Asian Journal of Pharmaceutical and Clinical Research
- Impact factor0.51
- 5-year impact0.00
- Cited half-life0.00
- Immediacy index0.00
- Article influence0.00
Publications in this journal
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ABSTRACT: ABSTRACT Objective: In developing countries, population explosion is one of the most important causes of poverty and pollution. Therefore, several approaches have been investigated to decrease fertility, including hormonal, chemical and immunological approaches. However, no suitable method has been found to be effective and free from side effects. Thus, the aim of this study was to investigate the effect of B. sulphureum and C. intybus extracts on various parameters of male fertility using a rat model. Methods: Ethanolic extracts of both plants at doses of 125, 250 and 500 mg/kg, were each given orally to male Wistar rats for 7 weeks. Sperm characters and serum levels of sex hormones were assessed. Mating success %, fertility success % and fertility index were also calculated. The testes, liver and kidney were processed for histological examination. The effect on some biochemical and hematological parameters were quantified. Results: Results showed significant decrease in the weight of testes, epididymis, seminal vesicle and ventral prostate in the 250 and 500 mg/kg groups after 7 weeks of treatment. Both extracts reduced the motility, count and viability of sperms. Significant reduction in serum levels of testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) with hyperprolactinemia were observed. Both extracts did not significantly alter any of the biochemical and hematologic parameters studied. Conclusion: These data suggest that administration of B. sulphureum and C. intybus extracts for 7 weeks contribute to reduce testicular and epididymal function in exposed rats.Asian Journal of Pharmaceutical and Clinical Research 01/2014; 7(1):211-218.
- Asian Journal of Pharmaceutical and Clinical Research 11/2013; 6:18-25.
- Asian Journal of Pharmaceutical and Clinical Research 11/2013; 6(5):184-186.
- Asian Journal of Pharmaceutical and Clinical Research 09/2013; 6(4):100-102.
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ABSTRACT: Objective: To evaluate the hypoglycemic and hypolipidemic effects of ethanol extract of Sarcostemma secamone whole plant in alloxan induced diabetic rats. Methods: Diabetes was induced in Albino rats by administration of alloxan monohydrate (150mg/kg i.p). The ethanol extracts of Sarcostemma secamone whole plant at a dose of 150 and 300 mg/kg of body weight were administrated at a single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Sarcostemma secamone whole plant extract on blood glucose, plasma insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol(LDL-C), very low density lipoprotein-cholesterol (VLDL-C), high density lipoprotein- cholesterol (HDL-C) and phospholipid (PL), serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases] (SGPT), serum glutamate oxaloacetate transaminases (SGOT) and alkaline phosphatase (ALP)] were measured in the diabetic rats. Results: In the acute toxicity study, ethanol extract of Sarcostemma secamone whole plant was non-toxic at 2000 mg/kg in rats. The increased body weight, decreased blood glucose, glycosylated haemoglobin and other biochemical parameters level was observed in diabetic rats treated with both doses of ethanol extract of Sarcostemma secamone whole plant compared to diabetic control rats. In diabetic rats, ethanol extract of Sarcostemma secamone whole plant administration, altered lipid profiles were reversed to near normal than diabetic control rats. Conclusion: Ethanol extract of Sarcostemma secamone whole plant possess significant hypoglycemic and hypolipidemic activity in diabetic rats.Asian Journal of Pharmaceutical and Clinical Research 08/2013; 6(4):65-70.
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