Asian Journal of Pharmaceutical and Clinical Research

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  • Impact factor
    0.51
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  • ISSN
    0974-2441

Publications in this journal

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    ABSTRACT: Objective: The current study was designed to investigate the hypoglycemic, hypolipidemic and insulin sensitizing effects of two marine brown algae, Padina pavonia and Turbenaria ornata. Materials and Methods: Type 2 diabetes was induced by intraperitoneal injection of 120 mg/kg body weight nicotinamide 30 minutes before injection of 50 mg/kg b.wt. streptozotocin. Extracts of both P. pavonia and T. ornata were orally and daily administered at a dose level of 100 mg/ kg b.wt. for 21 days to diabetic rats. At the end of the experimental period, blood, pancreas, and adipose tissue samples were taken for the subsequent studies. Results: Both P. pavonia and T. ornata supplementation potentially ameliorated the elevated levels of glucose, aspartate aminotransferase, lactate dehydrogenase and creatine kinase-MB and the declined serum insulin levels of Type 2 diabetic rats. Furthermore, the tested algae increased the β-cell number in pancreata of diabetic rats. Both extracts were also found to alleviate the altered lipid profile and serum adiponectin level, as well as the insulin resistance indices, homeostasis model of insulin resistance and quantitative insulin-sensitivity check index. In addition, both algae significantly upregulated adipose tissue adiponectin messenger ribonucleic acid expression. Conclusion: These experimental findings demonstrated that both P. pavonia and T. ornata exhibit anti-diabetic effects in a rat model of Type 2 diabetes by their insulinotropic and insulin sensitizing effects.
    Asian Journal of Pharmaceutical and Clinical Research 09/2014; 7(4):74-78.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective: The current study was designed to investigate the hypoglycemic, hypolipidemic and insulin sensitizing effects of two marine brown algae, Padina pavonia and Turbenaria ornata. Materials and Methods: Type 2 diabetes was induced by intraperitoneal injection of 120 mg/kg body weight nicotinamide 30 minutes before injection of 50 mg/kg b.wt. streptozotocin. Extracts of both P. pavonia and T. ornata were orally and daily administered at a dose level of 100 mg/kg b.wt. for 21 days to diabetic rats. At the end of the experimental period, blood, pancreas, and adipose tissue samples were taken for the subsequent studies. Results: Both Padina pavonia and Turbenaria ornata supplementation potentially ameliorated the elevated levels of glucose, AST, LDH and CK-MB and the declined serum insulin levels of type 2 diabetic rats. Also, the tested algae increased the β-cell number in pancreata of diabetic rats. Both extracts were also found to alleviate the altered lipid profile and serum adiponectin level as well as the insulin resistance indices, HOMA-IR and QUICKI. In addition, both algae significantly upregulated adipose tissue adiponectin mRNA expression. Conclusion: These experimental findings demonstrated that both Padina pavonia and Turbenaria ornata exhibit antidiabetic effects in a rat model of type 2 diabetes by their insulinotropic and insulin sensitizing effects.
    Asian Journal of Pharmaceutical and Clinical Research 08/2014; 7(3).
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    ABSTRACT: Objective: This work aims to analyze the proximate composition, minerals and vitamins content in the popularly consumed tuber of West Bengal, Amorphophallus campanulatus. Methods: The plant species were collected from farmers of Santragachhi, Howrah district and authenticated by Botanical Survey of India, Howrah district, West Bengal, India. Fresh tubers were analyzed for their content of crude proteins, total carbohydrate, soluble carbohydrate, fat, fibre, ash, moisture, carotenoids and vitamins. Mineral content was detected from the ash using Inductively Coupled Plasma Atomic Spectrophotometer. Results: The study reveals that the tuber of Amorphophallus campanulatus has high crude protein, moisture, fibre, ash, vitamin E and C content. Besides, the tuber is rich in almost all the essential macro and micro-nutrients. The tuber is interestingly an important source of potassium, calcium and sodium. Moreover, the tuber also lacks the presence of heavy metals like mercury, cadmium, lead and arsenic. Conclusion: Thus the results of the study form an important contribution to the knowledge about the complete nutritional profile of this tuber, which can lead to enhancement of its consumption for maintenance of healthy lifestyle and focus on its therapeutic approach as future perspective. Keywords: Amorphophallus campanulatus, Macro Micro-Nutrient, Nutritional Profile, Proximate Composition
