Gynecological Endocrinology (GYNECOL ENDOCRINOL)

Publisher: International Society of Gynecological Endocrinology, Informa Healthcare

Journal description

Gynecological Endocrinology, the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this increasingly new discipline. It includes papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction.

Current impact factor: 1.33

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.333
2013 Impact Factor 1.136
2012 Impact Factor 1.303
2011 Impact Factor 1.581
2010 Impact Factor 1.461
2009 Impact Factor 1.36
2008 Impact Factor 1.359
2007 Impact Factor 1.169
2006 Impact Factor 0.995
2005 Impact Factor 0.852
2004 Impact Factor 1.242
2003 Impact Factor 0.87
2002 Impact Factor 0.899
2001 Impact Factor 0.878
2000 Impact Factor 1.107
1999 Impact Factor 1.035
1998 Impact Factor 1.061
1997 Impact Factor 0.752
1996 Impact Factor 0.744
1995 Impact Factor 0.538
1994 Impact Factor 0.588
1993 Impact Factor 0.47
1992 Impact Factor 0.815

Impact factor over time

Impact factor

Additional details

5-year impact 1.37
Cited half-life 5.10
Immediacy index 0.31
Eigenfactor 0.01
Article influence 0.35
Website Gynecological Endocrinology website
Other titles Gynecological endocrinology (Online)
ISSN 0951-3590
OCLC 54860745
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Informa Healthcare

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • On author's personal website or institution website
    • Publisher copyright and source must be acknowledged
    • Non-commercial
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • NIH funded authors may post articles to PubMed Central for release 12 months after publication
    • Wellcome Trust authors may deposit in Europe PMC after 6 months
  • Classification

Publications in this journal

  • Fatma Ferda Verit · Hurkan Akyol · Mehmet Nafi Sakar ·
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    ABSTRACT: There is growing evidence that diminished ovarian reserve (DOR) may be associated with cardiovascular disease (CVD). The aim of the study was to investigate whether there was any relationship between antimullerian hormone (AMH) and CVD risk markers in the study. Ninety women with DOR and 90 women with normal ovarian reserve (NOR) attending the infertility unit at XXXX, were enrolled in the study. CVD risk markers such as insulin resistance [defined by the homeostasis model assessment ratio (HOMA-IR)], C-reactive protein (CRP), low density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), and triglyceride (TG) were assessed. HOMA-IR, CRP, TG, LDL levels were higher and HDL and AMH were lower among patients with DOR compared with controls (p < 0.05, for all). There were positive associations between low AMH and HOMA-IR, CRP, TG, LDL levels and a negative correlation with HDL (p < 0.05, for all). However, multivariate logistic regression analysis showed that HOMA-IR, CRP, TG and HDL were independent variables that were associated with low AMH. There was a close relationship between low AMH and CVD risk markers in the study. Further studies with larger groups are needed to investigate the nature of this link in these patients.
    Gynecological Endocrinology 11/2015; DOI:10.3109/09513590.2015.1116065
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    ABSTRACT: We assessed the associations between preoperative and postoperative serum anti-Müllerian hormone (AMH) levels and parameters of endometriosis and endometriomas surgery with the success of infertility treatments after cystectomy. Seventeen out of 54 patients got pregnant during the infertility treatments. In these patients, the median interval from surgery to conception was 16.3 months. The serum AMH levels 1-year postoperatively were significantly higher in the pregnant group compared to the non-pregnant group (3.44 ± 1.78 versus 2.17 ± 2.24 ng/ml, p = 0.049). The median interval from surgery to recurrence was 34.4 months, and no significant differences were found in the serum AMH levels at any time point between the recurrence and non-recurrence groups. Serum AMH levels 1 year after laparoscopic cystectomy for endometriomas may predict the success of postoperative infertility treatments, but not a recurrence of endometriomas.
    Gynecological Endocrinology 11/2015; DOI:10.3109/09513590.2015.1114078
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    ABSTRACT: Thecoma is a rare ovarian tumor, presenting usually in postmenopausal women as unilateral, benign, solid lesion. About 15% of affected patients develop endometrial hyperplasia (EH) and 20% are diagnosed with endometrial cancer. In this case report, we present 60-year-old women admitted because of recurrent spotting of 5 years duration, which started 1 year after menopause. In history, the patient underwent three times curettage procedures and once (1 year before admission) had estradiol levels typical for reproductive-age women. At admission, we found elevated serum levels of estradiol (222.5 pg/ml) and a small mass in the right ovary. The markers of germ cell tumors were negative. After the initial diagnosis, the patient was qualified for total abdominal hysterectomy with bilateral salpingo-oophorectomy. The histopathological examination and immunohistochemical staining confirmed the thecoma diagnosis. In follow-up examination after 8 weeks, we found decreased serum estradiol levels and relief of the symptoms. In conclusion, we want to underline that in cases of EH, especially in patients with a history of recurrences, the special attention should be paid for differential diagnosis. In such cases, the estrogen-secreting tumors should be excluded.
    Gynecological Endocrinology 11/2015; DOI:10.3109/09513590.2015.1113519

