European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies (Eur J Clin Chem Clin Biochem )

Publisher: Forum of European Clinical Chemistry Societies, Walter de Gruyter

Description

Discontinued - now European Journal of Clinical Investigation.

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  • ISSN
    0939-4974
  • OCLC
    23467023
  • Material type
    Periodical
  • Document type
    Journal / Magazine / Newspaper

Publisher details

Walter de Gruyter

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    • Author can archive a pre-print version
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    • Author cannot archive a post-print version
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    • 12 months embargo
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    • Pre-print and abstract on author’s personal website only
    • Publisher's version/PDF must be used
    • Publisher’s version on author’s personal website or open repository
    • Published source must be acknowledged
    • Institutional repositories may be allowed to include scanned version of articles not available in electronic format
    • Must link to publisher version or article’s DOI must be given
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    • NIH funded authors may submit their authors final version to PubMed Central for release 12 months after publication
  • Classification
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Publications in this journal

  • European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 01/1998; 35(12):939-40.
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    ABSTRACT: We have measured the bile acids in human serum as methyl ester-trimethylsilyl ethers by gas chromatography-mass spectrometry (GC-MS) using an electron ionization procedure. The overall method was validated and the detection limit (0.4 mumol/l), linearity (2-30 mumol/l), intra-day and inter-day precision, accuracy and recovery (96.2% for nor-23-deoxycholic acid as internal standard) were measured. Serum C24-bile acids profiles from 43 cholestatic patients were measured by GC-MS and by HPLC. The results obtained with the two methods were well correlated and the criteria for selecting either HPLC or GC-MS identified. The serum C24- and C27-bile acids and C29 dicarboxylic bile acid profiles for patients with generalized peroxisomal deficiencies, like Zellweger syndrome (n = 5), neonatal adrenoleukodystrophy (n = 1), infantile Refsum disease (n = 2) and from a single peroxisomal deficiency (n = 1) were also measured by GC-MS.
    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 01/1998; 35(12):919-22.
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    ABSTRACT: Type I collagen is the main type found in mineralized bone. Specific radioimmunoassay for the cross-linked carboxyterminal telopeptide of type I collagen allows assessing the degradation of type I collagen in serum samples. The aim of the present investigation was to determine the concentration of cross-linked carboxyterminal telopeptide of type I collagen in serum of dietary calcium and vitamin D-deficient rats, a good model disease of decreased formation and mineralization of bone matrix and excessive bone resorption. The studies were carried out on 20 young growing Wistar rats. Serum concentration of the cross-linked carboxyterminal telopeptide of type I collagen was analyzed by the Rat Telopeptide [125I]ICTP Radioimmunoassay Kit obtained from Orion Diagnostica (Finland). The data obtained from biochemical analysis showed increased concentration of the cross-linked carboxyterminal telopeptide of type I collagen in the serum of rats fed a low calcium and vitamin D-deficient diet after 14 days of the experiment. At the end of the experiment (day 21), the concentration of carboxyterminal telopeptide of type I collagen in serum was still elevated in these animals. In conclusion, dietary calcium and vitamin D-deficiency in rats produces hypocalcaemia together with the increased concentration of the cross-linked carboxyterminal telopeptide of type I collagen in serum.
    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 01/1998; 35(12):915-8.
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    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 01/1998; 35(12):937.
  • European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 01/1998; 35(12):941-2.
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    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 01/1998; 35(12):945-6.
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    ABSTRACT: More than 800 diagnostic laboratories situated throughout the Eur-Asian continent--from the Pacific Coast up to the North Sea littoral--were involved in a common survey of External Quality Assessment (EQA). It consisted of the simultaneous measurement of up to 30 analytes of 'general' clinical chemistry using the same batch of control material. The laboratories were associated in four EQA institutions: SKZL (The Netherlands), OQUASTA (Austria), SEKK (Czech Republic) and BKKSystem (Community of Independent States). The results demonstrated the feasibility of such a large-scale survey and provided a realistic idea about the state-of-the-art of laboratory diagnosis in these countries: Besides some local specific problems, such as poor quality of water or the forced use of reagents and calibrators from different sources, there are general problems hindering an efficient process of 'harmonization' in laboratory medicine, namely, the high methodological dispersion especially in the case of enzymes and of some organic analytes. At the same time there is a potential necessity for more concentrated implementation of internal quality assessment into the routine work of laboratories.
