Cell Biochemistry and Biophysics (CELL BIOCHEM BIOPHYS)

Publisher: Humana Press

Journal description

Cell Biochemistry and Biophysics is a laboratory-oriented journal devoted to illuminating the biophysical mechanisms controlling cell functions. Formerly Cell Biophysics, the journal publishes state-of-the-art basic, applied, and clinical research in all areas of cellular biochemistry, biophysics,and physiology, but favors studies focusing on the mechanistic aspects.

Current impact factor: 1.68

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.68
2013 Impact Factor 2.38
2012 Impact Factor 1.912
2011 Impact Factor 3.743
2010 Impact Factor 4.312
2009 Impact Factor 3.337
2008 Impact Factor 2.257
2007 Impact Factor 1.953
2006 Impact Factor 1.693
2005 Impact Factor 2.138
2004 Impact Factor 1.945
2003 Impact Factor 3.185
2002 Impact Factor 1.521
2001 Impact Factor 1.926

Impact factor over time

Impact factor

Additional details

5-year impact 2.10
Cited half-life 4.80
Immediacy index 0.26
Eigenfactor 0.01
Article influence 0.56
Website Cell Biochemistry and Biophysics website
Other titles Cell biochemistry and biophysics
ISSN 1085-9195
OCLC 33449553
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Humana Press

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Authors own final version only can be archived
    • Publisher's version/PDF cannot be used
    • On author's personal website immediately
    • On any open access repository after 12 months from publication
    • Published source must be acknowledged
    • Must link to publisher version
    • Set phrase to accompany link to published version: The original publication is available at www.springerlink.com
    • Articles in some journals can be made Open Access on payment of additional charge
    • 'Humana Press' is an imprint of 'Springer Verlag (Germany)'
  • Classification

Publications in this journal

  • Cell Biochemistry and Biophysics 11/2015; DOI:10.1007/s12013-015-0716-3

  • Cell Biochemistry and Biophysics 11/2015; DOI:10.1007/s12013-015-0715-4
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    ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a disease with high prevalence and substantial associated economical burden. A significant determinant of quality of life, long-term survival, and health care costs is an acute exacerbation of COPD. Acute exacerbations are provoked by respiratory viruses, altered airway microbiome, and environmental factors. The current treatment options are limited. In order to develop specific therapeutic measures, it is important to understand how acute exacerbations evolve. This review focuses on pathophysiology of stable and exacerbated COPD.
    Cell Biochemistry and Biophysics 11/2015; 73(2). DOI:10.1007/s12013-015-0605-9
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    ABSTRACT: To study the hypoglycemic effect of composite rice flour, the diabetic mouse model was established through the intraperitoneal injection of alloxan saline (twice, 200 mg/kg bw). The mice were randomly divided into 4 groups: negative control, positive control, metformin medication group, and composite rice flour feed group. After 21 days, the fasting blood glucose levels were determined by glucose oxidase method and followed with a glucose tolerance test. The results show that the body weight growth rate of mice in the rice flour group was significantly higher than that of the medication group (P < 0.01). Comparing with the positive control group, the fasting blood glucose levels of medication group and rice flour group were significantly lower, and the glucose tolerance was significantly increased in rice flour group (P < 0.01). In conclusion, the composite rice flour has obvious hypoglycemic and protective effect for diabetic mouse model.
    Cell Biochemistry and Biophysics 10/2015; DOI:10.1007/s12013-015-0714-5

