Sensors and Actuators B Chemical (SENSOR ACTUAT B-CHEM )

Publisher: Elsevier

Description

Sensors & Actuators, B: Chemical is an interdisciplinary journal dedicated to covering research and development in the field of chemical sensors, actuators and microsystems. The scope of the journal encompasses, but is not restricted to, the following areas: Sensing principles and mechanisms New materials development (transducers and sensitive/recognition components) Fabrication technology Actuators Optical devices Electrochemical devices Mass-sensitive devices Gas sensors Biosensors Analytical microsystems Environmental, process control and biomedical applications Signal processing Sensor and sensor-array chemometrics uTAS - Micro Total Analysis Systems Microsystems for the generation, handling and analysis of (bio)chemical information The special section of Sensors & Actuators, B: Chemical on uTAS is dedicated to contributions concerning miniaturised systems for (bio)chemical synthesis and analysis, also comprising work on Bio-MEMS, Lab-on-a-chip, biochips and microfluidics. Topics covered by the uTAS section include: Physics and chemistry of microfluidics Microfabrication technology for uTAS Analytical chemical aspects Detectors, sensors, arrays for uTAS uTAS applications DNA analysis Microinstrumentation Microsystems for combinatorial chemistry

  • Impact factor
    3.84
    Hide impact factor history
     
    Impact factor
  • 5-year impact
    3.67
  • Cited half-life
    5.80
  • Immediacy index
    0.53
  • Eigenfactor
    0.05
  • Article influence
    0.76
  • Website
    Sensors and Actuators B: Chemical website
  • Other titles
    TAS., Sensors and actuators., Chemical
  • ISSN
    0925-4005
  • OCLC
    39224654
  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Elsevier

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print allowed on any website or open access repository
    • Voluntary deposit by author of authors post-print allowed on authors' personal website, arXiv.org or institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate
    • Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists.
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months .
    • Set statement to accompany deposit
    • Published source must be acknowledged
    • Must link to journal home page or articles' DOI
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • NIH Authors articles will be submitted to PubMed Central after 12 months
    • Publisher last contacted on 18/10/2013
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: This paper presents a fast and sensitive approach for simultaneous electrochemical determination of lead and copper based on a commercial screen-printed gold electrode (SPGE) with gold nanoparticles (GNPs) modification. The influence of activation in sulfuric acid was discussed that the active surface area of SPGE was 1.65 times that of SPGE without activation. Deposition time for GNPs modification was optimized to be 150 s with a higher electrochemical response. Significantly enhanced electrochemical performance was observed in both cyclic voltammetry (CV) and square wave anodic stripping voltammetry (SWASV) compared to that of merely activated SPGE. To detect lead and copper qualitatively and quantitatively, deposition potential and deposition time were respectively optimized to be −0.5 V and 120 s. The GNPs modified SPGE presented a sensitivity of 0.154 μA/ppb and 0.084 μA/ppb towards lead and copper with a correlation coefficient of 0.9792 and 0.9896. GNPs modified SPGE revealed a wide detection range of lead from 20 ppb to 200 ppb with a limit of detection of 2.2 ppb and copper from 20 ppb to 300 ppb with a limit of detection of 1.6 ppb. Reproducibility and consistency of different GNPs modified SPGEs were investigated to verify the performance. The electrochemical behaviour of integrated pseudo-reference and counter electrode was compared with that of commercial electrodes in detail. The results exhibited a reliable approach for lead and copper detection simultaneously with high sensitivity, linearity and low limit of detection.