International Journal of PharmTech Research

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  • ISSN
    0974-4304

Publications in this journal

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    ABSTRACT: In the present article synthesis and evaluation for antibacterial and antifungal activity of a new series of 2,5-disubstituted-1,3,4-oxadiazole derivatives is described. 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized by the reaction of quinolinyl hydrazone derivatives with dichloromethane. The compounds (6a-h) were characterized by IR, NMR, and mass spectroscopy. All the synthesized compounds were screened for their antimicrobial activity. The antimicrobial results reveal that among the synthesized compounds 6b and 6f showed excellent antibacterial and antifungal activity. The compounds 6c, 6d and 6e did not show antifungal activity against the Colletotrichum capsici.
    International Journal of PharmTech Research 11/2014; 6(7).
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    ABSTRACT: Abstract: Objective of the present study is to formulate the controlled release of fluconazole microsponge using emulsion solvent diffusion with different proportions of ethyl cellulose and fluconazole and evaluate its therapeutic efficacy. These microsponge enriched gel formulation were prepared in 2 % and 3% w/w of sodium alginate and characterized as per WHO Good Manufacturing Guideline for its particle size, physical properties, rheological properties, gel strength, spreadability, mucoadhesive force, drug content, diffusion studies, HPLC analysis and scanning electron microscopy. The particle size ranged from 20 to 36 µm microsponge enriched gel was found to be in the range 2500 to 3900 cps. The maximum gel strength of the MEG was found to be (60 sec. ) and maximum mucoadhesion force was found to be (50.56 dynes/cm2). The formulations exhibited maximum spreadability (22.14 gm.cm/sec). The optimized formulations were able to release the drug up to 9 h. The pharmacological evaluation showed better therapeutic efficacy in rodents when compared with that of standard marketed fluconazole gel. Keywords: Microsponge enriched gel, In vivo studies, Fluconazole, HPLC, Scanning electron microscope.
    International Journal of PharmTech Research 10/2014; 6(6):1888-1897..
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    ABSTRACT: PCR based nucleic acid lateral flow assay is becoming a popular podium for fast, robust, nucleic acid detection with its biomedical application in diagnosis of infectious disease. Focusing on development of a novel nucleic acid lateral flow assay device coated with nano-probes onto nitrocellulose membrane for detection of PCR amplified pathogenic island of Mycobacterium tuberculosis complex in a sample.DNA samples were isolated from culture isolates of Mycobacterium species identified as H37Rv which was collected from Cooperative Medical College, Cochin. The PCR amplification of these DNA samples was carried out using primers specifically designed for targeting IS6110 sequence. This sequence is specific for Mycobacterium tuberculosis complex organisms. The amplified products were tested on Nucleic Acid Lateral Flow Assay (NALFA) device. NALFA was designed in such a way that it has a nano-probe specific for the PCR product of interest. The PCR product which contained the amplified DNA of Mycobacterium gave a positive result on NALFA thus detecting and confirming the presence of IS6110 sequence. The test results were confirmed with electrophoresis. The NALFA device has to be further optimized and then, it is sure to be a breakthrough product in tuberculosis diagnosis. The test developed is cost effective; time for diagnosis can be drastically reduced and can be produced and used in large numbers.
    International Journal of PharmTech Research 10/2014; 6(5):1695-1702.
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    ABSTRACT: A note on algae as potential source for alternate fuels – Biodiesel 1E.Manoj Kumar, 2D. Jagadish & R. Bharath Kumar*1 1School of Biotechnology& 2Mechanical Engineering, Vignan’s University, Vadlamudi, Guntur Dist., Andhra Pradesh 522213 *Corres.author: enamalamanoj0107@gmail.com,djagadish.009@gmail.com, drbharathravuru@gmail.com Ph.9346986845 Abstract: In the view of faster rates of depletion of fossil fuels and increased energy demand the world is looking for clean alternate fuels. Many researchers are exploring new ways of exploring the potent fuels like biofuels from various sources. The most used sources for the production of biofuels are the plants. Due to the inconsistency and cost effectiveness of the production of seeds for biodiesel production, the attention is now shifted to many other natural resources. Our rich source of algal and planktonic wealth has been providing niche for satisfying the future demands. A meagre amount of work has been carried out in this potential area, interms of exploring the new resources of algal & planktonic wealth. Out of many algal species like Monalithus Salina, Botrycoccus braunii, Dunliella primolecta, Chlorella vulgaris Botrycoccus braunii which yields a percentage of about 75 which is a suitable in production of biodiesel1. This article provides the information in detail about the potential algal sources & the procedures for separation of lipids and other hydrocarbons from different algal species and their importance. Keywords: Alternate fuels, Biofuel/biodiesel, algae, planktonic wealth
    International Journal of PharmTech Research 10/2014; 6(6):1783-1793.
  • International Journal of PharmTech Research 06/2014; 6(1):290-297.