International Journal of PharmTech Research

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ISSN 0974-4304

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    ABSTRACT: Cervical cancer is the most common and the second mayor cause of cancer-related mortality gynecologyc malignancies in developing countries. Cancer stem cell (CSC) theory suggested, cancer is a stem cell diseases and related to the recurrence and drug resistant. Tumor suppressor gene RARß2 expression is reduced or undetectable inmany malignancy including cervical cancerwhich involved in multiple process carcinogenesis such as apoptosis signaling. The purpose of this study was to prove the anti tumor effect of DLEE (Dandelion leaves ethanolic extract) to Cervical stem cells and induce apoptosic through up-regulating the expression both gene and RARß2 protein. We conducted a control study using primary culture human cervical cancer stem cell treated with DLEE in various doses (6.25, 12.5, 25, 50, and 100 μg/mL) for 24 h. RARß2 gene confirmed by PCR technique and Agarose gel electrophoresis. The protein RARß2 expression were measured and confirmed by immunocytochemistry technique. The result showed the Significant (p<0.001) effect of the DLEE to induced apoptosis as 12.25, 16.25, and 23.75% after administration DEE with doses of 25, 50, and 100 μg/mL, respectively, compared with control value of 4.00%. And also have significant(p<0.00) effect to induction expression of RARß2 gene as 89.136, 102.738, 124.459 after induced DEE with doses of 12.5, 25, and 50 μg/mL, respectively. The dose effective was 100 μg/mL that increased protein RARß2 expression as 14.00%. In Conclusion, DLEEproved to have antitumor effect againstto cervical cancer stem cells by inducing apoptosis through up-regulated tumor suppressor gene RARß2 expression and induction RARß2 protein expression in primary culture cervical cancer stem cells.
    International Journal of PharmTech Research 09/2015; 8(5):870-878.
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    ABSTRACT: Background and Aim: Early-onset VAP cause high morbidity/mortality, longer/higher cost of treatment. Secretory-IgA and neutrophils play important role in earlyonset VAP. Exploration the role of these components in local immunity of respiratory system, has been done toward concentration of s-IgA, percentage of neutrophil and kind of pathogens of BAL specimen in mechanical ventilator - patients > 48 hours. Methods: Cohort study of s-IgA levels, percentage of neutrophil and pathogensof BA specimen, in mechanical ventilator-patients.Sampling was carried out, on 1st and 3rd dayof using mechanical ventilator. On the 3rd day, subjects were divided into 2 groups: VAP(-) group:28 persons;and VAP(+)group: 33 persons.VAP (+), if scores of CPIS (Clinical Pulmonary Infection Score)>6. Results: In early-onset VAP patients, the level of s-IgA has increased significantly andcan reduce theneutrophils. The kind of pathogens play important role in stimulatingor destroying s-IgA, and contribute significantly to the VAP incidence, whereas percentage of neutrophil increased in all of pathogens infections. InVAP(-)MRSAinfection group, s-IgA level decreased belowthe baseline and percentage of neutrophil increased non-significantly and was controlled.In VAP(+) group,percentage ofneutrophil increased significantly and play important role in the incidence and deterioration of VAP.In this study, the four highestpathogensin mechanical ventilator - patientsare A. baumannii (42,31%), MRSA (21,79%), K. pneumonia (12,82%) and P. aeruginosa (8,97%). Conclusion: S-IgA and neutrophilscooperate each otherin local immunity mechanism,and s- IgA can suppress excessive reaction of neutrophils.S-IgAgive different responses to pathogens pattern and can destroyed by certain pathogen, while neutrophils do not give different response to different pathogens and give contribution in worsening the incidence of VAP.The most kind of pathogensin mechanical ventilator-patientsare A. baumanii, MRSA, K. pneumonia andP. Aeruginosa.
    International Journal of PharmTech Research 09/2015; 8(5):982-990.
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    ABSTRACT: The aim of this study is to investigate the hepatoprotective effect of ginger extract in different doses against hepatotoxicity caused by carbofuran in male wistar rats from the histological and biochemical aspects. Twenty five male rats were divided into five groups, each representing as A: control negative (normal saline), B: control positive (0.8mg of carbofuran 10%), C: first experimental dose (0.8mg of carbofuran ang 500mg of ginger extract), D: second experimental dose (0.8mg of carbofuran (10%) and 750mg of ginger extract), E: third experimental dose (0.8mg of carbofuran and 1000mg of ginger extract). Study duration was one month. Liver specimen were examined by light microscope and the serum from all groups were examined by spectrophotometry. Resulted in a significant reduction in the levels of alanine aminotransferase (ALT) enzymes in comparison with the carbofuran treated animals; ginger extract also improves the histological changes produced by carbofuran in the liver tissues. The present study indicated that ginger had protective effect against liver damage induced by carbofuran and this is caused by antioxidant activities.
    International Journal of PharmTech Research 09/2015; 8(5):889-897.
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    ABSTRACT: To evaluate the protective effects of Zingiber officinalle rosco (Ginger) against carbofuran-induced reproductive toxicity in rats and to study the mechanisms of these effects. Methods: Twenty five male rats were divided into five groups, each representing as A: control negative (normal saline), B: control positive (0.8 mg of carbofuran 10%), C: first experimental dose (0.8 mg of carbofuran and 500 mg of ginger extract), D: second experimental dose (0.8 mg of carbofuran (10%) and 750 mg of ginger extract), E: third experimental dose (0.8 mg of carbofuran and 1000 mg ginger extract). The research was done in one month. Results: Treatments with only carbofuran showed a significant decrease of testosterone and increase in proliferation of leydig cell, while the combination of ginger extract with carbofuran showed a significant increase of testosterone and decrease in proliferation of leydig cell (similar results to that of the control negative group: P>0.05). Conclusion: According to the obtained results, it can conclude that the extract of ginger (Z. Officinale) at 750 mg dose produced counteract effect to the deleterious effect on reproductive parameter (testosterone level, leydig cell histopathology) which produced by carbofuran and it is potential for therapeutic role.
    International Journal of PharmTech Research 09/2015; 8(5):879-888.
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    ABSTRACT: Several novel ethyl (5-substitutedacetamido)-3-methylthio-1-phenyl-1H-pyrazole-4-carboxylate were synthesized and screened for their anti-inflammatory at the dose of 25mg/kg and analgesic activity at the dose of 50mg/kg. The compound 5a and 5f are prominent candidate which showed good anti-inflammatory activity among the series. The compound 5a, 5g and 5h showed 60% analgesic activity to that of standard aspirin by acetic acid induced writhing method.
    International Journal of PharmTech Research 09/2015; 8(5):828-835.