Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo (ACTA DERMATOVENER CR)

Publisher: Hrvatsko dermatološko društvo

Journal description

Current impact factor: 0.58

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 0.581
2012 Impact Factor 0.481
2011 Impact Factor 0.36
2010 Impact Factor 0.272
2009 Impact Factor 0.461

Impact factor over time

Impact factor
Year

Additional details

5-year impact 0.45
Cited half-life 4.90
Immediacy index 0.04
Eigenfactor 0.00
Article influence 0.10
Other titles ADC
ISSN 1330-027X
OCLC 32363382
Material type Periodical
Document type Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: SUMMARY Autoimmune bullous diseases are systemic disorders with autoantibodies that result in blisters. Aim of this study was to indicate the spectrum and treatment modalities of five types of bullous disorders most prevalent in the south of Iran: pemphigus vulgaris (PV), pemphigus foliaceus (PF), epidermolysis bullousa aquisita (EBA), bullous pemphigoid (BP), and pemphigoid gestationis (PG). Patients with PV, PF, BP, EBA, and PG were included in this study. The data regarding the age, sex, and the treatment used for PV, PF, and BP were recorded and analyzed in our center, a tertiary referral center. T-test and Mann-Whitney test for independent samples were used for the analysis of parametric and nonparametric variables, respectively. Chi-square test was used for frequencies. Of the 441 patients included in this study, 82.9% had PV, 4.7% PF, 8.5% BP, 1.5% EBA, and 1.3% PG. 93.5% of patients with PV, 95.3% with PF, and 100% with patients with BP were treated and responded to first line therapies with one or two medications. The most frequent autoimmune bullous disease was PV, followed by PF. For PV and PF, combination of prednisolone and azathioprine was the most frequent first line medication. In the patients with BP, prednisolone monotherapy was the most frequent one. Only a minority of patients with PV and PF needed the third or fourth medications.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4).
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    ABSTRACT: "Non-Aromatic Very rich in Steranes" (NAVS) naphthalan is a purified natural oil derivative, abundant in steranes (geogenic "steroids"). The purpose of this study was to evaluate the effectiveness of NAVS in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS). We used NAVS oil in adhesive paste in 11 patients with clinically and histologically proven OLP (open label), and in 7 patients with RAS (double blind randomized; topical betamethasone in adhesive paste used as control). The severity of the OLP lesions was objectively scored. The number and diameter of RAS lesions were assessed on days 0, 3, and 5. The intensity of pain and discomfort was determined using visual analogue scale (VAS) and "Oral health impact profile" (OHIP-14) before and after therapy. OLP cumulative activity scores on days 0 and 28 were 101.5 and 48.5, respectively (t=5.99; P=0.0001). Using NAVS for 28 days resulted in 52.2% overall clinical improvement. Cumulative OHIP-14 scores on days 0 and 28 were 210 and 142, respectively (t=5.65; P=0.0002). Out of a total of 7 patients with RAS, 4 of them were treated with NAVS and 3 with topical corticosteroids. There were no statistically significant differences in improvement rate between the two groups (lesion number (day 3 P=0.29; day 5 P=0.32); lesion diameter (day 3 P=0.64; day 5 P=0.74)). NAVS successfully reduced the clinical signs and symptoms of OLP, and reduced the number, diameter, and symptoms in patients with RAS, statistically comparable with corticosteroids.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):250-258.
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    ABSTRACT: SUMMARY Juvenile systemic lupus erythematosus (JSLE) is a systemic autoimmune chronic disease that can affect any part of the body. It is characterized by the formation of antibodies against nuclear antigens. Vasculitis may be found in SLE, but it scarcely complies with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) criteria. We report five cases of severe JSLE associated with AAV diagnosed between 1991 and 2013 in three university-based tertiary care centers. The patients (3 girls and 2 boys, aged 12 to 17) presented with a severe clinical picture and the following features: cytopenia (n=5), autoimmune hepatitis (n=3), lupus nephritis (n=1), pancreatitis (n=1), secondary antiphospholipid syndrome (n=2), impending respiratory failure (n=2), and gastrointestinal bleeding (n=1). All patients were proteinase 3 (PR3) ANCA positive, while two of them were myeloperoxidase (MPO) and PR3 ANCAs positive at the same time. They were treated with corticosteroids and immunosuppressive drugs. Remission of the disease was achieved in three patients. The course of the disease was worsening in two patients and we included rituximab (anti-CD20) in therapy. All of our patients presented as the most severe SLE patients, who must be diagnosed as soon as possible and treated very intensively. Since the comorbidity of JSLE and AAV occurs very rarely in children, presentation of such patients, their clinical pictures, treatment, and the course of the diseases are experiences that can be of great help.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):164-270.
