen for significant contributions to medicine and dermatology and who by their achievement has served to enhance the role of women in the specialty of dermatology.Jasna Lipozenčić (2010-2013) and Branka Marinović (2012-2015), members of the International Affairs Committee of WDS from Europe, participated in this ceremony togeather with Luitgard Wiest co-chair (2010-2013) Dedee F. Murrell previous chair and current senior advisor of International Affairs Committee.Congratulation to Jean!
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 06/2012; 20(2):126-7.
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    ABSTRACT: Robert C. Gallo, MD, human immunodeficiency virus-codiscoverer and acclaimed scientist, returned to New Jersey Medical School after about a quarter century to serve as Alpha Omega Alpha (AΩA) Visiting Professor. The legendary Prof. Gallo and his co-workers discovered interleukin-2 in 1976, which set the stage for culturing human T-cells. Accordingly, he was able to discover HHV-6, HTLV-1 and HTLV-2, and co-discover HIV (HTLV-3) as well as devised the first blood test for HIV disease. He has won the vaunted Albert Lasker Prize twice and has 30 honorary doctorates and a multitude of other awards and accolades. It was a wonderful experience for faculty, residents and students as Prof. Gallo graciously shared his experiences in two overpacked one-hour lectures, discussions with individual faculty members, and an inspirational evening talk (Fig. 1). The inspiring keynote address, introduced by Stan Weiss and Robert A. Schwartz, was delivered by AΩA Visiting Professor Robert C. Gallo MD, who had himself been inducted into AΩA 50 years earlier as a medical student at the Jefferson Medical College. He enchanted the audience with inspiring stories of his early life complete with trepidation and challenges. He urged medical students to pursue a career in research, especially in virology. It was a day that faculty, residents, and students will long recall, thanks to the extraordinary graciousness and enthusiasm of legendary AΩA Visiting Professor Robert C. Gallo, MD.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 06/2012; 20(2):126-7.
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    ABSTRACT: 3rd World Psoriasis and Psoriatic Arthritis Conference 2012, Stockholm, Sweden, June 27 - July 1, 2012. Contact: 9th EADV Spring Symposium, Verona, Italy, June 6-10, 2012. Contact: 67th Congress of the Brazilian Society of Dermatology; 100 years celebration of the Brazilian Society of Dermatology, Rio de Janeiro, Brazil, September 1-4, 2012. Contact: 21st EADV Congress, Prague, Czech Republic, September 27-30, 2012. Contact: 3rd Croatian Congress of Psychodermatology with international participation, Split, Croatia, October 4-7, 2012. Contact: International Scientific Congress "Update in Dermatologic Drug Therapy", Opatija, Croatia, October 18-20, 2012. Contact: 6th World Meeting of Interdisciplinary Melanoma Skin Cancer Centers AND 8th EADO Congress, Barcelona, Spain, November 14-17, 2012 71th Annual Meeting of American Academy of Dermatology, Miami Beach, Florida, March 1-5, 2013. Contact: 10th EADV Spring Symposium, Cracow, Poland, May 23-26, 2013 Contact: 22nd EADV Congress, Istanbul, Turkey, October 3-7, 2013 Contact: 72th Annual Meeting of American Academy of Dermatology, Denver, Colorado, March 21-25, 2014.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 06/2012; 20(2):130.