  • Gynecological Endocrinology 11/2015; DOI:10.3109/09513590.2015.1102878
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    ABSTRACT: Ulipristal acetate (UA), a selective progesterone modulator, has been approved for short-term therapy for symptomatic fibroids. We decided to undertake a systematic review of the best available evidence and draw a more definitive conclusion regarding the efficacy of UA for the management of uterine fibroids. The outcomes included symptomatic relief, quality of life-related parameters, reduction in fibroid size, side effects and recurrence rate. We included four randomised controlled trials which consisted of three trials which compared UA with placebo, and one trial compared it with gonadotropin-releasing hormone analogues for symptomatic relief. The three trials comparing UA with placebo reported significant improvement in symptoms related to excessive uterine bleeding as evidenced by the attainment of amenorrhea or reduction in pictorial blood assessment chart. However, due to the heterogeneity of the available data, a meta-analysis was possible only for one the outcomes - attainment of amenorrhea which indicated improvement in symptoms [57.88 (19.81-169.16); p < 0.00001]. The improved quality of life parameters and reduction in fibroid size was noted in the UA group. With regards to adverse events, even though the three included studies reported increased non-physiological endometrial-related changes following UA, these changes reverted back to normal within 6 months. Short-term use of UA seems to be an effective and safe method of treating uterine fibroids.
    Gynecological Endocrinology 11/2015; DOI:10.3109/09513590.2015.1106471
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    ABSTRACT: We report on a 31-year old female who presented at genetic counseling for a small uterus, secondary amenorrhea and sterility. Gonadotropic hormone levels were low, suggesting a Hypogonadotropic Hypogonadism (HH) condition. Cytogenetic analysis demonstrated the presence of Trisomy X associated to an interstitial deletion of chromosome 4q13.2, resulting in the complete loss of a copy of the GNRHR gene. As GNRHR is known to be responsible for an autosomal recessive form of HH, we checked the status of the undeleted allele and we found the Q106R substitution. In conclusion, the results of our cytogenetic and molecular analyses have allowed us to clarify the etiology of the patient's condition.
    Gynecological Endocrinology 11/2015; DOI:10.3109/09513590.2015.1106472
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    ABSTRACT: Currently the significant part of reproductive disorders such as refractory pregnancy loss (RPL), infertility, unsuccessful in vitro fertilization (IVF) are thought to be connected with different genetic factors. One of the main hereditary risk factors for obstetrical pathology development is the presence of polymorph alleles in several genes of folic acid cycle. The present study is dedicated to investigation of the effect of folic acid cycle polymorph variants MTHFR C677 T, MTR A2756G and MTRR A66G on the RPL development and unsuccessful IVF. The samples of peripheral blood of 138 women were tested and showed a statistically significant increase of pathologic genetic alleles of MTRR A66G and MTHFR C677T frequency in two groups of patients with reproductive disorders, i.e. RPL and IVF, versus the control group. Also the advantage of simultaneous analysis of three folic cycle genetic polymorphisms at once in women with reproductive function disorder was demonstrated in comparison with the analysis of isolated polymorphism MTHFR C677T. The combination of polymorph alleles has a significant influence on the pathology development and by many times increases the risk of RPL development and unsuccessful IVF.
    Gynecological Endocrinology 10/2015; 31(sup1):34-38. DOI:10.3109/09513590.2015.1086504
