Pediatrics International (Pediatr Int)

Publications in this journal

• Article: 1. Quality of Life in Children Treated with Restrictive Diet for Inherited Metabolic Disease

  Eminoglu TF, Soysal SA, Tumer L, Okur I, Hasanoglu A
  Pediatrics International 01/2013;
• Article: Swine flu (H1N1) in children: preparing for future outbreaks

  Rashmi R Das
  Pediatrics International 01/2011; 53(3):414.
• Article: Different clinical manifestations of HCMV infection in preterm twins: methodological approach.

  Marcello Lanari, Tiziana Lazzarotto, Sara Pignatelli
  Pediatrics International 03/2008; 50(1):141; author reply 142.
• Article: Hepatitis C virus infection and interferon therapy in patients with Down syndrome.

  Yoko Miyoshi, Hitoshi Tajiri, Mariko Okaniwa, Sousuke Terasawa, Tomoo Fujisawa, Toshiyuki Iizuka, Keiichi Ozono
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  ABSTRACT: The clinical features of hepatitis C virus (HCV)-associated liver diseases, or the efficacy of interferon (IFN) therapy in children with Down syndrome (DS) remain to be elucidated. The purpose of the present paper was to survey the features of liver diseases in this subset of children and evaluate the efficacy of IFN treatment in those patients. A questionnaire was sent to 41 members of the Japan Society of Pediatric Hepatology. Ten of them reported on 11 patients with DS who had concomitant chronic HCV infection, providing information on liver disease and the response to IFN treatment. Interferon therapy of 24 weeks duration using natural IFN-alpha was instituted in six of the 11 patients with DS, but none of the six patients cleared HCV-RNA from their serum. Among 12 age- and sex-matched control children who were treated with IFN using the same regimen against chronic HCV infection, half of them had a favorable response to IFN therapy with a sustained clearance of HCV-RNA from their serum. The major baseline features including alanine aminotransferase levels, HCV genotype and viral load were not apparently different between the six patients with DS and the 12 controls. IFN therapy for HCV infection in patients with DS may be unfavorable as compared with non-DS children.
  Pediatrics International 03/2008; 50(1):7-11.
• Article: Kawasaki syndrome and 21-hydroxylase deficiency.

  Daisuke Hazeki, Yuichi Nomura, Michiyo Mizota, Keiko Yotsumoto, Yukiko Nonaka, Takayuki Tanabe, Yoshifumi Kawano
  Pediatrics International 03/2008; 50(1):119-20.
• Source

  Available from: nagasaki-u.ac.jp

  Article: Acute pancreatitis associated with systemic lupus erythematosus: Successful treatment with plasmapheresis followed by aggressive immunosuppressive therapy.

  Norio Tominaga, Shoko Takahira, Takashi Taguchi, Tomoyuki Imagawa, Shumpei Yokota, Hiroyuki Moriuchi
  Pediatrics International 03/2008; 50(1):109-11.
• Article: Gastrointestinal sequelae in survivors of congenital diaphragmatic hernia.

  Francesco Arena, Carmelo Romeo, Sergio Baldari, Salvatore Arena, Pietro Antonuccio, Alfredo Campennì, Biagio Zuccarello, Giuseppe Romeo
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  ABSTRACT: Gastrointestinal sequelae have been sporadically reported in survivors of congenital diaphragmatic hernia (CDH). The aim of the present paper was to evaluate the gastrointestinal morbidity in infant, adolescent and adult patients who had undergone repair of CDH. Thirty-one of 38 survivors after left-side CDH repair were followed up. They were subdivided in two groups. Group A consisted of 12 patients (39%) with a mean age of 4.5 years and group B, 19 patients (61%) with a mean age of 21.0 years. Patients underwent physical examination, barium meal study, gastroesophageal scintigraphy, esophageal pH monitoring and manometry of the esophagus and stomach. Upper intestinal endoscopy was performed in patients with confirmed gastroesophageal reflux (GER). All patients were within the normal range for height or weight. A total of 41.7% of group A and 15.8% of group B had typical symptoms suggesting GER. Barium meal study was pathological in 33.3% of group A and 21% of group B patients. In 58% of group A and 42% of group B, GER was documented on scintigraphy. In 41.7% of group A and 47% of group B the time taken for the stomach to empty half of its radioactive content (T(1/2)) was pathological. On 24 h pH monitoring pathological GER was documented in 54.5%, whereas in group B it was present in 33.3%. In 36.4% of group A and 46.7% of group B alteration of peristalsis of the stomach was recorded. Endoscopy showed esophageal pathology in 33%. Foregut dysmotility and GER are major sequelae in survivors of CDH repair. Long-term follow up of patients with CDH is recommended.
  Pediatrics International 03/2008; 50(1):76-80.
• Article: Nasal flow-synchronized intermittent positive pressure ventilation to facilitate weaning in very low-birthweight infants: unmasked randomized controlled trial.

