World Journal of Gastroenterology Impact Factor & Information

Publisher: Zhongguo Zhong xi yi jie he yan jiu hui

Journal description

WJG is an international learned journal of gastroenterology. It is published in English bimonthly and distributed worldwide, and it aims to strengthen international exchanges of modern and traditional gastroenterology, to promote the development of gastroenterology, and to make contributions to human health. WJG is the only international journal of gastroenterology published in English based in China. It mainly publishes original papers of basic research and clinical studies in gastroenterology from all of the world. Original articles with international competitiveness, articles from projects supported by scientific grants, original articles of traditional Chinese digestive medicine and herbs, of acupuncture, of ethinomedicine, and of combined traditional and modern digestive medicine are published with priority. Commentaries, literature reviews, rapid reports, clinical experience, and case reports of rare diseases are published preferentially as well.

Current impact factor: 2.43

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.433
2012 Impact Factor 2.547
2011 Impact Factor 2.471
2010 Impact Factor 2.24
2009 Impact Factor 2.092
2008 Impact Factor 2.081
2003 Impact Factor 3.318
2002 Impact Factor 2.532
2001 Impact Factor 1.445
2000 Impact Factor 0.993

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.59
Cited half-life 5.00
Immediacy index 0.22
Eigenfactor 0.06
Article influence 0.72
Website World Journal of Gastroenterology website
Other titles World journal of gastroenterology (Online), WJG, Shih chieh wei ch'ang ping hsüeh tsa chih
ISSN 1007-9327
OCLC 60638475
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein (CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer (CRC). Specifically, we focus on the effects of CBP- and p300-mediated Wnt activity on (1) neoplastic progression; (2) the activities of butyrate, a breakdown product of dietary fiber, on cell signaling and colonic cell physiology; (3) the development of resistance to histone deacetylase inhibitors (HDACis), including butyrate and synthetic HDACis, in colonic cells; and (4) the physiology and number of cancer stem cells. Mutations of the Wnt/β-catenin signaling pathway initiate the majority of CRC cases, and we have shown that hyperactivation of this pathway by butyrate and other HDACis promotes CRC cell apoptosis. This activity by butyrate may in part explain the preventive action of fiber against CRC. However, individuals with a high-fiber diet may still develop neoplasia; therefore, resistance to the chemopreventive action of butyrate likely contributes to CRC. CBP or p300 may modify the ability of butyrate to influence colonic cell physiology since the two transcriptional coactivators affect Wnt signaling, and likely, its hyperactivation by butyrate. Also, CBP and p300 likely affect colonic tumorigenesis, as well as stem cell pluripotency. Improvement of CRC prevention and therapy requires a better understanding of the alterations in Wnt signaling and gene expression that underlie neoplastic progression, stem cell fate, and the development of resistance to butyrate and clinically relevant HDACis. Detailed knowledge of how CBP- and p300 modulate colonic cell physiology may lead to new approaches for anti-CRC prevention and therapeutics, particularly with respect to combinatorial therapy of CBP/p300 inhibitors with HDACis.
    World Journal of Gastroenterology 07/2015; 6(9):825. DOI:10.3748/wjg.v21.i27.8238
  • World Journal of Gastroenterology 07/2015; 21(27):8238.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Exclusive enteral nutrition involves the use of a complete liquid diet, with the exclusion of normal dietary components for a defined period of time, as a therapeutic measure to induce remission in active Crohn's disease (CD). This very efficacious approach leads to high rates of remission, especially in children and adolescents newly diagnosed with CD. This intervention also results in mucosal healing, nutritional improvements and enhanced bone health. Whilst several recent studies have provided further elaboration of the roles of exclusive enteral nutrition in the management of CD, other reports have provided new understanding of the mechanisms by which this intervention acts.
    World Journal of Gastroenterology 06/2015; 21(22):6809-6816. DOI:10.3748/wjg.v21.i22.6809