The Gazette of the Egyptian Paediatric Association (Gaz Egypt Paediatr Assoc )

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  • ISSN
    1110-6638

Publications in this journal

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    ABSTRACT: Background: Pleural effusion sometimes complicates community-acquired pneumonia (CAP); it is thought that it is due to increased vascular permeability. Vascular endothelial growth factor (VEGF) is an endothelial cytokine with an important role in angiogenesis and vascular permeability. A suggested active role for VEGF development of pleural effusion has been postulated. Aim of the work: This study investigated serum levels of VEGF in hospitalized pediatric patients with CAP with and without pleural effusion. PATIENTS AND METHODS: Forty -one cases with CAP were enrolled in the study against 40 age- and sex- matched normal controls. The following investigations were performed: complete blood counts, chest x- ray, quantitative C - reactive protein, erythrocytic sedimentation rate and assay of serum VEGF. RESULTS: Patients with effusion were significantly older (p = 0.001), and their ESR, CRP and total leukocytic levels were significantly higher (p = 0.006, 0.007 and 0.004, respectively). Serum VEGF was significantly higher in cases when compared to controls (1060.29 ± 67 vs. 686.11 ± 50 pg/ml respectively, 95% CI: [111; 638], p = 0.006). Serum VEGF was significantly higher in cases with effusion when compared to cases without effusion (1329 ± 66 vs. 829 ± 60 pg/ml respectively, 95% CI: [95; 905], p = 0.017). There was a significant direct correlation between serum VEGF and pleural effusion (Spearman’s rho = 0.0492, p = 0.001). CONCLUSIONS: Elevated serum VEGF levels in children with pneumonia especially those with pleural effusion, and the significant positive correlation between serum VEGF and amount of effusion postulate that VEGF, a potent inducer of vascular permeability, plays a causal role in pleural fluid formation.
    The Gazette of the Egyptian Paediatric Association 07/2012; 60.
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    ABSTRACT: Pleural effusion complicates community-acquired pneumonia (CAP). It is thought that it is due to increased vascular permeability. Vascular endothelial growth factor (VEGF) is a cytokine with an important role in angiogenesis and vascular permeability. A suggested active role for VEGF in development of pleural effusion has been postulated. This study investigated serum levels of VEGF in hospitalized pediatric patients with CAP with and without pleural effusion. Forty-one cases with CAP were enrolled in the study against 40 age- and sex- matched healthy controls. The following investigations were performed: complete blood counts, chest x- ray, quantitative C-reactive protein, erythrocytic sedimentation rate and assay of serum VEGF. Patients with effusion were significantly older (p = 0.001), and their ESR, CRP and total leucocytic levels were significantly higher (p = 0.006, 0.007 and 0.004, respectively). Serum VEGF was significantly higher in cases when compared to controls (1060.29 ± 67 vs. 686.11 ± 50 pg/ml respectively, 95% CI= [111; 638], p = 0.006). Serum VEGF was significantly higher in cases with effusion when compared to cases without effusion (1329 ± 66 vs. 829 ± 60 pg/ml respectively, 95% CI= [95; 905], p = 0.017). There was a significant direct correlation between serum VEGF and pleural effusion (Spearman’s rho = 0.492, p = 0.001). The study concluded that there were elevated serum VEGF levels in children with CAP especially when associated with pleural effusion, and that the significant positive correlation between serum VEGF and amount of effusion postulate that VEGF, a potent inducer of vascular permeability, plays a causal role in pleural fluid formation.
    The Gazette of the Egyptian Paediatric Association 01/2012; 60(3).
  • The Gazette of the Egyptian Paediatric Association 01/2001; 49:4-7.
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    ABSTRACT: The rate of poliovirus excretion was found to be 64.6% in a group of 108 normal children and 11.95% in 184 diarrheal children. Diarrhea was due to Shigella in 70% of cases. This drew our attention to the presence of an etiologic relationship between the two findings, which may have a direct effect on the low efficiency of oral poliovaccine in our Country. Effect of Shigella infection on the take of oral poliovaccine was investigated in 14 normal and 10 children having acute diarrhea due to Shigella. Vaccine virus excretion was detected in 64.2% of normal children and only in 10% of diarrheal children. In vitro studies were done to determine the effect of killed Shigella suspensions or their endotoxin on the replication of poliovirus in tissue culture. Reduction of virus titre from 1-3 logs in the presence of killed Shigella or its endotoxin was observed. The sites of action and interfering factor (s) are discussed.
    The Gazette of the Egyptian Paediatric Association 01/1978; 24(1-2):82-91.
  • The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):83-93.