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    ABSTRACT: There has been an increase in publishing books on the topic of drug therapy. This handbook reflects advances in drug development but also reduced access to dermatology in patient care. Potent drugs with serious or life-threatening adverse effects are frequently prescribed by dermatologists. This book is an accessible and concise aid which can be consulted in the clinic with regard to prescribing and monitoring of systemic dermatologic therapy. Evidence-based data have been included where possible. Common and important adverse drug effects are described. The following issues have been tackled by the 46 handbook contributors: Acitretin; Acne antibiotics; Androgens and Antiandrogens; Antifungals; Antihistamines; Antimalarials; Azathioprine; Cyclosporin; Clofazimine; Colchicine; Corticosteroids; Cyclophosphamide; Dapsone; Hydroxyurea; Fumaric acid esters; Interferons; Intravenous Immunoglobulin; Isotretinoin; Methotrexate; Mycophenolate mofetil; Nicotinamide; Psoralens; Sulphapyridine and Sulphamethoxypyridazine; Thalidomide; Treatment in pregnancy and lactation; Treatment in childhood; Treatment in patients with kidney disease; and Treatment in patients with liver disease. For each of the systemic drugs, the following aspects are described: Classification and mode of action; Indications and dermatological uses; Presentation; Dosages and suggested regimens; Monitoring; Contraindications; Cautions; Main drug interactions; Adverse effects and their management; Patient information; Use in pregnancy and preconception; Use in lactation; Use in childhood; Use in renal impairment; and Use in liver disease. Update references follow description of each drug. At the end of the book, treatment in pregnancy and lactation is described in detail (Principles of treatment in pre-embryonic phase, in embryonic phase and fetal phase; Pregnancy testing; Categorization of drugs in pregnancy; Categorization of lactation risk with table of safe profile; and Comments on dermatological drugs that may be used during lactation (chloropheniramine, erythromycin (except for estolate), amoxicillin). Treatment in childhood is carefully described by the principles of treatment, use of unlicensed medicines, formulation and administration of drugs, special points on specific drugs, and risk categories. There is a list of drugs that are considered safe in dermatologic conditions in children: chloropheniramine, hydroxyzine, promethazine, cetirizine, desloratadine, zoratadine, terfenadine, cimetidine, erythromycin, tetracycline (≤8 years), trimethoprim, griseofulvin, fluconazole, ketoconazole, and immunoglobulins. There is a section dedicated to treatment in patients with renal disease (Principles of treatment, Alterations in pharmacokinetics in renal failure, Assessment of renal function, Prescribing in renal impairment, Special points on specific drugs). Of great value are guidelines for modification of drug doses in renal impairment for 24 systemic drugs. In addition, there is a section on the treatment in patients with liver disease (Principles of treatment, Factors to be considered in prescribing alternations, Special points on specific drugs for 16 drugs). At the end of the book there is an index of systemic drug treatment in dermatology. In conclusion, this handbook is recommended as advancement in systemic drug management in dermatology as an accessible guide that provides practical information to dermatologists, general practitioners, pharmacists and others, to ensure safe and effective care of dermatology patients on systemic drug treatment.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 06/2012; 20(2):128-9.
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    ABSTRACT: In recognition of his outstanding service to dermatology, his efforts through the Academy, and his commitment to the future of teaching and practice of cutaneous medicine, C. William Hanke, MD, former Academy president, was awarded the Academy's Gold Medal as a high honor. Wilma Bergfeld, MD, received the Academy's Marion B. Sulzberger MD Award and Gold Triangle Award, and is the namesake of WDS Visionary and Leadership Award. Thomas Waldinger, MD, receives Arnold P. Gold Foundation Humanism in Medicine Award to physicians who demonstrate commitment to patient care. Drs. Amandasabapathy and Cho win the Young Investigators Award of the Academy 2012. Dr. Raymond Cho and his group at UCSF investigate how the cells of the skin become vulnerable to genetic damage, acquire genomic mutations and progress to a cancerous state. AAD and the Dermatology Foundation play a critical role in encouraging new investigators and rendering the field contributions to molecular medicine.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 06/2012; 20(2):126-7.
