The Indian Journal of Medical Research (INDIAN J MED RES)

Publisher: Indian Council of Medical Research, Medknow Publications

Journal description

The Indian Journal of Medical Research (IJMR) is one of the oldest medical Journals not only in India, but probably in Asia, as it started in the year 1913. The Journal was started as a quarterly (4 issues/year) in 1913 and made bimonthly (6 issues/year) in 1958. It was made monthly (12 issues/year) in the year 1964. The Journal is being indexed and abstracted by all major global current awareness and alerting services (Annexure). The Indian Journal of Medical Research is published monthly, in two volumes and 12 issues per year. The IJMR publishes peer reviewed quality biomedical research in the form of original research articles, review articles, short papers and short notes. Special issues and supplements are published in addition to the regular issues.

Current impact factor: 1.66

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.661
2012 Impact Factor 2.061
2011 Impact Factor 1.837
2010 Impact Factor 1.826
2009 Impact Factor 1.516
2008 Impact Factor 1.883
2007 Impact Factor 1.67
2006 Impact Factor 1.224
2005 Impact Factor 0.869
2004 Impact Factor 0.6
2003 Impact Factor 0.452
2002 Impact Factor 0.445
2001 Impact Factor 0.34
2000 Impact Factor 0.383
1999 Impact Factor 0.365
1998 Impact Factor 0.4
1997 Impact Factor 0.318
1996 Impact Factor 0.251
1995 Impact Factor 0.198

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.31
Cited half-life 6.50
Immediacy index 0.33
Eigenfactor 0.01
Article influence 0.58
Website Indian Journal of Medical Research website
Other titles Indian journal of medical research (New Delhi, India: 1994)
ISSN 0971-5916
OCLC 59369085
Material type Periodical, Internet resource
Document type Internet Resource, Journal / Magazine / Newspaper

Publisher details

Medknow Publications

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Non-commercial
    • Publisher's version/PDF may be used
    • Creative Commons Attribution Non-Commercial Share Alike License
    • Published source must be acknowledged
    • All titles are open access journals
  • Classification
    ​ green