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: This paper reports the response behavior at room temperature of a composite sensor composed of single-walled nanotubes (SWCNTs) and polyaniline, to the nerve agent simulant gas dimethyl-methyl-phosphonate (DMMP), a typical Sarin simulant. The SWCNT–polyaniline composite was synthesized to obtain high-quality composites with good uniformity. The composites were drop-cast onto an oxidized Si substrate patterned with Pd electrodes. SWCNT–polyaniline composite sensors exhibited clear, sharp response curves for DMMP in air at room temperature, even at minuscule concentrations. The response and response time were 27.1% and 5.5 s, respectively, at 10 ppm DMMP, representing a significant improvement over the pure SWCNT network sensors previously reported. These results indicate that SWCNT–polyaniline composite sensors can be ideal DMMP sensors, operating at room temperature with high response, fast response time, and excellent reproducibility.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: The synthesis of micro-/nanostructures with desired structure and morphology is of great technological and scientific value owing to their superior physical and chemical properties. In this paper, high uniformity ZnSn(OH)6 (ZHS) with novel hollow polyhedral structures were prepared by a facile self-templating method. The structures and morphologies of ZHS samples were investigated by several techniques, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). On the basis of those characterizations, it was found that the solid polyhedras of ZHS were formed firstly by the co-precipitation and then the solid polyhedras converted into hollow ones by an inward etching process with the help of OH−. The diameter of the ZHS hollow polyhedra was around 0.8–1 μm and the thickness was about 150–200 nm. Owing to the well-shaped polyhedral and hollow structure, the sensor based on ZHS hollow polyhedras exhibited high response and good selectivity to ethanol gas, indicating that the ZHS hollow polyhedras are highly promising for applications as ethanol sensors.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: We investigate an application case study of a phase sensitive surface plasmon resonance (SPR) biosensor based on Mach–Zehnder configuration for efficient targeted drug screening, where calculating reaction kinetic constants, inhibition effect and cytotoxicity analysis are three key factors in the evaluation. As a typical targeted drug, cetuximab is selected in the measurements assisted by the phase SPR biosensor with a sensitivity of 10−6 in terms of refractive index unit (RIU) and stability of 6 × 10−7 RIU in 80 min. The reaction kinetic constants of cetuximab binding to epidermal growth factor receptor (EGFR) are found as: kd (dissociation constant) = 1.75 ± 0.29 × 10−3 S−1, kD (equilibrium dissociation constant) = 4.19 ± 0.58 nM. The results of inhibition effect analysis show that cetuximab can block EGFR binding to its two ligands, epidermal growth factor (EGF) and EGFR-transforming growth factor α (TGF-α). This effect has been tested in three cell lines of lung adenocarcinoma, colon cancer and breast cancer. Comparing to other conventional methods, we find that the phase SPR biosensor can determine the cell sensitivity to cetuximab in just 4 h. As a label-free, real-time, high sensitivity and stability biosensor, the phase SPR biosensor is a potential optical technique for targeted drug screening and analysis of cell resistance to drugs with comparative advantages.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: The use of self-assembled organic monolayers as the insulator in light-addressable potentiometric sensors (LAPS) is shown for the first time. Silicon on sapphire (SOS) substrates were modified with 1-octadecene or undecylenic acid. Experiments with a photoresist pattern as the model system showed the same good spatial resolution that was previously obtained with a conventional insulator on SOS, but also a significant improvement in the photocurrent contrast and therefore the sensitivity of LAPS. Surface potential imaging was validated by studying micropatterns of poly(allylamine hydrochloride) (PAH) and DNA on a PAH template using LAPS. The results showed that self-assembled organic monolayers provide an excellent, reproducible, ultrathin insulator for LAPS, which can be readily functionalized and used for high-sensitivity LAPS imaging and sensing.
    Sensors and Actuators B Chemical 03/2015; 209.