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    ABSTRACT: Purpose: To evaluate the aneuploidy rates of 13, 18, and 21 and the X and Y chromosomes in embryos from patients with morphologically normal oocytes and different oocyte dysmorphisms.Methods: This prospective cohort study included 84 patients treated with in vitro fertilization (IVF) at a single academic center. The patients were divided into the following three groups: group 1 - women with cytoplasmic dysmorphisms (n = 28), group 2 - women with extracytoplasmic dysmorphisms (n = 28), and group 3 - women with morphologically normal oocytes (n = 28). One blastomere from each embryo was analyzed for aneuploidies of chromosomes 13, 18, 21, X, and Y.Results: The highest prevalence of aneuploid embryos was observed in the group 1 (68.4%) followed by the group 2 (38.9%) and the group 3 (31.3%) (p < 0.0001). The adjusted OR for receiving an aneuploid embryo in the case of cytoplasmic dysmorphism was 3.6 (95% CI = 1.8; 7.2), in the case of extracytoplasmic dysmorphisms - 1.3 (95% CI = 0.7; 2.1).Conclusions: Women with morphological oocyte abnormalities are at risk for developing aneuploid embryos during IVF cycles. We recommend that woman with cytoplasmic oocyte dysmorphisms receive additional genetic counseling to define the indications for the genetic screening of embryos.
    Gynecological Endocrinology 10/2015; 31(sup1):61-64. DOI:10.3109/09513590.2015.1086511
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    ABSTRACT: For evaluating the effectiveness of intrauterine ultrasonic cavitational irrigation to restore the endometrium in women after pregnancy regression in the first trimester, 70 patients were randomly divided into two groups: group 1 - 38 patients, who received in combination therapy the intrauterine ultrasonic cavitation irrigation, and group 2 - 32 patients, in which treatment is not carried out by intrauterine irrigation. Intrauterine cavitation irrigation was carried out on the third day after regressing pregnancy interruption by unit "Fotek AK100" (five treatments for 3-5 min each). Immunohistochemical study of the endometrium, taken by pipelle-biopsy, was carried out at 7-10 d of the next menstrual cycle. ERα expression in endometrial glands in the group 1 was 188.54 ± 1.97, and group 2 was 177.01 ± 5.29 (p < 0.05). Stromal ERα demonstrated no significant differences in observation group, but they were below the reference values. Stromal PR expression in group 1 was 159.09 ± 4.82, whereas group 2 showed 143.01 ± 8.19 (p < 0.05); in the glands 196.18 ± 1.94 in the group 1, 181.66 ± 3.18 in the group 2 (p < 0.01). Ki67 expression in the glands was 145.63 ± 5.43 in group 1, 168.33 ± 14.59 in group 2; the control values 132.51 ± 4.25 (p < 0.01). Intrauterine ultrasonic cavitational irrigation after pregnancy regression is an effective rehabilitation technology of endometrial receptive area.
    Gynecological Endocrinology 10/2015; 31(sup1):27-30. DOI:10.3109/09513590.2015.1085198
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    ABSTRACT: Endometrial receptivity formation in in vitro fertilization (IVF) cycles was assessed both on molecular level: leukemia-inhibitory factor (LIF), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), granulocyte macrophage colony stimulating growth factor (GM-CSF) together with hemodynamic characteristics of uterine (Ua) arteries.Aim: Aim of study was to working out an endometrial receptivity evaluation-based prognostic model for IVF efficacy in examined patients.Materials and methods: A total of 97 infertility patients in IVF cycles enrolled in the study. Two groups were formed, retrospectively. Group I included 50 women with ultrasound-confirmed pregnancy (51.55%), while the second one embraced 47 women with failed pregnancy. Within the pre-supposed "window of implantation" (WOI) in the preceding IVF cycle, endometrial biopsy was done, succeeded by immunohistochemical assessment of LIF, VEGF and TGF-β1 expression in endometrial samples. The VEGF, GM-CSF and TGF-β1 content in the cervical mucus (CM) was measured by multiplex analysis on transvaginal puncture (TVP) and embryo transfer (ET) day. Hemodynamic characteristics (systolic/diastolic rate, S/D), resistance index (RI) and pulsation index (PI) of Ua arteries on the 2nd-3rd day of menstrual cycle, ovulation triggering (OT) and ET day were assessed.Results: Based on logistic regression analysis, it was found that LIF expression in endometrial epithelium obtained on WOI period of the preceding IVF cycle; VEGF content in the CM on the TVP day, S/D rate and RI of spiral arteries on the OT day are of significant importance in endometrial receptivity formation. Built math model allows high accuracy (85.6%) prediction for pregnancy achieved through IVF by means of applying the suggested parameters.
    Gynecological Endocrinology 10/2015; 31(sup1):74-78. DOI:10.3109/09513590.2015.1086514
