The Indian Journal of Medical Research (INDIAN J MED RES )

Publisher: Indian Council of Medical Research


The Indian Journal of Medical Research (IJMR) is one of the oldest medical Journals not only in India, but probably in Asia, as it started in the year 1913. The Journal was started as a quarterly (4 issues/year) in 1913 and made bimonthly (6 issues/year) in 1958. It was made monthly (12 issues/year) in the year 1964. The Journal is being indexed and abstracted by all major global current awareness and alerting services (Annexure). The Indian Journal of Medical Research is published monthly, in two volumes and 12 issues per year. The IJMR publishes peer reviewed quality biomedical research in the form of original research articles, review articles, short papers and short notes. Special issues and supplements are published in addition to the regular issues.

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  • Website
    Indian Journal of Medical Research website
  • Other titles
    Indian journal of medical research (New Delhi, India: 1994)
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  • Material type
    Periodical, Internet resource
  • Document type
    Internet Resource, Journal / Magazine / Newspaper

Publications in this journal

  • The Indian Journal of Medical Research 02/2015; In Press.
  • The Indian Journal of Medical Research 10/2014; 4(30):4926-4938.
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    ABSTRACT: Background & objectives : Little is known about the prevalence of Chlamydia trachomatis infection in Indian women with infertility. To improve the diagnosis of C. trachomatis infection in developing countries, there is an urgent need to establish cost-effective molecular test with high sensitivity and specificity. This study was conducted to determine the diagnostic utility of a real time-PCR assay for detention of C . trachomatis infection in infertile women attending an infertility clinic in north India. T he in house real time-PCR assay was also compared with a commercial real-time PCR based detection system. Method : Endocervical swabs, collected from 200 infertile women were tested for C. trachomatis by three different PCR assays viz. in-house real time-PCR targeting the cryptic plasmid using published primers, along with omp1 gene and cryptic plasmid based conventional PCR assays. Specimens were also subjected to direct fluorescence assay (DFA) and enzyme immunoassay (EIA) Performance of in- house real time-PCR was compared with that of COBAS Taqman C. trachomatis Test, version 2.0 on all in-house real time-PCR positive sample and 30 consecutive negative samples. Results : C. trachomatis infection was found in 13.5 per cent (27/200) infertile women by in-house real time-PCR, 11.5 per cent (23/200) by cryptic plasmid and/or omp1 gene based conventional PCR, 9 per cent (18/200) by DFA and 6.5 per cent (7/200) by EIA. The in-house real time-PCR exhibited a sensitivity and specificity of 100 per cent, considering COBAS Taqman CT Test as the gold standard. The negative and positive predictive values of the in-house real time-PCR were 100 per cent. The in-house real time- PCR could detect as low as 10 copies of C. trachomatis DNA per reaction. Interpretation & conclusions : I n-house real time-PCR targeting the cryptic plasmid of C. trachomatis exhibited an excellent sensitivity and specificity similar to that of COBAS Taqman CT Test, v2.0 for detection of C. trachomatis infection in women attending an infertility clinic. In an effort to prevent Chlamydia infection associated infertility, we recommend screening of women with infertility due to C. trachomatis infection by in-house molecular method as a cost-effective solution in resource limited sett
    The Indian Journal of Medical Research 08/2014; Indian J Med Res 140, August 2014, pp 157-326(140):pp 157-326.
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    ABSTRACT: Since the enactment of environmental protection Act in 1989 and Department of Biotechnology (DBT) guidelines to deal with genetically modified organisms, India has embarked on establishing various levels of biosafety laboratories to deal with highly infectious and pathogenic organisms. Occurrence of outbreaks due to rapidly spreading respiratory and haemorrhagic fever causing viruses has caused an urgency to create a safe laboratory environment. This has thus become a mandate, not only to protect laboratory workers, but also to protect the environment and community. In India, technology and science are progressing rapidly. Several BSL-3 [=high containment] laboratories are in the planning or execution phase, to tackle biosafety issues involved in handling highly infectious disease agents required for basic research and diagnosis. In most of the developing countries, the awareness about biocontainment has increased but planning, designing, constructing and operating BSL-3 laboratories need regular updates about the design and construction of facilities and clear definition of risk groups and their handling which should be in harmony with the latest international practices. This article describes the major steps involved in the process of construction of a BSL-3 laboratory in Indian settings, from freezing the concept of proposal to operationalization phase. The key to success of this kind of project is strong institutional commitment to biosafety norms, adequate fund availability, careful planning and designing, hiring good construction agency, monitoring by experienced consultancy agency and involvement of scientific and engineering personnel with biocontainment experience in the process.
    The Indian Journal of Medical Research 08/2014;