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    ABSTRACT: Pemphigus vulgaris (PV) is an infrequent autoimmune bullous disease involving the skin and mucous membranes, which is rare in pediatrics. Although the main therapy for childhood PV are steroids, immunosuppressive drugs are often needed to control the disease. We report the case of an 11-year-old Caucasian boy who presented with a 10 months history of PV unresponsive to steroids and to intravenous immunoglobulin. The therapeutic use of rituximab allowed a long-lasting and complete remission. According to a good safe profile and to our case report, as well as the literature, rituximab may be considered an safe and efficacious treatment for PV.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):288-290.
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    ABSTRACT: Dermoscopy plays an important role in the diagnosis of pigmented lesions, particularly in the differential diagnosis of early-stage melanoma. Dermoscopy systems that aim to enable automatic "unmanned-without physician" diagnosis are becoming increasingly common. We aimed to investigate the reliability and weaknesses of diagnosis programs. Furthermore, we attempted to determine whether such programs are superior to diagnosis by a physician, compared to histopathological assessment. The images stored in the DermoGenius ultra-computerized dermoscopy system of the Dermoscopy Unit between January 2008 and December 2008 were surveyed retrospectively. Dermoscopic images made prior to excision of 77 lesions from 51 patients verified by histopathology were reviewed. Nineteen patients were men and 32 were women. Mean age was 35.5 years. Diagnosis by a clinician or automatic analysis revealed that 23 (30%) of the lesions were atypical (dysplastic) nevi, 22 (29%) were compound nevi, 10 (13%) were dermal nevi, 8 (10%) were malignant melanomas, 7 (9%) were common nevi, 6 (7%) were junctional nevi, and 1 (1%) was a blue nevus. Compared to histopathological diagnosis, considered the gold standard, the sensitivity of the automated analysis program was 96.6%, its specificity 14.9%, and its diagnostic accuracy 47%. For the clinician, the values were 100% for sensitivity, 66.7% for specificity, and 95% for diagnostic accuracy. Based on histopathological results, the diagnostic accuracy of the physician was higher than that of the automatic analysis program. Therefore, errors are inevitable when an inexperienced physician assesses patients according to automatic program results.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):278-83.
  • Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):301-4.
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    ABSTRACT: In recent years, group G Streptococcus has been reported with increasing frequency as the cause of a variety of human infections. Underlying host factors such as immunosuppression, malignancy, diabetes mellitus, and rheumatoid arthritis may be predisposing conditions leading to infection. Toxic involvement and post-streptococcal sequalae, once believed to be exclusive to infections caused by group A Streptococcus, are now known to occur following acute group G Streptococcus and group C Streptococcus infections. We report on a case of group G Streptococcus bacteremia and recurrent cellulitis with toxic involvement. Patient blood cultures were always negative for β-hemolytic Streptococci in all the recurrences, except during the last one. Antibiotic therapy based on antibiogram quickly resolved the infection. A regimen of intramuscular injection of 1.2 million units of benzathine penicillin every 15 days for one year prevented recurrences of cellulitis.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):298-300.
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    ABSTRACT: The incidence of cutaneous melanoma has increased significantly worldwide over the last several decades. The aim of this study is to determine clinical and morphology characteristics of primary melanoma, since some of them are important prognostic factors. This retrospective study included 172 patients. The data were collected by the Consulting team for malignant skin tumors in the Banja Luka Clinical Centre from 2009 to 2011. We did not use dermoscopy as a diagnostic tool in our investigation. We determined that melanoma occurs equally commonly in both sexes, in women in the sixth decade and the seventh in men. The most common sub-type was nodular melanoma (59.5%, P<0.05), followed by superficial spreading (27.8%) and acral lentiginous melanoma (11.4%). The most common localization was on the back in men (34.3%) and on the legs in women (P<0.05). More than half of our patients (55.8%) had melanoma thickness from 1.0 to 4.0 mm, and 38% had a melanoma thicker than 4.0 mm. The average Breslow thickness is 4.6 mm. More women than men had melanoma thicker than 4 mm (P<0.05). Spread of the primary tumor localization was found in 31.4% of patients, more frequently in men than in women (P<0.05). In most cases it was abstraction of lymph nodes (P<0.05). The average thickness of the melanoma in our patients is much higher than the average in the world and the countries of Europe. The results of this study indicate a need for better unique regional registry in this part of Bosnia and Herzegovina and improvement of preventive measures in the early diagnosis of melanoma.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):271-7.
