Journal of AOAC International (J AOAC INT )

Publisher: AOAC International

Journal description

The Journal of AOAC International publishes fully refereed contributed papers in the fields of chemical and biological analysis: on original research on new techniques and applications, collaborative studies, authentic data of composition, studies leading to method development, meeting symposia, newly adopted AOAC approved methods and invited reviews.

Current impact factor: 1.39

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013/2014 Impact Factor 1.385
2012 Impact Factor 1.233
2011 Impact Factor 1.199
2010 Impact Factor 1.229
2009 Impact Factor 1.216
2008 Impact Factor 1.122
2007 Impact Factor 1.549
2006 Impact Factor 1.352
2005 Impact Factor 1.046
2004 Impact Factor 1.147
2003 Impact Factor 1.037
2002 Impact Factor 0.907
2001 Impact Factor 1.33
2000 Impact Factor 1.066
1999 Impact Factor 0.95
1998 Impact Factor 0.948
1997 Impact Factor 1.138
1996 Impact Factor 1.256
1995 Impact Factor 0.797
1994 Impact Factor 0.762

Impact factor over time

Impact factor
Year

Additional details

5-year impact 1.32
Cited half-life 8.10
Immediacy index 0.19
Eigenfactor 0.01
Article influence 0.30
Website Journal of AOAC (Association of Official Analytical Chemists) International website
Other titles Journal of AOAC International
ISSN 1060-3271
OCLC 24929715
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: A novel chelating resin for preconcentration of heavy metals from various seawater samples has been developed by condensing 1-amino-2-hydroxy-7-[(4-hydroxyphenyl)diazenyl] naphthalene-4-sulfonic acid (AHDNS) with formaldehyde (1:2 mole ratio) in the presence of oxalic acid as the catalyst. The resin thus obtained was used as a solid sorbent for the separation of divalent metal ions present at trace levels in seawater. The functionalized phenol (AHDNS) was characterized by spectral studies. The polymeric resin AHDNS-formaldehyde (AHDNS-F) obtained by condensing the functionalized phenol and formaldehyde was characterized by IR and NMR spectral studies. The chelating property of the AHDNS-F resin towards divalent metal ions was studied as a function of pH and in the presence of electrolyte. The metal uptake properties of the resin were determined by using an atomic absorption spectrophotometer. This procedure was validated for recovery of divalent metal ions from seawater samples. The recoveries of cadmium, cobalt, copper, manganese, lead, and zinc were above 92% under the optimum preconcentration conditions. The LOD was Document Type: Research Article DOI: http://dx.doi.org/10.5740/jaoacint.12-134 Publication date: January 1, 2015 More about this publication? The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents. Information for Authors Submit a Paper Subscribe to this Title Information for Advertisers Journal Information Masthead ingentaconnect is not responsible for the content or availability of external websites $(document).ready(function() { var shortdescription = $(".originaldescription").text().replace(/\\&/g, '&').replace(/\\, '<').replace(/\\>/g, '>').replace(/\\t/g, ' ').replace(/\\n/g, ''); if (shortdescription.length > 350){ shortdescription = "" + shortdescription.substring(0,250) + "... more"; } $(".descriptionitem").prepend(shortdescription); $(".shortdescription a").click(function() { $(".shortdescription").hide(); $(".originaldescription").slideDown(); return false; }); }); Related content In this: publication By this: publisher In this Subject: Agriculture/Food Sciences , Microbiology , Analytical Chemistry By this author: Manivannan, Dhanasekaran ; Biju, Valsala Madhavan Nair GA_googleFillSlot("Horizontal_banner_bottom");
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: This paper describes a comparative study of the influence of three sample preparation techniques (M1: hydration + oscillating extraction + partial extraction solution hexane partitioning cleanup; M2: hydration + oscillating extraction + overall extraction solution SPE cleanup; and M3: pure acetonitrile homogeneous extraction + overall extraction SPE cleanup) on the determination efficiency of 456 pesticide multiresidues in tea. First, it was discovered from the mathematical correlation equation of 329 pesticide recoveries established and log Kow values that the extraction efficiency of hydration method M1 has obvious correlation with pesticide log Kow, making the extraction efficiency of M1 take the shape of an arc trend line with a certain arc hanging down from both ends of polar pesticides and nonpolar pesticides. Second, regarding the M1 method, the interfering