Journal of Assisted Reproduction and Genetics (J ASSIST REPROD GEN)

Publisher: ALPHA, Scientists in Reproductive Medicine, Springer Verlag

Journal description

Journal of Assisted Reproduction and Genetics publishes original contributions and review articles covering human and animal data relevant to the process of in vitro fertilization and embryo replacement. Leading experts present the latest advances in new research areas that include assisted reproductive technologies; diagnostic and therapeutic procedures affecting the treatment of infertility; genetics of early gestation; laboratory sciences affecting the diagnosis and treatment of infertility; pharmacology of assisted reproduction; regulatory issues; technology of assisted reproduction. Published in association with the International Working Group on Preimplantation Genetics.

Current impact factor: 1.72

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.718
2013 Impact Factor 1.772
2012 Impact Factor 1.823
2011 Impact Factor 1.844
2010 Impact Factor 1.253
2009 Impact Factor 1.359
2008 Impact Factor 1.123
2007 Impact Factor 0.913
2006 Impact Factor 0.826
2005 Impact Factor 0.889
2004 Impact Factor 0.963
2003 Impact Factor 0.735
2002 Impact Factor 0.739
2001 Impact Factor 1
2000 Impact Factor 1.416
1999 Impact Factor 1.508
1998 Impact Factor 1.576
1997 Impact Factor 0.82
1996 Impact Factor 1.05
1995 Impact Factor 0.69
1994 Impact Factor 0.773
1993 Impact Factor 0.63

Impact factor over time

Impact factor

Additional details

5-year impact 1.90
Cited half-life 5.30
Immediacy index 0.33
Eigenfactor 0.01
Article influence 0.54
Website Journal of Assisted Reproduction and Genetics website
Other titles Journal of assisted reproduction and genetics (Online)
ISSN 1058-0468
OCLC 44094706
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Springer Verlag

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    • Author can archive a pre-print version
  • Post-print
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    • Author's pre-print on pre-print servers such as
    • Author's post-print on author's personal website immediately
    • Author's post-print on any open access repository after 12 months after publication
    • Publisher's version/PDF cannot be used
    • Published source must be acknowledged
    • Must link to publisher version
    • Set phrase to accompany link to published version (see policy)
    • Articles in some journals can be made Open Access on payment of additional charge
  • Classification
    ​ green

