Critical Reviews in Eukaryotic Gene Expression (CRIT REV EUKAR GENE)

Publisher: Begell House

Journal description

Critical Reviews in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our understanding of gene regulation, organization, and structure. The journal provides in-depth critical reviews of the current literature on a well-defined topic of immediate interest, written by recognized specialists in the field. Extensive reference lists accompany all articles, providing a comprehensive information resource. The contributions of molecular, cellular, biochemical, and genetic approaches to eukaryotic gene expression are incorporated into each review. The relationship between gene structure and function is stressed, with emphasis on coordinate control of biological processes. Regulatory mechanisms are explored from the perspective of sequences and regulatory molecules that influence structure and expression of eukaryotic genes, as well as within the context of cellular architecture and its relationship to development of cell specialization and tissue organization.

Current impact factor: 2.39

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.385
2012 Impact Factor 2.065
2011 Impact Factor 3.075
2010 Impact Factor 4.111
2009 Impact Factor 2.949
2008 Impact Factor 1.947
2007 Impact Factor 2.132
2006 Impact Factor 3.342
2005 Impact Factor 2.846
2004 Impact Factor 2.359
2003 Impact Factor 2.576
2002 Impact Factor 3.103
2001 Impact Factor 3.943
2000 Impact Factor 4.383
1999 Impact Factor 4.206
1998 Impact Factor 3.833

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.78
Cited half-life 7.40
Immediacy index 0.29
Eigenfactor 0.00
Article influence 0.86
Website Critical Reviews in Eukaryotic Gene Expression website
Other titles Critical reviews in eukaryotic gene expression, Eukaryotic gene expression
ISSN 1045-4403
OCLC 20114919
Material type Periodical
Document type Journal / Magazine / Newspaper

Publisher details

Begell House

  • Pre-print
    • Archiving status unclear
  • Post-print
    • Author cannot archive a post-print version
  • Conditions
    • Deposit in institutional repositories is not allowed
    • NIH Authors can deposit in PubMed Central for public release after 12 month embargo
  • Classification
    ​ white