  Corrado Moretti, Luigi Giannini, Carla Fassi, Camilla Gizzi, Paola Papoff, Patrizia Colarizi
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  ABSTRACT: Nasal flow-synchronized intermittent positive pressure ventilation (NFSIPPV) is a new non-invasive ventilatory mode that delivers synchronized mechanical breaths through the nasal prongs. An unmasked, prospective randomized controlled trial was conducted to compare the efficacy of NFSIPPV and conventional nasal continuous positive airway pressure (NCPAP) in increasing the likelihood for successful extubation in very low-birthweight infants. Consecutive infants who weighed <1251 g at birth, required endotracheal intubation within 48 h of birth and met specific predetermined criteria for extubation by day 14 of life were recruited. Each infant was randomized to receive either NFSIPPV or NCPAP soon after extubation. Extubation was deemed successful if re-intubation was not needed for at least 72 h. Criteria for re-intubation were persistent severe respiratory acidosis (arterial pH <7.20 with pCO2 >70 mmHg), severe recurrent apneic episodes not responding to increased ventilatory settings and then requiring bag ventilation, and hypoxemia (SaO2 <90% or pO2 <60 mmHg with FiO2 > or =0.70). There were no significant differences in clinical characteristics between the two groups at randomization. Ninety-four percent (30/32) infants were successfully extubated to NFSIPPV but only 61% (19/31) to conventional NCPAP (P > 0.005). Infants assigned to NCPAP failed extubation mainly because of apnea and hypercapnia, and those assigned to NFSIPPV because of hypoxia. Neither procedure induced major adverse effects. NFSIPPV in the post-extubation period is safe and more effective than NCPAP in preventing re-ventilation.
  Pediatrics International 03/2008; 50(1):85-91.
• Article: Expression of COX-1, COX-2, and PPAR-gamma in the gastric mucosa of children with Helicobacter pylori infection.

  Hidenori Haruna, Toshiaki Shimizu, Yoshikazu Ohtsuka, Yukiko Yarita, Tohru Fujii, Takahiro Kudo, Yuichiro Yamashiro
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  ABSTRACT: Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo-oxygenase (COX)-1, -2, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on gastric mucosal injury in children with H. pylori infection. The subjects were 24 children who underwent endoscopy for the evaluation of anemia or gastrointestinal symptoms, and they were divided into two groups: a H. pylori-positive group and -negative group. The numbers of neutrophils in the gastric mucosa of children with and without H. pylori infection and expression of COX-1, -2, and PPAR-gamma were examined, using reverse transcription-polymerase chain reaction. The numbers of neutrophils were significantly higher in the H. pylori-positive group than in the H. pylori-negative group. The ratio of COX-1 mRNA to COX-2 mRNA in the H. pylori-positive group was significantly lower than that in the H. pylori-negative group. The ratio of PPAR-gamma m-RNA to beta-actin mRNA was significantly higher in the H. pylori-positive group than the H. pylori-negative group. Enhanced production of COX-2 and PPAR-gamma in the gastric mucosa has cytoprotective and anti-inflammatory effects, although the relationship to the carcinogenic activity of COX-2 and PPAR-gamma should be clarified.
  Pediatrics International 03/2008; 50(1):1-6.
• Article: Anterior choroid plexus cysts: distinction from germinolysis by high-resolution sonography.