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    ABSTRACT: Background and Objectives: The use of clobazam in epilepsy has increased since its introduction in 1975. However it has not been audited for its overall usefulness in Indian setup. The present study aims to evaluate usage pattern, retention rate, effectiveness and tolerability of clobazam during routine practice in an out-patient epilepsy clinic of a tertiary care hospital in New Delhi. Methods: The audit was performed on the patients prescribed antiepileptic medication who had clobazam as last added drug in their treatment regimen during October 2010 – March 2012. Patients were followed up for 2 OPD visits. The primary points evaluated were: retention rate, percentage of seizure-free patients and reasons for discontinuing clobazam. Results: Out of 417 consecutive patients, 132 (31.7%) were on clobazam treatment for more than four years (median 6 years, range 4-15 years). No seizure for previous 12 months was considered as seizure free and was observed in 151 (36.2%) patients. There was no improvement in seizure control in 32 (7.7%) patients. A decrease in seizure severity without any change in seizure frequency was observed in 76 (18.2%) patients. Clobazam was discontinued by 15 (3.6%) patients due to complaints like drowsiness (13), fatigue/tiredness (8), headache (6), poor memory (6), irritated behavior (5), abdominal pain (3) and dizziness (3). Interpretation and conclusions: The present study provides valuable information about the clinical use of clobazam as add on antiepileptic drug therapy in the management of patients with epilepsy.
    The Indian Journal of Medical Research 08/2014;
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    ABSTRACT: Vascular ring with a Kommerell’s diverticulum: Neonatal presentation with oesophageal symptoms
    The Indian Journal of Medical Research 07/2014; 140(7):152-3.
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    ABSTRACT: Fisheries over the years evolved from subsistence fishing towards a capital intensive enterprise. There has been structural transformation in the fishing fleet with motorisation and mechanisation. The current scenario of marine fisheries in terms of fishing fleets clearly indicates a situation “too many boats chasing too few fishes”. Due to the tragedy of commons in operation, increasing fleet size as well as costs of fishing and the decreasing catch per unit efforts, the fishing operations have taken a toll. The mechanised sector is venturing into multiday fishing which negate the losses of fishing cost. Sizeable amount of low value fishes are landed across the landing centres on account of targeted fishing. Low value fishes include juveniles, bycatch, trash fishes and discards and it is estimated that around 30% of the mechanised landings constitute low value fishes which has a huge untapped economic value. Economic loss due to low value catch could be reduced by implementing mesh-size regulations to avoid juvenile catch, prevent discards and utilising bycatch. Appropriate utilisation strategies are to be developed with respect to discards, regulating multiday fishing operations or innovative measures may be adopted to land the catches on frequent intervals. There exists a huge consumer demand on account of the escalating domestic market prices of fish. The paper focuses on the targeted fishing and resultant huge amount of low value fishes that possess huge economic value which are being surpassed. The paper estimates the quantum of low value fish across the different fishing sectors. The paper suggests the possible policy intervention required for harnessing the market for low value fishes
    The Indian Journal of Medical Research 07/2014;
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    ABSTRACT: Background & objectives : Though diabetes affects multiple organs, most studies highlight the occurence of only one complication in isolation. We conducted a hospital-based study to estimate the co-existence of significant systemic co-morbid conditions in patients with varying grades of diabetic retinopathy. Methods : A total of 170 consecutive patients with diabetic retinopathy were prospectively recruited for the study between June 2009 to June 2010 at a tertiary care eye centre in north India. Retinopathy was graded by fundus biomicroscopy and fundus photography and classified into three categories (mild-moderate nonproliferative retinopathy, proliferative retinopathy requiring only laser and proliferative retinopathy requiring surgery). Nephropathy was classified by calculating the six variable estimated glomerular filtration rate (eGFR) for all patients. Nerve conduction studies and clinical assessment were used to determine presence of neuropathy. Co-existence of macrovascular disease and peripheral vascular disease was also ascertained. Results : The percentages of patients with overt nephropathy in the three groups were 19.2, 38.0 and 41.2, respectively. Significant linear trends were observed for serum creatinine (P=0.004), albumin (P=0.017) and eGFR (P=0.030). A higher per cent had abnormal nerve conduction on electrophysiology than that diagnosed clinically (65.4 vs. 44.2, 76.0 vs. 40.0 and 64.8 vs. 48.6, respectively). The odds ratio (95% CI) for co-existence of nephropathy, neuropathy, CVA (cerebrovascular accidents) and PVD (peripheral vascular disease) was 2.9, 0.9, 4.8 and 3.5, respectively. Independent of retinopathy severity, patients with clinically significant macular oedema (CSME) had a higher percentage of nephropathy ( p0 < 0.005). Interpretation & conclusions : The co-existence of overt nephropathy, nerve conduction based neuropathy and macrovascular co-morbidity in patients with early grades of diabetic retinopathy was significant. Screening for overt nephropathy by eGFR should be considered in all patients with clinically significant macular oedema.
    The Indian Journal of Medical Research 07/2014;
  • The Indian Journal of Medical Research 07/2014;