Journal of Liquid Chromatography &amp Related Technologies (J LIQ CHROMATOGR R T )

Publisher: Taylor & Francis

Description

The Journal of Liquid Chromatography & Related Technologies publishes an outstanding selection of critical, peer-reviewed papers dealing with analytical, preparative and process-scale liquid chromatography of all types and related technologies such as TLC; capillary electrophoresis; supercritical fluid extraction and chromatography; membrane separation technology; field-flow techniques; and others. Journal of Liquid Chromatography & Related Technologies also publishes special topical issues devoted to specific technologies and applications. Book reviews, software reviews, and a calendar of meetings, symposia, and expositions are also included.

  • Impact factor
    0.57
    Hide impact factor history
     
    Impact factor
  • 5-year impact
    0.67
  • Cited half-life
    9.20
  • Immediacy index
    0.09
  • Eigenfactor
    0.00
  • Article influence
    0.15
  • Website
    Journal of Liquid Chromatography & Related Technologies website
  • Other titles
    Journal of liquid chromatography & related technologies, Journal of liquid chromatography and related technologies
  • ISSN
    1082-6076
  • OCLC
    32501604
  • Material type
    Periodical, Internet resource
  • Document type
    Journal / Magazine / Newspaper, Internet Resource

Publisher details

Taylor & Francis

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Some individual journals may have policies prohibiting pre-print archiving
    • On author's personal website or departmental website immediately
    • On institutional repository or subject-based repository after either 12 months embargo for STM, Behavioural Science and Public Health Journals or 18 months embargo for SSH journals
    • Publisher's version/PDF cannot be used
    • On a non-profit server
    • Published source must be acknowledged
    • Must link to publisher version
    • Set statements to accompany deposits (see policy)
    • The publisher will deposit in on behalf of authors to a designated institutional repository including PubMed Central, where a deposit agreement exists with the repository
    • STM: Science, Technology and Medicine
    • SSH: Social Science and Humanities
    • Publisher last contacted on 25/03/2014
    • 'Taylor & Francis (Psychology Press)' is an imprint of 'Taylor & Francis'
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: A simple and efficient method for determination of Bisphenol A (BPA), an endocrine disrupting chemical (EDC), is developed without the requirement of derivatization. Due to the prevalence of exposure of BPA-containing products to the general public, high-quality testing and monitoring methods are essential. BPA was separated and quantified under reverse-phase conditions using a high-performance liquid chromatography/ultraviolet absorption (HPLC-UV) detection method. A silica hydride-based C8 column along with an effective gradient protocol yielded well-resolved peaks that allowed for the direct analyses of BPA in receipt paper and carbon copies of lab notebooks. Excellent linear correlation was observed (R2 = 0.9936) in the calibration curve obtained from the HPLC-UV analyses.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: A simple and low-cost solid-phase extraction methodology for isolating the bioactive flavonoid kaempferitrin from a defatted fraction of the Uncaria guianensis leaf ethanol extract was developed using the kaempferitrin retention behavior in reversed-phase-high-performance liquid chromatography as well as thin-layer chromatography coupled to ImageJ software (Bethesda, USA) for densitometric analyses. In addition, the method enabled the isolation of less-complex mixtures for the further separation of minor constituents. The target compound was successfully isolated from 1 to 5 mg of the fraction per 500 mg C18 cartridge using 6 mL of 15% acetonitrile at 60% relative recovery and 99% purity.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: This work presents a step-by-step study of a new methodology for capillary isotachophoretic determination (which is one of the green chemistry techniques) of mercury in aquatic environments. Hundreds of analyses resulted in the identification of optimal conditions for the determination of mercury(II) and the identification of problems related to such determination. Recovery for the analyzed compounds was 94 ± 4%, linearity of the method was between 10 and 75 µg/L, and detection limit was 5 µg/L.