World Journal of Gastroenterology (WORLD J GASTROENTERO )

Publisher: Zhongguo Zhong xi yi jie he yan jiu hui


WJG is an international learned journal of gastroenterology. It is published in English bimonthly and distributed worldwide, and it aims to strengthen international exchanges of modern and traditional gastroenterology, to promote the development of gastroenterology, and to make contributions to human health. WJG is the only international journal of gastroenterology published in English based in China. It mainly publishes original papers of basic research and clinical studies in gastroenterology from all of the world. Original articles with international competitiveness, articles from projects supported by scientific grants, original articles of traditional Chinese digestive medicine and herbs, of acupuncture, of ethinomedicine, and of combined traditional and modern digestive medicine are published with priority. Commentaries, literature reviews, rapid reports, clinical experience, and case reports of rare diseases are published preferentially as well.

  • Impact factor
    Show impact factor history
    Impact factor
  • 5-year impact
  • Cited half-life
  • Immediacy index
  • Eigenfactor
  • Article influence
  • Website
    World Journal of Gastroenterology website
  • Other titles
    World journal of gastroenterology (Online), WJG, Shih chieh wei ch'ang ping hsüeh tsa chih
  • ISSN
  • OCLC
  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

Publications in this journal

  • World Journal of Gastroenterology 11/2014; 20(43):16106-16112.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Over the last decade, the development of stabilised mi- crobubble contrast agents and improvements in avail- able ultrasonic equipment, such as harmonic imaging, have enabled us to display microbubble enhancements on a greyscale with optimal contrast and spatial resolu- tion. Recent technological advances made contrast har- monic technology available for endoscopic ultrasound (EUS) for the first time in 2008. Thus, the evaluation of microcirculation is now feasible with EUS, prompting the evolution of contrast-enhanced EUS from vascular imaging to images of the perfused tissue. Although the relevant experience is still preliminary, several reports have highlighted contrast-enhanced harmonic EUS (CH- EUS) as a promising noninvasive method to visualise and characterise lesions and to differentiate benign from malignant focal lesions. Even if histology remains the gold standard, the combination of CH-EUS and EUS fine needle aspiration (EUS-FNA) can not only render EUS more accurate but may also assist physicians in making decisions when EUS-FNA is inconclusive, in- creasing the yield of EUS-FNA by guiding the puncture with simultaneous imaging of the vascularity. The de- velopment of CH-EUS has also opened up exciting pos- sibilities in other research areas, including monitoring responses to anticancer chemotherapy or to ethanol- induced pancreatic tissue ablation, anticancer therapies based on ultrasound-triggered drug and gene delivery, and therapeutic adjuvants by contrast ultrasound-in- duced apoptosis. Contrast harmonic imaging is gaining popularity because of its efficacy, simplicity and non- invasive nature, and many expectations are currently resting on this technique. If its potential is confirmed in the near future, contrast harmonic imaging will become a standard practice in EUS.
    World Journal of Gastroenterology 11/2014; 20(42):15549-15563.
  • World Journal of Gastroenterology 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abstract AIM: To investigate the effect of meloxicam on the gut-liver axis after cirrhotic liver resection. METHODS: Forty-four male Wistar rats were assigned to three groups: (1) control group (CG); (2) bile duct ligation with meloxicam treatment (BDL + M); and (3) bile duct ligation without meloxicam treatment (BDL). Secondary biliary liver cirrhosis was induced via ligature of the bile duct in the BDL + M and BDL groups. After 2 wk, the animals underwent a 50% hepatectomy. In the BDL + M group 15 min prior to the hepatectomy, one single dose of meloxicam was administered. Parameters measured included: microcirculation of the liver and small bowel; portal venous flow (PVF); gastrointestinal (GI) transit; alanine aminotransferase (ALT); malondialdehyde; interleukin 6 (IL-6), transforming growth factor beta 1 (TGF-β1) and hypoxia-inducible factor 1 alpha (HIF-1α) levels; mRNA expression of cyclooxigenase-2 (COX-2), IL-6 and TGF-β1; liver and small bowel histology; immunohistochemical evaluation of hepatocyte and enterocyte proliferation with Ki-67 and COX-2 liver expression. RESULTS: Proliferative activity of hepatocytes after liver resection, liver flow and PVF were significantly higher in CG vs BDL + M and CG vs BDL group (P < 0.05), whereas one single dose of meloxicam ameliorated liver flow and proliferative activity of hepatocytes in BDL + M vs BDL group. COX-2 liver expression at 24 h observation time (OT), IL-6 concentration and mRNA IL-6 expression in the liver especially at 3 h OT, were significantly higher in BDL group when compared with the BDL + M and CG groups (P < 0.01, P < 0.001, P < 0.01, respectively). Liver and small bowel histology, according to a semi quantitative scoring system, showed better integrity in BDL + M and CG as compared to BDL group. ALT release and HIF-1α levels at 1 h OT were significantly higher in BDL + M compared to CG and BDL group (P < 0.001 and P < 0.01, respectively). Moreover, ALT release levels at 3 and 24 h OT were significantly higher in BDL group compared to CG, P < 0.01. GI transit, enterocyte proliferative activity and number of goblet cells were in favor of meloxicam treatment vs BDL group (P < 0.05, P < 0.001, P < 0.01, respectively). Additionally, villus length were higher in BDL + M as compared to BDL group. CONCLUSION: One single dose of meloxicam admistered after cirrhotic liver resection was able to cause better function and integrity of the remaining liver and small bowel.
