Journal of Surgical Research (J Surg Res )

Publisher: Association for Academic Surgery (U.S.); Association of Veterans Administration Surgeons (U.S.), Elsevier


The Journal of Surgical Research: Clinical and Laboratory Investigation publishes original articles concerned with clinical and laboratory investigations relevant to surgical practice and teaching. The journal emphasizes reports of clinical investigations or fundamental research bearing directly on surgical management that will be of general interest to a broad range of surgeons and surgical researchers. The articles presented need not have been the products of surgeons or of surgical laboratories.

  • Impact factor
  • 5-year impact
  • Cited half-life
  • Immediacy index
  • Eigenfactor
  • Article influence
  • Website
    Journal of Surgical Research website
  • Other titles
    Journal of surgical research (Online), Journal of surgical research, Surgical research
  • ISSN
  • OCLC
  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print allowed on any website or open access repository
    • Voluntary deposit by author of authors post-print allowed on authors' personal website, or institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate
    • Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists.
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months .
    • Set statement to accompany deposit
    • Published source must be acknowledged
    • Must link to journal home page or articles' DOI
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • NIH Authors articles will be submitted to PubMed Central after 12 months
    • Publisher last contacted on 18/10/2013
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background Neovasculogenesis, vital for wound healing, gets compromised in diabetics patients, which consequently delayed wound healing. Previous studies have shown curcumin as both stimulatory and inhibitory agent in neovasculogenesis process. So, present study was aimed to investigate the effects of curcumin on wound healing in diabetic rats and to explore the expressions of the various factors involved in neovasculogenesis. Materials and methods Open excisional diabetic wound was created in sixty rats and divided into three groups viz. i) control, ii) pluronic gel-treated and iii) curcumin-treated. The pluronic F-127 gel (25%) and curcumin (0.3%) in pluronic gel were topically applied once daily for 19 days. The wound healing and neovasculogenesis among these groups were evaluated by gross appearance of wounds and microscopically by H&E staining, immunohistochemistry for CD31, mRNA expressions of VEGF, TGF-β1, HIF-1α, SDF-1α, and HO-1, and Western blotting studies of VEGF and TGF-β1 in granulation/healing tissue on days 3, 7, 14 and 19. Results Curcumin application caused markedly fast wound closure with well formed granulation tissue dominated by fibroblast proliferation, collagen deposition and complete early regenerated epithelial layer. Immunohistochemistry for CD31 revealed well formed blood vessels with increased microvessel density on days 3, 7 and 14 in curcumin-treated group. Expressions of VEGF and TGF-β1 on days 3, 7 and 14, HIF-1α, SDF-1α, and HO-1 on days 3 and 7 were increased in curcumin-treated diabetic rats, as compared to other groups. Conclusion Curcumin enhanced the neovasculogenesis and accelerated the wound healing in diabetic rats by increased expressions of various factors.
    Journal of Surgical Research 10/2014;
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    ABSTRACT: Background Experience and application of recruitment packages can be critical in leadership efforts of surgical chairpersons in promoting research, although attrition of these efforts can happen over time due to lack of new resources. We aimed to examine the impact of experience of surgical chairpersons on departmental NIH funding. Methods Experience as a chairperson defined as the number of years spent as an interim or permanent chair was abstracted from the department webpage (US medical schools only). The NIH funding (US Dollars) of the departments were obtained from the Blue Ridge Medical Institute ( The change in NIH funding from the immediate previous financial year (2010-2009 & 2011-2010) was used to classify chairpersons into 4 groups: group 1 (-/-), group 2(-/+), group 3(+/+) and group 4(+/-) for analysis. Results Median NIH funding were $1.9 (0.7-6) million, 1.8(0.6-5) and 1.7 (0.7-5) for 2009, 2010 and 2011, respectively, and the median experience as a surgical chairperson was 6 (3 – 10) years. Recent chairpersons (<1 year) inherited departments that usually lost NIH funding (62%) and were frequently unable to develop a positive trend for growth over the next fiscal year ((-/-) n=4 and (+/-) n=2, 75%). Chairpersons who held their positions for 4-6 years were most likely to be associated with trends of positive funding growth, while chairpersons >10 years were most likely to have lost funding (66%,p=0.07). Conclusions Provision of new development dollars later in their tenure and retention of chairpersons might lead to more positive trends in increase in NIH funding.