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    ABSTRACT: The edition Fortschritte der praktischen Dermatologie und Venerologie 2010, in English Advances in Practical Dermatology and Venereology 2010, emphasizes all aspects of Dermatology and Venereology, as traditionally presented every year at the Congress providing continuing education for German dermatologists and venereologists, during the jubilee week on July 25-30, 2010. The book has been written in German by 146 dermatologists as well as Dia-Klinik authors from Ludwig-Maximillian-University and Department of Dermatology and Allergology in Munich. As stated in the Preface, this tradition of continuing education for German speaking dermatologists has been well known for 60 years now, starting with Professor Alfred Marchionini, Professor Otto Braun-Falco, Professor Gerd Plewig and now Professor Thomas Ruzicka. There was special atmosphere at the Congress, as reported by all the participants. Plenary and oral presentations, courses, lunch seminars, satellite seminars, special courses like Ultrasound and Laser Courses and breakfast seminars were all highly attractive and interesting. The book has 646 pages, while chapters are illustrated with excellent color photographs, tables in blue and color schemes, including the following: 1. Newest knowledge and view in the future Acne and rosacea; Psoriasis, autoinflammation syndrome, new dermatotherapeutic options; The evolution of human skin color; Over pigmentation and segmental manifestation and steam cells - friend or enemy? 2. Pediatric dermatology Congenital nevi - when anything to do; Neutrophilic dermatoses in childhood; Bullous lesions in childhood - differential diagnosis and therapy. 3. Dermatooncology Dermatooncology - current knowledge; Melanoma - view in the future; Innovation in the therapy of metastatic melanoma; Sentinel lymph nodes - Munich experience and follow-up dates. 4. Dermatological problem zones Dermatological problem zones on the skin of the head; Genito-anal region; Soul. 5. Eczema and Allergology Hematogenetic contact eczema (systemic contact dermatitis): what is this?; Atopic eczema - view in the future; New development in the management of atopic eczema; Allergology: tolerance or no tolerance - this is the central question; Primary allergology prevention; Anaphylaxis - new aspects in pathophysiology and management. 6. Aesthetic Dermatology Newest knowledge in aesthetic dermatology; Beautiful skin through hormones and cosmeceuticals? Good-looking hair - possibility of hair transplantation; Complications in aesthetic medicine. 7. Update and new technical advance Update - autoimmune dermatoses; Update - photodermatology; Update - laser; New labor diagnostic methods; New picturesque methods. 8. Undesired question on the skin Insects and Borrelias; Staphylococci. 9. Cases, mistakes and practical decisions Wolf in the sheep fur…or reversely; Bad running - from mistakes to learn; Pigment disturbance - actual to vitiligo and melasma; Nail diseases; Urticaria. 10. Courses Acne and rosacea; Andrology; Occupational dermatoses; Botolinum toxin I: base support; Botulinum toxin II: advanced stages; Filler. 11. Recipes and dermatological galenic - practical tips and Examples Pediatric dermatology; Update in wound management in Germany; Mycology; Nail diseases; Food allergy; New diagnostic and therapeutic methods; Phlebology; Photodermatology; Photodynamic therapy and fluorescence diagnostics; Cardiologic and lung resuscitation; Nail problems with cicatrix - actual therapeutic possibilities; Proctology; Psychodermatology - update 2010; Sexually transmitted diseases; Sonography of the skin and subcutis including Subcutaneous lymph nodes; Specific immunotherapy; Structure and function of the skin; Trichoscopy and trichogram. 12. Dia-Clinic Churg-Strauss syndrome; Adiponecrosis subcutanea neonatorum; Infection with cowpox; Angiofibromata gigantea by Morbus Bourneville-Pringle; Skin changes in type IIa - hypercholesteronemia; Spiky hyperkeratosis associated with malignant melanoma; Erythema a computatro; Loefgren syndrome; Erythrodysesthesia within chemotherapy; Cutaneous actinomycose; Unilateral Morbus Favre-Racouchot; Progressive nodular histiocytosis; Granular parakeratosis; Contact eczema on carrot-brandy corn wheat; Whirpool dermatitis with 'hot hands'; Subcorneal bleeding by anticoagulation; 'Yellow dots' in alopecia areata diffusa; Bullous pemphigoid induced by zoster; Granulomatous syphilis lesions masked with prurigo-like scabies; Aurantiasis cutis; Becker-Naevus on leg with lipoatrophy; Birt-Hogg-Dubé syndrome; Linear IgA dermatosis of childhood; Monozygotic twins with papillomatosis confluence and reticularis Gougerot-Carteaud; Pemphigus vulgaris juvenilis with skin and mucosal involvement; Histoplasmosis; Diffuse dermal angiomatosis; Poppers dermatitis. This book is highly valuable for German speaking dermatologists and venereologists because it connects scientific update knowledge in dermatology and venereology with practical knowledge from the Munich dermatology school. In 2011, it achieved the same success with European attendees and the English version of the book.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 04/2012; 20(1):59-60.
