Restorative neurology and neuroscience Journal Impact Factor & Information

Publisher: IOS Press

Journal description

The journal is interdisciplinary. Papers relating the plasticity and response of the nervous system to accidental of experimental injuries or in-terventions, transplantation, neurodegenerative disorders, and experimental strategies to improve regeneration or functional recovery will be considered for publication. Experimental and clinical research papers adopting fresh conceptual approaches are encouraged. The overriding criteria for publication are novelty, significant experimental or clinical relevance, and interest to a multidisciplinary audience. Experiments on unanesthetized animals should conform with the standards for the use of laboratory animals as established by the Institute of Laboratory Animal Resources, US National Academy of Sciences. Experiments in which paralytic agents are used must be justified. Patient identity should be concealed. All manuscripts are sent out for blind "peer review" to editorial board members or outside reviewers.

Current impact factor: 2.49

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 2.49
2013 Impact Factor 4.179
2012 Impact Factor 2.929
2011 Impact Factor 2.51
2010 Impact Factor 3.349
2009 Impact Factor 3.714
2008 Impact Factor 1.978
2007 Impact Factor 1.415
2006 Impact Factor 2.862
2005 Impact Factor 1.825
2004 Impact Factor 1.412
2003 Impact Factor 1.623
2002 Impact Factor 0.836
2001 Impact Factor 0.678
2000 Impact Factor 0.911
1999 Impact Factor 0.5
1998 Impact Factor 1.196
1997 Impact Factor 1.117
1996 Impact Factor 0.56
1995 Impact Factor 0.915
1994 Impact Factor 1.435
1993 Impact Factor 2.609

Impact factor over time

Impact factor

Additional details

5-year impact 3.22
Cited half-life 5.90
Immediacy index 0.89
Eigenfactor 0.00
Article influence 0.95
Website Restorative Neurology and Neuroscience website
Other titles Restorative neurology and neuroscience (Online)
ISSN 0922-6028
OCLC 47094437
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