matter after co-extraction increased in large quantities, which markedly lowered the S/N of the target pesticides and method sensitivity, leading to an obvious decrease of the method efficiency. The fortification experiment of the uniform limit 0.010 mg/kg proved that with the M1 hydration method there are 23 pesticides with recoveries between 70 and 120% and RSD Document Type: Research Article DOI: http://dx.doi.org/10.5740/jaoacint.13-279 Publication date: January 1, 2015 More about this publication? The Journal of AOAC INTERNATIONAL publishes refereed papers and reviews in the fields of chemical, biological and toxicological analytical chemistry for the purpose of showcasing the most precise, accurate and sensitive methods for analysis of foods, food additives, supplements and contaminants, cosmetics, drugs, toxins, hazardous substances, pesticides, feeds, fertilizers and the environment available at that point in time. The scope of the Journal includes unpublished original research describing new analytical methods, techniques and applications; improved approaches to sampling, both in the field and the laboratory; better methods of preparing samples for analysis; collaborative studies substantiating the performance of a given method; statistical techniques for evaluating data. The Journal will also publish other articles of general interest to its audience, e.g., technical communications; cautionary notes; comments on techniques, apparatus, and reagents. Information for Authors Submit a Paper Subscribe to this Title Information for Advertisers Journal Information Masthead ingentaconnect is not responsible for the content or availability of external websites $(document).ready(function() { var shortdescription = $(".originaldescription").text().replace(/\\&/g, '&').replace(/\\, '<').replace(/\\>/g, '>').replace(/\\t/g, ' ').replace(/\\n/g, ''); if (shortdescription.length > 350){ shortdescription = "" + shortdescription.substring(0,250) + "... more"; } $(".descriptionitem").prepend(shortdescription); $(".shortdescription a").click(function() { $(".shortdescription").hide(); $(".originaldescription").slideDown(); return false; }); }); Related content In this: publication By this: publisher In this Subject: Agriculture/Food Sciences , Microbiology , Analytical Chemistry By this author: Chen, Xi ; Li, Yan ; Chang, Qiao-Ying ; Hu, Xue-Yan ; Pang, Guo-Fang ; Fan, Chun-Lin GA_googleFillSlot("Horizontal_banner_bottom");
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: The citrus-derived bioactive monoterpene limonene is an important industrial commodity and fragrance constituent. An RP isocratic elution C18 ultra-HPLC (UHPLC) method using a superficially porous stationary phase and photodiode array (PDA) detector has been developed for determining the limonene content of sweet orange (Citrus sinensis) oil. The method is fast with a cycle time of 1.2 min, linear, precise, accurate, specific, and stability indicating, and it satisfies U.S. Pharmacopeia suitability parameters. The method may be useful in its present form for limonene processing, or modified for research on more polar compounds of the terpenome. A forced-degradation experiment showed that limonene is degraded by heat in hydro-ethanolic solution. PDA detection facilitates classification of minor components of the essential oil, including β-myrcene.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: Regulations aimed to protect public health from amnesic shellfish poisoning (ASP) are focused on the detection and accurate quantification of domoic acid (DA). The reference detection determination used by the different shellfish safety monitoring agencies worldwide is HPLC separation followed by UV detection, in which different chromatographic column lengths or brands are accepted as long as it is C18 column. A laboratory validation of this method showed different performance of two accepted chromatographic columns when analyzing Bolinus brandaris samples. A natural compound, present only in those samples that contained DA, was evidenced by one of the columns. The DA quantification obtained with the column that coelutes both compounds was approximately twice the amount obtained with the column that separates them. This difference has important consequences in the ASP toxins management for this fishery. The identity and toxicity of the compound are still unknown.