    Asian Journal of Pharmaceutical and Clinical Research 07/2014; 7(3):25-29.
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    ABSTRACT: Objective: This work aims to analyze the proximate composition, minerals and vitamins content in the popularly consumed tuber of West Bengal, Amorphophallus campanulatus. Methods: The plant species were collected from farmers of Santragachhi, Howrah district and authenticated by Botanical Survey of India, Howrah district, West Bengal, India. Fresh tubers were analyzed for their content of crude proteins, total carbohydrate, soluble carbohydrate, fat, fibre, ash, moisture, carotenoids and vitamins. Mineral content was detected from the ash using Inductively Coupled Plasma Atomic Spectrophotometer. Results: The study reveals that the tuber of Amorphophallus campanulatus has high crude protein, moisture, fibre, ash, vitamin E and C content. Besides, the tuber is rich in almost all the essential macro and micro-nutrients. The tuber is interestingly an important source of potassium, calcium and sodium. Moreover, the tuber also lacks the presence of heavy metals like mercury, cadmium, lead and arsenic. Conclusion: Thus the results of the study form an important contribution to the knowledge about the complete nutritional profile of this tuber, which can lead to enhancement of its consumption for maintenance of healthy lifestyle and focus on its therapeutic approach as future perspective. Keywords: Amorphophallus campanulatus, Macro Micro-Nutrient, Nutritional Profile, Proximate Composition
    Asian Journal of Pharmaceutical and Clinical Research 07/2014; 7(3):25-29.
  • Asian Journal of Pharmaceutical and Clinical Research 06/2014; Vol 7(Suppl 2):31-34.
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    ABSTRACT: Objective: Polypharmacy and the use of potentially inappropriate medications (PIM) are common among the elderly worldwide, but there is a paucity of data in patients with dementia in this regard. This study was aimed at assessing the average number of drugs being taken by the elderly patients with dementia presenting to our clinic and whether their prescriptions included the Potentially Inappropriate Medications (PIM) or not. Methods: In our study we recruited patients who presented to the Outpatient Department of Neurology. The use of PIM was estimated according to the Beer’s Criteria. Polypharmacy was defined as the consumption of 5 or more drugs. Results: We incorporated 143 patients in our study where the ratio of Males: females were 110:33. The mean age of our patients was 70.1 ± 10.1 years. Out of all the patients recruited, 55 had mild cognitive impairment, 45 patients had Alzheimer’s disease, 30 had vascular dementia and a minority had fronto-temporal dementia (3), progressive primary aphasia (7) and dementia with Lewy bodies (3). Out of the 143 patients of dementia in our study, 60 patients were taking drugs having the potential to cause cognitive impairment. Distribution of these drugs was as follows: beta blockers (by 10 patients), trihexyphenidyl (THP) (by 3 patients), carbamazepine (2), olanzapine (7), tolterodine (3), oxybutynin (2), amytriptaline (3), loperamide (2), zolpidem (25) and alprazolam (3). According to our study majority of the medications having the potential to cause cognitive impairment were prescribed by psychiatrists (27 patients), followed by physicians (23 patients) and Neurologists (10 patients). Among the 25 patients taking Zolpidem, 18 were taking 10mg per day while 7 were taking 5mg per day. A total of 86 patients were receiving other medications like multi-vitamins (55), calcium (20) and vitamin D (11). Lastly the average number of drugs being consumed by elderly patients with dementia was 8.24±3.2. Conclusion: Drugs having the potential to cause cognitive impairment were being prescribed to patients already suffering from dementia or mild cognitive impairment. A number of patients are consuming multivitamins and many a times these are prescribed without assessing whether they are actually needed in the patient or not. Also the prevalence of polypharmacy in Indian prescriptions is evident according to our study. Keywords: Alzheimer’s disease, polypharmacy, potentially inappropriate medications, cognitive impairment, dementias, mild cognitive impairments, elderly.
    Asian Journal of Pharmaceutical and Clinical Research 03/2014; 7(2):14-18.

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