Publications in this journal

  • Liliana Restelli · Silvia Delle Noci · Alice Mangiarini · Stefania Ferrari · Edgardo Somigliana · Alessio Paffoni
    Journal of Assisted Reproduction and Genetics 10/2015; DOI:10.1007/s10815-015-0583-2
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    ABSTRACT: Purpose The effect of age on telomere length heterogeneity in men has not been studied previously. Our aims were to determine the relationship between variation in sperm telomere length (STL), men’s age, and semen parameters in spermatozoa from men undergoing in vitro fertilization (IVF) treatment. Methods: To perform this prospective cross-sectional pilot study, telomere length was estimated in 200 individual spermatozoa from men undergoing IVF treatment at the NYU Fertility Center. A novel single-cell telomere content assay (SCT-pqPCR) measured telomere length in individual spermatozoa. Results: Telomere length among individual spermatozoa within an ejaculate varies markedly and increases with age. Older men not only have longer STL but also have more variable STL compared to younger men. STL from samples with normal semen parameters was significantly longer than that from samples with abnormal parameters, but STL did not differ between spermatozoa with normal versus abnormal morphology. Conclusion: The marked increase in STL heterogeneity as men age is consistent with a role for ALT during spermatogenesis. No data have yet reported the effect of age on STL heterogeneity. Based on these results, future studies should expand this modest sample size to search for molecular evidence of ALT in human testes during spermatogenesis.
    Journal of Assisted Reproduction and Genetics 09/2015; DOI:10.1007/s10815-015-0574-3
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    ABSTRACT: Purpose: The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women <25 years, 25 to <30 years, and 30 to <35 years. Methods: A retrospective cohort study of all women 18 to <35 years of age at their first fresh-embryo, non-donor IVF cycle from January 1995 through December 2012 at a single center was conducted. A competing-risk regression model was used to estimate the cumulative probability and 95 % confidence interval (CI) of the first live birth in up to 6 cycles during the study period with IVF cycle number as the time metric. Results: Among 7243 women who underwent 16,792 cycles, there were 163 (2.3 %) women <25 years, 1691 (23.3 %) women 25 to <30 years, and 5389 (74.4 %) women 30 to <35 years. Women <25 years had the lowest cumulative live birth rate after each cycle, followed by women 30 to <35 years. In both groups, the cumulative live birth rate after 6 cycles was significantly lower than that of women 25 to <30 years; these rates were 58 % (95 % CI 0.51-0.66) among women <25 years, 69 % (95 % CI 0.67-0.71) among women 25 to <30 years, and 64 % (95 % CI 0.63-0.65) among women 30 to <35 years. Conclusions: Our findings are consistent with other reports of less favorable IVF treatment outcomes in women <25 years of age following their first IVF cycle. This indicates that there are underlying factors in couples with a female <25 years of age that should lead to different treatment counseling when they attempt IVF.
    Journal of Assisted Reproduction and Genetics 09/2015; DOI:10.1007/s10815-015-0570-7
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    ABSTRACT: Purpose The aim of this study is to investigate the effect of female BMI and metabolic dysfunction on blastocyst formation rate. Methods This was a retrospective cohort study that was performed in an academic center for reproductive medicine. Patients who were normal weight, overweight with metabolic dysfunction, or obese who had ≥6 oocytes retrieved in a fresh IVF cycle were included in the study. The blastocyst formation rate was calculated from the number of ≥5 cell embryos on day 3 observed in culture until day 5 or day 6. Only good quality blastocysts were included in the calculation as defined by a morphologic grade of 3BB or better. Results The blastocyst formation rate was significantly better in the normal-weight controls versus overweight/obese patients (57.2 versus 43.6 %, p
    Journal of Assisted Reproduction and Genetics 06/2015; DOI:10.1007/s10815-015-0515-1
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    ABSTRACT: Purpose To investigate the impact of late follicular phase serum estradiol (E2) levels on implantation and pregnancy outcomes of cleavage stage cryopreserved/thawed embryos transferred in programmed cycles with exogenous hormonal replacement. Methods Retrospective cohort analysis of IVF patients with transfer of cryopreserved-thawed day-3 embryos in E2 and progesterone (P4) supplemented cycles (n = 208 cycles). Main outcome measures: implantation and pregnancy rates according to late follicular phase serum E2 levels and early secretory phase E2/P4 ratios. Results Logistic regression performed for embryo implantation and for pregnancy outcome in relation to E2 (day 15), P4 (day 15 and 16), before (crude analysis) and after adjustment (adjusted analysis) for baseline characteristics (including age, BMI, serum basal cycle day 3 FSH levels, embryo quality, endometrial lining thickness) showed no significant association. Similarly, ROC analysis showed no impact of cycle day 16 E2/P4 ratio. Conclusions Neither late follicular phase serum E2 nor the early E2/P4 ratio were able to predict implantation or pregnancy outcome of day-3 cryopreserved-thawed embryos transferred in artificially programmed cycles.
    Journal of Assisted Reproduction and Genetics 01/2015; 32(3). DOI:10.1007/s10815-014-0402-1
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    ABSTRACT: Background: Spermatogenesis is an intricate biological event wherein an undifferentiated spermatogonium develops into mature sperms. MicroRNAs are a type of single strand small non-coding RNA molecule and are implicated in the regulation of many crucial pathways during cell proliferation, apoptosis, and differentiation. Method: Here, we present a comprehensive comparison of miRNA expression profiling in three main stages during porcine spermatogenesis using high-throughput sequencing. Results: We built three small RNA libraries for the testis, the epididymis and the ejaculated sperm from a Landrace boar, and in total obtained 3821 precursor hairpins encoding for 4761 mature miRNAs, of which 23 are miRNA*. Notably, 940 precursor miRNAs produced both the 5'- and 3'- strands as sister pairs, indicating the distinctive expression patterns of germ cell miRNAs. Additionally, 418 out of 710 co-expressed miRNAs were identified as being differentially expressed between libraries (P < 0.001). Apart from the sexual specific X chromosome, many miRNAs were found to be located on chromosome 12, which may play potential roles in spermatogenesis according to the result of synteny analysis with human and mouse. The Gene Ontology and KEGG pathway analysis revealed that the target genes of co-expressed miRNAs were highly involved in the cell cycle process, metal ion binding, modification of plasma membrane, and the p53 signal pathway.