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: Amberlite® XAD-16 was functionalized with p-aminobenzene sulfonic acid via an azo spacer in order to prepare a new chelating resin, which was then characterized by water regain value, hydrogen ion capacity, elemental analyses, and IR spectral and thermal studies. The maximum uptake of Cu(II), Ni(II), Zn(II), Co(II), Cr(III), Fe(III), and Pb(II) ions was observed in the pH range 4.0–6.0 with the corresponding half-loading times of 6.5, 7.0, 8.0, 9.0, 11.0, 8.5, and 16.5 min. The sorption data followed Langmuir isotherms and a pseudo-second-order model. Thermodynamic quantities, ΔH and ΔS, based on the variation of the distribution coefficient with temperature were also evaluated. High preconcentration factors of 60–100 up to a low preconcentration limit of 4.0–6.6 μg/L have been achieved for the metal ions. The validity of the method was checked by analyzing standard reference materials and recoveries of trace metals after spiking. The analytical applications of the method were explored by analyzing natural water, mango pulp, mint leaves, and fish.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: Gentiana rigescens (“Dian Longdan” in Chinese) medicinal plant is usually used for its activities of liver protection, cholagogic, anti-inflammatory, anti-fungal, anti-hyperthyroidism, anti-hypertension, hyperglycemia, and relieving spasm and pain. In this study, methods for the discrimination of different geographical origins of G. rigescens by FTIR spectroscopy in hyphenation with chemometric methods were developed. Different pretreatments including standard normal variate, multiplicative scatter correction, first or second derivative, Savitzky-Golay filter, and Norris derivative filter were applied on the spectra to optimize the calibrations. According to spectrum SD, spectrum ranges (3559–2709 and 2026–756 cm–1) were selected, and principal component analysis-Mahalanobis distance (PCA-MD) model was built [the cumulative contribution rate of the first 10 principal components, determination coefficient (R2), root-mean-square error of calibration (RMSEC), and root-mean-square error of prediction (RMSEP), and prediction accuracy were 96.4%, 98.6%, 0.5031, 0.7758, and 96.23%, respectively]. The spectral regions (3791–3442, 3043–2765, and 2013–646 cm–1) were selected by using the variable importance in projection, and partial least squares discriminant analysis (PLS-DA) model was built (the cumulative contribution rate of the first 10 principal components, R2, RMSEC, RMSEP, and prediction accuracy were 91.3%, 92.0%, 0.1171, 0.1806, and 100%, respectively). This research showed that FTIR spectroscopy in combination with chemometrics methods (PCA-MD and PLS-DA) was suitable for the discrimination of different geographical origins of G. rigescens. Furthermore, it was found that PLS-DA provided better results than PCA-MD.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: Fabrication and general performance characteristics of novel screen-printed sensors for potentiometric determination of sodium dodecylsulfate (SDS) are described. The sensors are based on the use of ion-association complexes of SDS with cetylpyridinium chloride (electrode I) and cetyltrimethylammonium bromide (electrode II) as exchange sites in a screen-printed electrode matrix. Electrodes (I) and (II) show fast, stable, and near-Nernstian response for the mono-charge anion of SDS over the concentration range of 1 × 10–2 – 5.8 × 10–7 and 1 × 10–2 – 6.3 × 10–7 mol/L at 25°C and the pH range of 2.0–9.0 and 2.0–8.0 with anionic slope of 57.32 ± 0.81 and 56.58 ± 0.65 mV/decade, respectively. Electrodes (I) and (II) have lower LODs of 5.8 × 10–7 and 6.3 × 10–7 mol/L and response times of about 8 and 13 s, respectively. Shelf life of 5 months for both electrodes is adequate. Selectivity coefficients of SDS related to a number of interfering cations, and some inorganic compounds were investigated. There were negligible interferences caused by most of the investigated species. The direct determination of 0.10–13.50 mg of SDS by electrodes (I) and (II) shows average recoveries of 99.96 and 99.85%, and mean RSDs of 0.83 and 1.04%, respectively. In the present investigation, both electrodes were used successfully as end point indicators for determination of SDS in pure pharmaceutical preparations and real spiked water samples. The results obtained using the proposed sensors to determine SDS in solution compared favorably with those obtained by the standard addition method.