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    ABSTRACT: Fuchs' syndrome (Stevens-Johnson syndrome without skin involvement) is a sporadically diagnosed disease. Most authors consider it to be a pure mucosal variant of Stevens-Johnson syndrome; however, some consider the syndrome a separate entity. The complete absence of cutaneous symptoms may be the reason that not all cases of Fuchs' syndrome are diagnosed and properly classified. The authors describe a case of a 22-year-old patient suffering only from mucosal symptoms, diagnosed as Fuchs' syndrome from the context of the tests performed. A Mycoplasma pneumoniae infection triggered the disease onset. Mycoplasma infection, as a trigger factor of Fuchs' syndrome in adults, has so far been described in only a few isolated cases worldwide.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):284-7.
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    ABSTRACT: Bacillary angiomatosis is a systemic disease caused by Bartonella (B.) henselae and B. quintana. Today it is a rare disease that occurs predominantly in patients with poor adherence to antiretroviral therapy or with late diagnosis of human immunodeficiency virus (HIV). We report on the case of a 40-year-old Caucasian female with HIV-1 and hepatitis B virus (HBV) co-infection diagnosed 17 years ago. She presented to the emergency department with an erythematous, painless nodule located on the left naso-genian fold. In the next few weeks the disease disseminated to the oral and left tarsal mucosa and to the palm of the left hand. The histopathological findings were suggestive of bacillary angiomatosis which was confirmed by polymerase chain reaction (PCR). The patient was treated with clarithromycin 500 mg bid per os for 3 months, with complete remission of the mucocutaneous lesions. Bacillary angiomatosis is a potentially fatal disease. Early diagnosis and treatment are critical in reducing the morbidity and mortality associated with it.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):294-7.
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    ABSTRACT: Pearly penile papules (PPP) are benign and common lesions in the male population. Several terms have been used to describe this entity, including Tyson glands, hirsutoid papillomas, papilla in the corona glandis, hirsutis papillary corona of the penis, corona capilliti, and pink pearly papules (1,2). PPP commonly develop after puberty and their incidence decreases with age (1). The prevalence of this condition is estimated to be 14%-48%, the incidence being higher among black males and uncircumcised men (1,3). Their histologic features are characteristic of angiofibroma and are typically localized to the corona and the sulcus of the penis but can also affect the shaft (1). PPP may resemble other entities such as condylomata acuminata, ectopic sebaceous glands, molluscum contagiosum and lichen nitidus, leading to hazardous and unwarranted treatments (1,2). Pearly penile papules are commonly seen in clinics for sexually transmitted disease (STD) and are a cause of anxiety in adolescence and young manhood (4). In some studies about PPP, human papillomavirus (HPV) was suggested to play a role (5), however, Hogewoning et al. showed that there is no association between PPP and HPV (3). Several modes of therapy are used for treating PPP, including cryotherapy, electrodesiccation, podophyllin, curettage, and carbon dioxide laser ablation; however, treatment should be reserved for patients who have cosmetic or psychological concerns from the appearance of this benign entity (2). We report on the case of a 41-year-old Caucasian man with a history of several months of two non-painful, smooth papules with a central depression, elevated borders, and annular shape on the dorsal surface of the penis near the neck (Fig. 1). Physical examination of the genitalia was otherwise unremarkable. Before his referral, the lesions had been misdiagnosed as primary syphilis and treated with penicillin without response. Because of the uncommon presentation and the patient´s fear of having a sexually transmitted disease, a skin biopsy was performed. Histologic examination revealed dermal ectatic venules embedded in a collagenous stroma with several stellate fibroblasts, recovered by a dome shaped acanthotic epidermis (Fig. 2). These findings matched the histologic features of angiofibroma, and the diagnosis of PPP was established. The benign nature of these lesions was explained to the patient and therefore no treatment was necessary. PPP may vary in shape, size, and color (1), usually range from 1 to 2 mm in width and 1 to 4 mm in length, and can be acuminate, dome, or annular shaped (6). Their color may be pink, white, yellowish, or rarely almost translucent, and they are commonly oriented in a single or double row on the corona, which may partially or completely encircle the glans (1). There are reports of profound proliferating PPP arranged radially from the meatus to the corona, spreading all over the glans (7), ectopic PPP on the penile shaft of a young boy without typical lesions on the corona (6), and typical coronal lesions on the ventral aspect of the penis in an adult man (8). However, PPP localized exclusively near the neck of the penis with the abovementioned morphology and without typical lesions in other localizations in an adult man, as in our patient, has not yet been described. This case thus represents an atypical and rare presentation of PPP that could be confused with primary syphilis or condylomata acuminata. The clinical manifestations of syphilis, the "great imitator" of skin diseases, are variable in appearance and have been reported for centuries (9). HPV is the most frequent sexually transmitted viral infection in the world (10) and a common reason to seek medical attention in sexually transmitted disease clinics. Physicians should be aware of the different clinical presentations of PPP and when the diagnosis is uncertain, a biopsy should be performed.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):311-2.