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    ABSTRACT: Aim: Uterine myoma (UM) is the most common benign tumor of the uterus and is found in 20-40% of women of reproductive age, thus significantly reducing the reproductive function of women. UM is still treated surgically, and is the most common cause of hysterectomy.Methods: The study included 234 patients at the age of 29-45 years, who had UM, who have been treated by the drug group of selective progesterone receptor modulators (SPRM) of ulipristala acetate 5 mg for three months. Women were scheduled for surgery.Results: One hundred and forty-one (60.3%) of women had amenorrhea in 7-9 days. A clear reduction of anemia appeared after the treatment (mild degree - 108 (46.2%) women, 126 (53.8%) of women had a normal level of hemoglobin, p > 0.05).The mean value of the uterine size reduction was 30.7% (min - 8%, from 425 to 391 cm3, maximum - 78%, from 1282 to 282 cm3); MM - 27.8% (min 12%, from 285 to 251 cm3, max 55%, from 949 to 427 cm3). In 54 (23.1%) women size of the uterus and fibroids has not changed. Two hundred and sixteen (92.3%) patients were successfully performed laparoscopy, myomectomy. Eighteen (7.7%) patients avoided surgery after treatment, p > 0.05.Conclusions: An innovative approach in the use of ulipristala acetate led to a significant regression of the UM, which allowed for the surgical treatment with a minimal impact on the uterus, improving the reproductive prognosis.
    Gynecological Endocrinology 10/2015; 31(sup1):22-26. DOI:10.3109/09513590.2015.1085197
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    ABSTRACT: A 31-year-old woman with oligomenorrhea and primary infertility consulted for evaluation. A clinical investigation, sonographic imaging of the reproductive organs, and an assessment of endogenous hormone production were performed. During the initial visit, the ultrasound identified a "pseudogestational sac" (i.e. fluid [blood or secretions] in the uterine cavity Pregnancy was excluded by serum beta-HCG assessment, and after 3 weeks, spontaneous menstruation occurred. Serum follicle-stimulating hormone, AMH, and inhibin B levels confirmed premature ovarian insufficiency (POI). High-resolution chromosomal evaluation identified normal 46XX karyotype with double satellites on chromosome 15 (46XX, 15 pss). Two months later, our patient presented with typical symptoms of hypoestrogenism: hot flushes, night sweats, and dyspareunia. Chromosome 15 with double satellites was not considered to be clinically significant. No cases of POI in women with karyotype 46XX 15pss have been reported. By reporting a case of POI in an infertile woman with double satellites on the short arm of chromosome 15 (15pss), we consider that autosomal chromosomes polymorphism may have clinical significance, and we recommend that the genetic cause of POI be investigated more seriously.
    Gynecological Endocrinology 10/2015; 31(sup1):83-85. DOI:10.3109/09513590.2015.1086516
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    ABSTRACT: Background: Elevated antibody titers to Chlamydia trachomatis are detected in up to 70% of women with tubal factor infertility (TFI). In order to evaluate the influence of past chlamydial infection on the results of IVF treatment, a prospective cohort study was performed.Materials and methods: A total of 242 women with TFI were enrolled in the study. Serum samples (n = 242) and follicular fluid (n = 197) were analyzed using enzyme-linked immunosorbent assay for anti-C. trachomatis IgG, IgA, IgM and anti-chlamydial heat shock protein 60 kDa IgG.Results: "Poor response" to ovarian stimulation was two times more frequent in seropositive subjects (22.9% versus 13.3%, p = 0.039). Seropositive and seronegative women had similar IVF outcomes, expressed by clinical pregnancy (20.5% versus 25.0%), life birth (13.1% versus 20.0%) and miscarriage rates (36.0% versus 16.7%, p = 0.092). Incidence of missed abortion after IVF was higher in women with previous exposure to C. trachomatis (28.0%) as compared to those without antibodies (3.3%), p = 0.018.Conclusions: Anti-chlamydial antibody detection is not related to oocyte maturity, embryo quality, pregnancy and life birth rates. However, past chlamydial infection in TFI patients is associated with decreased IVF success: "poor response" to ovarian stimulation and missed abortion rate.
    Gynecological Endocrinology 10/2015; 31(sup1):69-73. DOI:10.3109/09513590.2015.1086513