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: A 3 month study was conducted on the ruggedness of a multiresidue method for accuracy and stability. The results indicate that in terms of Youden pair ratios of 201 pesticide aged tea samples falling approximately within 1.00–1.20 of the ratio of theoretical spraying concentrations, the differences do not exceed 5% for percentages made up by ratios of the fixed values obtained by two kinds of instruments for two teas and those made up by 18 circular determinations. However, regarding two kinds of SPE cartridges, the Cleanert TPT cartridge is higher than the ENVI-CARB + primary secondary amine (PSA) cartridge by 10%. Pertaining to RSD values of “parallel samples” and whether it is green tea or Woolong tea, the percentages of RSD ≤15% values of the parallel samples all exceed 88%. Whether it is the first or circular determination for two teas and analytical results from two kinds of instruments, the percentages of RSD ≤15% values have a difference of less than 6%, while the TPT cartridge is better than ENVI-CARB + PSA by above 6% for the two cartridges. Concerning RSDs of Youden pair ratios, RSD ≤15% values have a proportion exceeding 85% for both green tea and Woolong tea, and the percentage is greater than 87% whether it is for two kinds of SPE cartridges or two kinds of instruments. In terms of Youden pair ratios and the classified statistical analysis of the ruggedness data of parallel samples, the proportion of RSD ≤15% values of Youden pair ratios is 8% higher for the TPT cartridge than the ENVI-CARB + PSA cartridge; the proportion of RSD ≤15% values of parallel samples is 6.2% higher for the TPT cartridge than the ENVI-CARB + PSA cartridge. Data show no marked differences for two teas and two kinds of instruments. A comparison of the aforementioned aspects finds that good ruggedness was obtained with both SPE cleanup methods, and the results from the TPT cartridge are better than those from the ENVI-CARB + PSA cartridge.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: In this study, the phase-separation phenomenon of non-ionic surfactants was used for separation and preconcentration of Pd(II). The cloud point extraction (CPE) method is based on the formation of PdI2 which is then entrapped in the non-ionic surfactant Triton X-114. Ethanol acidified with 0.5 M HNO3 was added to the surfactant-rich phase prior to its analysis by flame atomic absorption spectrometry. The main factors affecting CPE efficiency, such as sample solution pH, concentration of iodide ion and Triton X-114, equilibration temperature and time, were all investigated and optimized. At optimum conditions, a calibration curve was constructed for the determination of palladium according to the ligandless CPE procedure. Linearity was maintained between 1.0 to 500.0 ng/mL. The LOD based on three times the SD of the blank divided by the slope of analytical curve, (3Sb/m) was 0.3 ng/mL. Seven replicate determinations of a solution containing of 4.0 μg palladium gave a mean absorbance of 0.359 with RSD ±1.85%. The high efficiency of CPE to carry out the determination of palladium in complex matrixes was demonstrated. The proposed method has been applied to the determination of trace amounts of palladium in a platinum-iridium alloy, water, and dust samples, with satisfactory results.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: An HPLC-UV method was developed for the quantitative analysis of nine skin whitening agents in a single injection. These compounds are α-arbutin, β-arbutin, kojic acid, nicotinamide, resorcinol, ascorbic acid, hydroquinone, 4-methoxyphenol, and 4-ethoxyphenol. The separation was achieved on a reversed-phase C18 column within 30 min. The mobile phase was composed of water and methanol, both containing 0.1% acetic acid (v/v). The stability of the analytes was evaluated at different pH values between 2.3 and 7.6, and the extraction procedure was validated for different types of skin whitening product matrixes, which included two creams, a soap bar, and a capsule. The best solvent system for sample preparation was 20 mM NaH2PO4 containing 10% methanol at pH 2.3. The analytical method was validated for accuracy, precision, LOD, and LOQ. The developed HPLC-UV method was applied for the quantitation of the nine analytes in 59 skin whitening products including creams, lotions, sera, foams, gels, mask sheets, soap bars, tablets, and capsules.