  • [Show abstract] [Hide abstract]
    ABSTRACT: A simply prepared, low-cost, and sensitive electrochemically activated glassy carbon electrode (GCEa) modified with absorbed chitosan (CHIT) film for quantification of tryptophan (Trp) is reported. Combination of cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) techniques were used for characterization of the electro-oxidation of the amino acid and the electro-analytical performance of the CHIT-modified electrode. The electro-oxidation of Trp involves an irreversible two-electron and two-proton transfer process in both bare and modified electrodes, but the adsorption of CHIT as a polycation onto GCEa produces a ≈4-fold increase of the oxidation current of Trp without changing both the oxidation potential and the heterogeneous reaction rate constant, suggesting that the biopolymer behaves as a proton relay species, probably due to hydrogen bonding/proton acceptor capability of hydroxyl and ether groups of CHIT. Finally, the electro-analytical features of the CHIT-modified electrode as Trp sensor were also evaluated, obtaining a linear response range up to 130 μM Trp, sensitivity of 0.68 μA μM−1 and detection limit of 0.04 μM Trp, with almost no interference of other amino acids.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: Lanthanum oxyfluoride powders (LaOF) doped with Eu3+ were successfully synthesized using combustion synthesis technique. Through this facile fabrication method, the most effective dopant concentration was found. Luminescent properties of LaOF:Eu3+ powders were investigated by collecting the fluorescence spectral and temporal profiles. The samples illuminated with ultraviolet (λ = 256 nm) and blue (λ = 465 nm) radiation showed the characteristic red fluorescence corresponding to 4f intraband 5D0 → 7FJ transitions of Eu3+. The fluorescence quantum efficiencies were estimated from the experimental data using Judd–Ofelt theory. The fluorescence quenching with temperature was investigated in the sample with the highest fluorescence quantum efficiency. Our results indicate that this phosphor has potential application in optical thermometry. It is assumed that this phenomenon occurs due to thermal activation of nonradiative energy transfer between europium 5D2 state and charge transfer states (CTS) of the host. The energy bandgap and the energy transfer rate between 5D2 and CTS were estimated by analyzing the dynamics of the fluorescence of transition 5D0 → 7F2 as a function of temperature. The activation energy for thermal quenching of the fluorescence was found to be the 5D2 → CTS energy bandgap.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: A miniaturized, high-sensitive, and high-precision gas sensor for the measurement of methane concentration was realized in a cryptophane E infiltrated photonic crystal (PC) microcavity, by combing selective adsorption property of cryptophane E to methane and excellent resonant property of PC microcavity. The concentration variation of methane would change the refractive index (RI) of cryptophane E that infiltrated in defected holes of PC microcavity, and then induce a shift in resonant wavelength, allowing precision measurement of methane concentration. Simulation results of PC microcavity showed that the RI sensitivity of 363.8 nm/RIU, quality factor of 12,923, and transmission of 0.9122 could be obtained by increasing the radii of defected holes, which does not require sophisticate geometrical adjustment and high-precision requirement for fabrication. However, its resonant property is comparable to other subtle-tuned PC microcavities. Besides, the designed methane sensor is only in response to methane, which can prevent the interrupt of other gases and enhance the measurement accuracy. Benefiting from the high RI sensitivity and high quality factor of the microcavity, a theoretical detection limit of 697.35 ppm for methane sensing can be achieved.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: This paper describes the development of a paper-based microfluidic device that detects long DNA amplicons on the basis of hybridization reactions with a covalently immobilized DNA probe and biotin-labeled signal DNA strands, and chemiluminescent (CL) reactions catalyzed by a horseradish peroxidase (HRP)-streptavidin conjugate. The paper-based microfluidic CL biosensor is developed for detection of 198-bp DNA fragments obtained by PCR amplification of the Listeria monocytogenes hlyA gene, where the CL intensity is detected by a simple, inexpensive CCD. To our knowledge, the combined use of the CCD sensing and paper-based microfluidic CL detection is first proposed here. The paper-based device includes wax-screen printed channels, and further explores origami-type folds to create an easy-to-operate valve that makes it possible to successively wash the detection zone in-between hybridization steps. Compared with other paper-based wax-screen-printing methods, the proposed method is faster and needs lower heating temperature. In our DNA biosensor, CL signals generated using a HRP-luminol-H2O2 system are heightened with p-iodine phenol (PIP) and detected with a CCD system. Under optical conditions, a linear range of 1.94 × 10−1 pmol/L to 1.94 × 104 pmol/L is achieved and the limit of detection is found to be 6.3 × 10−2 pmol/L. And, this detection limit is 3–5 orders of magnitude lower than those obtained from other CCD-based microfluidic CL DNA assays. The results show that the proposed integration of paper-based microfluidics, CL method and CCD sensing offers great promises in providing a highly-sensitive, reliable and cost-effective solution for gene biosensing applications.