Asian Journal of Pharmaceutical and Clinical Research


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    ABSTRACT: plant in folklore system. The principal theme of the study is to develop applied chromatographic techniques for the separation, isolation and detection of the compounds. Methods: A petroleum extract of bark were analyzed by GC/MS, IR, and UV. The structures were elucidated on the basis GC-MS library of reported data. Result: Three known compounds Stigmasterol, Cholest-5-EN -3OL (3 Beta)-Carbonyl chlorinated, Camphesterol were determined from Cordia macleodii bark. These compounds were isolated from this plant for the first time. Conclusion: From the present study, it is concluded that chromatographic and spectroscopy has potential as rapid and simple tools in the isolation and analysis of various compounds from Cordia macleodii bark.
    Asian Journal of Pharmaceutical and Clinical Research 11/2014; 7(5):86-88.
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    ABSTRACT: ABSTRACT Objectives: Fever in children under the age of 5 years can be a diagnostic challenge for pediatricians and primary care physicians since it is often complicated to recognize the rationale. In this study, we intend to ascertain their understanding, attitudes and misapprehensions concerning fever in children. Methods: This transversal study was conducted from March to August 2014 by adopting a pre-validated questionnaire. The study population comprised of physicians working in different public and private sector hospitals and clinics of Karachi. Descriptive statistics was employed to acquire the response of respondents to questionnaire items. Kruskal-Wallis H test was executed to evaluate the association of gender, position, experience and institution of physicians with their responses. Results: The response rate for filling the questionnaire was 71%. More than 97% considered fever risky for a child, 92.25% considered that neurological disorders, seizures and fatality are problems associated with fever. More than 95% opined that when the fever increases then the possibility of febrile convulsions increases. High fever was considered as a sign of severe bacterial infection by majority (90.14%) of participants. Many (79%) opined that the body temperature of above 38°C must absolutely be treated in spite of the causal pathology. Majority of the physicians recommended physical methods such as baths (90.14%), cold application, (82.39%) and rubbing the body with alcohol (28.87%) to be utilized in reducing fever. Conclusion: The study revealed that there were misapprehensions about fever and its associated problems. This demands the execution of educational intervention employing international guiding principles concerning the appropriate management of the febrile child. Keywords: Fever, Physicians, Febrile child, Pakistan.
    Asian Journal of Pharmaceutical and Clinical Research 11/2014; Vol 7(5):173-177.
  • Asian Journal of Pharmaceutical and Clinical Research 09/2014; 7(3).
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    ABSTRACT: Objective: We assessed the antimicrobial activity of methanol extracts of 4 medicinal plants against human pathogenic Gram positive and Gram negative bacteria and fungi. Four medicinal plants namely Terminalia arjuna(bark), Butea monosperma(bark), Mollugo nudicaulis(whole plant), Evolvulus alsinoides(whole plant) were collected from different places in Tamil Nadu, India. Methods: Methanol extracts of these plants were assessed for antimicrobial activity using disc diffusion method at 5mg/disc and 10mg/disc. Minimum inhibitory concentration (MIC) and phytochemical analysis were also determined. Results: Methanol extract inhibited the growth of bacterial and fungal strains. Minimum inhibitory concentration (MIC) of T.arjuna (bark) methanol extract was 500g/ml against Gram positive and Gram negative bacteria. The MIC of B.monosperma (bark) methanol extract was 250g/ml against fungi. The phytochemical analysis of methanol extracts of T.arjuna and B.monosperma showed the presence of glycosides, flavinoids, steroids and tannins. T.arjuna and B.monosperma showed good antimicrobial activity. Conclusion: It can be concluded that the methanol extract possesses potent bactericidal and
    Asian Journal of Pharmaceutical and Clinical Research 07/2014; 7(2).
  • Asian Journal of Pharmaceutical and Clinical Research 06/2014; Vol 7(Suppl 2):31-34.
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    ABSTRACT: Objective: The objective of the study was to assess the lipase inhibitory activities of methanolic extracts from thirty two selected medicinal plants in Malaysia, for potential use in the treatment of obesity. Methods: Methanolic extracts of these plants were evaluated for lipase inhibitory activity using porcine pancreatic lipase (PPL: triacylglycerol lipase, EC and p-nitrophenyl butyrate in an in vitro assay. Standard phytochemical tests for alkaloids, tannins, saponins, glycosides, flavonoids and terpenoids were conducted. Results: Among the thirty two local plant species examined, four plants exhibited inhibition activities of more than 15%. Eleusine indica showed the highest pancreatic lipase inhibitory activity of 31.36%, followed by Myristica fragrans (20.23%), Melastoma candidum (19.67%)and Phyla nodiflora (18.26%), respectively. There was no significant difference between activity produced by Eleusine indica methanolic extract and the standard drug orlistat. Conclusion: Crude methanolic extracts of Eleusine indica, Myristica fragrans, Melastoma candidum and Phyla nodiflora are potential candidates as pancreatic lipase inhibitory agents.
    Asian Journal of Pharmaceutical and Clinical Research 05/2014; 7(2):19-24.