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: A rapid, efficient, and simple one-step ultrasound-assisted extraction (UAE) method was developed for the analysis of seven fungicides (cymoxanil, metalaxyl, mandipropamid, folpet, chlorothalonil, kresoxim-methyl, and famoxadone) in horticultural soils. Analytes in the samples were determined by HPLC with variable wavelength detection. Key parameters that influence the UAE procedure were optimized, such as the nature and volume of extraction solvent, number of sonication steps, and sonication time. The highest extraction efficiencies in the range of 61.1–87.8% were obtained by using only 7.5 mL of ethyl acetate–hexane (1 + 1, v/v) and sonicating for 10 min. At 0.5 and 2.0 μg/g fortification levels, satisfactory recoveries (>60%) with RSD 52%). The method was linear over the range of 0.005 to 10 μg/g and the correlation coefficients (r2) obtained ranged from 0.9955 to 0.9992. The LODs (S/N = 3) varied from 0.0015 to 0.006 μg/g. The proposed UAE procedure was compared to classical extractions (shake-flask and Soxhlet extraction) and showed satisfactory extraction efficiencies using shorter time and smaller amounts of organic solvents, thereby minimizing the costs of the analysis and the disposal of waste solvent.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: Methods under consideration as part of the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals process are to be evaluated against a set of Standard Method Performance RequirementsSM (SMPRs) via peer review by an expert review panel (ERP). A validation protocol and a checklist have been developed to assist the ERP to evaluate experimental data and to compare multiple candidate methods for each nutrient. Method performance against validation parameters mandated in the SMPRs as well as additional criteria are to be scored, with the method selected by the ERP proceeding to multilaboratory study prior to Final Action approval. These methods are intended to be used by the infant formula industry for the purposes of dispute resolution.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: A method was developed for detection of V, Cr, Cu, As, and Pb in water and biological samples by combining online flow injection and preconcentration with inductively coupled plasma-MS. The 2-nitroso-1-naphthol-4-sulfonic acid (Nitroso-S) impregnated MCI GEL CHP20P resin was prepared as an enrichment sorbent. Some parameters affecting the efficiency of the preconcentration process were investigated in the experiment, including the pH and volume of sample solution, the flow rate for sample loading, the type and concentration of eluent, and the influence of co-existing ions. Under the optimal experimental conditions, the enrichment factor and LOD (3s) of chosen metal ions V, Cr, Cu, As, and Pb were in the ranges of 71–268 and 4.89–23.76 ng/L, respectively. Based on 11 repeated measurements of standard solutions (1.0 μg/L), the RSD of the ions ranged from 1.2 to 2.9%. The detection procedure was also performed for analyzing two certified reference materials, GBW 08607 (water) and GBW 10052 (green tea), as well as environmental water and biological samples. Good agreement with certified values and high recoveries have demonstrated improved accuracy of the proposed method.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: The biodegradation of fluorene by immobilized Coprinus plicatilis was studied in pinewood and foam glass bead-packed reactors. The reactors were operated in a sequencing batch system. Removal efficiency increased over time and elevated influent fluorene concentration (85 mg/L) was removed 100% in 24–30 h batch cycles. Increased laccase activity was detected with the introduction of the compounds, and optimum activity corresponded to optimum removal periods. Significantly higher laccase activity (16.7–19 U/L) was detected in the glass bead-packed reactor compared to the pinewood-packed reactor (0.2–5 U/L). The presence of Mn2+ ions in the wood material possibly caused elevated manganese peroxidase activity (0.3–5.8 U/L) compared to low to negligible activity in the glass bead reactor. Reactor performances are discussed in relation to sequencing batch operation and nutrient requirements necessary to induce and sustain fungal enzyme activity in inert-like organic material packed systems. Biodegradation metabolites were detected in samples via GC/MS.