Journal of AOAC International (J AOAC INT)

Publisher: AOAC International, AOAC International

Journal description

The Journal of AOAC International publishes fully refereed contributed papers in the fields of chemical and biological analysis: on original research on new techniques and applications, collaborative studies, authentic data of composition, studies leading to method development, meeting symposia, newly adopted AOAC approved methods and invited reviews.

Current impact factor: 1.39

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.385
2012 Impact Factor 1.233
2011 Impact Factor 1.199
2010 Impact Factor 1.229
2009 Impact Factor 1.216
2008 Impact Factor 1.122
2007 Impact Factor 1.549
2006 Impact Factor 1.352
2005 Impact Factor 1.046
2004 Impact Factor 1.147
2003 Impact Factor 1.037
2002 Impact Factor 0.907
2001 Impact Factor 1.33
2000 Impact Factor 1.066
1999 Impact Factor 0.95
1998 Impact Factor 0.948
1997 Impact Factor 1.138
1996 Impact Factor 1.256
1995 Impact Factor 0.797
1994 Impact Factor 0.762

Impact factor over time

Impact factor

Additional details

5-year impact 1.32
Cited half-life 8.10
Immediacy index 0.19
Eigenfactor 0.01
Article influence 0.30
Website Journal of AOAC (Association of Official Analytical Chemists) International website
Other titles Journal of AOAC International
ISSN 1060-3271
OCLC 24929715
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

AOAC International

  • Pre-print
    • Author cannot archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Conditions
    • The publisher will deposit in PubMed Central on behalf of NIH authors
  • Classification
    ​ white