Publications in this journal

  • The Indian Journal of Medical Research 04/2015; 141(February 2015):242-244.
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    ABSTRACT: Background and objectives: Tribal people often depend on herbal medicines and the traditional Knowledge Practitioners (TKPs) serve as their healthcare service providers. This study was an attempt to document the use of medicinal plants by the Nicobarese of Nancowry group of Islands. Materials and Methods: Field survey was conducted in all the five inhabited Islands of the Nancowry group of Islands. All the TKPs were interviewed with a questionnaire-guided ethnomedicinal survey protocol. Voucher specimens of all the cited plants (botanic species) were collected and a community biodiversity register of Nicobarese of Nancowry was prepared. Results: A total of 77 TKPs were identified, who together were using 132 medicinal plant species belonging to 113 genera and 62 families. The TKPs were treating a total of 43 ailments. Seven endemic and 3 rare plant species were recorded. The most common plant part used was leaves. Remedies were usually prepared using water as the excipient. The medicinal plant preparations are administered through oral, topical and others routes. The information collected from the TKPs were collated in the form of Community Biodiversity Registers. Interpretation and conclusions: Traditional knowledge of the remedies is passed down from the older generation to the younger through narrations and no written documents are maintained. Medicinal plants still play a pivotal role in the healthcare of the Nicobarese tribe of Nancowry group of Islands. Efforts to document at the medicinal plant species and the formulations are necessary to prevent the loss of the precious knowledge due to a loss of the oral tradition or other reasons.
    The Indian Journal of Medical Research 03/2015;
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    ABSTRACT: Spinocerebellar ataxia 7 (SCA7) is a rare form of neurodegenerative disorder with the clinical manifestation of cerebellar ataxia and retinal degeneration. In this study we describe the clinico-genetic characteristics of nine SCA7 families of Indian origin and cross compare these with other available worldwide studies. Thirty five individuals from nine SCA7 families were clinico-genetically characterized and CAG repeat distribution analysis was carried out in 382 control DNA samples from healthy controls (derived from 21 diverse Indian populations based on ethnic and linguistic and geographical location). Of the nine families studied, 22 affected individuals and one asymptomatic carrier were identified. The average age at disease onset was 23.4±12.6 yr. The length of expanded CAG ranged from 40-94 with mean value of 53.2±13.9. The main clinical findings in affecteds individuals included cerebellar ataxia, and retinal degeneration along with hyper-reflexia (95%), slow saccades (85%) and spasticity (45%). Analysis of the association of number of CAG repeats with disease onset revealed that <49 repeats were associated with earlier age at onset in South East Asians compared to European populations. Further analysis of CAG repeats from 21 diverse Indian populations showed pre-mutable repeats (28-34) alleles in the IE-N-LP2 population. Six of the nine families identified in this study belonged to the same ethnic population. Our results show that presenece of SCA7 is relatively rare and confined to one ethnic group from Haryana region of India. We observed a homogeneous phenotypic expression of SCA7 mutation as described earlier and an earlier age of onset in our patients with CAG <49. The identification of pre-mutable allele in IE-N-LP2 suggests this population to be at the risk of SCA7.
    The Indian Journal of Medical Research 02/2015; 141(2):187-98.
  • The Indian Journal of Medical Research 02/2015; 141(2):236-8.
  • The Indian Journal of Medical Research 02/2015; 141(2):245.
  • The Indian Journal of Medical Research 02/2015; 141(2):143-4.
  • The Indian Journal of Medical Research 02/2015; 141(2):154-61.
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    ABSTRACT: Clostridium difficile infection (CDI) can trigger various responses, ranging from asymptomatic carriage to fulminant colitis. Hard-to-cure CDI, such as severe CDI, multiple recurrences of CDI, refractory CDI, and hypervirulent strains of C. difficile, require new treatments, although antibiotics such as metronidazole and vancomycin are the treatment of choice for initial and first relapsing CDI. Active immunization with C. difficile toxins and faecal microbiota transplantation deserve special attention. Here we describe these strategies for difficult-to-treat CDI.
    The Indian Journal of Medical Research 02/2015; 141(2):172-4.
  • The Indian Journal of Medical Research 02/2015; 141(2):148-50.
  • The Indian Journal of Medical Research 02/2015; 141(2):247-8.
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    ABSTRACT: Cryptorchidism or undescended testis is one of the most common anomalies encountered in paediatric urology and is estimated to affect 1 to 4 per cent of full term and upto 30 per cent of preterm male neonates. The associated problems of sub-fertility or infertility and malignant transformation have been recognized for long. Fertility is impaired after both unilateral and bilateral cryptorchidism. The reported paternity rates in adults are about two-third for unilateral undescended testis and less than one-third for bilateral disease. Over the last five decades, the concepts related to cryptorchidism have changed dramatically as knowledge about its effects has accrued from research conducted worldwide. The recommended age of orchidopexy has fallen progressively from adolescence to less than one year. The realization that the infantile testes are not in a state of 'suspended animation' and the recognition of the defect in the androgen dependent transformation of gonocytes into adult dark spermatogonia in cryptorchidism have been recognized as the primary cause of sub-fertility in these patients. This has paved the way for hormone therapy in an attempt to simulate the 'post-natal gonadotropin surge' or 'mini-puberty'. This review summarizes the current knowledge about the various factors affecting the fertility status in cryptorchidism with a particular focus on the derangements in the development and maturation of the germ cells and the role of surgery, hormone therapy and antioxidants in reversing these changes.