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: A simple ion imprinted amino-functionalized sorbent was synthesized by coupling activated carbon with iminodiacetic acid, a functional compound for metal chelating, through cyanoric chloride spacer. The resulting sorbent has been characterized using FTIR spectroscopy, elemental analysis, and thermogravimetric analysis and evaluated for the preconcentration and determination of trace Zn(II) in environmental water samples. The optimum pH value for sorption of the metal ion was 6–7.5. The sorption capacity of the functionalized sorbent was 66.6 mg/g. The chelating sorbent can be reused for 10 cycles of sorption-desorption without any significant change in sorption capacity. A recovery of 100% was obtained for the metal ion with 0.5 M nitric acid as the eluent. Compared with nonimprinted polymer particles, the prepared Zn-imprinted sorbent showed high adsorption capacity, significant selectivity, and good site accessibility for Zn(II). Scatchard analysis revealed that the homogeneous binding sites were formed in the polymer. The equilibrium sorption data of Zn(II) by modified resin were analyzed by Langmuir, Freundlich, Temkin, and Redlich-Peterson models. Based on equilibrium adsorption data, the Langmuir, Freundlich, and Temkin constants were determined as 0.139, 12.82, and 2.34, respectively, at 25°C.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: A new separation and preconcentration method based on adsorption on a cellulose acetate membrane filter and elution with ethanol was established for the UV-Vis spectrophotometric determination of Sudan blue II. Various analytical parameters such as pH of working media, flow rates of solutions, and sample volumes were optimized. Matrix effects of concomitants were investigated for the quantitative recovery values of Sudan blue II. The preconcentration factor was 200. LOD was calculated as 0.96 μg/L. RSD was 5.1%. The optimized procedure was applied to the spectrophotometric determination of Sudan blue II in river and industrial wastewater samples from oil and dye products.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: Specifications in the Code of Federal Regulations limit the levels of As, Pb, and Hg in most certifiable color additives, and some have additional specification limits for Cr and Mn. A new ICP/MS method was developed and validated for the quantitative determination of these elements in various certifiable color additives. One dissolution and two microwave-assisted digestion sample preparation procedures were optimized to address initial low Hg and enhanced As recoveries. Results using the three sample preparation procedures were generally equivalent for all of the elements determined. LOQ values were 0.3 mg/kg for As, 0.7 mg/kg for Cr, 0.4 mg/kg for Pb, 0.7 mg/kg for Mn, and 0.1 mg/kg for Hg.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: A fluidized bed enrichment technique was developed to improve sensitivity of near infrared (NIR) spectroscopy with features of rapidness and large volume solution. D301 resin was used as an adsorption material to preconcentrate β-naphthalenesulfonic acid in solutions in a concentration range of 2.0–100.0 μg/mL, and NIR spectra were measured directly relative to the β-naphthalenesulfonic acid adsorbed on the material. An improved partial least squares (PLS) model was attained with the aid of multiplicative scatter correction pretreatment and stability competitive adaptive reweighted sampling wavenumber selection method. The root mean square error of cross validation was 1.87 μg/mL at PLS factor of 7. An independent test set was used to assess the model, with the relative error (RE) in an acceptable range of 0.46 to 10.03% and mean RE of 3.72%. This study confirmed the viability of the proposed method for the measurement of a low content of β-naphthalenesulfonic acid in water.
    Journal of AOAC International 02/2015; 98(1).
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    ABSTRACT: Residues of 37 polar veterinary drugs belonging to six families (quinolones, tetracyclines, macrolides, lincosamides, sulfonamides, and others) in livestock and fishery products were determined using a validated LC-MS/MS method. There were two key points in sample preparation. First, extraction was performed with two solutions of different polarity. Highly polar compounds were initially extracted with Na2EDTA-McIlvaine's buffer (pH 7.0). Medium polar compounds were then extracted from the same samples with acetonitrile containing 0.1% formic acid. Secondly, cleanup was performed using a single SPE polymer cartridge. The first extracted solution was applied to the cartridge. Highly polar compounds were retained on the cartridge. Then, the second extracted solution was applied to the same cartridge. Both highly and medium polar compounds were eluted from the cartridge. This method satisfied the guideline criteria for 37 out of 37 drugs in swine muscle, chicken muscle, bovine muscle, prawn, salmon trout, red sea bream, milk, and honey; 35 out of 37 in egg; and 34 out of 37 in flounder. The LOQ ranged from 0.1 to 5 μg/kg. Residues were detected in 24 out of 110 samples and analyzed using the validated method.
    Journal of AOAC International 02/2015; 98(1).