  Andreas van Baalen, Hans Versmold
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  ABSTRACT: The aim of the present paper was to develop criteria identifying anterior choroid plexus cysts (ACPC) and distinguish these from germinolytic pseudocysts. Cerebral sonography was performed in 2200 neonates with mean gestational age 40 completed weeks (range 23-42 weeks) and mean birthweight of 3450 g (range 340-4610 g). In the last 300 neonates cystic formations in the caudothalamic groove were studied prospectively using a high-resolution ultrasound system with linear scanhead, and the previous results were re-evaluated. In 22 neonates choroid plexus cysts outside the typical location in the choroid plexus glomus could be attributed to the anterior part of the choroid plexus in the lateral ventricles (prospectively analyzed in 16 of 300 neonates: 5% prevalence on high-resolution sonography). ACPC were located medial and behind germinolytic pseudocysts and best realized during sweep of the scanhead through the caudothalamic groove. In contrast to germinolytic pseudocysts, they had a spherical form, no septation and a thick, partial double wall. Larger cysts seemed to bounce. ACPC are not rare and are identified by their location, form, and movement.
  Pediatrics International 03/2008; 50(1):57-61.
• Article: Molecular epidemiology of norovirus gastroenteritis in Soma, Japan, 2001-2003.

  Noriko Onishi, Mitsuaki Hosoya, Ayumi Matsumoto, Takashi Imamura, Masahiko Katayose, Yukihiko Kawasaki, Osamu Hashimoto, Akio Hayashi, Hiroaki Ishiko, Hitoshi Suzuki
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  ABSTRACT: The aim of the present paper was to investigate the molecular epidemiology of norovirus gastroenteritis in Japan using polymerase chain reaction (PCR) and subsequent phylogenetic analysis. From September 2001 to August 2003, 515 stool samples or rectal swabs were collected from almost all children visiting the Department of Pediatrics, Public Soma General Hospital with gastroenteritis. Samples were examined on reverse transcription (RT)-PCR to detect norovirus genome. The nucleotide sequences of the PCR products were determined and phylogenetic analysis performed. The norovirus genome was detected in 66 samples. The peak season of norovirus gastroenteritis was from November 2001 to February 2002 and from September 2002 to December 2002. Norovirus gastroenteritis occurred most frequently in 1-year-old children. Norovirus strains produced four distinct clusters on phylogenetic analysis. Some strains detected in Soma were closely related to the strains detected in other regions in the world. The Mexico type and Lordsdale type were predominant in the 2001/2002 and 2002/2003 seasons, respectively, and the outbreaks continued for several months. Genetically different noroviruses might cause repeated gastroenteritis outbreaks every year in the Soma area. The long duration of the outbreak by a predominant strain in an epidemic season and the prevalence of infection mainly in the young age group suggested that norovirus epidemics were caused by person-to-person transmission rather than foodborne transmission. Based on molecular epidemiology, it is suggested that the annual prevalence of norovirus gastroenteritis in the Soma area might be caused by person-to-person transmission of genetically different norovirus strains, which might be transmitted from other region in the world.
  Pediatrics International 03/2008; 50(1):65-9.
• Article: Neonatal non-ketotic hyperglycinemia: report of five cases.

  Nihal Demirel, Ahmet Yagmur Bas, Aysegul Zenciroglu, Cumhur Aydemir, Serap Kalkanoglu, Turgay Coskun
  Pediatrics International 03/2008; 50(1):121-3.
• Article: Relation of ferritin levels with symptom ratings and cognitive performance in children with attention deficit-hyperactivity disorder.

  Ozgur Oner, Ozden Yalcinkaya Alkar, Pinar Oner
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  ABSTRACT: The aim of the present paper was to investigate the relationship between behavioral symptoms and attentional and executive functions and hematological variables related to iron deficiency and anemia, ferritin, hemoglobin, mean corpuscular volume (MCV), and red cell distribution width (RDW) in children and adolescents with attention deficit-hyperactivity disorder (ADHD). The sample consisted of 52 ADHD children (42 boys, 10 girls; age 7-13 years; mean +/- SD, 9.9 +/- 2.1 years). Conners Parent and Teacher Rating Scales were obtained. The neuropsychological test battery included Wisconsin Card-Sorting Test (WCST), Stroop, Continuous Performance Test, Digit Symbol and Digit Span subtests of the Wechsler Intelligence Scale for Children Revised (WISC-R), and Trail Making Test A and B, which taps abstraction-flexilibity (WCST), sustained attention (CPT), mental tracking and complex attention (WISC-R Digit Span, Digit Symbol, Trail Making A and B) and interference control (Stroop). Multiple linear regression was used to evaluate the relation of ferritin, hemoglobin, MCV, RDW, age, gender, and presence of comorbidity. While seven children had iron deficiency, none of them was anemic. Lower ferritin levels were associated with higher hyperactivity scores in parental ratings. While performance increased with age for most of the neuropsychological tests utilized, ferritin, hemoglobin, MCV and RDW and gender were not significantly related with cognitive performance in this sample. At least for the present clinical sample, ferritin levels might be related with behavioral but not cognitive measures in ADHD cases.
  Pediatrics International 03/2008; 50(1):40-4.
• Article: Efficacy of fluticasone metered-dose inhaler and dry powder inhaler for pediatric asthma.

