Asian Journal of Pharmaceutical and Clinical Research Impact Factor & Information

Journal description

Current impact factor: 0.51

Impact Factor Rankings

Additional details

5-year impact 0.00
Cited half-life 0.00
Immediacy index 0.00
Eigenfactor 0.00
Article influence 0.00
ISSN 0974-2441

Publications in this journal

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    ABSTRACT: Lymphatic filariasis is an endemic disease affecting humans in more than 83 countries and it is crucial to find drugs to cure this disease. Nearly 1.33 billion were at risk of filariasis. In this study, we have targeted Brugia malayi asparaginyl tRNA synthetase (AsnRS) for new drug development against filariasis. AsnRS is an essential enzyme for protein synthesis in nematodes and required at various steps of their life cycle. We used computational tools for identifying potential molecule which can act as inhibitor for our target AsnRS. 4133 molecules were selected after screening using Zinc Pharmer and were docked in high throughput manner using vina and top 10% highest scoring molecules were selected. These molecules were re-docked and only those molecules were selected which shows less than 2Å rmsd difference in the top pose predicted by both Autodock4 and Autodock Vina. We identified 11 molecules fitting these criteria which were further subjected to interaction analysis. Molecular dynamics simulations were performed on molecules showing best interaction based on their binding energy and hydrogen bond formation. It was seen that these molecules were bound tightly inside the active site of the receptor. These molecules seem suitable candidate to undergo in-vitro testing
    Asian Journal of Pharmaceutical and Clinical Research 07/2015; 8(4).
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    ABSTRACT: Dryopteris cochleata (D. Don) C. Chr., is one of the important traditional medicinal plants. Therefore, the present investigation was undertaken to analyze the bioactive compounds from D. cochleata through gas chromatography-mass spectroscopy. Analysis was carried out in two different solvents viz., ethanol and chloroform. In ethanolic extract, seven compounds and chloroform extract 14 compounds were identified. The common compounds in these two extracts are Germacrene D; 1, 3-cyclohexanedione, 2-methyl-2 (3-oxobutyl); neoisolongifolene, 8, 9-dehydro.
    Asian Journal of Pharmaceutical and Clinical Research 05/2015; 8(4):1-4.
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    ABSTRACT: Toxoplasma gondii is an obligate intracellular parasite that infects homoeothermic animals. It is also the major cause of retinochoroiditis in humans. Drugs targeting T. gondii proteins involved in the establishment of host-pathogen interactions is well documented to be an efficient way to combat the infections. Basically, parasitic invasion of T. gondii occurs by the sequential secretion of apical membrane antigen 1 and rhoptry neck proteins on the parasite and host cell surfaces, respectively. These proteins operate synergistically and form the moving junction (MJ) complex, thereby, enabling attachment and penetration of the parasite into the host cell. Better understanding of molecular interactions of these proteins is essential to develop highly efficient therapeutic modalities. Hence, by this review it is intended to update the current status of rhoptry and other MJ complex proteins as ideal candidates for targeting T. gondii.
    Asian Journal of Pharmaceutical and Clinical Research 05/2015; 8(3):52-57.
  • Asian Journal of Pharmaceutical and Clinical Research 05/2015; 8(3).
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    ABSTRACT: ABSTRACT Objective: The objective of this study is to prepare efficient dosage form using nanocrystal technology and to compare with micro and marketed formulations for its in-vitro and the in-vivo behavior. The nanocrystal technology has good potential to enhance the dissolution profile of poorly soluble drugs by reducing particle size, increasing surface area, and also by raising the saturation solubility of the drug. Methods: In this study, solubility of rosuvastatin calcium is increased by adopting nanocrystal technology. Rosuvastatin calcium nanocrystals was formulated using various stabilizers like sodium lauryl sulfate, hydroxyl propyl cellulose, hydroxyl propyl methyl cellulose, poloxamer 188, tween 80, poly vinyl pyrrolidine, by adopting two different methods top down and bottom up techniques. Formulations were compressed and physical parameters of tablets evaluated dissolution studies were performed to evaluate release and pharmacokinetic studies were done to evaluate in-vivo behavior. Results: Particle size obtained by employing top down method was found to be <749.04 nm (F-1 to F-7) whereas particle size obtained by following bottom up method was higher than 2000 nm. The micronized particles possessed a size range of 61.51 μm, whereas nanoparticle formulations showed particle size of 0.509 μm, 0.399 μm respectively. Differential scanning calorimetry studies showed good compatibility between drug and excipients. Friability values ranging from 0.15±0.0565% to 0.59±0.0283% and disintegration time lies between 29±1.414 and 44±1.414 seconds for the prepared formulations. The hardness of prepared tablets was between 3.0 and 4.5±0.707 kg/cm2 which are sufficient for maintaining the integrity of tablets. Friability, disintegration time and hardness for the micronized formulation (M-1) were 0.875±0.0919%, 50±2.828 seconds, 3.5±0.707 kg/cm2, which are higher than the values obtained for lyophilized nanocrystals in formulation. In-vitro studies have shown a 36% increase in dissolution of nanocrystal formulation while in-vivo studies exhibited 1.87-fold increases in the bioavailability of rosuvastatin when compared to the micronized dosage form. Conclusion: Formulations containing different constituents were prepared by following bottom up and top down techniques and evaluated in-vitro, in-vivo, observed significant differences between the formulations. The results proved that the bioavailability of rosuvastatin calcium has been improved considerably by applying nanocrystal technology. In-vitro and in-vivo evaluations showed that solubility and bioavailability have been enhanced considerably. Keywords: Rosuvastatin calcium, Nanocrystal technology, Solubility, Bioavailability, Pharmacokinetics.
    Asian Journal of Pharmaceutical and Clinical Research 03/2015; 8(2):88-92.
  • Asian Journal of Pharmaceutical and Clinical Research 03/2015; 8(2):284-287.