    Journal of Surgical Research 09/2014;
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    ABSTRACT: Background Biliary strictures present a diagnostic challenge to differentiate benign disease from hepatopancreaticobiliary (HPB) malignancies. Endoscopic retrograde cholangiopancreatography cytology is commonly performed in these patients; however, its sensitivity for diagnosis of HPB malignancy is poor (41.6%). Many adjunctive tests have been investigated to improve the sensitivity of HPB biopsies. To determine the best tests available, however, we reviewed the literature and performed a comparative analysis of all recently investigated tests and their sensitivities. Methods A PubMed search identified articles published between 2003 and 2014, describing alternate methods for diagnosing HPB malignancies, reported sensitivity, final pathology, and had data available online. Meta-analysis was conducted for tests with multiple articles. Tests with the highest sensitivity and specificities were reported. Results A total of 77 studies were identified. Meta-analysis was performed on the sensitivity of EUS-FNA (74.2%), fluorescence in situ hybridization (54.2%), immunostain of insulin-like growth factor 2 mRNA-binding Protein 3 (IMP3; 80.4%), IMP3 + cytology (86.4%), K homology domain containing protein overexpressed in cancer (KOC; 85.9%), S100P (77.8%), serum CA19-9 (69.3%), and K-ras mutations (47.0%) to detect malignancy. Ultimately, 12 tests were identified with superior sensitivity (85.3%–100%) and specificities (81.6%–100%) including stricture scrapping, brush sectioning, IMP3 stain + cytology, IMP3+S100A4, bile carcinoembryonic cell adhesion molecule 6 protein (±CA19-9), bile micro RNA (miRNA)-135b, serum miRNA-RNU2-1f, serum miRNA-21 (+CA19-9), peripheral blood mononuclear cells miRNA-27a-3p (+CA19-9), serum miRNA-16 + miRNA-196a (+CA19-9), peripheral blood mononuclear cells mRNAs h-TERT + CK20 + CEA + C-MET. Conclusions We recommend immunostaining with a panel of IMP3+KOC + S100A4 + cytology to achieve maximum sensitivity and specificity from HPB biopsies. One biliary protein (carcinoembryonic cell adhesion molecule 6) and several RNAs (bile and blood) offer exceptional sensitivity and specificity and should be tested prospectively in larger populations. Overall, this review identifies several tests to improve the sensitivity of diagnostic algorithms to identify HPB malignancies.
    Journal of Surgical Research 08/2014; 190(2):535–547.
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    ABSTRACT: Abstract Introduction The use of a prosthetic material is the best treatment option for ventral hernia repair, one of the most frequently performed abdominal surgery procedures. This preclinical study compares the behavior of a new mesh (Parietex™ composite ventral patch; Ptx) with that of two existing meshes used for ventral hernia repair. Materials and methods Fifty four New Zealand White rabbits (3000g) were used in an experimental model of umbilical hernia repair (diameter 1.5 cm). The materials tested were: Ventralex®ST hernia patch (Vent) (Bard Davol Inc., USA) (n=18); Proceed®ventral patch (Ethicon, USA) (PVP) (n=18); and Ptx (Covidien, Sofradim, France) (n=18). At 3, 7, 14 days and 6 weeks post-implant, peritoneal behavior and adhesion formation were assessed by sequential laparoscopy. Mesh mesothelial cover was determined by SEM. Host tissue ingrowth (collagens I and III) and the macrophage response were assessed by immunohistochemical labeling. Animals were euthanized at 2, 6 weeks and 6 months postsurgery. Data were compared using the Mann-Whitney U test. Results Adhesion formation from 3 days to 6 weeks was significantly greater (p<0.05) for PVP compared to Vent or Ptx. Three encapsulated PVP implants showed “tissue-integrated” adhesions affecting the intestinal loops. All three implant types showed similar patterns of collagen l and III deposition. The PVP mesh elicited the greater macrophage response both at 2 weeks and 6 months. Conclusions Ptx and Vent showed excellent mesothelialization, which led to minimum adhesion formation. The appropriate tissue integration of Ptx in the parietal neoperitoneum is likely attributable to its deployment system. Keywords ventral hernia; umbilical hernia; epigastric hernia; mesh repair; polypropylene; abdominal wall repair
    Journal of Surgical Research 07/2014;
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    ABSTRACT: Anastomotic leakage (AL) is a major complication after anterior resection. However, its therapeutic strategies and technical risk factors have not been well established. Therefore, we endoscopically evaluated anastomotic regions after laparoscopic colorectal anastomosis using a double-stapling technique (DST) for determination of treatment and investigation of technical factors.
    Journal of Surgical Research 07/2014;
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    ABSTRACT: Diabetic (DM) patients frequently lack autologous vascular tissue required for revascularization procedures and dialysis access creation. We have developed a tissue-engineered graft that uses adipose-derived stem cells (ASC) as endothelial cell substitutes. Here, we compare DM versus nondiabetic (NDM) ASC in terms of isolation efficiency, proliferation, commitment toward endothelial lineage, and seeding onto the luminal surface of a graft.
    Journal of Surgical Research 07/2014;
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    ABSTRACT: Background Recent findings have elucidated that netrin-1 has ability of promoting angiogenesis besides the functions in nervous system. Autologous mesenchymal stem cells (MSCs) transplantation is now proved to be an effective method to treat peripheral arterial disease (PAD). However there are still many patients cannot complete full treatments. Therefore it is necessary to improve the effectiveness. This study estimated the curative effects in chronic limb ischemia when MSCs allied with netrin-1. Materials and methods Thirty-six rats were made into chronic limb ischemia models. They were randomly assigned to four groups, netrin-1+MSCs group (treated with netrin-1 and MSCs derived from peripheral blood), MSCs group (treated with MSCs individually), netrin-1 group (treated with netrin-1 individually) and control group (treated with saline). Measurements of murine behaviors, vascular endothelial growth factor (VEGF) expression and capillary density in ischemia limb were performed on day 7, 14, 28 after treatments, measurements of contraction force in ischemia limb was performed on day 28 after treatments to compare differences among the groups. Results Netrin-1 allied with MSCs significantly increased Tarlov score, VEGF expression, capillary density and muscular strength in ischemia limb. Conclusions Netrin-1 allied with MSCs derived from peripheral blood significantly promoted angiogenesis in aged rats with chronic limb ischemia. It may be a promising method of treating PAD in future.