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: Hippophae rhamnoides L., a fruit which is rich in natural chemical ingredients, has become an important raw material of health food, medicine, and cosmetics. In the present work, a method using 2-(5-benzoacridine)ethyl-p-toluenesulfonate as pre-column derivatization reagent with high sensitivity, selectivity, and short separation time was developed to analyze triterpenic acids (TTAs) in H. rhamnoides L. by HPLC with fluorescence detection and simultaneously confirmed by post-column atmospheric pressure chemical ionization-mass spectrometry. The method was validated by linearity, limits of detection (LODs) and lower limits of quantification (LLOQs), precision, and accuracy. Good linear correlations were observed for all TTAs with correlation coefficients greater than 0.9996. LODs and LLOQs were in the range of 1.71–2.14 and 7.45–8.23 ng mL−1, respectively. The method was successfully employed to analyze TTAs in H. rhamnoides L. from various origins in the Qinghai–Tibetan plateau with trace amount of samples within 15 min. A systemic mapping of the TTAs in H. rhamnoides L. of different origins was established. The results indicated that H. rhamnoides L. is rich in TTAs, especially in oleanolic and ursolic acids, and the content of TTAs varies across origins. This work will support the research on pharmaceutical applications of H. rhamnoides L. and provide information for quality control.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: Reversed phase high-performance liquid chromatography (RP-HPLC) was used to determine the chromatographic fingerprints of multiple batches of decoction pieces of Corydalis yanhusuo samples. The samples were acquired from different production sites, had different numbers of growth years, and were processed using different methods. The standard operating procedure (SOP) for a similarity evaluation system for chromatographic fingerprints of traditional Chinese medicine (version 2004) was used to analyze and evaluate the chromatographic fingerprints. This paper explored the factors that affected the quality of the decoction pieces of Corydalis yanhusuo by analyzing the differences among the chromatographic fingerprints. The results revealed that the processing method is the most important factor contributing to the difference in the chromatographic fingerprints of the samples. This study provides a point of reference for the quality control of decoction pieces of Corydalis yanhusuo samples.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: The present study developed a systematic method for the degradation products and dynamics of valtrate in artificial intestinal fluid and gastric fluid. HPLC-electrospray tandem mass spectrometry (HPLC-ESI-MSn) was applied to separate the degradation products of valtrate and identify structures of the main degradation products. Samples were separated on an Agilent Extend-Cl8 by gradient elution using acetonitrile and water–acetic acid (0.25%, v/v). Analysis was performed in positive ion mode with 3000 V of capillary voltage, 40 psi of atomization pressure, 10 L min−1 dry nitrogen gas velocity, and m/z 100–1000 of scan range. Six degradation products were all identified to own the stem-nucleus structures of baldrinals. Two of them were identified through the reference substances. An HPLC method with isocratic elution using acetonitrile and water (68:32, v/v) at 254 nm was established to determine content change of valtrate in artificial intestinal fluid and gastric fluid at different time points. The method was validated with good linearity in wide linear ranges (r2 = 0.9999), and good intra-day precision (RSD = 1.0%). The degradations of valtrate in artificial intestinal fluid and gastric fluid follow pseudo-first-order kinetic process, the half-life period in artificial gastric fluid is 1.73 hr, and in artificial intestinal fluid it is 1.61 hr. This study enriched the knowledge on degradation products of valtrate and may reveal the mechanism of the degradation of valtrate.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: We evaluated the effect of pH on other optimization factors for quantification of biogenic amines and metabolites by ion-pair reverse phase HPLC–ECD. Sequential changes were made in mobile phase pH, concentration of ion pairing agent and organic modifier to assess the primary function and secondary interaction of these parameters. The data show that pH adjustments within the range commonly reported alter the effects of other optimization factors on the retention of acid metabolites, but not neutral metabolites or the biogenic amines. The biogenic amine assay often requires fine adjustments to optimize retention of the target compounds. An understanding of the multiple effects of changes in mobile phase pH will facilitate optimization of this complex assay.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: The introduction to high-speed countercurrent chromatography of a spiral tubing support rotor has enabled the application of more polar volatile solvent systems for natural products separation, especially water soluble compounds and their metabolites. Here is reported the use of spiral countercurrent chromatography with the spiral tubing support rotor to fractionate extracts of the African medicinal plant Sutherlandia frutescens (L.) R.Br. A two-phase solvent system of ethyl acetate, methanol, water, and n-butanol, with the lower aqueous phase mobile, separated sutherlandioside B efficiently from other compounds. The purity of sutherlandioside B was determined by high-performance liquid chromatography and mass spectrometry analysis. Sufficient quantities of sutherlandioside B can be purified by this method for use in cell culture assays and the development of a sensitive antibody by which to detect the consumption and metabolism in vivo of this novel botanical.