Life Science Journal Impact Factor & Information

Journal description

Current impact factor: 0.17

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2012 Impact Factor 0.165
2011 Impact Factor 0.073
2010 Impact Factor 0.158

Impact factor over time

Impact factor
Year

Additional details

5-year impact 0.00
Cited half-life 2.00
Immediacy index 0.08
Eigenfactor 0.00
Article influence 0.00
ISSN 1097-8135

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: PMF is a natural selective anticancer, fraction extracted from camel urine (PM701), resemble in their actions the new drugs now used and manufactured in nanomedicine and nanotechnology. The PMF nanoparticles and its effect on the lung cancer cells A549 were studied by scanning electron microscope (SEM), Transmission electron microscope (TEM), energy dispersive X-ray (EDX) and the vibrational spectroscopy. A549 were treated with PMF for 2, 5, 10, 20 seconds and 1 minute. Fourier transforms Infrared Spectroscopy (FTIR) and TEM were used to study the membrane lipid profile and the morphology of the treated cells. The results revealed that several ions that present in a relatively high concentration in PMF were confirmed such as K, Ca, Cd, Y, Eu, Th and zinc, zinc is present in form of ZnO and Ca, Cd & Y are in form of sulfates as confirmed by the oxide and sulfate bands in the FTIR spectrum of PMF. Arginine, hippuric and benzoic acids as well were also detected. The PMF contains different types of macro and nanoshells with different types of metals that attack first, the A549 cell membrane and influenced the membrane polarity, packing and the hydrocarbon chain length of the phospholipids. These changes were indicated by the changes in the asymmetric stretching CH 2 /CH 3, symmetric stretching of membrane CH 2 /CH 3, symmetric stretching CH 2 /total lipids ratios respectively. Second, these nanoparticles directed after endocytosis to the nucleus and other cell organelles some of these metals are responsible for the selectivity of PMF fraction to cancer cells only. This new smart drug based on the most new frontiers in nanotechnology which include nanoshells as drug carrier. [Gehan A-R. Ahmed, Faten A. Khorshid, Alaa Khedr, Salem M. El-Hamidy, Numan A. Salah. The effect of PMF Camel Urine Nanoparticles on A549 Cells: The Mechanism of Action and Drug Delivery. Life Sci J 2015;12(7):63-75]. (ISSN:1097-8135). http://www.lifesciencesite.com. 8
    Life Science Journal 07/2015; 12(7):63-75.
  • Life Science Journal 06/2015; 12(6):155-160.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To determine whether polycystic ovarian syndrome (PCOS) is a causative factor in dysregulation of leptin levels in obese subjects and to identify effect of PCOS on the relationship of serum leptin with hormonal, metabolic and anthropometric parameters in obese PCOS women. Methods: A cross sectional study in Jinnah Postgraduate Medical Center Karachi, Pakistan recruited twenty nine obese (BMI >30 kg/m2) and 20 normal-weight (BMI <25 kg/m2) PCOS women together with twenty seven normal cycling (NC) obese (BMI >30 kg/m2) and 25 normal-weight females (BMI <25 kg/m2). Serum leptin, prolactin, follicle stimulatimg hormone (FSH), lutenizing hormone (LH), free testosterone, estradiol (E2) and fasting blood glucose (FBG) levels were measured by Radioimmunoassay. Results: Mean serum leptin levels were higher in obese compared to normalweight PCOS (54.00 ± 9.33 vs. 26.08±2.44 ng/ml; p <0.01) and in obese compared to normal-weight NC (51.54 ±9.19 vs. 25.39 ± 2.37 ng/ml; p <0.01). Significantly lower level of FSH, LH, E2 (p <0.01), was observed in both groups of PCOS as compared to non-PCOS while higher levels of testosterone, progesterone and FBG were found in obese PCOS in comparison to obese NC (p <0.01). Leptin levels correlated with BMI in all four groups. There was a significant correlation of FBG with obese NC (r=0.42, p<0.05) and normal-weight and obese groups of PCOS (r=0.45, p<0.05; r=0.58, p<0.05 respectively). The leptin level correlated with E2 and testosterone in obese PCOS subjects (p<0.05; p<0.05 respectively). Conclusion: It seems that leptin has a role in pathogenesis of PCOS in obese patients.
    Life Science Journal 03/2015; 12(4).
  • Life Science Journal 03/2015;