International Journal of PharmTech Research

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ISSN 0974-4304

Publications in this journal

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    ABSTRACT: The objective of this research is to examine how people point of view about diarrhea in children under five years old related to the cause, sign and symptom, diagnosis, treatment, prognosis, and its prevention in BugisPonjo ethnic culture viewpoint, South Sulawesi Province. This research is using qualitative research with ethnography approach which tries to understand the cultural aspect through a series of observation and interpretation human behavior. In more specific, an ethnography research focuses on what a group of people (cultural behavior) was performed, what they know (cultural knowledge), and what things that they make and wear (cultural artifacts).It is found that the diarrhea cause understood by BugisPonjo ethnic community is a result of supernatural factor as well as by nature and body disharmonisation. Through the understanding, it is identified the types of diarrhea which well known by the public namely sai, wolang, lenynyeisimulajajinna, urekeng, jambanglempu, and dyspepsia. Diagnostic, treatment, prognostic, and diarrhea prevention in children under five are an empiric norm and have become a pattern in the BugisPonjo ethnic community. The sign and symptoms of diarrhea become a basis to determine diarrhea types. Treatment will be conducted using traditional medicine plants like guava leave (Psidiumguajava), turmeric concoction (Curcuma domestica), candlenut concoction (Aleuritismoluccana), pepper (Piper betle), pepper concoction (Piper betle), bangle concoction (Zingiberofficinalepurpureum).
    International Journal of PharmTech Research 06/2015; 1(2):974-4304.
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    ABSTRACT: Growing numbers of antibiotic-resistant bacteria are putting this golden era of medicine at risk and stresses the need for regular monitoring of antibiotic susceptibility, and developing a new design being active against resist pathogens. In this view seven Schiff base ligands of Cephalosporin group antibiotics were synthesized by their condensation with salicylaldehyde in equimolar ratio. Complexes of these Schiff bases with Pd (II) metal were synthesized in 1:2 stoichiometric ratio. The complexes were formulated as [Pd(L)2].3H2O, where L is Schiff base of seven different cephalosporin antibiotics. Complexes were characterized by elemental analyses, molar conductance, UV-Visible, FT-IR, 1H-NMR, 13C{1H}-NMR, 2D-NMR and ESI-Mass spectrometry. Schiff bases were coordinated with metal through phenolic oxygen and azomethine-N, giving simple square planar geometry to complexes. Complexes were tested for antibacterial activity and MIC against gram-negative bacteria E. coli and gram positive bacteria S. aureus and were found more potent than Schiff bases and precursor antibiotics.
    International Journal of PharmTech Research 04/2015; 5(2):1-5.
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    ABSTRACT: Extensive research has been conducted in the recent years with a focus on drug administration via the skin for both topical and systemic drug delivery. Understanding the drug permeation through the skin is crucial for the development of an optimal product. In this study, the permeation of clindamycin phosphate through the pig's ear was evaluated. Both plugged and non-plugged skin was used. In non-plugged skin, the hair follicle orifices were open and a significant amount of clindamycin phosphate was detected. However, plugged skin, in which hair follicle orifices were artificially blocked, clindamycin phosphate can only penetrate to a less extent through interfollicular epidermis and possible through sweat glands. The study was performed using a Franz-type diffusion cell for 24 hours. The samples were withdrawn for each time interval and were analyzed by UV spectrophotometer. Cumulative amount of permeated clindamycin phosphate was compared using the drug concentration. The difference in the percentage of drug permeated through plugged and non-plugged was57.67%. Based on the obtained results, it can be concluded that the follicular route is an important route for the drug delivery through the skin.
    International Journal of PharmTech Research 01/2015; 5(2):1-11.
  • International Journal of PharmTech Research 11/2014; 6(7):1957-1963.
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    ABSTRACT: PCR based nucleic acid lateral flow assay is becoming a popular podium for fast, robust, nucleic acid detection with its biomedical application in diagnosis of infectious disease. Focusing on development of a novel nucleic acid lateral flow assay device coated with nano-probes onto nitrocellulose membrane for detection of PCR amplified pathogenic island of Mycobacterium tuberculosis complex in a sample.DNA samples were isolated from culture isolates of Mycobacterium species identified as H37Rv which was collected from Cooperative Medical College, Cochin. The PCR amplification of these DNA samples was carried out using primers specifically designed for targeting IS6110 sequence. This sequence is specific for Mycobacterium tuberculosis complex organisms. The amplified products were tested on Nucleic Acid Lateral Flow Assay (NALFA) device. NALFA was designed in such a way that it has a nano-probe specific for the PCR product of interest. The PCR product which contained the amplified DNA of Mycobacterium gave a positive result on NALFA thus detecting and confirming the presence of IS6110 sequence. The test results were confirmed with electrophoresis. The NALFA device has to be further optimized and then, it is sure to be a breakthrough product in tuberculosis diagnosis. The test developed is cost effective; time for diagnosis can be drastically reduced and can be produced and used in large numbers.
    International Journal of PharmTech Research 10/2014; 6(5):1695-1702.
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    ABSTRACT: A note on algae as potential source for alternate fuels – Biodiesel 1E.Manoj Kumar, 2D. Jagadish & R. Bharath Kumar*1 1School of Biotechnology& 2Mechanical Engineering, Vignan’s University, Vadlamudi, Guntur Dist., Andhra Pradesh 522213 *Corres.author: enamalamanoj0107@gmail.com,djagadish.009@gmail.com, drbharathravuru@gmail.com Ph.9346986845 Abstract: In the view of faster rates of depletion of fossil fuels and increased energy demand the world is looking for clean alternate fuels. Many researchers are exploring new ways of exploring the potent fuels like biofuels from various sources. The most used sources for the production of biofuels are the plants. Due to the inconsistency and cost effectiveness of the production of seeds for biodiesel production, the attention is now shifted to many other natural resources. Our rich source of algal and planktonic wealth has been providing niche for satisfying the future demands. A meagre amount of work has been carried out in this potential area, interms of exploring the new resources of algal & planktonic wealth. Out of many algal species like Monalithus Salina, Botrycoccus braunii, Dunliella primolecta, Chlorella vulgaris Botrycoccus braunii which yields a percentage of about 75 which is a suitable in production of biodiesel1. This article provides the information in detail about the potential algal sources & the procedures for separation of lipids and other hydrocarbons from different algal species and their importance. Keywords: Alternate fuels, Biofuel/biodiesel, algae, planktonic wealth
    International Journal of PharmTech Research 10/2014; 6(6):1783-1793.