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: Infection can lead to severe complications during wound healing. We have developed an electrochemical sensor for fast and simple detection of wound infection based on the quantification of myeloperoxidase activity as a marker for infection. Applicability of the enzyme was confirmed with a correlation study with silver standard wound diagnostics. Significant higher enzyme activities comparing non infected and infected wound fluids were determined (P = 0.01). To eliminate supplemental substrate addition, the chlorination activity of the enzyme – the formation of hypochlorous acid (HOCl) from chloride and hydrogen peroxide – was investigated in different wound fluids and correlated with the peroxidation activity measurements. Significant activity differences were likewise obtained (P = 0.01). Based on this we constructed an electrochemical hydrogen peroxide sensor system for the quantification of chlorination activity in wound fluids. Furthermore, immobilized glucose oxidase was integrated into the system to provide hydrogen peroxide required by myeloperoxidase. Infected wound fluids were indeed identified by using the sensor system quantifying the consumption of hydrogen peroxide consumed by myeloperoxidase. Thereby, immobilized glucose oxidase was shown to produce enough hydrogen peroxide for the myeloperoxidase reaction from glucose present in wound fluids. There is a strong need for a simple but effective sensor system to determine infections in wounds. This sensor measuring hydrogen peroxide consumption could effectively identify infected wound fluids based on the myeloperoxidase activity.
    Sensors and Actuators B Chemical 03/2015; 209:265-274.
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    ABSTRACT: Mercury is widely used in industry and easily leads to environmental pollution if discharged without proper waste control. On-site visual detection of mercuric ion is thus in demand and remains a great challenge. We herein demonstrate a detection method for rapid and on-site visualization of mercuric ion on the basis of integrating green-emissive imidazol fluorophore (PIPT) and red-emissive quantum dots (QDs) embedded in silica nanospheres. Such a nanohybrid fluorescent probe exhibits dual emissions at 500 nm and 657 nm under a single excitation wavelength. Due to the high chelating ability of PIPT toward mercuric ion, the fluorescence of PIPT could be selectively quenched while the fluorescence of the QDs is almost constant, leading to a distinct fluorescence color change from green to red, which can be applied for the rapid visualization of mercuric ion. This ratiometric fluorescent approach shows high sensitivity, high selectivity and anti-interference toward mercury against other metal ions. The detection limit of this method is determined to be 6.5 nM. The probe has also been successfully demonstrated for the determination of mercuric ion in real water samples.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: The acetone sensors based on In-doped WO3 nanostructures have been investigated for different operating temperatures and test gas concentrations. The sensor based on 1.5 at% In-doped WO3 nanostructure shows maximum response (∼93%) at the operating temperature of 250 °C for 50 ppm concentration of acetone vapor in air, and also exhibits fast response/recovery time. The XRD results confirm the monoclinic phase of the as-prepared WO3 nanostructures. TEM images reveal that there is an enhancement in the particle size upon indium doping, relative to the undoped WO3. The SEM images exhibit different surface morphology, whereas the EDX spectra confirm the presence of indium ions into the WO3 lattice. Raman spectroscopy studies also confirm the monoclinic structure of the undoped and In-doped WO3 samples.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: A chemosensor 3-[(2-hydroxybenzylidene)-amino]-1H-pyridin-2-one (HL) for multi-ions was synthesized and characterized by single-crystal X-ray diffraction. HL is a turn-on fluorescence chemosensor for Al3+, F−, and CN− ions in DMSO. F− and CN− anions could be further distinguished by the ratiometric absorption spectrometry method. Job plot and 1H NMR data showed that the binding stoichiometries of HL with Al3+, F−, or CN− all were 1:1. Further observations of 1H NMR titration and ESI-MS showed that the possible fluorescent species of Al3+ with HL was [AlL(OH)(DMSO)2]+ in DMSO. The spectroscopic observations of the Al(III) complex showed that the two oxygen atoms and one imine nitrogen atom of HL were coordinated to the Al(III) ion. While the crystal structure of the Ni(II)-L complex confirmed the tridentate coordination mode of HL in the complexes. The experimental results revealed that HL and F− ion formed hydrogen bond in DMSO, while CN− attacked the carbon atom at –CN of HL to undergo a nucleophilic addition. The theoretical calculations confirmed that HL showed very weak fluorescence because of the excited-state intramolecular proton transfer (ESIPT). The turn-on sensing of HL to Al3+, F−, and CN− ions arose from the inhibition of ESIPT. MTT tests showed that HL was low toxic to cells. Also, HL could probe intracellular Al3+ and F− ions by bioimaging.