IOS Press

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • On author's personal website, institutional website or funder's website, including PubMed Central
    • Non-commercial use only
    • Publisher copyright and source must be acknowledged
    • Author's version can be used
    • Publisher's pdf can be used on institutional website, company website or funding agency website for a fee
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: The co-occurrence of autobiographical memory (AM) and episodic future thinking (EFT) impairment has been documented in relapsing-remitting multiple sclerosis (RR-MS) patients. On these bases, we aimed at probing the efficacy of a mental visual imagery (MVI)-based facilitation programme on AM and EFT functioning in the context of a randomised-controlled trial study in RR-MS patients. Methods: Using the Autobiographical Interview (AI), 40 patients presenting with an AM/EFT impairment were randomly assigned in three groups: (i) the experimental (n = 17), who followed the MVI programme, (ii) the verbal control (n = 10), who followed a sham verbal programme, and (iii) the stability groups (n = 13), who underwent the AM/EFT test twice, with no intervention in between. Results: AI's second assessment scores showed a significant improvement of AM and EFT performance only for the experimental group, with a long-term robustness of treatment benefits. Conclusions: The control and stability groups' results ruled out nursing and test learning effects as explanations of AM/EFT improvement. These benefits were corroborated by the patients' comments, which indicated an effective MVI strategy transfer to daily life. Our results suggest that the MVI programme tackles a common cognitive process of scene construction present in AM and EFT.
    Restorative neurology and neuroscience 08/2015; DOI:10.3233/RNN-140461
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    ABSTRACT: Abstract Purpose: Characterization of sedative, possible anticonvulsant, and protective effects of Acacetin-7-O-glucoside (7-ACAG). Methods: 7-ACAG was separated and its purity was analyzed. Its sedative and anti-seizure effects (1, 10, 20, and 40 mg/kg) were evaluated in male mice. Synaptic responses were acquired from area CA1 of hippocampal slices obtained from male Wistar rats. Rats were subjected to stereotaxic surgeries to allow Electroencephalographic (EEG) recordings. Functional recovery was evaluated by measuring the time rats spent in completing the motor task. Then the rats were subjected to right hemiplegia and administered 7-ACAG (40 mg/kg) 1 h or 24 h after surgery. Brains of each group of rats were prepared for histological analysis. Results: Effective sedative doses of 7-ACAG comprised those between 20 and 40 mg/kg. Latency and duration of the epileptiform crisis were delayed by this flavonoid. 7-ACAG decreased the synaptic response in vitro, similar to Gamma-aminobutyric acid (GABA) effects. The flavonoid facilitated functional recovery. This data was associated with preserved cytoarchitecture in brain cortex and hippocampus. Conclusions: 7-ACAG possesses anticonvulsive and sedative effects. Results suggest that GABAergic activity and neuroprotection are involved in the mechanism of action of 7-ACAG and support this compound’s being a potential drug for treatment of anxiety or post-operative conditions caused by neurosurgeries.
    Restorative neurology and neuroscience 08/2015; DOI:10.3233/RNN-140486
  • Restorative neurology and neuroscience 06/2015;
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    ABSTRACT: Purpose: Grasp recovery after C6-C7-spinal cord injury (SCI) requires learning "tenodesis grasp" whereby active wrist extension elicits passive thumb-to-forefinger and finger-to-palm flexion. Evidence that motor imagery (MI) promotes upper limb function after tetraplegia is growing, but whether MI potentiates grasp recovery in C6-C7-SCI individuals who have successfully learned the "tenodesis grasp" remains unknown. Methods: Six chronic stable C6-C7-SCI inpatients and six healthy control participants were included. C6-C7-SCI participants imagined grasping movements and controls visualized geometric forms for 45 minutes, three times a week for five weeks. Three separate measures taken over a five week period before the intervention formed the baseline. Intervention effects were assessed immediately after the intervention and eight weeks later. Each testing session consisted of kinematic recordings during reach-to-grasp and magnetoencephalographic (MEG) recordings during wrist extension. Results: During baseline, kinematic wrist extension angle during "tenodesis grasp" and MEG contralateral sensorimotor cortex (cSMC) activity during wrist extension were stable. Moreover, SCI participants exhibited a greater number of voxels within cSMC than controls. After MI sessions, wrist extension angle increased during "tenodesis grasp" and the number of voxels within cSMC during wrist extension decreased and became similar to controls. Conclusion: These findings provide further support for the use of MI to reinforce a compensatory grasping movement (tenodesis) and induce brain plasticity.
    Restorative neurology and neuroscience 06/2015; DOI:10.3233/RNN-140466
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    ABSTRACT: Background and Purpose: Previous studies demonstrated that administering extradural cortical stimulation (ECS) to rats during the acute phase of a photothrombotic infarct enhances motor recovery. However, the effect of ECS during the subacute phase was unknown. We aimed to evaluate the effects of ECS on motor recovery in a rat model of subacute photothrombotic stroke. Methods: Photothrombotic ischemic injury to the left sensorimotor cortex (SMC) was induced in 41 male Sprague-Dawley rats using Rose-bengal dye (20 mg/kg) and cold light. The rats were randomly divided into two groups: ECS on infarcted SMC (ECS group) and no ECS on infarcted SMC (non-stimulated group). The ECS group received continuous ECS for 14 days starting from day 5 after the stroke onset. Behavioral training with the single-pellet reaching task (SPRT) was performed daily for all of the rats from the fifth day after stroke onset. After 19 days, brain sections were immunostained to allow the quantification of infarct volumes and the evaluation of the neuronal markers. Results: The SPRT scores showed significantly faster and greater improvement in the ECS group than in the non-stimulated group. There were no significant differences in infarct size. However, in the ECS group, significantly more doublecortin-labeled cells were identified close to the penumbra region of the cerebral cortex. Conclusion: ECS in the subacute phase improved the behavior motor function in the stroke rat model, and induced a significant axonal sprouting in the peri-infarct area.
    Restorative neurology and neuroscience 03/2015; DOI:10.3233/RNN-140445
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    ABSTRACT: Purpose: The present study was conducted to determine changes in the expression of voltage-gated sodium channels (VGSCs) α-subunits after nerve injury and their relation with development of neuropathic pain. Methods: We used the crush injury model of regeneration of the sciatic nerve (Crush) and the spared nerve injury (SNI) model of neuropathic pain in the rat. Measurements of thermal and mechanical pain thresholds were performed until 3 months after injury. Real-time PCR and immunohistochemistry of VGSC α-subunits were used to evaluate the mRNA and protein expression in the DRG. Results: Both nerve injuries induced similar alterations in the VGSCs expression at 7 dpi, with upregulation of Nav1.3, and downregulation of Nav1.7, Nav1.8 and Nav1.9. These changes persisted until 28 days, when hyperalgesia was still present in SNI but not in Crush rats. At 90 days, mRNA expression of all analyzed α-subunits returned to basal levels in the Crush group. However, SNI rats still showed altered expression of VGSCs, and neuropathic pain responses. Immunohistochemical staining revealed that Nav1.8 and Nav1.9 were widely expressed in IB4-positive neurons of the DRG, relevant in pain processing. The population of neurons coexpressing each α-subunit and IB4 was also affected by the injury, more markedly after the Crush. Conclusion: Shifts in VGSCs expression occur in parallel to neuropathic pain behavior in rats early after injury, while at later times they appear to be more related to sensory nerve degeneration and regeneration processes.
    Restorative neurology and neuroscience 02/2015; 33(3). DOI:10.3233/RNN-140444