    Journal of Surgical Research 07/2014;
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    ABSTRACT: Background MicroRNA-100 (miR-100) has been demonstrated to be implicated in tumorigenesis and tumor progression of human esophageal squamous cell carcinoma (ESCC). However, its expression patterns in ESCC are controversial and its prognostic value in this malignancy has not been fully elucidated. The aim of this study was to investigate the expression and clinical significance of miR-100 in ESCC. Materials and methods Real-time quantitative RT-PCR was performed to detect expression levels of miR-100 in 120 self-paired specimens of ESCC and adjacent normal esophageal tissues. The associations of miR-100 expression with clinicopathological features, locoregional progression-free survival (LPFS), distant progression-free survival (DPFS), and overall survival (OS) of patients with ESCC were statistically analyzed. Results Compared with adjacent normal esophageal tissues, the expression levels of miR-100 in ESCC were significantly decreased (normal vs. ESCC: 3.53±1.22 vs. 1.89±0.38, P<0.001). Additionally, low miR-100 expression in ESCC tissues was significantly associated with the advanced clinical stage (P=0.008), the presence of distant metastasis (P=0.008) and the great depth of invasion (P=0.02). Moreover, univariate analysis revealed that low miR-100 expression was associated with poor LPFS, DPFS, and OS. In multivariate analysis, miR-100 expression was identified as an independent prognostic factor for all LPFS, DPFS, and OS. Conclusion These findings show the reduced expression of miR-100 in human ESCC tissues and suggest a crucial role of its downregulation in ESCC progression and prognosis. More interestingly, the detection of miR-100 expression may be used to efficiently screen those ESCC patients who would benefit from radiotherapy.
    Journal of Surgical Research 07/2014;
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    ABSTRACT: Identification of occult shock (OS) or hypoperfusion is critical in the initial management of trauma patients. Analysis of inferior vena cava (IVC) ratio on computed tomography (CT) scan has shown promise in predicting intravascular volume. We hypothesized that a flat IVC is a predictor of OS and associated with worse outcomes in major trauma patients.
    Journal of Surgical Research 07/2014;
  • Journal of Surgical Research 06/2014;
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    ABSTRACT: Phosphoinositide 3-kinase (PI3K) delta and gamma (the p110δ and p110γ isoforms of PI3K) actively participate in the process of inflammation. We sought to elucidate the possible roles of PI3Kδ and PI3Kγ in mediating the anti-inflammation effects of naloxone.
    Journal of Surgical Research 06/2014;
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    ABSTRACT: High-mobility group box 1 (HMGB1), a key late mediator of systemic inflammation, is a potentially useful biomarker for predicting outcome in patients with severe blunt chest trauma. The purpose of this study was to define the relationship between plasma levels of HMGB1 and posttraumatic stress disorder (PTSD) in patients with severe blunt chest trauma.
    Journal of Surgical Research 06/2014;
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    ABSTRACT: Enteric neuromuscular disease is a characteristic of several disease states, including Hirschsprung disease, esophageal achalasia, Chagas disease, and gastroparesis. Medical therapy for these conditions is limited, and surgical intervention may incur significant morbidity. Alternatively, transplantation of neural progenitor cells may regenerate enteric ganglia. Existing aganglionosis model systems are limited by swift animal demise or by spontaneous regeneration of native ganglia. We propose a novel protocol to induce permanent aganglionosis in a segment of rat jejunum, which may serve as an experimental transplantation target for cellular therapy.
    Journal of Surgical Research 06/2014;
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    ABSTRACT: Published comparisons of the different available laparoendoscopic single-site surgery (LESS) devices focused on its economic cost and technical aspects. With this study, we aimed to objectively compare the use of three different LESS access devices in controlled experimental tasks.
    Journal of Surgical Research 06/2014;
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    ABSTRACT: Blood products containing leukocytes have been associated with negative immunomodulatory and infectious effects. Transfusion-related acute lung injury is partially explained by leucocyte agglutination. The Food and Drug Administration has therefore recommended leukoreduction strategies for blood product transfusion. Our institution has been using leukocyte-reduced blood via filtration for neonates on Extracorporeal Membrane Oxygenation (ECMO). We hypothesized that the use of leukocyte-reduced blood would decrease mortality and morbidity of neonatal ECMO patients.
    Journal of Surgical Research 06/2014;
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    ABSTRACT: Surgical burden is a large and neglected global health problem in low- and middle-income countries. With the increasing trauma burden, the goal of this study was to evaluate the trauma capacity of hospitals in the central plateau of Haiti.
    Journal of Surgical Research 06/2014;