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    ABSTRACT: A 66-year-old Japanese man presented with a painless skin tumor in his left axillae which had been present for several years without receiving any medical treatment. The tumor enlarged and lesions appeared on several areas on his body within a few months of April 2012 (Fig. 1). Histopathological examination of a skin biopsy specimen taken from a right inguinal tumor showed a dense infiltrate of atypical plasmacytoid cells in the dermis and subcutis (Fig. 2). The epidermis and papillary dermis were not involved. Immunohistological analysis revealed that the tumor cells were negative for T- and B-cell surface markers CD3, CD4, CD8, CD20, CD56, CD79, and HLA-DR (Fig. 3), as well as the mature plasma cell and plasma neoplasm marker, CD138 (Fig. 3), but were positive for IgG, IgG λ light chain, bcl-2 and multiple myeloma oncogene-1 (MUM-1) (Fig. 4). Laboratory investigation revealed a small amount of Bence-Jones protein in the urine and elevated serum levels of total protein (10.5 g/dL), creatinine (1.4 mg/dL), calcium (1.4 mg/dL), immunoglobulin G (5720 mg/dL), and β2 microglobulin (8.1 mg/dL). Chest and abdominal computed tomography showed multiple subcutaneous masses; however, other organs were unaffected. Histopathological examination of a bone marrow biopsy specimen showed no abnormalities. The diagnosis of primary cutaneous plasmacytoma (PCP) was made based on the International Myeloma Working Group criteria (1). The patient was treated with bortezomib and combined vincristine, doxorubicin, and dexamethasone therapy. The tumors initially responded to therapy by decreasing in size and temporarily disappearing. Several months later, the subcutaneous tumors reappeared and enlarged, and the patient subsequently died from bleeding from a tumor in the abdomen 14 months after initial presentation. Extramedullar plasmacytoma (EMP) is a plasma cell tumor that arises outside the bone marrow and may occur in the upper respiratory tract, gastrointestinal tract, and central nervous system, but cutaneous involvement is rare (1). PCPs constitute approximately 2-4% of EMP (2). A prognostic difference between the solitary and multiple forms of the disease has been highlighted by some clinicians who pointed out that the latter runs a more aggressive course and has a relatively high mortality rate, as was seen in our patient (3). PCP cells usually express CD79a, CD38, and CD138, but are negative for CD20 and leukocyte common antigen. Monotypic expression of IgG light chains is usually present (3). In our case, tests were negative for CD79 and CD138, but positive for MUM-1, bcl-2, and IgG light chain. Bcl-2 is member of a family of signaling molecules with proapoptotic and anti-apoptotic activities (4). Located in the mitochondrial membrane, bcl-2 prevents cell death by inhibiting adapter molecules involved in the activation of caspases in the intrinsic pathway. Overexpression of bcl-2 is found in most human tumor types, and is associated with prolonged tumor cell survival, an aggressive clinical course, drug resistance, and a decreased survival rate (5). Tumor expression of bcl-2 and the presence of multiple tumors in the present case were associated with a poor prognosis.
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 12/2014; 22(4):308-10.
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    ABSTRACT: Dermatology is a specific branch of medicine which includes dermatologic manifestations of systemic underlying diseases as well as primary cutaneous diseases. In this study, specialists’ abilities of defining and diagnosing dermatologic diseases were assessed. 381 hospitalized patients who were referred to the Dermatology Clinic were reviewed via electronic medical charts. 121 of the clinicians (31.2%) made a dermatologic definition when referring their patients to dermatology. 136 of the the clinicians (35.1%) made a pre-diagnosis for their patients’ dermatologic condition of which 90 (66,2%) were correct and 46 (33,8%) were non-relevant. Internists wrote a definitive dermatologic examination note significantly more often than surgeons (P=0.03). However, there was not a significant difference between internists and surgeons when we compared the ratio of correct and complete dermatologic definitions of patient condition (P=0.503). There was also no difference between surgeons and internists in terms of making a pre-diagnosis, making a correct diagnosis, and making a wrong diagnosis (P>0.05 for each comparison). In conclusion, dermatologic consultations are crucial and necessary for the improvement of patient care and treatment. Specialists lack basic skills to recognize and define dermatologic conditions they are confronted with
    Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 09/2014; 22(22):259-263.
  • Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 06/2014; 8(2):119.
  • Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 03/2014;