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: A simple, sensitive, precise, and stability-indicating high-performance thin-layer chromatographic method has been developed and validated for the quantitative determination of pitavastatin calcium (PTV) in a pharmaceutical dosage form in the presence of its degradation products. The stability of PTV was investigated under different stress conditions, including hydrolytic, oxidative, photolytic, and thermal, as recommended by the International Conference on Harmonization guidelines. PTV was separated on aluminum-backed silica gel 60 F254 high-performance thin-layer chromatography (HPTLC) plates as a stationary phase with ethyl acetate–methanol–toluene–glacial acetic acid (4:1:5:0.1, v/v/v/v) as a mobile phase. Regression analysis data for the calibration plots were indicative of good linear relationships between responses and concentration over the range 25–150 ng per band. The method was validated for linearity, precision, accuracy, robustness, specificity, and sensitivity. The drug was subjected to stress degradation and peaks of all the degradation products were well resolved from that of the pure drug, with significantly different Rf value, which indicates the specificity and stability-indicating properties of the method. The kinetic determination was evaluated in acid conditions. The acid degradation of PTV showed an apparent first-order kinetics and rate constants were found to be 0.00202 µg/mL/min in 0.1 N HCl at 75°C.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(4).
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    ABSTRACT: Metal speciation has increasing applications with regard to environmental chemistry, toxicology, and the biomedical sciences. Much of this interest arises from a growing need to identify the metal species responsible for toxic effects on environmental and biological systems. Previous studies have shown that the mobility, bioavailability, and toxicological properties of metals are all very dependent on the chemical forms in which they occur in the nature.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(3).
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    ABSTRACT: This paper presents a comprehensive literature review on liquid chromatography (LC) techniques, singular and/or in tandem with mass spectrometry (MS), applied to identify and quantify inorganic and organic chemical constituents in atmospheric aerosols. Significant contributions in the field of aerosol chemical composition, obtained either by field measurements or laboratory investigations, are also highlighted. The two major LC techniques that have been used to date to identify aerosol chemical constituents are ionic chromatography (IC) and high performance liquid chromatography (HPLC). They have been used more often in off-line than in on-line mode and both of them can be coupled with several types of mass spectrometry (MS). The two techniques seem to be suitable to obtain information on water-soluble inorganic and organic ions with low molecular weight (IC) or on organic compounds with higher molecular mass (HPLC). LC–MS with electrospray ionization is among the most powerful LC techniques to elucidate possible major contributors to the so-called “unidentified substances” fraction, and it is often reported in studies aimed to investigate the chemical composition of the aerosols. The information generated by liquid chromatography, especially related to different organic compounds into the aerosol particles, helped to elucidate some reaction pathways or improve some postulated mechanisms that may be responsible for the formation of secondary organic aerosols (SOA). However, despite the efforts made to elucidate the aerosols chemical composition, a significant part still remains highly unclear. It is expected that new studies carried out by using complementary analytical techniques will help answering such questions, but further development is needed to make such techniques applicable to large-scale analysis all over the world.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(3).
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    ABSTRACT: The materials, techniques, and instruments for the detection and quantification of radiolabeled compounds by planar radiochromatography are described. Included is sample preparation; separations on Instant Thin Layer Chromatography sheets, thin layer plates, and chromatography papers; and detection and quantification by film autoradiography, liquid scintillation counting, storage phosphor imaging, and in situ radioactivity scanning. These methods are widely applied in radiopharmaceutical purity determination, metabolism studies, and many other types of chemical, biochemical, and biological investigations.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(3).