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    ABSTRACT: The most probable cause of an anembryonic gestation is an abnormal karyotype. The analysis of 59 cases of missed abortion with anembrionia prior to 12 weeks of gestation after spontaneous conception and the assisted reproductive technologies (ART) was carried out. Patients were divided into two groups: those pregnant after natural conception and those with pregnancies after the ART programs. Upon embryoscopy and direct chorion biopsy, samples were sent for karyotyping. High frequency of normal karyotypes of chorion was found: 28.6% and 44.7%, respectively.
    Gynecological Endocrinology 10/2015; 31(sup1):58-60. DOI:10.3109/09513590.2015.1086510
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    ABSTRACT: Objective: To estimate the impact of quantitative parameters such as number of retrieved oocytes, number of transferred embryos and availability of surplus embryos for cryopreservation on clinical pregnancies in assisted reproductive technology (ART).Design: We used the database of fertility clinic on in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment cycles from year 2000 to 2010. Follicular fluids containing oocyte-cumulus complexes were recovered by a single lumen follicle aspiration needle, and IVF or ICSI procedure was used depending on infertility indications. Fertilization determination was performed on the second day. Zygotes were transferred into fresh medium and cultivated until the embryo transfer procedure. According to morphological criteria, the best quality embryos were transferred into uterus on the second or third day. Surplus embryos were frozen by slow freezing or by vitrification. We evaluated only clinical pregnancies that were diagnosed by ultrasonography.Patients: We allocated all 1161 women cohort into three age groups: 671 women were <35; 397 were 35-40 years old and 93 women were >40. Indications for IVF treatment were as follows: mechanical factor (436 cases), male infertility (361 cases), idiopathic infertility (129 cases), endometriosis (78 cases), immunological infertility (14 cases), anovulation (28 cases), and other indications (28 cases). There were no data about the cause of infertility of 87 patients. The stimulation protocol was composed from gonadotropin hormone stimulation with antagonist or agonist supplementation. The triggering of luteinizing hormone (LH) surge was performed by recombinant human chorionic gonadotropin (hCG). The clinical pregnancy rates were: 42.2% (283/671) for women <35, 31.2% (124/397) for women 35-40-year-old and 16.1% (15/93) for women >40.Interventions: All materials and methods that we used were based on results from our daily practice in IVF clinic and have no experimental design.Main outcome measures: We evaluated clinical pregnancies in terms of the number of obtained oocytes, the amount of transferred embryos and the availability of surplus embryos for freezing. The number of retrieved oocytes was divided as follows: 1-5 (group I); 6-10 (group II); ≥11 (group III). The number of transferred embryos was from 1 to 3. Cases at which cryopreservation of embryos was not performed were evaluated as well.Results: For women <35 and 35-40 years old, the highest percentage of pregnancies was achieved when 11 and more oocytes were obtained. Differences in women under 35 between groups were statistically significant. Statistically significant differences in clinical pregnancies depend on the number of transferred embryos in the age groups of <35 and 35-40. Women <35 and 35-40 years old, with the availability of surplus embryos for freezing, had better chances for pregnancy compared with women, who had no excess embryos for freezing.Conclusions: The number of obtained oocytes, the number of transferred embryos and the availability of surplus embryos for freezing may serve as predictors of pregnancy rates in ART.
    Gynecological Endocrinology 10/2015; 31(sup1):46-50. DOI:10.3109/09513590.2015.1086507
