Trends in Microbiology (TRENDS MICROBIOL)

Publisher: Elsevier

Journal description

Interest in molecular microbiology is gaining new impetus from the relative ease and rapidity with which such small genomes can be entirely sequenced. This development is beginning to have significant impact on all areas of prokaryote biology, from pathogens to extremophiles, and will fuel new developments, for example, in drugs, vaccines and industrial enzyme research. Trends in Microbiology provides a multidisciplinary forum for the discussion of all aspects of microbiology: from cell biology and immunology to genetics and evolution, and ranges across virology, bacteriology, protozoology and mycology. The contents includes a lively mix of commentary, correspondence and review. Reviews are commissioned and peer reviewed and, consequently, make an authoritative basis for teaching and keeping abreast of developments across the field. The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host-pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

Current impact factor: 9.81

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 9.808
2012 Impact Factor 8.434
2011 Impact Factor 7.91
2010 Impact Factor 7.5
2009 Impact Factor 6.894
2008 Impact Factor 6.138
2007 Impact Factor 7.618
2006 Impact Factor 8.335
2005 Impact Factor 6.648
2004 Impact Factor 7.748
2003 Impact Factor 8.16
2002 Impact Factor 6.665
2001 Impact Factor 6.523
2000 Impact Factor 6.006
1999 Impact Factor 5.101
1998 Impact Factor 4.953

Impact factor over time

Impact factor

Additional details

5-year impact 8.09
Cited half-life 7.40
Immediacy index 2.15
Eigenfactor 0.02
Article influence 3.15
Website Trends in Microbiology website
Other titles Trends in microbiology
ISSN 0966-842X
OCLC 28154412
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details


  • Pre-print
    • Author cannot archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • On authors personal or authors institutions server
    • Published source must be acknowledged
    • Must link to journal home page
    • Publisher's version/PDF cannot be used
    • 'Elsevier (Cell Press)' is an imprint of 'Elsevier'
  • Classification
    ​ blue