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    ABSTRACT: Amniotic fluid total lipids (T.L.), lipid phosphorus (L.Ph.), phospholipids (Ph.L.), total cholesterol (T.Ch.), total proteins (T.P.) and inorganic phosphorus (I.Ph) were determined in a number of high risk pregnancies and compared to parallel data obtained for full term normal pregnancies. Amniotic fluid T.L., L.Ph., Ph.L. and T.Ch. were significantly decreased in diabetic and toxaemic cases. The decrement in L.Ph. and Ph.L. was more pronounced in diabetic and toxaemic mothers who delivered either still-births or neonates suffering from RDS or in cases of intrapartum death. The L.Ph. and Ph.L. were increased in case of toxaemic mothers who delivered living neonates with no RDS. In spite of the increase in T.Ch. in the same cases; the ratio of T.Ch to T.L. was constant except in cases with prolonged intrauterine foetal death where it was increased.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):1-9.
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    ABSTRACT: Oral lactose tolerance test was performed on a total of 100 cases of normal Egyptian infants and children aged 6 months to 12 years. The same test was performed on 30 cases of protein calorie malnutrition (15 cases of marasmus and 15 cases of kwashiorkor). Detection of sugar and determination of pH were also carried out on all stools passed after the test. Lactose intolerance, as judged by a maximal blood glucose rise of 20 mg. or less and/or stools positive for sugar with a pH less than 6 following lactose ingestion, was observed as follows in normal cases: 12% in the age group 6 months to 2 years, 32% in the age group 2 to 5 years, 32% in the age group 5 to 9 years, and 80% in the age group 9 to 12 years. On the other hand, lactose intolerance was demonstrated in 73.3% of cases suffering from protein malnutrition. The aetiology and practical implications of the present findings of lactose intolerance on normal and malnourished children are discussed.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):27-33.
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    ABSTRACT: On an attempt to illustrate the influence of maternal socio-economic status on birth weight, this study was carried out on 689 full term new borns. The weight, age, parity, income and occupation of their mothers were compared to the birth weight. A correlation was also performed between birth weight and the presentation of the babies and the ante-natal care offered to their mothers. A positive correlation was only found to be present between birth weight and family income below 10 pounds/month. A similar correlation was noticed between birth weight and the interpregnancy interval up to 30 months. The presentation of the foetus might be of influence on birth weight only in cephalic and breeck presentation. The age of the mother, occupation, weight were negatively correlated with birth weight.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):11-7.
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    ABSTRACT: Serum copper level (SCL) determination was carried out on sixteen normal children and on 16 with acute leukaemia. A significant increase in SCL was observed in cases of leukaemia than in normal controls. Drop of SCL occurs in cases who respond to quadruple chemotherapy, while those who failed to respond showed persistantly high serum copper level.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):67-72.
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    ABSTRACT: The electrolytes sodium, potassium, calcium and magnesium were determined in both plasma and erythrocytes of 300 PCM subjects and 26 parallel healthy controls. The results obtained revealed that: The level of plasma sodium was lower than normal in all PCM cases except in marasmic kwashiorkor. The RBC's sodium content was more or less not affected. Plasma potassium level was markedly lower than normal in all groups of malnourished subjects. RBC's potassium was significantly lower than normal in severe K.W.O. and marasmic kwashiorkor, while it was high in 3rd grade marasmus. Magnesium level was lower than normal in both plasma and RBC's in all malnourished subjects. Calcium level dropped in plasma and was elevated in RBC's. Estimation of RBC's minerals may be useful in reflecting the concerned changes in tissues of PCM subjects.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):51-5.
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    ABSTRACT: Twenty cases of thalassemia major and 20 children with glucose-6-phosphate dehydrogenase deficiency were studied for the protein content of their red cell membrane as well as for its fractions, compared to 20 normal controls. The results showed that the total membrane proteins per red cell and the various fraction percentages in both conditions were not significantly different from normal controls. Also the acrylamide gel electrophoretic studies of the red cell membrane proteins gave band patterns identical with those of normal controls. These results are discussed.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):73-81.
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    ABSTRACT: Studies on tryptophan metabolism in PEM were performed. In this respect, the basal excretion of tryptophan and some of its metabolites, namely, kynurenine, 3 OH-anthranilic, anthramilic, indol-3-acetic, 5 OH-indol acetic and xanthurenic acids were determined. The response of these metabolites to oral tryptophan load, singly and in combination, with pyridoxine, were performed in kwashiorkor cases compared to normal controls. The study revealed that kynurenine leads to niacine pathway is hindered, Indole-3-acetic acid levels are lower and respond poorly to tryptophan loading in PEM. Increased levels of 5 OH-indol acetic were found in kwashiorkor compared to marasmus, although lower response to tryptophan was noted. Xanthurenic acid excretion is much higher in PEM and poorly responds to tryptophan load either singly or in combination with pyridoxine. These errors of tryptophan metabolism in PEM are suggested to be due to defects in the enzyme systems involved rather than to vitamin B6 deficiency.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):57-66.
  • The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):95-6.
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    ABSTRACT: This work has been carried out on 28 cases of respiratory distress syndrome (R.D.S.), 17 cases of mild and moderate severity were treated by oxygen therapy, excess humidity, and correction of acid-base balance with 100% recovery within an average time of 72 hrs., while 11 cases of severe R.D.S. needed continuous negative external pressure (C.N.P.) in addition to routine management. The use of C.N.P. in spontaneously breathing infants reduced the need for high ambient oxygen, raised PaO2", shortened the duration of therapy; average time of recovery was 48 hrs. In addition, C.N.P. reduced the need for excessive alkali therapy and assisted ventilation. So, in addition to routine therapy, C.N.P. is recommended as an additional line of management of severe cases of R.D.S., i.e. cases that cannot maintain an arterial oxygen of 60 mmHg. at 60% ambient oxygen or above; or cases with frequent apnoeic attacks.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):19-26.