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    ABSTRACT: This study was undertaken to compare the concentrations of pro- and anti-angiogenic growth factors, nitric oxide (NO) stable metabolites in maternal serum and embryonic left ventricular (LV) isovolumic relaxation time (IRT, ms) during the first trimester in two groups of women: with pregnancy conceived by assisted reproductive technologies (ART, n = 39) and normally conceived (control group, n = 68) pregnancy. The concentration of vasoconstrictor endothelin 1 was 45.5 times more in ART than in control group. On the contrary, the concentrations of NO stable metabolites in ART were 1.9 times less than in control women. The assessment of angiogenic suppressors in ART women demonstrates the decrease in s-endoglin concentration was 1.6 times and in soluble receptor to vascular endothelial growth factor concentration was 2.0 times in comparison with control group. There was a significant increase in LV IRT in ART embryos in comparison to control ones. These data suggest significant changes in pro- anti-angiogenic factors balance and increase in vascular impedance in ART-conceived embryos.
    Gynecological Endocrinology 10/2015; 31(sup1):31-33. DOI:10.3109/09513590.2015.1085199
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    ABSTRACT: To present results of autotransplantation of vitrified human ovarian tissue to thyroid cancer patient, who underwent radioiodine treatment, performed at Medical Radiological Research Center (MRRC). Cryopreservation of ovarian tissue is increasingly used in the multimodality treatment of cancer patients. The main purpose of ovarian tissue cryopreservation is to preserve the patient's fertility before gonadotoxic chemo- and radiotherapy. The first Russian case of orthotopic transplantation of ovarian tissue to the patient previously treated with radioactive iodine was performed at the MRRC in 2012. Monitoring changes in the ovarian reserve allowed us to assess the efficacy of the orthotopic transplantation. The results demonstrated the recovery of the patient's reproductive potential.
    Gynecological Endocrinology 10/2015; 31(sup1):91-92. DOI:10.3109/09513590.2015.1086518
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    ABSTRACT: So far there is no consensus on the optimal dosage of GnRH-a when using it as a trigger for final oocyte maturation in in vitro fertilization (IVF) cycles. We compared embryological characteristics in IVF-intra-cytoplasmic sperm injection (ICSI) cycles when applying triptorelin at a dose of 0.2 mg (test group 2), 0.5 mg (test group 3) and human chorionic gonadotropin (HCG) at a dose of 10 000 IU (test group 1). In group 1, the average number of oocytes per oocyte retrieval (11.7 ± 4.8) was lower in comparison with groups 2 and 3, which can be explained by the differences in the selection of the patients. The number of oocytes per retrieval in group 3 (20.2 ± 6.3) was significantly higher (p = 0.02) compared to group 2 (17.0 ± 6.2). The percentage of mature oocytes (MII) and fertilization rate did not differ between the groups. The rate of blastocyst formation in group 3 (71.9 ± 17.1%) was significantly higher (p = 0.02) in comparison with group 2 (57.9 ± 24%). We conclude that the application of triptorelin at a dose of 0.5 mg may be more effective for triggering final oocyte maturation in IVF cycles in comparison with the dose of 0.2 mg, due to the increase in the number of retrieved oocytes and the improved rate of the blastocyst formation.
    Gynecological Endocrinology 10/2015; 31(sup1):6-8. DOI:10.3109/09513590.2015.1085180
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    ABSTRACT: The assessment of oocyte quality in human in vitro fertilization (IVF) is in focus of intensive studies. Follicular fluid (FF) constitutes the major medium for the developing oocyte and therefore it is a perfect target to search for the biomarkers of female infertility. The objective of this study was to compare the amino acid (AA) profile of human FF and plasma (PL) (from 96 IVF patients) and to examine if the AA composition is related to oocyte quality, IVF results and womens infertility. In both biological fluids, Gln, Gly and Ala appeared as dominant AAs. Most of AAs are more abundant in PL; the exceptions are Glu, Thr, Ala and Gly, which are higher in FF and Gln, Arg and Phe, the contents of which are similar in both biological fluids. Ser in FF and Met and Phe in PL were detected as potential biomarkers as their content varied depending on the IVF outcome. Significant differences were also detected between the groups of different infertility reasons. Our results suggest that intra-follicular AAs might reflect the condition of the preovulatory follicle and together with PL, AAs can be used to characterize the infertility etiology and oocyte quality related to IVF outcome.
    Gynecological Endocrinology 10/2015; 31(sup1):9-17. DOI:10.3109/09513590.2015.1085186