    World Journal of Gastroenterology 10/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Alimentary tract duplications are rare congenital lesions normally diagnosed in newborns and children that can occur anywhere from the mouth to the anus and have a reported incidence of approximately 1 in 4500 life births. Symptoms and clinical presentation vary greatly. The presentation varies according to age and location. The treatment finally is surgical; total resection when possible should be the aim of the intervention. In pediatric surgery minimally invasive surgical procedures became more and more important over the last decades. In consequence the operative procedure on alimentary tract duplications changed in this manner. We review on case reports and clinical reports on minimally invasive surgery in the treatment of alimentary tract duplications, determine the importance of minimally invasive techniques in the treatment of this rare entity and rule out that further studies in the field should be performed.
    World Journal of Gastroenterology 10/2014; 20(39):14263-14271.
  • [Show abstract] [Hide abstract]
    ABSTRACT: outcome. Routine laboratory tests can play an important role in the early assessment of AP. The objective of this study was to evaluate accuracy of RDW to platelet ratio(RPR) for prediction of in-hospital mortality in AP. METHODS: A total of 102 patients with AP were recruited to the study. Demographic data of patients at hospital admission, etiology of pancreatitis, organ failure, metabolic disorder, hospitalization time, routine laboratory measures were obtained. Additionally we calculated RPR. Multivariate logistic regression was used to evaluate the impact of admission RPR on mortality. RESULTS: RPR persistently higher among nonsurvivors than survivors on admission ( P < .0001). Median RPR was 0.0087 in non survivor group and 0.0058 in survivor group. Receiver operating characteristic curves of RPR were used to identify nonsurvivors on a statistically significant level (area under the curve of 0.783; 95% confidence interval [CI], 0.688-0.878) . With a cutoff value of 0.0067 for RPR, mortality could be predicted in approximately 80% of cases . CONCLUSION: We identified RPR as the valuable, novel laboratory test for predicting mortality in AP. Key words:Acute pancreatitis, RDW, RDW to platelet ratio
    World Journal of Gastroenterology 10/2014; In press.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Gastric cancer represents a serious health problem on a global scale. It is the second leading cause of cancer-related death worldwide. Novel therapeutic targets are desperately needed because the meager improvement in the cure rate of about 10% realized by adjunctive treatments to surgery is unacceptable as > 50% patients with localized gastric cancer succumb to their disease. Either postoperative chemoradiotherapy (United States), pre-and post-operative chemotherapy (Europe), and adjuvant chemotherapy after a D2 resection (Asia) can all be regarded as standards of care in the localized gastric cancer management. In metastatic disease the addition of trastuzumab to chemotherapy is standard of care in Her2 positive disease. In the HER2 negative population, the treatments remain limited. In the first line setting, the standard of care is a combination of fluoropyrimidine and platinum containing chemotherapy, with or without epirubicin or docetaxel. The results of targeted therapy trials have by and large been disappointing, but none of these trials looked at an appropriately enriched population. Finally there is a meager overall survival benefit in treating patients with metastatic disease in the second line setting, with either irinotecan, docetaxel or ramucirumab however none of these drugs have been compared head to head in a well-powered randomized controlled trial.
    World Journal of Gastroenterology 10/2014; 20(38):13637-13647.
  • [Show abstract] [Hide abstract]
    ABSTRACT: To highlight magnetic resonance enterography (MRE) for diagnosis of patients with refractory iron deficiency anemia and normal endoscopy results.
    World Journal of Gastroenterology 10/2014; 20(38):14004-14009.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Alternative splicing, which is a common phenomenon in mammalian genomes, is a fundamental process of gene regulation and contributes to great protein diversity. Alternative splicing events not only occur in the normal gene regulation process but are also closely related to certain diseases including cancer. In this review, we briefly demonstrate the concept of alternative splicing and DNA damage and describe the association of alternative splicing and cancer pathogenesis, focusing on the potential relationship of alternative splicing, DNA damage, and gastrointestinal cancers. We will also discuss whether alternative splicing leads to genetic instability, which is considered to be a driving force for tumorigenesis. Better understanding of the role and mechanism of alternative splicing in tumorigenesis may provide new directions for future cancer studies.
    World Journal of Gastroenterology 10/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: During the last several decades, colorectal cancer surgery has experienced some major perioperative improvements. Preoperative risk-assessment of nutrition, frailty, and sarcopenia followed by interventions for patient optimization or an adapted surgical strategy, contributed to improved postoperative outcomes. Enhanced recovery programs or fast-track surgery also resulted in reduced length of hospital stay and overall complications without affecting patient safety. After an initially indecisive start due to uncertainty about oncological safety, the most significant improvement in intraoperative care was the introduction of laparoscopy. Laparoscopic surgery for colon and rectal cancer is associated with better short-term outcomes, whereas long-term outcomes regarding survival and recurrence rates are comparable. Nevertheless, long-term results in rectal surgery remain to be seen. Early recognition of anastomotic leakage remains a challenge, though multiple improvements have allowed better management of this complication.
    World Journal of Gastroenterology 09/2014; 20(35):12445-12457.