  Hiroaki Miyahara, Seigo Korematsu, Tomokazu Nagakura, Tatsuro Izumi
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  ABSTRACT: For the treatment of bronchial asthma, two types of fluticasone inhaler devices are available, namely, metered-dose inhaler with spacer (MDI-S) and the dry powder inhaler (DPI). The former is recommended for young children with a low peak inspiratory flow (PIF) and the latter for adolescents and adults. But the difference in the therapeutic efficacy between them has been studied only rarely in adolescent patients. In the present study, 21 post-elementary school-age patients with moderate persistent bronchial asthma (age 8-15 years, 10.3 +/- 2.1 years), who all had a sufficient PIF of 114 +/- 29 L/min, were examined in order to compare the two types of fluticasone inhalers. Eleven of 21 patients inhaled 200 microg/day Flutide using the MDI-S twice daily for 1 month in the first month, and the same dose using the DPI for the next month. The other 10 patients inhaled the opposite regimens. At the end of the each treatment, spirometry was examined. Measurements done before therapy and then at the end of MDI-S and DPI therapy, respectively, were as follows: forced expiratory volume in 1 s (FEV(1.0)), 72.4 +/- 18.2%, 91.5 +/- 18.2% and 84.1 +/- 16.3% (MDI-S vs DPI, P > 0.040); maximal mid-expiratory flow (MMEF), 62.0 +/- 23.6%, 88.7 +/- 26.5%, 79.3 +/- 33.4% (P > 0.044) and the peak expiratory flow (PEF) was 73.9 +/- 25.0%, 95.6 +/- 32.8%, and 90.5 +/- 29.5%, respectively (n.s.). MDI-S was thus found to be more effective in terms of %FEV(1.0) and in %MMEF. High therapeutic efficacy was obtained with the use of the MDI-S in fluticasone inhalation for post-elementary school-age patients with sufficient inspiration ability.
  Pediatrics International 03/2008; 50(1):103-8.
• Article: Prenatally detected cystic adrenal neuroblastoma.

  Atsushi Horiuchi, Yuji Watanabe, Katsutoshi Miyauchi, Kanji Kawachi, Yasushi Ishida, Kiriko Tokuda, Hisamichi Tauchi
  Pediatrics International 03/2008; 50(1):130-1.
• Article: Adolescent with Henoch-Schönlein purpura glomerulonephritis and intracranial hemorrhage possibly secondary to the reactivation of latent CMV.

  Hitohiko Murakami, Shori Takahashi, Yasuaki Kawakubo, Noriko Kinukawa, Satoshi Funaki, Kensuke Harada
  Pediatrics International 03/2008; 50(1):112-5.
• Article: Guidelines for care of pregnant women carrying hepatitis C virus and their infants.

  Kazuo Shiraki, Hitoshi Ohto, Noriyuki Inaba, Tomoo Fujisawa, Hitoshi Tajiri, Susumu Kanzaki, Akira Matsui, Tsuneo Morishima, Kenji Goto, Akihiko Kimura, Shigeo Hino
  Pediatrics International 03/2008; 50(1):138-40.
• Article: Molecular characterization of two novel VEGFR3 mutations in Japanese families with Milroy's disease.

  Takeshi Futatani, Eiji Nii, Makoto Obata, Fukiko Ichida, Yoshie Okabe, Hirokazu Kanegane, Toshio Miyawaki
  Pediatrics International 03/2008; 50(1):116-8.
• Article: Intravenous rifampicin for persistent staphylococcal bacteremia in premature infants.

  Amuchou Singh Soraisham, Mohammed Yasir Al-Hindi
  Pediatrics International 03/2008; 50(1):124-6.
• Article: Short stature as a presenting feature of pheochromocytoma.

  Koichi Asai, Shigeru Ohta, Chihiro Ishioka, Kiyoshi Kikuchi
  Pediatrics International 03/2008; 50(1):132-4.