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    ABSTRACT: Phenolic acids are secondary metabolites of plants. Although less studied of other phenolic compounds such as flavonoids, the interest in their determination is also due to their antioxidant activity. In the past, gas chromatography coupled with mass spectrometry detection (GC–MS), as well as liquid chromatography (LC) coupled to UV detection, have been widely used for determining phenolic acids. Recently, the significant improvements in LC technology (for example, with the introduction of ultra-high performance LC systems) as well as in MS instrumentation (with the development of last generation, high resolution mass analyzers) have favored the development of LC–MS based methods with respect to GC–MS methods for the determination of phenolic compounds. The present review aims to provide an overview on the most recent works in the field.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(3).
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    ABSTRACT: The stationary phases employed in both hydrophilic interaction chromatography and ion chromatography contain highly polar groups and there is an overlap between them. This review summarizes the recent development of the stationary phases in the overlap over approximately the last five years.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(3).
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    ABSTRACT: The use of ionic additives to dramatically extend the range of solute polarity amenable to RP-HPLC began to be exploited in the 1970s. Ion pair chromatography has readily become an intriguing separation strategy: it makes use of ionic Ion Pair Reagents to increase retention of oppositely charged analytes, under RP-HPLC conditions. It is also well recognized that these additives have a significant influence on the peak shape of ionogenic analytes and on the figures of merit of their chromatographic separations. As evidenced by the studies described in this review, retention modeling may offer much potential to help chromatographers perform educated guesses and shorten the optimization process of separations. Although the last years have seen many application of IPC in routine analyses, there is a minimal amount of published work concerning retention modeling in IPC. The purpose of the current review is to bridge the past with the future, with regard to the theoretical facets of this technique, and to provide a critical and comparative survey of the latest theoretical advances in IPC.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(3).
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    ABSTRACT: During the last ten to fifteen years a huge development in the field of analytical techniques used for deciphering the complex nature of the proteome took place. Instrumentation and methods development for sample cleanup, fractionation, preconcentration, chromatographic separation, and detection become affordable to a broad range of laboratories and new, exciting methods for both separation and detection were published and applied. Newly developed techniques and equipment for separation and detection, such as high pressure nano-HPLC and new techniques for multidimensional HPLC separation, enabled proteomics to experience dynamic growth and enter new paths. Furthermore, proteomics starts entering the “real life” and it is increasingly applied for clinical diagnostics and follow-up of patient's status during the treatment.For any proteomic analysis, one of the most important and sometimes the most difficult task is the separation of the complex mixtures of proteins or peptides prior to their detection and data analysis. This review describes some aspects and limitations of HPLC, both multidimensional and one-dimensional, in proteomics research without attempting to discuss all available HPLC methods, their benefits and shortcomings which would need far more space than available here.
    Journal of Liquid Chromatography &amp Related Technologies 02/2015; 38(3).
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    ABSTRACT: Toxicity of fresh Ferula communis (Apiaceae) among cattle in North Jordan is a recently reported problem. Ferula toxicity “Ferulosis” is still ambiguous and not fully understood. Metabolomic approach was applied in the present study to address this problem. Metabolomics based on Attenuated Total Reflectance/Fourier Transformed-Infrared (ATR/FT-IR) results showed that chloroform extract of fresh F. communis has constituents significantly different from those detected in dried plants. Additionally, metabolomics based on HPLC analysis revealed a chromatographic peak with higher concentration in fresh samples. Based on the mass fragments (620, 549, 371, and 274) m/z and neutral losses of acetyl groups (549–505) m/z and (505–461) m/z this compound was identified as acetylated ferulenol-oxy-ferulenol (AFOF).
    Journal of Liquid Chromatography &amp Related Technologies 01/2015; 38(2).
