International Journal of PharmTech Research

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ISSN 0974-4304

Publications in this journal

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    ABSTRACT: The objective of this research is to examine how people point of view about diarrhea in children under five years old related to the cause, sign and symptom, diagnosis, treatment, prognosis, and its prevention in BugisPonjo ethnic culture viewpoint, South Sulawesi Province. This research is using qualitative research with ethnography approach which tries to understand the cultural aspect through a series of observation and interpretation human behavior. In more specific, an ethnography research focuses on what a group of people (cultural behavior) was performed, what they know (cultural knowledge), and what things that they make and wear (cultural artifacts).It is found that the diarrhea cause understood by BugisPonjo ethnic community is a result of supernatural factor as well as by nature and body disharmonisation. Through the understanding, it is identified the types of diarrhea which well known by the public namely sai, wolang, lenynyeisimulajajinna, urekeng, jambanglempu, and dyspepsia. Diagnostic, treatment, prognostic, and diarrhea prevention in children under five are an empiric norm and have become a pattern in the BugisPonjo ethnic community. The sign and symptoms of diarrhea become a basis to determine diarrhea types. Treatment will be conducted using traditional medicine plants like guava leave (Psidiumguajava), turmeric concoction (Curcuma domestica), candlenut concoction (Aleuritismoluccana), pepper (Piper betle), pepper concoction (Piper betle), bangle concoction (Zingiberofficinalepurpureum).
    International Journal of PharmTech Research 06/2015; 1(2):974-4304.
  • International Journal of PharmTech Research 11/2014; 6(7):1957-1963.
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    ABSTRACT: PCR based nucleic acid lateral flow assay is becoming a popular podium for fast, robust, nucleic acid detection with its biomedical application in diagnosis of infectious disease. Focusing on development of a novel nucleic acid lateral flow assay device coated with nano-probes onto nitrocellulose membrane for detection of PCR amplified pathogenic island of Mycobacterium tuberculosis complex in a sample.DNA samples were isolated from culture isolates of Mycobacterium species identified as H37Rv which was collected from Cooperative Medical College, Cochin. The PCR amplification of these DNA samples was carried out using primers specifically designed for targeting IS6110 sequence. This sequence is specific for Mycobacterium tuberculosis complex organisms. The amplified products were tested on Nucleic Acid Lateral Flow Assay (NALFA) device. NALFA was designed in such a way that it has a nano-probe specific for the PCR product of interest. The PCR product which contained the amplified DNA of Mycobacterium gave a positive result on NALFA thus detecting and confirming the presence of IS6110 sequence. The test results were confirmed with electrophoresis. The NALFA device has to be further optimized and then, it is sure to be a breakthrough product in tuberculosis diagnosis. The test developed is cost effective; time for diagnosis can be drastically reduced and can be produced and used in large numbers.
    International Journal of PharmTech Research 10/2014; 6(5):1695-1702.
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    ABSTRACT: A note on algae as potential source for alternate fuels – Biodiesel 1E.Manoj Kumar, 2D. Jagadish & R. Bharath Kumar*1 1School of Biotechnology& 2Mechanical Engineering, Vignan’s University, Vadlamudi, Guntur Dist., Andhra Pradesh 522213 *,, Ph.9346986845 Abstract: In the view of faster rates of depletion of fossil fuels and increased energy demand the world is looking for clean alternate fuels. Many researchers are exploring new ways of exploring the potent fuels like biofuels from various sources. The most used sources for the production of biofuels are the plants. Due to the inconsistency and cost effectiveness of the production of seeds for biodiesel production, the attention is now shifted to many other natural resources. Our rich source of algal and planktonic wealth has been providing niche for satisfying the future demands. A meagre amount of work has been carried out in this potential area, interms of exploring the new resources of algal & planktonic wealth. Out of many algal species like Monalithus Salina, Botrycoccus braunii, Dunliella primolecta, Chlorella vulgaris Botrycoccus braunii which yields a percentage of about 75 which is a suitable in production of biodiesel1. This article provides the information in detail about the potential algal sources & the procedures for separation of lipids and other hydrocarbons from different algal species and their importance. Keywords: Alternate fuels, Biofuel/biodiesel, algae, planktonic wealth
    International Journal of PharmTech Research 10/2014; 6(6):1783-1793.
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    ABSTRACT: This study examines the sustained release behaviour of venlafaxine hydrochloride from Hydroxyl propyl methyl cellulose & sodium carboxy methyl cellulose. Venlafaxine hydrochloride is an antidepressant agent. The present research endeavor was directed towards the development of a sustained release dosage form of venlafaxine in the form of tablets to be taken once daily. All lubricated formulations were compressed by direct compression. The compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness and In-vitro dissolution study. Release studies were carried out using USP type 2 apparatus in 900 ml of Distilled Water as dissolution media. Release kinetics were analyzed using zero-order, Higuchi’s square root and Peppa’s exponential equations. All formulations showed compliance with pharmacopoeial standards. Among different formulations F7 showed sustained release of drug for 12 hours with 99.73% of drug release respectively. The regression coefficient value of zero order plots was found to be 0.993. The slope of peppas model was found to be 0.981 for F7.Thus the matrix system of HPMC & SCMC was found to be effective in retarding release of venlafaxine hydrochloride.
    International Journal of PharmTech Research 08/2014; 4(5).
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    ABSTRACT: Objective- The aim of this study was to evaluate the hepatoprotective effect of Acorus calamus against carbon tetrachloride induced liver injury in rats. Method – In the present study, the protective effect of Acorus calamus was investigated against carbon tetrachloride induced hepatotoxicity and compared with silymarin, a standard hepatoprotective reference drug. Total 30 animals were taken and divided into five groups .Group I is control group and group II induction group and group III and IV are test groups to which administered the ethanolic extract of powder of Acorus calamus at doses of 30mg/kg and 100mg/kg and group V administered standard drug Silymarin 5mg/kg orally for 07days respectively .On seventh day single dose of 1mg/kg.b.wt.i.p with olive oil 1:1 was administered. Result-Administration of ccl4 induced mark increase in serum hepatic enzyme level of SGPT, SGOT, ALP and decrease in normal protein as compared to normal control. Conclusion-Pretreatment of rats with Acorus calamus 30mg/kg and 100mg/kg prior to ccl4 administration caused significant reduction in values of SGPT, SGOT and increase in total protein level but ALP and total bilirubin not affected significantly.
    International Journal of PharmTech Research 08/2014; 6(4):1315-1321.