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    ABSTRACT: The effect of feeding rats a low-protein diet (1%) and its duration (4, 8, 12 and 16 weeks) on the protein content and the amino acids pattern of hair were studied. These variations were compared with control group fed an adequate protein diet (16%). Protein content of hair was diminished in the protein deficient rats after four weeks followed by a gradual decrease till the end of the experiment. Sulphur-containing amino acids cystine and cysteine were significantly reduced in the hair of the protein deficient rats when compared with the controls. The amino acids patterns showed significant differences from controls by the end of the whole experimental period.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):43-50.
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    ABSTRACT: Serum protein components were evaluated by the specific radial immunodiffusion technique in a number of protein energy malnourished infants and young children, as well as in a group of parallel controls. Results show a drop in both serum prealbumin and albumin in concordance with the severity of the condition in both KWO and marasmus. Serum level of varies as 1-acidic glycoprotein was elevated, being more marked in KWO than in marasmus. Serum oc1-antitrypsin, haemopexin, ceruloplasmin and transferrin were all reduced but to a varying extent in both KWO and marasmus. The levels of serum IgA and IgM were above normal in all disease entities except for a slight decrease of IgA in 2nd grade marasmus. On the other hand, serum IgG was reduced in the majority of cases. The ratio of serum cerutoplasmin to transferrin in KWO was found to be of diagnostic value in different grades of the disease.
    The Gazette of the Egyptian Paediatric Association 02/1977; 26(1):35-42.
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    ABSTRACT: Induced hypercalcemia in rheumatic and rheumatoid children revealed the following : 1. Rheumatic and rheumatoid patients deal more effectively with induced hypercalcemia than control children. 2. A higher percentage of infused calcium in these patients is retained. This may by due to higher calcitionin activity relative to controls. 3. Induced hypercalcemia resulted in an increase in urinary 17 OH C.S. This is suggested to be due to stimulation of the adrenal cortex. These findings suggest that calcium infusion is an effective additional measure in the treatment of rheumatic and rheumatoid affection in the absence of contraindication to calcium.
    The Gazette of the Egyptian Paediatric Association 01/1976; 24(1-2):73-9.
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    ABSTRACT: "Twenty cases of Down's syndrome and 25 age-matched normal controls were subjected to hematologic study including Hb, R.B.Cs, W.B.Cs., HbF., bone marrow, protein electrophoresis and chromosomal study. Peripheral blood and bone marrow showed noticeable increase in granulocytes, increase in staff, and decrease in lymphocytes in mongols as compared to the controls. HbF was lower than normal in 18 cases. The other two showed abnormally high HbF. Protein electrophoretic study showed normal pattern except one case in which a remarkable decrease in the Beta and Gamma Fraction was noticed".
    The Gazette of the Egyptian Paediatric Association 01/1976; 24(3-4):209-16.
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    ABSTRACT: Study of serum and urinary enzyme pattern in nephropathies revealed that before treatment, cases of both acute nephritis and nephrotic syndrome were found to have an increased activity of the three enzymes studied in both serum and urine (Alkaline and acid phosphatases and Lactic dehydrogenase). However, there was no constant correlation between the level of serum and urinary enzyme activities. Distorted pattern of the enzymes has a more protracted course in nephrotics. After treatment, serum and urinary enzymes tended to normalise in cases of acute glomerulonephritis. However, urinary alkaline phosphatase remained high nephrotics after clinical remission. In some cases of acute nephritis, a persistently high level of serum enzyme may indicate an incipient nephrotic element. Nephrotics not responding to the four weeks course of corticosteroid therapy have persistently high serum and urinary enzyme activities. Thus, estimation of serum and urinary enzyme pattern in nephropathies may be of diagnostic and prognostic value.
    The Gazette of the Egyptian Paediatric Association 01/1976; 24(3-4):163-7.
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    ABSTRACT: Several high risk factors were evaluated in an attempt to determine the Egyptian children who are more prone to become malnourished. The study included 110 children with energy protein malnutrition and 98 normal children. Their ages were between 4 months and 3 years. Among the factors investigated, the 2nd 6 months of life was found to be the most critical for nutritional deficiency. Presence of previous siblings with malnutrition, presence of more than 2 sibling deaths and presence of history of severe diarrhoea with dehydration were significantly related to the nutritional status of children. Twinning, birth order and birth interval showed some relation to malnutrition but were not statistically significant. The sex of the child and maternal weight did not influence the nutritional state of children. However, these low-socialclass children were found to be mostly (92.8%) breast fed.
    The Gazette of the Egyptian Paediatric Association 01/1976; 24(1-2):31-42.

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