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    ABSTRACT: A poly(pyrrole-co-phenol) film synthesized by the constant potential coulometry technique was coated on stir-bar for sorptive extraction. The extraction properties of this stir-bar were evaluated for the extraction of polycyclic aromatic hydrocarbons (PAHs), followed by liquid chromatography analysis. The copolymer coatings of polypyrrole/polyphenol doped with dodecylbenzenesulfonate and oxalate were synthesized in aqueous solution. The scanning electron micrographs, energy-dispersive X-ray spectroscopy, and FTIR spectra for the coated stir-bar are presented. The effects of potential, time, and solution concentration (pyrrole, phenol, sodium dodecylbenzenesulfonate, and oxalic acid) were evaluated in the coating step. The effects of extraction time, extraction temperature, and ionic strength in the sorption step, and the effects of type and volume of desorption solvent, desorption time, and desorption temperature in the desorption step were studied. The detection limits obtained for the various compounds studied varied between 0.02 and 0.12 ng mL−1, the intra-day (N = 7) relative standard deviations at 8 ng mL−1 concentration level using a single stir-bar were 2.4–12%, respectively. The bar-to-bar reproducibilities, also at 8 ng mL−1, were 3.4–13%. The linear ranges and recoveries varied from 0.1 to 400 ng mL−1, and 69% to 113%, respectively. The method was successfully applied for the determination of a group of PAHs in real samples.
    Journal of Liquid Chromatography &amp Related Technologies 01/2015; 38(2).
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    ABSTRACT: Bisphenol-A (BPA), Triethylene glycol dimethacrylate (TEGDMA), Bisphenol A glycerolatedimethacrylate (Bis-GMA), and Urethane dimethacrylate (UDMA) are organic monomers that can be released from dental composites and, depending on their concentration in biological fluids, can cause adverse reactions and toxic or other effects. Herein, a simple and rapid method has been developed for the simultaneous determination of the aforementioned monomers in human blood serum and urine. Chromatographic analysis was performed isocratically on a Perfect Sil 120 ODS-2 analytical column (250 mm × 4.0 mm, 5 µm) with CH3CN:H2O, 70:30%, v/v as mobile phase within 6 min. The developed method was validated in terms of selectivity, linearity, accuracy, precision, and sensitivity in spiked matrices. Repeatability and between-day precision over a period of five days revealed Relative Standard Deviation (RSD) values lower than 13.1% for blood serum samples and lower than 6.6% for urine samples. Recovery of the examined analytes ranged from 92.6% to 106.1% in blood serum samples and from 95.0% to 106.9% in urine samples. The stability of the four monomers in blood serum and urine samples was studied in terms of long-term storage (at 4°C and −18°C), short-term storage (room temperature), and during sequential freeze-thaw cycles.
    Journal of Liquid Chromatography &amp Related Technologies 01/2015; 38(2).
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    ABSTRACT: Jujuboside A (JuA), a dammarane-type triterpene glycoside, is a main bioactive saponin in Zizyphi Spinosi Semen (a traditional Chinese herbal food). In this research, the distribution of JuA in Sprague-Dawley rats was investigated with a new and efficient HPLC–ESI-MS/MS method. The results showed that JuA distributed rapidly and widely in various rat tissues (including heart, liver, spleen, kidney, and lung) after intravenous administration. In addition, it was initially found that JuA could pass through the blood-brain barrier and reach various areas of the brain quickly. At 0.25 hr, the concentration of JuA in the hippocampus (204.10 ng · g−1) was significantly higher than in the cerebrum (144.27 ng · g−1), olfactory bulb (98.42 ng · g−1), and corpus striatum (76.04 ng · g−1) (p Keywords: HPLC–ESI-MS/MS; Jujuboside A; Ziziphi Spinosae Semen; brain; hippocampus; tissue distribution Document Type: Research Article DOI: http://dx.doi.org/10.1080/10826076.2014.896821 Affiliations: College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China Publication date: January 20, 2015 $(document).ready(function() { var shortdescription = $(".originaldescription").text().replace(/\\&/g, '&').replace(/\\, '<').replace(/\\>/g, '>').replace(/\\t/g, ' ').replace(/\\n/g, ''); if (shortdescription.length > 350){ shortdescription = "" + shortdescription.substring(0,250) + "... more"; } $(".descriptionitem").prepend(shortdescription); $(".shortdescription a").click(function() { $(".shortdescription").hide(); $(".originaldescription").slideDown(); return false; }); }); Related content In this: publication By this: publisher By this author: Zhang, Yanqing ; Ma, Guijie ; Xie, Junbo GA_googleFillSlot("Horizontal_banner_bottom");
    Journal of Liquid Chromatography &amp Related Technologies 01/2015; 38(2).