  • Cell Biochemistry and Biophysics 09/2015; DOI:10.1007/s12013-015-0711-8

  • Cell Biochemistry and Biophysics 09/2015; DOI:10.1007/s12013-015-0710-9
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    ABSTRACT: Currently, as there is no systematic norm or standard for drug safety and inspection, it cannot be judged whether the regulatory authority or regulators have fulfilled their administrative responsibilities entirely or not, when a drug safety-related incident occurs. And there is a probability that some may even be wrongly punished. In this study, we have analyzed the risk of not having appropriate norms in place and also put forward recommendations for the government or the regulatory authorities to set up norms to be fulfilled for drug safety and inspection issues. This, on one hand, could provide a basic guideline for the regulatory authorities and regulators to improve their professional levels and administrative acumen and on the other hand, it could also provide a baseline for society to judge whether the regulatory authorities and regulators have fulfilled their responsibilities correctly and thereby also help prevent regulators from being mistakenly punished. This study proposes that a systematic and functional norm for drug safety and inspection could be set up relating to the determination of the responsibilities of regulatory authorities and scope of various inspections, number and frequency of inspections, number and qualifications of regulators, handling of inspection results, inspection records, and disciplinary codes for inspectors. This study also puts forward suggestions on who should be responsible for drafting the norms and what are the factors that need to be considered while formulating the norms.
    Cell Biochemistry and Biophysics 09/2015; 73(1). DOI:10.1007/s12013-015-0568-x
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    ABSTRACT: Bevacizumab can be potentially applied in filtration surgery in glaucoma patients. However, its mechanism remains unclear. In order to explore it, here, we established rat filtration surgery model and treat rat with Bevacizumab. At different time points after surgery, filtering blebs were collected and subjected to angiogenesis and inflammation genes analysis. Our results found that Bevacizumab significantly improved the outcome of filtration surgery and reduced complications (P < 0.05). Furthermore, angiogenesis factor, VEGF, and inflammation factors, TGFβ1 and TGFβ2, were dramatically inhibited by Bevacizumab treatment according to analysis of real-time PCR and western blot. Altogether, our findings suggested that Bevacizumab’s beneficial effects on filtration surgery were not limited to antiangiogenesis effect and anti-inflammation effects may be also involved.
    Cell Biochemistry and Biophysics 09/2015; 73(1). DOI:10.1007/s12013-015-0566-z

