Description

Published regularly since Nov-2009.

Publications in this journal

• COMPARATIVE EVALUATION OF ANTIMICROBIAL ACTIVITY OF METHANOLIC EXTRACTS OF LEAVES, STEM OF ECLIPTA ALBA AND NATURAL OILS

  Authors: Varish Ahmad, Lokesh Kumar, Q.M.Sajid Jamal, Gaurav Dhama, Tej Prakash, Ajeet Singh

  International Journal of Pharmacy and Technology. Volume. 3(ISSN: 0975-766X):3015-3028.

  Plants are the oldest source of pharmacologically active compounds, and have provided humankind with many medically useful compounds for centuries. In this study a comparative evaluation ofPlants are the oldest source of pharmacologically active compounds, and have provided humankind with many medically useful compounds for centuries. In this study a comparative evaluation of methanolic extract of leaves, stem of Eclipta alba and natural oils namely Clove oil, Olive oil, peppermint oil and eucalyptus were tested for antimicrobial activity by disc diffusion method against E. coli, E. cloacae, E. faecalis, P. vulgaris, S. aureus, K. pneumoniae, S. saprophyticus. It was observed that methnolic extract of leaf, stem and natural oils shown reliable Zone of inhibition (ZOI) against all tested microbes. The variable inhibition effect were observed with methanolic extract and natural oil with organisms to organism. Clove oil found most potent inhibitor among all tested agents. Maximum inhibitory effect of methanolic extract of leaves was found against E. cloacae and lowest against E. coli and S. aureus and methanolic extract of stem shown highest against S. saprophyticus and lowest against E. coli. The highest ZOI of clove oil was found against K. pneumoniae and lowest against E. coli Olive oil was found to be resistant against all microbes. Thus natural oils were found effective as positive control and were more effective as compared to methanolic extract of Eclipta alba.

• PPARg polymorphisms and their association with type 2 diabetes in south Indian population

  Authors: A.Krishna sailaja, SP.Bhatnagar

  International Journal of Pharmacy and Technology. 2(3-ISSN: 0975-766X):623-633.

  Type2 Diabetes is highly prevalent in India. Several studies on Asian Indians have shown that they are characterized by higher insulin resistance, early onset type2 diabetes and hypertension. For aType2 Diabetes is highly prevalent in India. Several studies on Asian Indians have shown that they are characterized by higher insulin resistance, early onset type2 diabetes and hypertension. For a given BMI Indians have a higher percentage of body fat and more visceral fat than members of other population. The tendency of Indians to have higher percentage of body fat and central adiposity compared with other races may be programmed in utero. This thin fat phenotype is present at birth. Small size at birth coupled with subsequent obesity increases risk for insulin resistance syndrome in later life.Dietary modifications play an important role in initiation of insulin resistance syndrome. This may also lead to Type2 diabetes in Indian population.The oil preferred for cooking India is considerably changes the ratio of W6/W3 fatty acids. A number of free fatty acids are PPARg activators. When individual with thrifty genotype are supplied energy rich food with reduction in physical activity there will be a greater prevalence of obesity, impaired glucose tolerance and type2 diabetes. PPARg activation enhances adipocyte differentiation make the people more obese. PPARg coordinates the thrifty response and urges the need for studying PPARg in Indians. Because this could explain the heterogeneity of insulin resistance and type2 diabetes in Indians. Aim of this study is to find out PPARg polymorphisms and their association with type2 diabetes in south Indian population.

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