    The Indian Journal of Medical Research 02/2015; 141(2):163-71.
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    ABSTRACT: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies. Mannose binding lectin (MBL) is an important element of the innate defense system. t0 he present study was undertaken to determine whether variant alleles in MBL2 gene were associated with disease severity in SLE patients. The MBL alleles [-550, -221, +4, Codon 52, Codon 54 and Codon 57] were studied by PCR- RFLP (restriction fragment length polymorphism) method in 100 SLE patients fulfilling ACR (American College of Rheumatology) criteria along with 100 healthy controls. SLE disease activity was evaluated using SLE Disease Activity Index (SLEDAI) score. Homozygosity for MBL variant allele (O/O) was observed in 24 per cent of the SLE patients compared to 16 per cent of the normal controls, while no difference was found for heterozygosity (A/O) (37 vs 35%). A significant difference was reported in incidence of double heterozygosity for mutant allele B and D (B/D) among SLE patients as against control group ( p = 0.015). MBL genotypes did not show any association with renal involvement. In this study from western India, MBL gene polymorphism showed an influence as a possible risk factor for susceptibility to SLE, but had no direct effect on disease characteristics. Further studies need to be done on a larger number of SLE patients in different regions of the country.
    The Indian Journal of Medical Research 02/2015; 141(2):199-204.
  • The Indian Journal of Medical Research 02/2015; 141(2):154.
  • The Indian Journal of Medical Research 02/2015; In Press.
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    ABSTRACT: Malaria is a serious problem in the countries of the developing world. As the malaria parasite has become resistant to most of the antimalaria drugs available currently, there is a need to search for newer drugs. This study reports the pharmaceutical quality and in vivo antimalarial activities of a polyherbal formulation (SAABMAL ® ) used as malarial remedy in Nigeria. The antiplasmodial activity of SAABMAL ® was determined by using the 4-day suppressive test in Plasmodium berghei-infected mice. The formulation was tried on three different experimental animal models for in vivo antimalarial activities, which are prophylactic, suppressive and curative in mice. Chloroquine and pyrimethamine were used as standard drugs for comparison. The suppressive study showed that, SAABMAL ® (200 and 400 mg/kg/bw) significantly (p <0.01) produced a suppression (29.39 - 100%) of parasitaemia in a dose-dependent manner, while the curative study showed that SAABMAL ® at 400 mg significantly (p <0.01) reduced (95.80%) parasitaemia compared with controls. The mean survival time of SAABMAL ®-treated groups (100 and 200 mg/kg) was higher than that of the chloroquine-treated group. Histopathologically, no changes were found in the spleen of both untreated and treated groups. SAABMAL ® capsules were of good mechanical properties with low weight variation and high degree of content mass uniformity. The results obtained in this study showed the efficacy of SAABMAL ® , a herbal antimalarial formulation against chloroquine sensitive malaria and its potential use in the treatment of uncomplicated malaria infection. Further studies need to be done in humans to test its efficacy and safety for its potential use as an antimalarial drug.
    The Indian Journal of Medical Research 02/2015; 141(2):221-7.
  • The Indian Journal of Medical Research 02/2015; 141(2):249-50.
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    ABSTRACT: Hepatitis A virus usually causes acute viral hepatitis (AVH) in the paediatric age group with a recent shift in age distribution and disease manifestations like acute liver failure (ALF). This has been attributed to mutations in 5'non-translated region (5'NTR) which affects the viral multiplication. The present study was aimed to carry out the molecular detection and phylogenetic analysis of hepatitis A virus strains circulating in north western India. Serum samples from in patients and those attending out patient department of Pediatric Gastroenterology in a tertiary care hospital in north India during 2007-2011 with clinically suspected AVH were tested for anti-hepatitis A virus (HAV) IgM antibodies. Acute phase serum samples were subjected to nested PCR targeting the 5'NTR region followed by sequencing of the representative strains. A total of 1334 samples were tested, 290 (21.7%) were positive for anti-HAV IgM antibody. Of these, 78 serum samples (< 7 days old) were subjected to PCR and 47.4% (37/78) samples showed the presence of HAV RNA. Children < 15 yr of age accounted for majority (94%) of cases with highest seropositivity during rainy season. Sequencing of 15 representative strains was carried out and the circulating genotype was found to be III A. The nucleotide sequences showed high homology among the strains with a variation ranging from 0.1-1 per cent over the years. An important substitution of G to A at 324 position was shown by both AVH and ALF strains. The cumulative substitution in AVH strains Vs ALF strains as compared to GBM, Indian and prototype strain in the 200-500 region of 5' NTR was comparable. Our results showed hepatitis A still a disease of children with III A as a circulating genotype in this region. The mutations at 5'NTR region warrant further analysis as these affect the structure of internal ribosomal entry site which is important for viral replication.
    The Indian Journal of Medical Research 02/2015; 141(2):213-20.