    Journal of Assisted Reproduction and Genetics 01/2015; 32(3). DOI:10.1007/s10815-014-0406-x
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    ABSTRACT: Purpose: To investigate the expression of GRIM-19 (Gene associated with retinoid-interferon-induced mortality 19) in mouse oocytes and preimplantation embryos, and to study the effect of GRIM-19 on the developmental competence of mouse oocytes and embryos. Methods: GRIM-19 was evaluated at both mRNA and protein levels. The expression of GRIM-19 gene was downregulated in mouse oocytes cultured in vitro by specific small interfering RNA (siRNA) injection, while the activity of GRIM-19 was decreased by microinjection of a GRIM-19 antibody into the cytoplasm of germinal vesicle (GV) oocytes. Oocytes matured in vitro were then fertilized by intracytoplasmic sperm injection (ICSI), followed by observation and evaluation of fertilization rate, cleavage rate, blastocyst formation rate and implantation rate. Results: GRIM-19 is expressed throughout oocyte maturation and preimplantation embryo development stages. GRIM-19 was localized primarily in the cytoplasm of all cells examined. Downregulation of gene expression and activity of GRIM-19 resulted in decreased oocyte viability, potency of oocyte maturation, embryo development and implantation. Conclusions: GRIM-19 may play important roles in mouse oogenesis and early embryonic development and implantation.
    Journal of Assisted Reproduction and Genetics 01/2015; 32(3). DOI:10.1007/s10815-014-0413-y
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    ABSTRACT: Purpose The Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble Fas Ligand, malondialdehyde, superoxide dismutase and total antioxidant capacity in patients undergoing IVF and compared with controls. Methods This study included 109 patients. Patients were classified as unexplained infertility (N = 31), PCOS (N = 19), tubal factor (N = 9) and endometriosis (N = 10) and compared with male factor infertility (N = 40) that was the control group. sFas and sFasL levels were measured by immunoassay method. MDA, SOD and TAC levels were measured by colorimetric method. Results Patients with unexplained infertility, PCOS and tubal factor had significantly lower sFas levels compared with their controls (respectively, p
    Journal of Assisted Reproduction and Genetics 12/2014; 32(2). DOI:10.1007/s10815-014-0396-8
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    ABSTRACT: Purpose To determine the factors that affect oocyte extraction efficiency when using the “combined procedure”. In the present “combined procedure” ovarian tissue cryopreservation and oocyte extraction from an isolated ovary, later used in In Vitro Maturation (IVM), are performed concurrently. Methods Data were analyzed retrospectively and obtained from the clinical records of 27 young breast cancer patients referred for fertility preservation. Results The patients’ mean age was 33.7 (±3.8) years, mean serum anti-Müllerian hormone (AMH) concentration was 3.5 (±2.1) ng/ml, and mean number of extracted oocytes was 8.3 (±6.1). The phase of menstruation (follicular or luteal) did not affect either the number of oocytes extracted (P = 0.99) nor oocyte survival or maturation rates. Likewise, the number of oocytes that could be extracted was not affected by the type of laparoscopic procedure (multiple-port or single-incision laparoscopy; P = 0.94) or the molecular subtype of breast cancer (either Luminal A or B; P = 0.52). Analysis revealed that the number of extracted oocytes was well-correlated with the patient’s AMH serum level and age (coefficient of correlation: 0.60 and −0.48, respectively). Conclusion We conclude that the outcome of the “combined procedure” primarily depends upon the patient’s serum AMH level and age. Importantly, the “combined procedure” may be used during any phase of the menstrual cycle to preserve the fertility of breast cancer patients.
    Journal of Assisted Reproduction and Genetics 12/2014; 32(2). DOI:10.1007/s10815-014-0392-z
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    ABSTRACT: Purpose: The aim of this retrospective study was to compare the competence of oocytes obtained from preovulatory and antral follicles. Methods: Mature oocytes from preovulatory follicles were retrieved from women selected for standard IVF treatment (Group A). Mature oocytes from antral follicles were recovered from women undergoing hCG-primed in vitro maturation (IVM) treatment (Group B). Patients groups were matched for age, BMI, FSH, AMH and antral follicle count (AFC) values. In vivo matured oocytes from both groups were microinjected and resulting embryos were culture and selected on day 3 for embryo transfer. Results: Oocyte pick-ups (OPU) were 315 and 204 in Groups A and B, respectively. Fertilization rates were comparable (72.8 and 75.9 %, respectively; P = 0.137). In Group A, in which the average number of embryos transferred was higher, clinical pregnancy rates per OPU (37.5 %) and embryo transfer (38.4 %) were superior in comparison to Group B (27.0 %, P = 0.013; 29.4 %, P = 0.041; respectively). On the other hand, implantation rates (Group A, 23.7 %; Group B, 20.8 %) and proportions of babies born per transferred embryo (Group A, 19.5 %; Group B, 16.9 %) were similar (P = 0.528 and 0.332, respectively). Conclusions: Overall, this suggests that oocyte competence is already achieved at the antral stage of follicle development.
    Journal of Assisted Reproduction and Genetics 12/2014; 32(2). DOI:10.1007/s10815-014-0386-x
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    ABSTRACT: IntroductionRing chromosome abnormalities are rare abnormalities potentially involving any chromosome and the vast majority of previously reported cases were seen in patients with various congenital malformations and mental retardation. On the other hand, only few subjects carrying ring chromosomes and with normal phenotype have been described [1]. Until now only 30 cases of ring autosome 9 (r(9)) have been reported in the literature [2]. The prevalence of this pathology is 1 in 50,000 foetuses and in the majority of cases serious malformations were described [3].The most typical ring formation occurs after terminal deletion and fusion of the p arm and the q arm and under this process genetic material can be lost [4]. The most common breakpoints are found between 9p24-p22 and 9q33-q34, but end-to-end fusion of palindromic telomere sequences have also been reported [5].The Danish cytogenetic register, which contains data from all cytogenetic testing in Denmark from 1960 onwards (altoget ...
    Journal of Assisted Reproduction and Genetics 12/2014; 32(2). DOI:10.1007/s10815-014-0388-8