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: An IrOx modified electrode was characterized and proposed as an amperometric sensor for the detection of semicarbazide using cyclic voltammetry, chronoamperometry and amperometry techniques. The modified electrode was characterized as sensing probe in both acid and alkaline medium toward the electrocatalytic oxidation and detection of semicarbazide. A liquid chromatography approach based on the strong cation exchange mode (LC-SCX column) was used in acid conditions for the separation and analysis of semicarbazide in a synthetic mixture. Operating under a constant applied potential of 1.1 V vs. Ag/AgCl and using HClO4 as carrier electrolyte, the limit of detection (LOD) is attested at level of 0.1 μM (i.e., 7.5 μg L−1), while an excellent precision and temporal stability of the amperometric signal, was observed. The linear ranges spanning over three order of magnitude of the detection limit with a correlation coefficients higher than 0.995.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: We developed a capacitance sensor with parallel plate geometry to measure epithermal growth factor receptor (EGFR) expression levels on cell membrane in real-time. We first proved correlations between capacitance changes and cell numbers settled down between electrodes, and then observed capacitance changes elicited by interactions between EGFR on membrane and EGF proteins in real time. Consequently, we confirmed that the EGFR expression levels of varied typed cells were successfully quantified. This approach can effectively distinguish differences of EGFR levels of cancer cells and normal cells in real-time. Also, up to 600% sensitivity enhancements and around 2.2 h on average sensing time saving were achieved by using the capacitance sensor over a conventional immunoassay technique. Such a capacitance biosensor can be extended to broad fields where the receptor–antibody reactions, the receptor–virus reactions or DNA hybridizations are involved.
    Sensors and Actuators B Chemical 03/2015; 209.
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    ABSTRACT: Novel use of SC-ISEs based on PANI nanoparticles as transducer layer in pharmaceutical analysis.•The inclusion of PANI nanoparticles added more stability to the electrical signal due to their excellent electronic and chemical properties.•The fast ion-to-electron transduction allows obtaining short response times.•The hydrophobic behavior of PANI nanoparticles avoids the formation of thin water layers at the electrode/membrane interface.•Good piece to piece reproducibility allow its future use as real-time analyzer in PAT applications.
    Sensors and Actuators B Chemical 03/2015; 208.
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    ABSTRACT: In the field of blood transfusion, there is a need to improve the bedside pre-transfusion ABO compatibility test. In France, this test is mandatory for each red cell concentrates transfusion. It is performed manually and serious transfusion accidents still occur, principally due to human errors. Therefore, an automated ABO compatibility test is required. Works concerning objective interpretation of ABO compatibility test have been reported but the proposed techniques cannot be easily translated to the patient's bedside. We propose a prototype device which demonstrates the easy use of biochip technology to perform this test: it contains a fluidic system, biochips (two to test the patient and two to test the red cell concentrates) and an optical absorbance detection module. When blood is applied to the biochips, red blood cells are trapped onto the surface if antigens and antibodies are complementary (positive chips). If they are not complementary, very little red blood cells are adsorbed (negative chips). Percentages of surface covered with red blood cells in negative biochips are 2% ± 2 (red cell concentrates) and 1% ± 1 (whole blood). This proves that the fluidic configuration leads to an optimum control of fluids flows with little retention of red blood cells in the circuitry. These percentages increase to 96% ± 3 and 82% ± 8 for red cell concentrates and whole blood respectively. This demonstrates a strong and specific immunocapture of red blood cells on positive chips. Furthermore, optical detection proves to be efficient at critical red blood cells concentrations (108 C/mL) and absorbance strongly correlates to the percentage of red blood cells captured by antibodies.
    Sensors and Actuators B Chemical 03/2015; 208.