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    ABSTRACT: At the beginning of 2010, Paediatric Dermatology, first edition, was published by the Oxford Specialist Handbooks in Paediatrics. This book has been written jointly by members of the British Society for Paediatric Dermatology (BSPD), an organization that for the last 25 years has provided an educational forum for dermatologists and pediatricians practicing in this area. This book aims to make the full range of dermatological diagnosis accessible to any doctor seeing children, including pediatricians, general practitioners, accident and emergency staff, trainee dermatologists, and other healthcare professionals faced with assessment, diagnosis and treatment of children with skin diseases. This book is an indispensable and a highly accessible guide for all readers. Six sections are subdivided into 37 chapters written by experts. The book is organized according to presentation and body site rather than diagnosis, making it ideal for quick reference in clinical setting. The book offers many algorithms and treatment protocols for skin diseases in children. Boxes are used to flag up important points and provide lists of differential diagnoses. Terms and abbreviations are clearly explained. In section one, the basics of dermatology are tackled in chapters on the structure and function of the skin, dermatological consultation, dermatological treatments, patterns, shapes and distribution in skin disease, endocrine dysfunction and the skin, and failure to thrive and skin. In section two, neonatal skin problems and vascular birthmarks are described. The section on the diagnosis by body distribution includes chapters on skin problems of the face, nose, eyelids and ears, oral problems, trunk and flexures, genital skin disorders, hair and scalp disorders, nail changes, and photosensitivity. Other sections are dedicated to rashes, textural skin changes (blisters, crusts, scabs, dry skin disorders, changes in skin thickness and elasticity, ulceration of the skin). The last, sixth section deals with discoloration of the skin and contains chapters on various forms of skin discoloration and melanocytic nevi. Although attention is focused on more common skin diseases in children, the features of many less frequent diseases are listed under relevant clinical signs to aid diagnosis. This book contains over 300 full-color clinical photographs positioned alongside the text to aid the diagnosis. This valuable book is the right example how to write to make the text useful to a wide reading public.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2011; 19(4):213.
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    ABSTRACT: The fourth edition of Dermatology Secrets Plus has been received with high interest among dermatologists. This valuable book is based on the Socratic method of teaching, which involves asking and answering questions to stimulate critical thinking. It is the goal of this textbook to simulate the kinds of questions that might be used on dermatology patients rounds as the senior attending physician applies the Socratic method of teaching to medical students and residents. The book begins with 100 secrets that summarize the concepts, principles and most salient issues of diagnosis and therapy in dermatology. Skim the Top 100 Secrets chapter and Key Point Boxes offer fast overview of the secrets, which dermatologists must know for success on the boards and in practice. The first part includes chapters with questions and answers about the structure and function of the skin, morphology of primary and secondary skin lesions, and diagnostic techniques. For example, the question is what is apocopation. The answer is that apocopation is that process by which melanocytes transfer melanosomes to keratinocytes. In this process, the tips of the melanocytic dendritic processes are phagocytized by keratinocytes. Answers to most questions are quite long, depending on the topic complexity. The part of the book about inherited disorders includes chapters with questions and answers about disorders of keratinization, neurocutaneous disorders and mechanobullous disorders. In the third part are questions and answers about inflammatory skin disorders, i.e. papulosquamous skin eruptions, dermatitis (eczema), contact dermatitis, vesiculobullous disorders, pustular eruptions, lichenoid eruptions, granulomatous diseases of the skin, drug eruptions, vasculitis, deposition disorders, photosensitive dermatitis, disorders of pigmentation, panniculitis, alopecia, acne and acneiform eruptions, autoimmune connective tissues diseases, urticaria and angioedema. The fourth part contains chapters with questions and answers about infections and infestations, and the fifth part about cutaneous manifestations of internal diseases. In the sixth and seven parts there are questions and answers about benign and malignant tumors of the skin, while the eighth part contains chapters about treatment of skin disorders, i.e. sunscreens, topical steroids, fundamentals of cutaneous surgery, cryosurgery, Mohs surgery, lasers, photomedicine and retinoids. Special chapters are dedicated to neonatal infections, pediatric dermatology, geriatric dermatology, dermatoses in pregnancy, disorders of female genitalia, and cultural dermatology. The last chapters deal with emergencies and miscellaneous problems such as approaching a pruritic patient, occupational dermatology, psychocutaneous diseases and nail disorders. The benefit from the proven Secrets format is that it is concise, easy to read, and highly effective. All chapters are illustrated with more than 500 excellent photographs.In this edition, there are 8 new tables and more than 90 new figures. Also, there are new references in all chapters and Web Resources added to the bibliography. This valuable book will certainly find its place in every dermatology library.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2011; 19(4):279.