Medical Journal of Trakya University / Trakya Universitesi Tip Fakultesi Dergisi (TRAK UNIV TIP FAK DE)
Trakya Universitesi Tip Fakultesi Dergisi (Medical Journal of Trakya University) is an open-access, peer-reviewed periodical that considers for publication clinical or experimental studies, original articles, case reports, invited reviews of scientific merit, letters to the editor, information on scientific meetings, and brief reports on original studies or evaluations, book reviews, and article abstracts. The Journal is published three times a year. Manuscripts may be written in English as well as in Turkish.
- Impact factor0.11Show impact factor historyHide impact factor history
- WebsiteMedical Journal of Trakya University / Trakya Universitesi Tip Fakultesi Dergisi website
Publications in this journal
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ABSTRACT: Objective: In this study, kinetic analysis was performed to understand the functional importance of the amino terminal of the active site of previously mutated Plasmodium vivax Lactate Dehydrogenase enzyme by mimicking Toxoplasma gondii I, II, Eimeria acervulina and Eimeria tenella LDH's. Material and Methods: Mutant LDH genes were amplified by PCR and 6xHistag was added to the C-terminal of the enzymes. Then LDH enzymes are overproduced as recombinant in E. coli cells, purified by Ni-NTA agarose matrix and kinetic properties were analysed. Results: Observing increase of Km values of mutant enzymes showed that mutations in this place caused decreasing affinity of enzyme for its substrate. However kcat values were about the same throughout all mutant proteins. Conclusion: Sensitivity of the studied region emphasizes the significance of this site for drug design studies for both Plasmodium and some other Apicomplexans.Medical Journal of Trakya University / Trakya Universitesi Tip Fakultesi Dergisi 12/2012; 29(4):364-369.
- Medical Journal of Trakya University / Trakya Universitesi Tip Fakultesi Dergisi 01/2010;
- Medical Journal of Trakya University / Trakya Universitesi Tip Fakultesi Dergisi 09/2008; 2008(25(3)):186-188.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.
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