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Fecal pollution indicators are essential to identify and remediate contamination sources and protect public health. Historically, easily cultured facultative anaerobes such as fecal coliforms, Escherichia coli, or enterococci have been used but these indicators generally provide no information as to their source. More recently, molecular methods have targeted fecal anaerobes, which are much more abundant in humans and other mammals, and some strains appear to be associated with particular host sources. Next-generation sequencing and microbiome studies have created an unprecedented inventory of microbial communities associated with fecal sources, allowing reexamination of which taxonomic groups are best suited as informative indicators. The use of new computational methods, such as oligotyping coupled with well-established machine learning approaches, is providing new insights into patterns of host association. In this review we examine the basis for host-specificity and the rationale for using 16S rRNA gene targets for alternative indicators and highlight two taxonomic groups, Bacteroidales and Lachnospiraceae, which are rich in host-specific bacterial organisms. Finally, we discuss considerations for using alternative indicators for water quality assessments with a particular focus on detecting human sewage sources of contamination.
    Trends in Microbiology 12/2014; DOI:10.1016/j.tim.2014.08.002
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    ABSTRACT: Improving undergraduate science, technology, engineering, and math (STEM) education requires faculty with the skills, resources, and time to create active learning environments that foster student engagement. Current faculty hiring, promotion, and tenure practices at many universities do not measure, reward, nor encourage faculty pursuit of these skills. A cultural change is needed to foster improvement.
    Trends in Microbiology 12/2014; 22(12). DOI:10.1016/j.tim.2014.09.006
  • Trends in Microbiology 11/2014; DOI:10.1016/j.tim.2014.11.001
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    ABSTRACT: Until recently, the origin of the HIV-1 group M pandemic largely remained a scientific mystery. The use of comprehensive evolutionary analyses has revealed a unique story regarding viral migration, starting in the 1920s in Kinshasa, and the social and infrastructural changes associated with the early spread of this deadly virus. Copyright © 2014 Elsevier Ltd. All rights reserved.
    Trends in Microbiology 11/2014; DOI:10.1016/j.tim.2014.11.004
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    ABSTRACT: The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply of new antibiotics. It is therefore of great importance to find and create new antibiotics. Nucleoside antibiotics are a large family of natural products with diverse biological functions. Their biosynthesis is a complex process through multistep enzymatic reactions and is subject to hierarchical regulation. Genetic and biochemical studies of the biosynthetic machinery have provided the basis for pathway engineering and combinatorial biosynthesis to create new or hybrid nucleoside antibiotics. Dissection of regulatory mechanisms is leading to strategies to increase the titer of bioactive nucleoside antibiotics. Copyright © 2014. Published by Elsevier Ltd.
    Trends in Microbiology 11/2014; 23(2). DOI:10.1016/j.tim.2014.10.007
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    ABSTRACT: Bacterial microcompartments (BMCs) are protein-bound organelles predicted to be present across 23 bacterial phyla. BMCs facilitate carbon fixation as well as the aerobic and anaerobic catabolism of a variety of organic compounds. These functions have been linked to ecological nutrient cycling, symbiosis, pathogenesis, and cardiovascular disease. Within bacterial cells, BMCs are metabolic modules that can be further dissociated into their constituent structural and functional protein domains. Viewing BMCs as genetic, structural, functional, and evolutionary modules provides a framework for understanding both BMC-mediated metabolism and for adapting their architectures for applications in synthetic biology. Copyright © 2014 Elsevier Ltd. All rights reserved.
    Trends in Microbiology 11/2014; DOI:10.1016/j.tim.2014.10.003
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    ABSTRACT: Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa. Copyright © 2014 Elsevier Ltd. All rights reserved.
    Trends in Microbiology 11/2014; 22(12). DOI:10.1016/j.tim.2014.10.008
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    ABSTRACT: Mycobacterium tuberculosis was historically associated with limited genotypic diversity.•Recent evidence suggests infecting bacillary populations are more diverse than previously thought.•We consider the consequences of diversity for mycobacterial pathogenesis.•Diversity enables exploration of fitness landscapes while retaining core functions.•Systems biology approaches must be developed to understand TB.
    Trends in Microbiology 11/2014; DOI:10.1016/j.tim.2014.10.005
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    ABSTRACT: Human noroviruses cause significant morbidity, mortality, and economic losses worldwide. The inability to grow human noroviruses in cell culture has hampered our collective understanding of virus–host interactions and development of therapeutics. A newly described single-plasmid reverse genetics system for noroviruses has the potential to facilitate basic and applied research.
    Trends in Microbiology 11/2014; 22(11). DOI:10.1016/j.tim.2014.10.001
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    ABSTRACT: TIM proteins are known to promote viral entry into host cells. Unexpectedly, a recent study has shown that TIM proteins also inhibit HIV-1 release from the host cell by directly binding to phosphatidylserine exposed on the virus surface, providing details on a new role of TIM proteins in HIV replication.
    Trends in Microbiology 11/2014; 22(11). DOI:10.1016/j.tim.2014.09.008
  • [Show abstract] [Hide abstract]
    ABSTRACT: If we use the analogy of a virus as a living entity, then the replicative organelle is the part of the body where its metabolic and reproductive activities are concentrated. Recent studies have illuminated the intricately complex replicative organelles of coronaviruses, a group that includes the largest known RNA virus genomes. This review takes a virus-centric look at the coronavirus replication transcription complex organelle in the context of the wider world of positive sense RNA viruses, examining how the mechanisms of protein expression and function act to produce the factories that power the viral replication cycle.
    Trends in Microbiology 11/2014; DOI:10.1016/j.tim.2014.06.003
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    ABSTRACT: Inflammasomes are multiprotein complexes that induce downstream immune responses to specific pathogens, environmental stimuli, and host cell damage. Components of specific viruses activate different inflammasomes; for example, the influenza A virus M2 protein and encephalomyocarditis virus (EMCV) 2B protein activate the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome, whereas viral double-stranded RNA (dsRNA) activates the retinoic acid inducible gene-I (RIG-I) inflammasome. Once activated in response to viral infection, inflammasomes induce the activation of caspases and the release of mature forms of interleukin-1β (IL-1β) and IL-18. Here we review the association between viral infection and inflammasome activation. Identifying the mechanisms underlying virus-induced inflammasome activation is important if we are to develop novel therapeutic strategies to target viruses.
    Trends in Microbiology 10/2014; DOI:10.1016/j.tim.2014.09.007
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    ABSTRACT: Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of blaKPC involves both horizontal transfer of blaKPC genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.
    Trends in Microbiology 10/2014; DOI:10.1016/j.tim.2014.09.003
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    ABSTRACT: Passive immunization studies, including a recent one by Pegu et al., have repeatedly shown that HIV-specific broadly neutralizing antibodies (bnAbs) protect rhesus macaques from HIV acquisition. In vitro neutralization potency and in vivo protection correlate very strongly, supporting the quest for an HIV vaccine that induces potent bnAbs.
    Trends in Microbiology 10/2014; 22(10). DOI:10.1016/j.tim.2014.08.006
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    ABSTRACT: The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in 2012 and, subsequently, many cases were reported with a lower case fatality rate than initial cases. Humans can become infected within their communities and transmission can then be amplified in the healthcare setting. Contact investigation among cases shows a variable amount of spread among family members and healthcare workers. So far, circulating virus strains remain similar under continuous monitoring, with no genetic changes. Here, we discuss the transmission pattern, phylogenetic evolution, and pathogenesis of MERS-CoV infection.
    Trends in Microbiology 10/2014; 22(10). DOI:10.1016/j.tim.2014.08.001