Publications in this journal

  • Critical Reviews in Eukaryotic Gene Expression 01/2015; DOI:10.1615/CritRevEukaryotGeneExpr.2015012447
  • Critical Reviews in Eukaryotic Gene Expression 01/2015; DOI:10.1615/CritRevEukaryotGeneExpr.2015012369
  • Critical Reviews in Eukaryotic Gene Expression 01/2015; DOI:10.1615/CritRevEukaryotGeneExpr.2015012376
  • Critical Reviews in Eukaryotic Gene Expression 01/2015; DOI:10.1615/CritRevEukaryotGeneExpr.2015013022
  • Critical Reviews in Eukaryotic Gene Expression 01/2015; DOI:10.1615/CritRevEukaryotGeneExpr.2015012975
  • Critical Reviews in Eukaryotic Gene Expression 01/2015; DOI:10.1615/CritRevEukaryotGeneExpr.2015012469
  • Critical Reviews in Eukaryotic Gene Expression 01/2015; DOI:10.1615/CritRevEukaryotGeneExpr.2015012425
  • Critical Reviews in Eukaryotic Gene Expression 01/2015; DOI:10.1615/CritRevEukaryotGeneExpr.2015011074
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    ABSTRACT: Changes of the level and ratios of pyridine nucleotides determine metabolism- dependent cellular redox status and the activity of poly(ADP-ribose) polymerases (PARPs) and sirtuins, thereby influencing several processes closely related to cell survival and death. Pyridine nucleotides participate in numerous metabolic reactions whereby their net cellular level remains constant, but the ratios of NAD+/NADP+ and NADH/NADPH oscillate according to metabolic changes in response to diverse stress signals. In non-redox reactions, NAD+ is degraded and quickly, afterward, resynthesized in the NAD+ salvage pathway, unless overwhelming activation of PARP-1 consumes NAD+ to the point of no return, when the cell can no longer generate enough ATP to accommodate NAD+ resynthesis. The activity of PARP-1 is mandatory for the onset of cytoprotective autophagy on sublethal stress signals. It has become increasingly clear that redox status, largely influenced by the metabolism-dependent composition of the pyridine nucleotides pool, plays an important role in the synthesis of pro-apoptotic and anti-apoptotic sphingolipids. Awareness of the involvement of the prosurvival sphingolipid, sphingosine-1-phosphate, in transition from inflammation to malignant transformation has recently emerged. Here, the participation of pyridine nucleotides in redox and non-redox reactions, sphingolipid metabolism, and their role in cell fate decisions is reviewed.
    Critical Reviews in Eukaryotic Gene Expression 10/2014; 24(4):287-309. DOI:10.1615/CritRevEukaryotGeneExpr.2014011828
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    ABSTRACT: A full-atom structure of a protein provides an important piece of information for molecular biologists, but has to be complemented by further knowledge concerning its conformational mobility and functional properties. Some scholars have proposed to integrate proteomics-derived data (mainly obtained with techniques like X-ray and NMR crystallography) with protein bioinformatics and computational approaches, above all molecular dynamics (MD), in order to gain better elucidations about proteins. MD simulations have been applied to different areas of protein sciences, but so far little efforts have been made to couple MD with an understanding of the different crystallization techniques which have been proposed during the decades, like classical vapor diffusion hanging drop and its variants (such as sitting drop), in space- and LB (Langmuir-Blodgett)-based crystallization procedures. Using MD, here we show that the optimal protein crystallization techniques prove to be significantly those based on LB-nanotemplate and on in space when compared to the classical vapour diffusion hanging drop and its variants.
    Critical Reviews in Eukaryotic Gene Expression 10/2014; 24(4). DOI:10.1615/CritRevEukaryotGeneExpr.2014010201
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    ABSTRACT: Crystallization is a highly demanding and time-consuming task, being a real bottle-neck in the nowadays basic research. Several efforts have been made in order to understand which factors and parameters can influence this process and how to finely tune these parameters, facilitating and enabling crystal growth. Different crystallization techniques have been proposed during the decades, like among the others classical vapor hanging drop and its variant (sitting drop), dialysis, cryo-temperature, gel, batch, and even in space (using techniques like free interface diffusion or FID, counter-ion diffusion or CID). Here we present a review of the strategies for obtaining optimal high quality crystals utilizing Langmuir-Blodgett or LB-based nanotechnologies, and space, as proven by Molecular Dynamics (MD) and bioinformatics approaches, namely clustering algorithm and protein alignment.
    Critical Reviews in Eukaryotic Gene Expression 10/2014; 24(4). DOI:10.1615/CritRevEukaryotGeneExpr.2014008275
  • [Show abstract] [Hide abstract]
    ABSTRACT: Crystallization is a highly demanding and time-consuming task that causes a real bottle-neck in basic research. Great effort has been made to understand the factors and parameters that influence this process and to finely tune them to facilitate crystal growth. Different crystallization techniques have been proposed over the past decades, such as the classical vapor hanging drop method, its variant the sitting drop method, dialysis, cryo-temperature, gel, batch, and the innovative microgravity (space) techniques like free interface diffusion (FID) and counter-ion diffusion (CID). Here, we present a review of the strategies utilizing Langmuir-Blodgett (LB)-based nanotechnologies, and microgravity techniques for obtaining optimal high-quality crystals, as proven by molecular dynamics (MD) and bioinformatics approaches, namely using a clustering algorithm and protein alignment.
    Critical Reviews in Eukaryotic Gene Expression 01/2014; 24(4):325-39.
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    ABSTRACT: Alternative splicing of precursors messenger RNA (pre-mRNA) is commonly used to increase the diversity of messenger RNAs expressed by the genome in normal multicellular organisms. Dysregulation of alternative splicing underlies a number of human diseases, including cancers. Increasing evidence supports the important role of this expansive layer of gene regulation in hepatocarcinogenesis. Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide because of its aggressive property and limited therapeutic options. Studies suggest that aberrant alternative splicing promotes generation of oncogenic variants in HCC, whereas tumor suppressors are self-inactivated by aberrant alternative splicing in HCC. Moreover, different spliced variants of the same gene can display distinct and even antagonistic biological functions in HCC. As a result, inhibiting the splicing of oncogenic variants and the self-inactivation of tumor suppressors are likely to be new therapy strategies. This review provides a perspective of the emerging evidence of both alternative splicing as a critical mechanism for the development of HCC and that potential cross-talk through signaling pathways among different variants might aid in the development of novel molecular targets of HCC.
    Critical Reviews in Eukaryotic Gene Expression 01/2014; 24(2):133-49. DOI:10.1615/CritRevEukaryotGeneExpr.2014007702
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    ABSTRACT: Nearly 20% of all breast cancer cases are ductal carcinoma in situ (DCIS), with over 60,000 cases diagnosed each year. Many of these cases would never cause clinical symptoms or threaten the life of the woman; however, it is currently impossible to distinguish which lesions will progress to invasive disease from those that will not. DCIS is generally associated with an excellent prognosis regardless of the treatment pathway, but there is variation in treatment aggressiveness that seems to exceed the medical uncertainty associated with DCIS management. Therefore, it would seem that a significant proportion of women with DCIS receive more extensive treatment than is needed. This overtreatment of DCIS is a growing concern among the breast cancer community and has implications for both the patient (via adverse treatment-related effects, as well as out-of-pocket costs) and society (via economic costs and the public health and environmental harm resulting from health care delivery). This article discusses DCIS treatment pathways and their implications for patients and society and calls for further research to examine the factors that are leading to such wide variation in treatment decisions.
    Critical Reviews in Eukaryotic Gene Expression 01/2014; 24(4):281-6. DOI:10.1615/CritRevEukaryotGeneExpr.2014011495
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    ABSTRACT: Although considerable controversy surrounds the legitimacy of acupuncture as a treatment, a growing literature on the physiological effects of acupuncture needling in animals and humans is providing new insights into basic cellular mechanisms including connective tissue mechanotransduction and purinergic signaling. This review summarizes these findings and proposes a model combining connective tissue plasticity and peripheral sensory modulation in response to the sustained stretching of tissue that results from acupuncture needle manipulation.
    Critical Reviews in Eukaryotic Gene Expression 01/2014; 24(3):249-53. DOI:10.1615/CritRevEukaryotGeneExpr.2014008284
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    ABSTRACT: Cytoskeleton is one of the essential forms of protein, important in the existence of both eukaryotic as well as prokaryotic cells. Its transformation plays a vital role in cell division and intracellular transportation by facilitating intracellular vesicular traffic. Among the various tissue types in the body, the neural tissue exhibits the maximum heterogeneity, and hence the role of cytoskeleton at both developmental and functional levels becomes paramount. Cytoskeleton dynamics have been established in the neural physiology, but only at the level of axonal development and growth. Retina has not been adequately studied in the context of cytoskeletal proteins.
    Critical Reviews in Eukaryotic Gene Expression 01/2014; 24(3):255-68. DOI:10.1615/CritRevEukaryotGeneExpr.2014010561