  • Cell Biochemistry and Biophysics 08/2015; DOI:10.1007/s12013-015-0708-3

  • Cell Biochemistry and Biophysics 08/2015; DOI:10.1007/s12013-015-0707-4

  • Cell Biochemistry and Biophysics 08/2015; DOI:10.1007/s12013-015-0704-7

  • Cell Biochemistry and Biophysics 07/2015; DOI:10.1007/s12013-015-0703-8
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    ABSTRACT: Our objective is to explore the tumor-specific mutated genes by transcriptome sequencing of patients with acute myeloblastic leukemia. 96 patients with subtype M2 acute myeloid leukemia (AML), admitted during January 2007 to January 2012, were selected. Bone marrow and peripheral blood samples from the patients after the first visit and the patients who were improved or alleviated, were subjected to high-throughput sequencing to compare the gene expression. The single nucleotide mutation related to subtype M2 AML was detected. Meanwhile, real-time fluorescent quantitation RT-PCR was used to detect the AML1/ETO fusion gene and its correlation with prognosis after treatment. Among 96 patients, AML1-ETO fusion gene was positive in 52 cases, the positive rate was 54.17 %. The complete relief (CR) rate of AML1-ETO fusion gene positive patients was 84.62 %, and the CR rate of AML1/ETO fusion gene negative patients was 77.27 %; the CR rate of AML1-ETO positive patients was higher than that of patients without the fusion gene, however there was no statistical difference. In the analysis of recurrent gene mutation in AML-M2 patients, IDH2, ASXL1, TET2, JAK1 and JAK2 gene expressions were not significantly different before treatment and after CR, however, IDHI, JAK3, ABL1 and BCR gene expressions were significantly different. In the study of transcriptome in AML-M2 patients, high-throughput sequencing could effectively detect the difference of the gene expression before treatment and after CR. Furthermore, positive expression of AML1-ETO fusion gene had effect on the prognosis of patients.
    Cell Biochemistry and Biophysics 07/2015; 72(3). DOI:10.1007/s12013-014-0432-4
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    ABSTRACT: The aim of the study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of personalized nutrition guidance on birth rate of fetal macrosomia in the pooled studies. A comprehensive search was conducted to identify all eligible studies using the databases of PubMed, MEDLINE, Embase, Wanfang, Chongqing Weipu Database for Chinese Technical Periodicals and China National Knowledge Infrastructure and reference lists of relevant articles. The methodological quality of the included trials was assessed based on the Jadad scale. We used risk ratios (RRs) to assess the strength of the association, and 95 % confidence intervals (CIs) to evaluate the precision of the estimate. Heterogeneity, publication bias, and sensitivity analysis were also explored. A total of nine RCT studies, including 7,458 pregnant women, were included in the present meta-analysis. The overall results showed that personalized nutrition guidance significantly reduced the birth rate of fetal macrosomia (RR 0.289, 95 % CI 0.184–0.453, P < 0.01) in Chinese population. Simultaneously, publication bias was detected in this meta-analysis. The personalized nutrition guidance can significantly reduce the birth rate of fetal macrosomia. However, due to the limited number of RCTs, especially those with large sample size and multicenter that were quantitatively insufficient, further studies of high quality are required.
    Cell Biochemistry and Biophysics 07/2015; 72(3). DOI:10.1007/s12013-015-0512-0
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    ABSTRACT: Gastric cancer has high morbidity and mortality. Identification of patients with high gastric cancer risk at early stage will improve patient prognosis. In this study, we examined two single nucleotide polymorphism (SNP) sites of COX-2 gene in gastric cancer patients and explored the effect of the SNPs on the morbidity of gastric cancer. We found that the SNPs COX-2-1195G/A and COX-2-8473T/C are correlated with the occurrence of gastric cancer, and the patients with variants A and C of the SNPs are liable to have gastric cancer. Our study provides a potential method for screening of susceptible population of gastric cancer for early-stage intervention in patients.
    Cell Biochemistry and Biophysics 07/2015; 72(3). DOI:10.1007/s12013-014-0465-8
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    ABSTRACT: This study tried to dissect BAFF/BAFF-R-mediated non-canonical NF-κB signaling in the drug resistance of B-cell non-Hodgkin’s lymphoma. FQ-PCR was employ to determine the mRNA expression of BAFF, BAFF-R, Bcl-xL, and RIPK2 in the circulating blood of B-cell non-Hodgkin’s lymphoma patients. Further correlation studies were performed with the gene expression in the circulating blood and tumor tissue. MTT assay as used to determine BAFF’s role on lymphoma cell proliferation. Western blot was employed to determine protein expression after BAFF stimulation. The mRNA expression of BAFF, BAFF-R, Bcl-xL, and RIPK2 in the circulating blood of the resistant group was higher than that of the non-resistant group, which was statistically significant. The mRNA expression of the target genes was positively correlated. The mRNA expression was positively correlated with disease progression, which was statistically significant. The Bcl-xL mRNA expression in the resistant group was relatively higher than that in the non-resistant group, which was also statistically significant. However, the mRNA expression of other genes only showed increased tendency compared with non-resistant group. There was no significant change between target genes in different tumor tissues. With increased BAFF concentration and prolonged exposure, the proliferation of the tumor cells increased significantly, which was statistically significant. Western blot showed the expression of BAFF, BAFF-R, Bcl-xL, and RIPK2 all increased with increased BAFF concentration, which was also statistically significant. In B-cell, non-Hodgkin’s lymphoma, BAFF may activate non-canonical NF-κB signaling to regulate drug resistance.
    Cell Biochemistry and Biophysics 07/2015; 72(3). DOI:10.1007/s12013-015-0518-7
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    ABSTRACT: Intestinal inflammation is one of the major factors that increase colorectal cancer (CRC) incidence worldwide. Inflammation in the gastrointestinal tract is directly linked to tumor development at the early stages of the disease, thus a key issue toward the prevention and the treatment of colonic neoplasia. Thus, the use of anti-inflammatory drugs has emerged first as a strategy to reduce chronic inflammation in case of many inflammatory bowel diseases (IBD), but it has proven its efficacy by reducing the risk of colonic neoplasia. This comprehensive review highlights the role of chronic inflammation, mainly in IBD, in the development of CRC including molecular and immune mechanisms that have tumorigenic effects. Multiple lines of evidence indicate that several bioactive and phytochemical compounds used as anti-inflammatory drugs have also antitumoral attributes. The uses of orally delivered cytokines and small molecules, as well as key dietary supplementation as anti-inflammatory therapeutics are discussed. In addition, comprehensive knowledge about CRC and intestinal inflammation, and the importance of the intestinal mucosal wall as a mucosal immunological barrier that comes into play during interactions with gut microbiota (pathogens and commensal), luminal secretions (bile acids, and bacterial and epithelial metabolites), and ingested chemicals (food components, high fat content, heterocyclic amines, and low intake of dietary fiber) are underscored. The multifunctionality of several anti-inflammatory drugs opens a line for their application in the treatment and prevention not only in IBD but also in CRC. Current bioengineering approaches for oral delivery of anti-inflammatory agents including cytokines, genetically modified bacteria, or small molecule inhibitors of inflammation directly contribute to the early management of CRC. Limitations of the current therapeutics, which stem from the lack of complete understanding of the complex molecular interactions between the intestinal microbiota, colonic epithelial barrier, and host immune system, are also discussed.
    Cell Biochemistry and Biophysics 07/2015; 72(3). DOI:10.1007/s12013-015-0528-5