    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 01/1998; 35(12):927-35.
  • European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 01/1998; 35(12):943.
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    ABSTRACT: An animal (rat) model of gingival injury ("impaction") induced a gingival inflammatory reaction, which was characterized by a breakdown of gingival collagen and the elastic network, as well as a significant increase of gingival elastase. The present study was conducted to investigate whether ceramides, sphingolipids composed of sphingosine N-acyl-linked to fatty acids, a chemical structure with antielastase properties, could counteract the development of such an inflammatory process. The ceramides used in these experimental series were extracted from wheat and characterized. The main fatty acids were 16:0, 18:1, 18:2, and the sphingoid moiety was phytosphingosine. Inhibition of elastase by ceramides was demonstrated in vitro and the concentration necessary to inhibit 50% of elastase activity was 41 mg/l using the synthetic substrate methoxysuccinyl-alanine-alanine-proline-valine-p-nitroanilide (MeOSuc-AlaAlaProValpNA). However, this anti-elastase activity was not observed in vivo in our animal model of gingival inflammation. A glycosaminoglycan (Heparin), recognized as a potent inhibitor of elastase, was entrapped in ceramides. A local treatment of impacted gingivae by encapsulated heparin led to a dose-related decrease of the elastase level in gingival extracts. Encapsulation in ceramides potentiated the effect exerted by heparin alone. This inhibitory effect of encapsulated heparin on elastase suggested a vector effect of these amphipathic molecules.
    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 12/1997; 35(11):867-71.
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    ABSTRACT: Different results are usually observed when a quantity is measured in different specimens from the same individual obtained over a time span. For an individual, this variation is due to the imprecision of the measurement procedure, that is to say the metrological variability, as well as to the rhythmic and random fluctuations of the quantity value around a virtual homeostatic set point, that is to say the intra-individual biological variability. On the other hand, when studying the intra-individual biological variation of a quantity a mean value, the virtual homeostatic set point, is estimated for each individual participating in the study. The variation among these mean values is due to the inter-individual biological variability.
    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 12/1997; 35(11):845-52.
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    ABSTRACT: One hundred sera from intensive care patients, and 93 sera from endocrinological outpatients were used for a comparison between two automated assays for free triiodothyronine (Enzymun Test, and Elecsys 2010, both Boehringer Mannheim, Mannheim, Germany). In outpatients a good correlation between both methods was found (r = 0.932). In contrast, comparability between the two assays was poor in intensive care patients (r = 0.75, after exclusion of two outliers); significantly more values in the hypothyroid range were found with the Elecsys 2010 assay (n = 83, compared with n = 33 with the Enzymun Test; chi 2 test p = 0.001). We conclude that routine measurement of free triiodothyronine which has the theoretical advantage of quantifying the biologically active fraction of thyroid hormones may have methodological limitations in severely ill patients.
    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 12/1997; 35(11):873-5.
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    ABSTRACT: We have established reference intervals for healthy adults of serum thyrotropin, free thyroxine and free triiodothyronine using the AutoDELFIA (Wallac, Finland) automatic measuring device. The determination of reference intervals in a proper manner is costly, and many laboratories adopt reference ranges from the literature rather than determining them alone. This is the first report on reference values in thyroidology where this automatic system based on time-resolved fluorescence has been used. The reference intervals for thyrotropin, free thyroxine and free triiodothyronine were 0.6-4.3 mIU/l, 9.6-17.1 pmol/l and 4.3-7.5 pmol/l, respectively.
    European journal of clinical chemistry and clinical biochemistry: journal of the Forum of European Clinical Chemistry Societies 12/1997; 35(11):889-90.