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: All fruits, vegetables, grains and other plant materials contain small amounts of plant sterols, which are essential for the function of the biological membranes in living cells. The average human consumption of plant sterols has been estimated to be about 150-350 mg/day and trace amounts of stanols (which are defined as saturated sterols such as sitostanol), but this number varies regionally and is higher for vegetarians. When consumed in the diet, plant sterols reduce the levels of serum cholesterol. In 1995 the first functional food product, Benecol spread (enriched in plant stanol fatty acid esters), was developed by Raisio and marketed, first in Finland and then globally. Since then many other functional food products have been developed and are now available globally. In addition to stanol esters, other functional food products contain plant sterol esters and/or free (unesterified) plant sterols and stanols. In essentially all of the current functional foods that are enriched in sterols and stanols, the feedstock from which the sterols and stanols are obtained is either tall oil (a byproduct/coproduct of the pulping of pine wood) or vegetable oil deodorizer distillate (a byproduct/coproduct of the refining of vegetable oils).
    Journal of AOAC International 05/2015; DOI:10.5740/jaoacint.SGEMoreau
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    ABSTRACT: Cholesterol-lowering properties of plant sterols were reported approximately six decades ago. However, over the past couple of decades we have learnt more about other cardiovascular benefits of regular consumption of plant sterols and/or plant stanols. In particular a series of animal studies has consistently reported that dietary plant sterols and/or plant stanols or their fatty acid esters can reduce atherogenesis to a different extent in different animal models. Such effects may be mediated not only through reductions in LDL cholesterol levels, but also through other mechanisms including anti-inflammatory effects. In this manuscript, various animal models including mice, rabbits, hamsters, and others which have been used to establish cardiovascular benefits of plant sterols are discussed.
    Journal of AOAC International 05/2015; DOI:10.5740/jaoacint.SGESolati
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    ABSTRACT: The format and matrix in which functional food ingredients are delivered may influence their bioactivity in vivo. Therefore, this paper will review studies which have examined plant sterols and stanols being consumed in varying formats and matrices, i.e., fat-containing foods versus low or non-fat foods, solid foods versus liquid foods, capsules or tables versus foods. Furthermore, this paper will examine the issue of providing plant sterols and stanols in either free or esterified form. Finally, a discussion on the importance of microemulsion stability of the sterols and stanols is elaborated. Based on the reviewed information, it would seem that plant sterols and stanols are effective in all food and capsule/tablet formats, and in both free and esterified form. Some failures in clinical trials may be due to unstable microemulsion of sterols.
    Journal of AOAC International 05/2015; DOI:10.5740/jaoacint.SGEClifton
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    ABSTRACT: This chapter reviews regulatory frameworks for plant sterol containing functional foods in various jurisdictions including Europe, North America, South America, Asia and, Australia/New Zealand. Included is a discussion on approval of plant sterols as novel food ingredients in some countries, as well as details on the type of health claims permitted in the marketing and sale of foods enriched with plant sterols within each jurisdiction. Based on the abundance of clinical trial data, many countries around the world have now approved the use of claims relating the cholesterol-lowering effect of plant sterols, further attesting to their value as functional food ingredients.
    Journal of AOAC International 05/2015; DOI:10.5740/jaoacint.SGEZawistowski
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    ABSTRACT: Cholesterol, its biosynthetic precursors, its metabolite 5α-cholestanol and plant sterols are widely used today in clinical lipid research as surrogate markers of cholesterol synthesis and absorption. Advances in analytical methods for the determination of serum noncholesterol sterols and stanols within the last century are highlighted. This review focuses on sample preparation, separation, and detection techniques. Various aspects related to sterol and stanol analysis from biological samples are discussed.
    Journal of AOAC International 05/2015; DOI:10.5740/jaoacint.SGELutjohann
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    ABSTRACT: Despite the abundance of clinical trial data demonstrating the cholesterol-lowering action of plant sterol supplementation, substantial variability in efficacy exists in responsiveness across individuals. The goal of this review is to examine factors responsible for this heterogeneity in responsiveness of blood cholesterol levels to dietary plant sterols. Although initially thought to be due to random noise in the data, demonstrated consistency in degree of responsiveness in the context of controlled feeding designs from person to person suggests that other systematic drivers are responsible. Genetic explanations explaining this phenomenon appear to be gaining momentum. Particularly, single nucleotide polymorphisms within the genes coding for CYP7A1 and ApoE, as well as possibly other genes including ABC G5 and G8, exist as predictors of whether LDL-C levels will decrease or even increase subsequent to plant sterol administration. In summary, nutrigenetic differences across genes associated with cholesterol trafficking pathways may be important in predicting how well any given individual will respond to dietary interventions. It is anticipated that eventually genetic tests will be developed that can guide health care professionals to optimize dietary strategies for health optimization.
    Journal of AOAC International 05/2015; DOI:10.5740/jaoacint.SGEJones
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    ABSTRACT: Phytosterolemia (sitosterolemia) is a rare autosomal recessive sterol storage disease caused by mutations in either of the adenosine triphosphate (ATP) binding cassette transporter genes; (ABC)G5 or ABCG8, leading to impaired elimination of plant sterols and stanols, with their increased accumulation in the blood and tissues. Thus the disease is characterized by substantially elevated serum plant sterols and stanols, with moderate to high plasma cholesterol levels, and increased risk of premature atherosclerosis. Hematologic abnormalities including macrothrombocytopenia, stomatocytosis and hemolysis are frequently observed in sitosterolemia patients. Currently, ezetimibe, a sterol absorption inhibitor, is used as the routine treatment for sitosterolemia, with reported improvement in plant sterol levels and hemolytic parameters. This review summarizes the research related to the health impact of plant sterols and stanols on sitosterolemia.
    Journal of AOAC International 05/2015; DOI:10.5740/jaoacint.SGEAjagbe
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    ABSTRACT: Plant sterols and stanols as components of functional foods are widely used for cholesterol lowering. The regular intake of these functional foods is associated with a decrease in low density lipoprotein cholesterol of about 10 % and an increase in plasma plant sterol or stanol concentrations by about a factor of 2. There is no doubt that a decrease in low density lipoprotein cholesterol is beneficial to cardiovascular health. However, due to the concomitant increase in circulating plant sterols safety issues associated with the intake of plant sterol containing functional foods have been raised. Herein, we will review and evaluate those arguments raised against the use of plant sterols and stanols.
    Journal of AOAC International 05/2015; DOI:10.5740/jaoacint.SGESilbernagel
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    ABSTRACT: The human diet is naturally varied and contains not only essential nutrients, but also contains molecules that the body actively excludes or minimizes exposure. Among these molecules are xenosterols, of which plant sterols comprise the greatest exposure risk. These sterols comprise approximately 50% of the total sterols we eat, yet we retain <0.5% of these in our bodies. The bulk of this exclusion takes place in the intestine and the heterodimeric transporters ABCG5 and ABCG8 are key to keeping these xenosterols out of our bodies. In normal humans, pharmacological supplementation with plant sterols (and stanols) has been used to lower cholesterol as these impair intestinal absorption/re-absorption of this molecule; lowering plasma cholesterol has cardiovascular risk benefits. This review challenges whether this intervention is beneficial and may even be harmful. We summarize the evidence involving humans who have genetic disruption of ABCG5/ABCG8 function, from clinical trial data examining plant sterols and cardiovascular risk, from genetic data affecting normal humans and ABCG5/ABCG8 variations to data obtained using animal models. Accumulation of xenosterols in any significant amount is clearly associated with increased toxicity, and data suggest that at even low levels there may be effects. Importantly, there is also a paucity of data showing cardiovascular end-point benefits with plant sterol/stanol supplementation. The summary of evidence highlights not only caution in recommending such strategies to lower plasma cholesterol, but also in investigating how these xenosterols can affect processes ranging from cardiovascular, endocrine, and neurological function.
    Journal of AOAC International 05/2015;
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    ABSTRACT: Sampling water is no different than sampling any other media. It starts with the development of Sample Quality Criteria, understanding of material properties, then application of the Theory of Sampling. The main difference with sampling water as opposed to solids is the material properties. This paper addresses some of the material properties and consequences of those properties for the development of the sampling protocols. Two properties that must be addressed for water are the temporal nature and the inclusion of suspended solids. Examples are provided for three specific water sampling scenarios which may have application to other water sampling scenarios.
    Journal of AOAC International 03/2015; 98(2). DOI:10.5740/jaoacint.14-251
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    ABSTRACT: Sampling agricultural soils for contaminants is relatively new. Existing standard sampling protocols used for the evaluation of soil nutrients are likely insufficient for contaminants. The main reasons are the very low analyte levels and differences in heterogeneity between nutrients and contaminants. To evaluate the adequacy of existing sampling protocols or to develop new protocols, a systematic scientific approach is needed. This approach begins with the development of the Sample Quality Criteria followed by a realistic understanding of the properties of the material to be sampled, most notably its heterogeneity. The Sample Quality Criteria and material properties are inputs into the Theory of Sampling. With these inputs, the Theory of Sampling can be used to determine the specifics of the sampling protocol (e.g., mass, number of increments, tool selection) that must be implemented to control error to reliably estimate the concentration of the analyte(s) of interest. Development of sampling protocols in this manner will ensure sample representativeness and therefore improve data equivalency among various parties involved. This is the only way to provide a sound technical basis for defensible decision making to ensure increased safety of food and feed, specifically with respect to contaminants in agricultural soils.
    Journal of AOAC International 03/2015; 98(2). DOI:10.5740/jaoacint.14-268