Asian Journal of Pharmaceutical and Clinical Research


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Publications in this journal

  • Asian Journal of Pharmaceutical and Clinical Research 01/2015;
  • Asian Journal of Pharmaceutical and Clinical Research 11/2014; 7(5):220-221.
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    ABSTRACT: plant in folklore system. The principal theme of the study is to develop applied chromatographic techniques for the separation, isolation and detection of the compounds. Methods: A petroleum extract of bark were analyzed by GC/MS, IR, and UV. The structures were elucidated on the basis GC-MS library of reported data. Result: Three known compounds Stigmasterol, Cholest-5-EN -3OL (3 Beta)-Carbonyl chlorinated, Camphesterol were determined from Cordia macleodii bark. These compounds were isolated from this plant for the first time. Conclusion: From the present study, it is concluded that chromatographic and spectroscopy has potential as rapid and simple tools in the isolation and analysis of various compounds from Cordia macleodii bark.
    Asian Journal of Pharmaceutical and Clinical Research 11/2014; 7(5):86-88.
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    ABSTRACT: ABSTRACT Objectives: Fever in children under the age of 5 years can be a diagnostic challenge for pediatricians and primary care physicians since it is often complicated to recognize the rationale. In this study, we intend to ascertain their understanding, attitudes and misapprehensions concerning fever in children. Methods: This transversal study was conducted from March to August 2014 by adopting a pre-validated questionnaire. The study population comprised of physicians working in different public and private sector hospitals and clinics of Karachi. Descriptive statistics was employed to acquire the response of respondents to questionnaire items. Kruskal-Wallis H test was executed to evaluate the association of gender, position, experience and institution of physicians with their responses. Results: The response rate for filling the questionnaire was 71%. More than 97% considered fever risky for a child, 92.25% considered that neurological disorders, seizures and fatality are problems associated with fever. More than 95% opined that when the fever increases then the possibility of febrile convulsions increases. High fever was considered as a sign of severe bacterial infection by majority (90.14%) of participants. Many (79%) opined that the body temperature of above 38°C must absolutely be treated in spite of the causal pathology. Majority of the physicians recommended physical methods such as baths (90.14%), cold application, (82.39%) and rubbing the body with alcohol (28.87%) to be utilized in reducing fever. Conclusion: The study revealed that there were misapprehensions about fever and its associated problems. This demands the execution of educational intervention employing international guiding principles concerning the appropriate management of the febrile child. Keywords: Fever, Physicians, Febrile child, Pakistan.
    Asian Journal of Pharmaceutical and Clinical Research 11/2014; Vol 7(5):173-177.
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    ABSTRACT: Objective: The aim of the present study was to evaluate antioxidant activity and phenol and flavonoid content of three flowers viz. Nerium indicum, Peltophoram pterocarpum and Rosa spps extracts. Methods: The extraction was done by individual cold percolation method using solvents like hexane, ethyl acetate and acetone. Total phenolic and total flavonoid content of different extracts was determined using Folin-ciocalteu assays and aluminium chloride colorimetric method respectively. Antioxidant activity was carried out by ferric reducing antioxidant power (FRAP) and ABTS radical cation scavenging activity. Results: Total phenol content was more in acetone extract while total flavonoid content was more in ethyl acetate extract, in all the three flower species. FRAP activity was maximum in acetone extracts while ABTS activity was more in ethyl acetate extracts. Conclusion: Phenolic and non-phenolic compounds contribute to the antioxidant activity of these three flower extracts. The best antioxidant activity was shown by P. pterocarpum flowers suggesting it to be a good source of natural antioxidants. Keywords: Flowers, Antioxidant activity, 2, 2’-Azino-bis-(3-ethyl) benzothiazoline-6-sulfonic acid, Ferric reducing antioxidant power, Total phenol content, Total flavonoid content.
    Asian Journal of Pharmaceutical and Clinical Research 10/2014; 8(1):91-97.
  • Asian Journal of Pharmaceutical and Clinical Research 09/2014; 7(3).